• 제목/요약/키워드: structure of knowledge

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산업별 혁신시스템과 R&D 지원서비스 : 엔유씨전자 사례를 중심으로 (Sectoral System of Innovation and R&D Support Service: Focused on the Case of NUC Electronics)

  • 김용열
    • 기술혁신학회지
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    • 제22권3호
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    • pp.362-381
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    • 2019
  • 본 논문에서는 기술혁신에 영향을 미치는 요인 중 산업별 혁신시스템과 R&D 지원서비스의 요인이 엔유씨전자의 사례에서 어떻게 작용하는지 살펴보았다. 엔유씨전자는 투입구 변경과 착즙률 개선의 기술혁신을 통해 높은 혁신성과를 달성하였다. 이는 산업별 혁신시스템의 각 구성요소가 엔유씨전자의 기술혁신과 부합하는 측면이 있었기 때문이다. 엔유씨전자의 성과향상은 자체적인 혁신노력과 함께 정부출연연구소의 R&D 지원서비스가 있었기 때문에 가능했다. 기술혁신 과정에서 제품설계와 가상실험 등 기업 스스로 해결할 수 없는 영역의 고차원적인 서비스를 받을 수 있었다. 중소기업에게 부족한 부분을 보완해주는 정부와 공공기관의 지원 역할이 중요했다고 할 수 있다. 산업별 혁신시스템의 각 구성요소별로 보면 새로운 기술기회가 많은 만큼 지속성이 낮다, 모방이 쉽고 전유성이 낮지만 복합적인 측면도 있다, 기술축적의 누적성은 비교적 높은 편이다, 외부지식의 활용 가능성이 높다, 주체와 네트워크 모두 중요한 역할을 하였다, 시장여건이 매우 유리하였다 등으로 요약될 수 있다. R&D 지원서비스의 측면에서는 직접적인 효과로서 스크류의 재질과 형상에 대한 가상실험을 통해 엄청난 시간과 비용의 절약이 이루어졌다는 점을 들 수 있다. 간접적인 효과로서는 외부지원에 의한 기술개발을 계기로 엔유씨전자의 자체적인 핵심역량이 크게 강화되었고 혁신의 선순환구조가 정착되었다는 점을 들 수 있다.

사람 뇌의 3차원 영상과 가상해부 풀그림 만들기 (Manufacture of 3-Dimensional Image and Virtual Dissection Program of the Human Brain)

  • 정민석;이제만;박승규;김민구
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1998년도 추계학술대회
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    • pp.57-59
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    • 1998
  • For medical students and doctors, knowledge of the three-dimensional (3D) structure of brain is very important in diagnosis and treatment of brain diseases. Two-dimensional (2D) tools (ex: anatomy book) or traditional 3D tools (ex: plastic model) are not sufficient to understand the complex structures of the brain. However, it is not always guaranteed to dissect the brain of cadaver when it is necessary. To overcome this problem, the virtual dissection programs of the brain have been developed. However, most programs include only 2D images that do not permit free dissection and free rotation. Many programs are made of radiographs that are not as realistic as sectioned cadaver because radiographs do not reveal true color and have limited resolution. It is also necessary to make the virtual dissection programs of each race and ethnic group. We attempted to make a virtual dissection program using a 3D image of the brain from a Korean cadaver. The purpose of this study is to present an educational tool for those interested in the anatomy of the brain. The procedures to make this program were as follows. A brain extracted from a 58-years old male Korean cadaver was embedded with gelatin solution, and serially sectioned into 1.4 mm-thickness using a meat slicer. 130 sectioned specimens were inputted to the computer using a scanner ($420\times456$ resolution, true color), and the 2D images were aligned on the alignment program composed using IDL language. Outlines of the brain components (cerebrum, cerebellum, brain stem, lentiform nucleus, caudate nucleus, thalamus, optic nerve, fornix, cerebral artery, and ventricle) were manually drawn from the 2D images on the CorelDRAW program. Multimedia data, including text and voice comments, were inputted to help the user to learn about the brain components. 3D images of the brain were reconstructed through the volume-based rendering of the 2D images. Using the 3D image of the brain as the main feature, virtual dissection program was composed using IDL language. Various dissection functions, such as dissecting 3D image of the brain at free angle to show its plane, presenting multimedia data of brain components, and rotating 3D image of the whole brain or selected brain components at free angle were established. This virtual dissection program is expected to become more advanced, and to be used widely through Internet or CD-title as an educational tool for medical students and doctors.

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In silico Design of Discontinuous Peptides Representative of B and T-cell Epitopes from HER2-ECD as Potential Novel Cancer Peptide Vaccines

  • Manijeh, Mahdavi;Mehrnaz, Keyhanfar;Violaine, Moreau;Hassan, Mohabatkar;Abbas, Jafarian;Mohammad, Rabbani
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권10호
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    • pp.5973-5981
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    • 2013
  • At present, the most common cause of cancer-related death in women is breast cancer. In a large proportion of breast cancers, there is the overexpression of human epidermal growth factor receptor 2 (HER2). This receptor is a 185 KDa growth factor glycoprotein, also known as the first tumor-associated antigen for different types of breast cancers. Moreover, HER2 is an appropriate cell-surface specific antigen for passive immunotherapy, which relies on the repeated application of monoclonal antibodies that are transferred to the patient. However, vaccination is preferable because it would stimulate a patient's own immune system to actively respond to a disease. In the current study, several bioinformatics tools were used for designing synthetic peptide vaccines. PEPOP was used to predict peptides from HER2 ECD subdomain III in the form of discontinuous-continuous B-cell epitopes. Then, T-cell epitope prediction web servers MHCPred, SYFPEITHI, HLA peptide motif search, Propred, and SVMHC were used to identify class-I and II MHC peptides. In this way, PEPOP selected 12 discontinuous peptides from the 3D structure of the HER2 ECD subdomain III. Furthermore, T-cell epitope prediction analyses identified four peptides containing the segments 77 (384-391) and 99 (495-503) for both B and T-cell epitopes. This work is the only study to our knowledge focusing on design of in silico potential novel cancer peptide vaccines of the HER2 ECD subdomain III that contain epitopes for both B and T-cells. These findings based on bioinformatics analyses may be used in vaccine design and cancer therapy; saving time and minimizing the number of tests needed to select the best possible epitopes.

비 개념에 대한 역사적, 수학적, 심리적 분석 (A Historical, Mathematical, Psychological Analysis on Ratio Concept)

  • 정은실
    • 대한수학교육학회지:학교수학
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    • 제5권4호
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    • pp.421-440
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    • 2003
  • 본 논문에서는 비 개념이 역사적으로 어떤 의미를 가지고 있으며, 비에 대한 생각이 어떻게 변화되어 왔는지 살펴본다. 또한 비에 대한 여러 가지 수학적 의미를 찾아보고, 비 개념의 본질이 어떠해야 하는지를 알아본다. 그리고 비례적 추론의 직관적 근원과 발달 과정을 찾아보고 비 개념의 심리적 측면을 분석해 봄으로써 비 개념 지도와 관련하여 교육적 시사점을 탐구한다.

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국가등록문화재로 지정된 옛 담장의 정비 양상 (A Study on Structural Maintenance of 'Old Wall' Designated as National Registered Cultural Heritage )

  • 소현수;정명석
    • 한국전통조경학회지
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    • 제41권1호
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    • pp.21-34
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    • 2023
  • 본 연구는 13개 마을 옛 담장의 국가등록문화재 지정 당시 사용된 재료와 축조법을 파악하고, 현장조사를 중심으로 정비에 따른 옛 담장의 구조별 변화 양상을 고찰하였다. 연구의 결과는 다음과 같다. 첫째, 옛 담장은 토석담 10개소와 돌담 5개소로 구성되었으며, 지정 당시 자연석 메쌓기로 막쌓은 돌담은 비슷한 형태를 유지하는 비율이 높았지만, 토석담은 사용한 돌과 줄눈 및 맞댄 면 축조법에 따라서 담장별로 다양하게 변형되었다. 둘째, 옛 담장의 정비로 인해서 변화된 구간을 추출하고 재료의 대체와 첨가, 축조법의 변형 양상을 파악하였다. 지붕부는 내구성과 가격의 효율이 높은 시멘트 기와나 석면 슬레이트로 대체되고, 우수 유입을 막고자 한식 기와에 와구토가 첨가되었다. 벽체부의 자연석은 시공 편의에 따른 발파석, 마름돌, 가공 석재로 대체되고, 보수에 시멘트 블록, 시멘트 벽돌이 사용되었으며, 시멘트 모르타르가 도포되었다. 토석담의 막쌓기가 빗쌓기로 변형되고 찰쌓기는 메쌓기로 바뀌어 경관적, 구조적 문제를 야기하였다. 또한 기초부에 시멘트 모르타르층이 시공되어 자연석 메쌓기로 유도했던 우수의 흐름을 막아버렸다. 셋째, 이러한 정비 양상은 주거공간에 배치된 옛 담장의 속성상 소유주가 일상적 훼손에 대한 비전문적 보수를 반복하고, 문화재 지정으로 인하여 정비를 담당한 수리업체가 지역 재료를 수급하기 어려우며, 옛 담장에 대한 차별성있는 수리시방서가 적용되지 않는 환경에서 기인한다고 판단된다.

창업기업의 경영성과에 있어서 컨설팅품질과 컨설턴트역량의 영향에 대한 연구: 흡수능력과 자원역량의 매개효과를 중심으로 (The Effects of Management Consulting Quality and Consultant Capability on Entrepreneurial Firms' Performance)

  • 윤기창
    • 유통과학연구
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    • 제14권5호
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    • pp.81-89
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    • 2016
  • Purpose - Prior researches have empirically focused on the effect of management consulting quality and consultant capability on entrepreneurial firms' performance. This study, however, focused on investigating the moderating role of absorptive capacity and resource capability between management consulting and entrepreneurial firms' performance. So, this study investigated the relationship among consulting quality, consultant capability, absorptive capacity, resource capability, and entrepreneurial firms' performance from the resource based view (RBV). Especially, this study focused on the mediating role of absorptive and resource capability in relational structure of entrepreneurial firms' dimensions. Research design, data, and methodology - In this study, research hypotheses and model are established by the prior researches from the fields of strategic management and entrepreneurial behavior. Concretely, H1~H4 are the relationship between consulting (consulting quality, consultant capability) and innovation (absorptive capacity, resource capability); H5 is the relationship between absorptive capacity and resource capability; and H6~H7 are the relationship between innovation (absorptive capacity, resource capability) and management performance. The data was collected 207 copies from entrepreneurial firms in South Korea. These firms were established in January 2014 and maintained by November 2015 in high-tech industry. The questionnaire was consisted of five dimensions; consulting quality, consultant capability, absorptive capacity, resource capability, and management performance. Each dimension measured multi items on a 5-point Likert scale. The hypotheses and research model are analyzed using structural equation modeling (SEM) with AMOS 22. Results - The results of this study are as follows. 1) Consulting quality significantly influenced on the absorptive capacity of entrepreneurial firms. 2) But, consultant capability did not influence on the absorptive capacity of entrepreneurial firms. 3) Consulting quality and consultant capability significantly influenced on the resource capability of entrepreneurial firms. 4) Absorptive capacity significantly influenced on the resource capability of entrepreneurial firms; 5) Absorptive capacity did not significantly influence on the management performance of entrepreneurial firms. 6) Resource capability, however, significantly influenced on the management performance of entrepreneurial firms. By these results, absorptive capacity of entrepreneurial firms had a mediating role partly among consulting quality, consultant capability, and management capability. The resource capability of entrepreneurial firms had a mediating role among consulting quality, consultant capability, and management capability, perfectly. Conclusions - According to this study, the high level of consulting quality and consultant capability may enforce the resource capability of entrepreneurial firms. It means, practically, that external knowledge is a driver for innovation, and then the innovation effects on the management performance of entrepreneurial firms. So, at the initial stage, the management consulting programs are very important to entrepreneurial firms and should be conceived as an essential element. This study may contribute to the advancement of academic in field of new start business, small business, or venture business based on resources, especially the role of absorptive capacity and resource capability between consulting programs and management performance. However, this study has some limitations. They are the measurement of consulting quality's items, cross-sectional research, and the limitation of concept and industry.

개념제시자의 특성이 고등학생의 물리 개념 변화에 미치는 영향 (The Effects of Instructors' Characteristics on the Concept Change of Korean High-School Students.)

  • 임정수;권재술
    • 한국과학교육학회지
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    • 제16권4호
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    • pp.340-350
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    • 1996
  • Knowledge is composed through the interaction between the concept structure already held by students and their experience, and learning can be said to be the active process of solving the cognitive conflict caused by this interaction. Therefore, this study consists in showing the effective learning method and finding out the elements which the teacher has to own, through examining several forms of pre-conception or mis-conception of the inertia, the force-equilibrium, the action and reaction, the heat, and the electric current, and then finding out their solution and studying student's change in science concepts. For this study, the types of concept on the five above-mentioned materials which students have were examined through the concept-classifying question paper, and the classes to which the class mode for the change of concepts applied, were practised in each different classroom by each different instructor - a professor, a scientist, a teacher, and two students, respectively. And the effect of the teaching strategy based on these classes, and each different instructor' influence on the change of concept in students. were examined. The result of my study is as follows; 1. Students have various types of pre-conception which are different from science concept, and these types of pre-conception tend to last even after learning in class. 2. The thoughts on the correct science concept of the high school third-grade students who learned the physics in the traditional teaching method, and the second grade students who don't learn the physics yet, were nearly equal those of the second grade students by receiving the physics class through the cognitive conflict course were greatly changed especially that students showed the distinct change on mechanics and electric current. 3. Students didn't show the remarkable change of the science concept on the five materials in the four kinds of experimental classes by each different instructor but in the part of mechanics, there was the distinct change between the class by professor and those by the students. This was due to the difference of the authority and the attitude of the concept demonstrator. 1) The authority, the kind attitude, and the responsibility of the expert played an important role in the correct concept-formation of mechanics part - especially in the case of the mis-conception caused by the intuitive belief. 2) In the class by instructor with the democratic teaching method, the change of concept took place more easily, because in his class students could discuss the subject freely, so that they might experience the thought course to give them the confidence on the science concept.

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Hydrogen and Ethanol Gas Sensing Properties of Mesoporous P-Type CuO

  • Choi, Yun-Hyuk;Han, Hyun-Soo;Shin, Sun;Shin, Seong-Sik;Hong, Kug-Sun
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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    • pp.222-222
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    • 2012
  • Metal oxide gas sensors based on semiconductor type have attracted a great deal of attention due to their low cost, flexible production and simple usability. However, most works have been focused on n-type oxides, while the characteristics of p-type oxide gas sensors have been barely studied. An investigation on p-type oxides is very important in that the use of them makes possible the novel sensors such as p-n diode and tandem devices. Monoclinic cupric oxide (CuO) is p-type semiconductor with narrow band gap (~1.2 eV). This is composed of abundant, nontoxic elements on earth, and thus low-cost, environment-friendly devices can be realized. However, gas sensing properties of neat CuO were rarely explored and the mechanism still remains unclear. In this work, the neat CuO layers with highly ordered mesoporous structures were prepared by a template-free, one-pot solution-based method using novel ink solutions, formulated with copper formate tetrahydrate, hexylamine and ethyl cellulose. The shear viscosity of the formulated solutions was 5.79 Pa s at a shear rate of 1 s-1. The solutions were coated on SiO2/Si substrates by spin-coating (ink) and calcined for 1 h at the temperature of $200{\sim}600^{\circ}C$ in air. The surface and cross-sectional morphologies of the formed CuO layers were observed by a focused ion beam scanning electron microscopy (FIB-SEM) and porosity was determined by image analysis using simple computer-programming. XRD analysis showed phase evolutions of the layers, depending on the calcination temperature, and thermal decompositions of the neat precursor and the formulated ink were investigated by TGA and DSC. As a result, the formation of the porous structures was attributed to the vaporization of ethyl cellulose contained in the solutions. Mesoporous CuO, formed with the ink solution, consisted of grains and pores with nano-meter size. All of them were strongly dependent on calcination temperature. Sensing properties toward H2 and C2H5OH gases were examined as a function of operating temperature. High and fast responses toward H2 and C2H5OH gases were discussed in terms of crystallinity, nonstoichiometry and morphological factors such as porosity, grain size and surface-to-volume ratio. To our knowledge, the responses toward H2 and C2H5OH gases of these CuO gas sensors are comparable to previously reported values.

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'연구 업무 전담제'를 통해 살펴보는 국립현대미술관 전시 기획의 새로운 패러다임 (New Paradigm in exhibition organization at the National Museum of Contemporary Art)

  • 최은주
    • 미술이론과 현장
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    • 제3호
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    • pp.67-84
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    • 2005
  • Since the evaluation of its intellectual activities and abilities is done by curator's capabilities, planning exhibition is very important as the final result achieved by their own knowledge, information, and research. ARPA(Advanced Research Project on Arts) is suggested as the system which enables curators responding simultaneously to the society in the times, based on its special characteristics. If this system settles well, which means that the curators at NMCA(National Museum of Contemporary Art, Korea) play their roles as the professionals in each of their fields, the goal of consolidating the status of museum as the representative national museum, and building up competent department of curators, will be achieved at the same time. To clarify above, the curators set up the various assignments of research about the types of arts such as painting, Korean painting, sculpture, installation, new-media, design, craft, photogarphy, architecture, etc. And they establish the art objects classified by the regions, such as the Northern American, Southern American, European, Asian, and other Third World countries. They elaborate art objects more on the history, the work, the artist, and the issue of contemporary art. Furthermore, when the curators devote deeper study to those research subjects, they can have the opportunities to design an exhibition upon the research. Today, the museum of art is 'The Place for Communication and Encounter', it is regarded important to share the aesthetical, creative values with current artists, and to understand mutually with the spectators. It is needed to improve the curator's work, in order to meet the demands of the times and even to advance. Because the form of 'exhibition' is the tool that reveals the identity NMCA aiming at, the motivation, the development, and the realization should be leaded by the curators, who are the mainstream of the museum. ARPA is a system for identifying the exhibition like mentioned above. The main purpose of this system is to produce synergy effect, having the researching, collecting work in liaison with planning exhibition. ARPA will be able to improve the quality of exhibition through the way of developing the exhibition, passing through the stable process in the long run. So far, I have referred to a new paradigm of the exhibition design at NMCA via ARPA. Yet, there still remain missions in reality, such as analyzing the previous exhibition and reshuffling personnel and system, which should be done. When these matters settled, these plans would be suggested practically. At this point, it is the most significant that NMCA is attempting to let others aware of the importance of exhibition planning based on research. when the ARPA and exhibition planning is conjoined together successfully, the competent exhibition will be achieved, which can offer a meaningful exhibition to the art world, strengthen infra structure thru exchanging with public museum in the region, and eventually, establish a network with museum in foreign countries.

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공사현장 근로자의 임시소방시설에 대한 집단 간 Ambivalence 차이분석 (Analysis of Ambivalence Differences among Groups for Temporary Firefighting Facilities of Workers at Construction Sites)

  • 문필재;공하성
    • 문화기술의 융합
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    • 제7권4호
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    • pp.765-778
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    • 2021
  • 이 연구는 공사현장 근로자의 임시소방시설에 대한 집단 간의 사전 지식을 비교 문제점을 도출하고 그에 맞는 개선방안을 강구하여 화재사고를 미연에 예방하는데 연구의 목적이 있다. 연구결과는 다음과 같다. 첫째, 소화기의 경우 시공사, 감리원, 협력사 근로자와 소화기 관리책임자를 지정 간 통계적으로 유의하였다. 시공사 공종별로 소화기 관리책임자를 지정이 필요하다고 응답한 소방관리자 87%, 설비감독자 70%로 차이가 있음을 알 수 있었고, 이는 근로자들이 임의로 화기 작업장으로 이동하여 배치하고 작업 후 그냥 방치하는 사례가 많기 때문에 소화기 관리책임자를 지정하고 수시로 점검하고 재배치하는 관리지정이 필요하다. 둘째, 간이소화장치의 경우 시공사, 감리원, 협력사 근로자와 간이소화장치 무단사용 시 벌칙적용 간 통계적으로 유의하였다. 셋째, 비상경보장치의 경우 시공사, 감리원, 협력사 근로자와 임시방송설비로 비상경보음 발생 적용 간 통계적으로 유의하였다. 넷째, 유도등의 경우 시공사, 감리원, 협력사 근로자와 통로유도등 및 비상조명등 연계 적용 간에는 통계적으로 유의하였다. 협력사 공종별로 피난구 유도등과 통로유도등 및 비상조명등 연계 적용은 건축근로자 65%, 전기근로자 55%가 통로유도등 및 비상조명등 연계 적용 차이가 있음을 알 수 있었다. 이는 건축물 구조상 피난구 유도등의 사각지대를 해소하기 위해서 통로유도등 및 비상조명등과 연계 적용하여 출입문의 방향을 먼 거리에서도 쉽게 구별하여 작업자가 인지하여 안전하게 대피하는 장치가 필요하다.