• Honam Mathematical Journal
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• v.34 no.1
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• pp.85-92
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• 2012

Our purpose of this paper is to introduce and study some properties related to approximations by points. More precisely, we introduce strongly AP, strongly AFP, strongly ACP, and strongly WAP properties which are stronger than AP, AFP, ACP, and WAP respectively. Also they are weaker than strongly Fr$\acute{e}$chet property. And we study general properties and topological operations on such spaces and give some examples.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.145-149
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• 1997

STEP AP224 includes the information of machining feature and tolerances. Machining features are machined from raw material. Tolerance constrain feasible methods of manufacture, strongly influence the cost of manufacture. And tolerances influence the machining process. We need to decide the precedence between features .tool radius and tool direction for minimum tool changes. This paper deals with the method of decision of precedence between features and process parameters using feature information and tolerances in STEP AP224.

• Journal of applied mathematics & informatics
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• v.6 no.1
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• pp.253-264
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• 1999

In this paper we introduce and study a new class of vari-ational inequalities which are called the generalized strongly nonlin-ear quasi-variational inequalities. An algorithm for finding the ap-proximate solution of generalized strongly nonlinear quasi-variational inequalities is also given. These variational inequalities include the previously known classes of variational inequalities as special cases.

• Honam Mathematical Journal
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• v.31 no.2
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• pp.233-237
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• 2009

In this paper, we show that: (1) every strongly ${\omega}$-monolithic space X with countable fan-tightness is Fr$\'{e}$chet-Urysohn; (2) a direct proof of that X is Lindel$\"{o}$f when $C_p$(X) is Fr$\'{e}$chet-Urysohn; and (3) X is Lindel$\"{o}$f when X is paraLindel$\"{o}$f and $C_p$(X) is AP. (3) is a generalization of the result of [8]. And we give two questions related to Fr$\'{e}$chet-Urysohn and AP properties on $C_p$(X).

• Molecules and Cells
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• v.19 no.3
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• pp.452-457
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• 2005

The adaptor protein (AP) complexes are involved in membrane transport of many proteins. There are 3 AP complexes in C. elegans unlike mammals that have four. To study the biological functions of the AP-3 complexes of C. elegans, we sought homologues of the mouse and human genes that encode subunits of the AP-3 complexes by screening C. elegans genomic and EST sequences. We identified single copies of homologues of the ${\mu}3$, ${\sigma}3$, ${\beta}3$ and ${\delta}$ genes. The medium chain of AP-3 is encoded by a single gene in C. elegans but two different genes in mammals. Since there are no known mutations in these genes in C. elegans, we performed RNAi to assess their functions in development. RNAi of each of the genes caused embryonic and larval lethal phenotypes. APM-3 is expressed in most cells, particularly strongly in spermatheca and vulva. We conclude that the products of the C. elegans ${\mu}3$, ${\sigma}3$, ${\beta}3$ and d genes are essential for embryogenesis and larval development.

• Korean Journal of Medicinal Crop Science
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• v.18 no.6
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• pp.398-404
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• 2010

Complementary and alternative medicines are considered as a promising research field to develop new therapies for various allergic diseases. In this study, we investigated the anti-allergic effect of Agrimonia pilosa Ledeb (AP) by using passive cutaneous anaphylaxis in mice and its mechanism of action in mast cells. The extract of AP reversibly inhibited degranulation in RBL-2H3 cells and bone marrow-derived mast cells (BMMCs). AP also suppressed the passive cutaneous anaphylaxis inducing by IgE and antigen (Ag) in a dose-dependent manner. In the study to find its mechanism of action, AP inhibited the phosphorylation of Syk kinase, a pivotal protein which is regulated by Src-family kinase for activation of mast cells. In addition, AP also suppressed activation of Akt and Erk1/2 that are critical for the production of cytokines in mast cells. The results strongly suggest that AP exerts anti-allergic activity in vitro and in vivo through the inhibition of activation of Syk in mast cells.

• Bulletin of the Korean Mathematical Society
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• v.43 no.2
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• pp.299-307
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• 2006

The following results ale extended from P-injective rings to AP-injective rings: (1) R is left self-injective regular if and only if R is a right (resp. left) AP-injective ring such that for every finitely generated left R-module M, $_R(M/Z(M))$ is projective, where Z(M) is the left singular submodule of $_{R}M$; (2) if R is a left nonsingular left AP-injective ring such that every maximal left ideal of R is either injective or a two-sided ideal of R, then R is either left self-injective regular or strongly regular. In addition, we answer a question of Roger Yue Chi Ming [13] in the positive. Let R be a ring whose every simple singular left R-module is Y J-injective. If R is a right MI-ring whose every essential right ideal is an essential left ideal, then R is a left and right self-injective regular, left and right V-ring of bounded index.

• The Journal of the Acoustical Society of Korea
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• v.18 no.5
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• pp.3-11
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• 1999

The conventional stereophonic acoustic echo cancellers need two adaptive filters to estimate one channel echo signal. Since the two channel signals are strongly correlated, the ESR of the input signals is considerably increased whatever the input signals may be. This causes the slow convergence of the adaptive filter for echo cancellation. To speed up the convergence, the AP algorithm is frequently used for the stereophonic acoustic echo canceller although there isn't a fast version for 2-channel case. The AP algorithm can be approximated with the Gram-Schmidt orthogonalization and a TDL structure. We propose a two channel algorithm for stereophonic acoustic echo canceller with the approximated AP algorithm.

• Journal of Ginseng Research
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• v.39 no.2
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• pp.155-161
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• 2015

Background: Korean ginseng is an ethnopharmacologically valuable herbal plant with various biological properties including anticancer, antiatherosclerosis, antidiabetic, and anti-inflammatory activities. Since there is currently no drug or therapeutic remedy derived from Korean ginseng, we developed a ginsenoside-enriched fraction (AP-SF) for prevention of various inflammatory symptoms. Methods: The anti-inflammatory efficacy of AP-SF was tested under in vitro inflammatory conditions including nitric oxide (NO) production and inflammatory gene expression. The molecular events of inflammatory responses were explored by immunoblot analysis. Results: AP-SF led to a significant suppression of NO production compared with a conventional Korean ginseng saponin fraction, induced by both lipopolysaccharide and zymosan A. Interestingly, AP-SF strongly downregulated the mRNA levels of genes for inducible NO synthase, tumor necrosis factor-${\alpha}$, and cyclooxygenase) without affecting cell viability. In agreement with these observations, AP-SF blocked the nuclear translocation of c-Jun at 2 h and also reduced phosphorylation of p38, c-Jun N-terminal kinase, and TAK-1, all of which are important for c-Jun translocation. Conclusion: Our results suggest that AP-SF inhibits activation of c-Jun-dependent inflammatory events. Thus, AP-SF may be useful as a novel anti-inflammatory remedy.

• Journal of Microbiology
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• v.45 no.6
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• pp.499-504
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• 2007

A new antagonistic strain of actinomycete, designated AP19-2, was isolated from the feces of giant pandas inhabiting the Foping National Nature Reserve in China. Cultural characteristic studies strongly suggested that this strain is a member of the genus Streptomyces. The nucleotide sequence of the 16S rRNA gene of strain AP19-2 evidenced profound similarity (97-99 %) with other Streptomyces strains. Two pure active molecules were isolated from a fermentation broth of Streptomyces sp. strain AP19-2 via extraction, concentration, silica gel G column chromatography, and HPLC. The chemical structures of the two related compounds (referred to as chromomycin $A_2$ and chromomycin $A_3$) were established on the basis of their Infrared spectra (IR), High Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS), and Nuclear Magnetic Resonance (NMR) data, and by comparison with published data.