• Journal of the Korean Magnetic Resonance Society
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• v.24 no.3
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• pp.91-95
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• 2020

Transthyretin (TTR) is an abundant protein in blood plasma and cerebrospinal fluid (CSF), working as a homo-tetrameric complex to transport thyroxine (T₄) and a holo-retinol binding protein. TTR is well-known for its amyloidogenic property; several types of systemic amyloidosis diseases are caused by aggregation of either wild-type TTR or its variants, for which more than 100 mutations were reported to increase the amyloidogenicity of TTR. The rate-limiting step of TTR aggregation is the dissociation of a monomeric subunit from a tetrameric complex. A wide range of biochemical and biophysical techniques have been employed to elucidate the TTR aggregation processes, among which nuclear magnetic resonance (NMR) spectroscopy contributed much to characterize the structural and functional features of TTR during its aggregation processes. The present review focuses on discussing the recent advances of our understanding to the amyloidosis mechanism of TTR and to the structural features of its monomeric aggregation-prone state in solution. We expect that the present review provides novel insights to appreciate the molecular basis of TTR amyloidosis and to develop novel therapeutic strategies to treat diverse TTR-related diseases.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.268-274
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• 2003

Most currently known molecular structures were determined by X-ray crystallography or Nuclear Magnetic Resonance (NMR). These methods generate a large amount of structure data, even far small molecules, and consist mainly of three-dimensional atomic coordinates. These are useful for analyzing molecular structure, but structure elements at higher level are also needed for a complete understanding of structure, and especially for structure prediction. Computational approaches exist for identifying secondary structural elements in proteins from atomic coordinates. However, similar methods have not been developed for RNA due in part to the very small amount of structure data so far available, and extracting the structural elements of RNA requires substantial manual work. Since the number of three-dimensional RNA structures is increasing, a more systematic and automated method is needed. We have developed a set of algorithms for recognizing secondary and tertiary structural elements in RNA molecules and in the protein-RNA structures in protein data banks (PDB). The present work represents the first attempt at extracting RNA structure elements from atomic coordinates in structure databases. The regularities in the structure elements revealed by the algorithms should provide useful information for predicting the structure of RNA molecules bound to proteins.

• Journal of architectural history
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• v.7 no.4 s.17
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• pp.77-91
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• 1998

The theory of tectonic appeared in the midst of 19th century as German architects adopted new materials and structural technology, invented by creative engineers, into architectural design. This does not merely mean a technical problem but concern the redefinition of architecture in term of an aesthetic, cultural, and ontological identity. Furthermore it alluded to a desire on the part of architectural theorists to actualize artistic and spiritual goals out of new constructional necessities. Because of their complex discourse that assumed the possibility of communication between philosophical and technical aspects, between ideal and real concerns, tectonics becomes until now the most important issue in architecture. The concept of tectonic was intensively investigated by Gottfried Semper's and Karl B$\ddot{o}$tticher architectural writings. They contributed to clarify the principle aspects of tectonic within architectural, philosophical, and anthropological discourses of 19th century. Gottfried Semper stressed an understanding of how architecture took on physical form in earliest human culture. He placed great importance on the artistic expression of materials. But unlike Semper who argued the cladding of the structural frame by decorative wall system, Karl Botticher required maximum visibility of structural frame. This represents the different positions between Gottfried Semper and Karl Botticher

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.6
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• pp.229-234
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• 2014

As association between sensor networks that collect environmental information by using numberous sensor nodes and smartphones that are equipped with various sensors, many applications understanding users' context have been developed to interact users and their environments. Collected data should be stored with XML formatted metadata containing semantic information to share the collected data. In case of distance based clustering schemes, the efficiency of data collection decreases because metadata files are extended and changed as the purpose of each system developer. In this paper, we proposed a clustering scheme considering the structural similarity of metadata to reduce clustering construction time and improve the similarity of metadata among member nodes in a cluster.

• The Journal of Korean Association of Computer Education
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• v.18 no.4
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• pp.63-70
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• 2015

Program source code is a set of complex syntactic information which are expressed in text forms, and contains complex logical structures. Structural and logical complexity inside source code become barriers in applying visualization techniques shown in traditional big-data approaches when the volume of source code become over ten-thousand lines of code. This paper suggests a procedure for making visualization of structural characteristics in source code. For this purpose, this paper defines internal data structures as well as inter-procedural relationships among functions. The paper also suggests a means of outlining the structural characteristics of source code by visualizing the source codes with network forms The result of the research work can be used as a means of controling and understanding the massive volume of source code.

• Smart Structures and Systems
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• v.25 no.5
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• pp.593-604
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• 2020

Temperature may have more significant influences on structural responses than operational loads or structural damage. Therefore, a comprehensive understanding of temperature distributions has great significance for proper design and maintenance of bridges. In this study, the temperature distribution of the steel box girder is systematically investigated based on the structural health monitoring system (SHMS) of the Sutong Cable-stayed Bridge. Specifically, the characteristics of the temperature and temperature difference between different measurement points are studied based on field temperature measurements. Accordingly, the probability density distributions of the temperature and temperature difference are calculated statistically, which are further described by the general formulas. The results indicate that: (1) the temperature and temperature difference exhibit distinct seasonal characteristics and strong periodicity, and the temperature and temperature difference among different measurement points are strongly correlated, respectively; (2) the probability density of the temperature difference distribution presents strong non-Gaussian characteristics; (3) the probability density function of temperature can be described by the weighted sum of four Normal distributions. Meanwhile, the temperature difference can be described by the weighted sum of Weibull distribution and Normal distribution.

• Computers and Concrete
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• v.5 no.3
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• pp.217-241
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• 2008

In this paper, a total strain-based hysteretic material model based on MCFT is proposed for non-linear finite element analysis of reinforced concrete structures. Although many concrete models have been proposed for simulating behavior of structures under cyclic loading conditions, accurate simulations remain challenging due to uncertainties in materials, pitfalls of crude assumptions of existing models, and limited understanding of failure mechanisms. The proposed model is equipped with a fully generalized hysteresis rule and is formulated for 2D plane stress non-linear finite element analysis. The proposed model has been formulated in a tangent stiffness-based finite element scheme so that it can be used for most general finite element analysis packages. Moreover, it eliminates the need to check that tensile stresses can be transmitted across a crack. The tension stiffening model is a function of the bar orientation and any orientation can be accommodated. The proposed model has been verified with a series of experimental results of 2D RC planar panels. This study also demonstrates how parameters of the proposed model associated with cyclic damage modeling influences the pinched cyclic shear behavior.

• Architectural research
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• v.4 no.1
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• pp.1-6
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• 2002

Every year new tall buildings are being conceived, designed, and built with new schemes. Thus it is important to explore the factors that affect tall building design. Thus it is important to explore the tall building design factors. The planning and design of tall buildings require different criteria than those that exist in regular size buildings. Tall buildings are uniquely expressed by their structural systems where exterior esthetic and requirements of space drive the form and composition of the structural systems. Therefore the exploration of design factors is the key to achieve optimum building systems. Optimization as mentioned here is associated with the efficiency of the different building systems. To achieve an optimal system, there is a need for an understanding of the factors that affect on overall tall building design such as planning module, building function, lease span, floor-to-floor-height, building height (aspect ratio), structural system, environmental systems. In this paper a statistical approach will be used and will be based on data collected from the practice through a rigorous survey taken. This information is tabulated and analyzed. The major target of investigation will be lease span related to space requirement in the tall building planning. Factors related to lease spans, such as function, floor-to-floor height, planning module, building height, overall plan dimension, and plan ratio (building geometry), will be looked at carefully. IN conclusion, this approach of optimization can introduce a preliminary design guideline for tall building projects. The purpose of the paper should shed some light on the optimum tall building design criteria.

• Smart Structures and Systems
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• v.7 no.3
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• pp.229-240
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• 2011

Recent developments in Smart Structures with very large scale embedded sensors and actuators have introduced new challenges in terms of data processing and sensor fusion. These smart structures are dynamically classified as a large-scale system with thousands of sensors and actuators that form the musculoskeletal of the structure, analogous to human body. In order to develop structural health monitoring and diagnostics with data provided by thousands of sensors, new sensor informatics has to be developed. The focus of our on-going research is to develop techniques and algorithms that would utilize this musculoskeletal system effectively; thus creating the intelligence for such a large-scale autonomous structure. To achieve this level of intelligence, three major research tasks are being conducted: development of a Bio-Inspired data analysis and information extraction from thousands of sensors; development of an analytical technique for Optimal Sensory System using Structural Observability; and creation of a bio-inspired decision-making and control system. This paper is focused on the results of our effort on the first task, namely development of a Neuro-Morphic Engineering approach, using a neuro-symbolic data manipulation, inspired by the understanding of human information processing architecture, for sensor fusion and structural diagnostics.

• International Journal of High-Rise Buildings
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• v.6 no.1
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• pp.1-9
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• 2017

The Pertamina Energy Tower (PET) and Manhattan West North Tower (MWNT) are two supertall towers recently designed and engineered by Skidmore, Owings & Merrill (SOM). The structural system for both buildings consists of an interior reinforced concrete core and a perimeter moment frame system, which is primarily structural steel. As is typical for tall towers with both concrete and steel elements, staged construction analysis was performed in order to account for the long term effects of creep and shrinkage, which result in differential shortening between the interior concrete core and steel perimeter frame. The particular design of each tower represents two extremes of behavior; PET has a robust connection between the perimeter and core in the form of three sets of outriggers, while the perimeter columns of MWNT do not reach the ground, but are transferred to the core above the base. This paper will present a comparison of the techniques used during the analysis and construction stages of the design process with the goal of understanding the differences in structural behavior of these two building systems in response to the long term effects of creep and shrinkage. This paper will also discuss the design and construction techniques implemented in order to minimize the differential shortening between the interior and exterior over the lifespan of these towers.