• Journal of Ship and Ocean Technology
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• v.4 no.2
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• pp.38-57
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• 2000

This paper deals with reliability analysis of specially orthotropic plates subjected to transverse lateral pressure loads by using Monte Carlo simulation method. The plates are simply supported around their all edges and have a low short span to plate depth ratio with rectangular plate shapes. Various levels of reliability analyses of the plates are performed within the context of First-Ply-Failure(FPF) analysis such as ply-/laminate-level reliability analyse, failure tree analysis and sensitivity analysis of basic design variables to estimated plate reliabilities. In performing all these levels of reliability analyses, the followings are considered within the Monte Carlo simulation method: (1) input parameters to the strengths of the plates such as applied transverse lateral pressure loads, elastic moduli, geometric including plate thickness and ultimate strength values of the plates are treated as basic design variables following a normal probability distribution; (2) the mechanical responses of the plates are calculated by using simplified higher-order shear deformation theory which can predict the mechanical responses of thick laminated plates accurately; and (3) the limit state equations are derived from polynomial failure criteria for composite materials such as maximum stress, maximum strain, Tsai-Hill, Tsai-Wu and Hoffman.

• YAKHAK HOEJI
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• v.55 no.6
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• pp.466-472
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• 2011

NF-E2-related factor 2 (Nrf2), a master regulator of antioxidant genes in animals, has been associated with the resistance of cancer cells to several cytotoxic chemotherapeutics. Bortezomib, a reversible inhibitor of the 26S proteasome, is a novel class anti-cancer therapeutics approved for the treatment of refractory multiple myeloma. However, the molecular mechanism of drug-resistance remains elusive. In the present study, bortezomib sensitivity has been investigated in Nrf2 knockdown ovarian cancer cells. When Nrf2 expression is stably repressed using interfering RNA expression, bortezomib-induced apoptosis and cell death were significantly enhanced compared to nonspecific RNA control cells. Knockdown cells showed elevated expression in the catalytic subunit PSMB5, PSMB6, and PSMB7 compared to the control, and failed to induce heme oxygenase-1 expression following bortezomib treatment. These indicate that differential proteasome levels and altered expression of stress-response genes could be underlying mechanisms of bortezomib sensitization in Nrf2-inhibited ovarian cancer cells.

• Smart Structures and Systems
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• v.12 no.5
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• pp.523-545
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• 2013

Piezoelectric and dielectric behaviors of a piezoceramic patch adhesively centered on a carbon composite plate are identified using a robust multi-objective optimization procedure. For this purpose, the patch piezoelectric stress coupling and blocked dielectric constants are automatically evaluated for a wide frequency range and for the different identifiable behaviors. Latters' symmetry conditions are coded in the design plans serving for response surface methodology-based sensitivity analysis and meta-modeling. The identified constants result from the measured and computed open-circuit frequencies deviations minimization by a genetic algorithm that uses meta-model estimated frequencies. Present investigations show that the bonded piezoceramic patch has effective three-dimensional (3D) orthotropic piezoelectric and dielectric behaviors. Besides, the sensitivity analysis indicates that four constants, from eight, dominate the 3D orthotropic behavior, and that the analyses can be reduced to the electromechanically coupled modes only; therefore, in this case, and if only the dominated parameters are optimized while the others keep their nominal values, the resulting piezoelectric and dielectric behaviors are found to be transverse-isotropic. These results can help designing piezoceramics smart composites for various applications like noise, vibration, shape, and health control.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.07a
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• pp.471-474
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• 2000

A flat type microgas sensor was fabricated on the p-type silicon wafer with low stress S $i_3$ $N_4$, whose thickness is 2${\mu}{\textrm}{m}$ using MEMS technology and its characteristics were investigated. W $O_3$thin film as a sensing material for detection of N $O_2$gas was deposited using a tungsten target by sputtering method, followed by thermal oxidation at several temperatures (40$0^{\circ}C$~$600^{\circ}C$) for one hour. N $O_2$gas sensitivities were investigated for the W $O_3$thin films with different annealing temperatures. The highest sensitivity when operating at 20$0^{\circ}C$ was obtained for the samples annealed at $600^{\circ}C$. As the results of XRD analysis, the annealed samples had polycrystalline phase mixed with triclinic and orthorhombic structures. The sample exhibit higher sensitivity when the system has less triclinic structure. The sensitivities, $R_{gas}$ $R_{air}$ operating at 20$0^{\circ}C$ to 5 ppm N $O_2$of the sample annealed at $600^{\circ}C$ were approximately 90. 90.

• Current Optics and Photonics
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• v.4 no.4
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• pp.293-301
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• 2020

In this paper we propose and theoretically analyze a monolithic multiparametric sensor consisting of a superstructure of surface-relief waveguide Bragg gratings (WBGs), a micro-machined diaphragm, and a cantilever beam. Diaphragms of two different configurations, namely circular and square, are designed and analyzed separately for pressure measurement. The square diaphragm is then selected for further study, since it shows relatively higher sensitivity compared to the circular one, as it incurs more induced stress when any pressure is applied. The cantilever beam with a proof mass is designed to enhance the sensitivity for acceleration measurement. A unique mathematical method using coupled-mode theory and the transfer-matrix method is developed to design and analyze the shift in the Bragg wavelength of the superstructure configuration of the gratings, due to simultaneously applied pressure and acceleration. The effect of temperature on the wavelength shift is compensated by introducing another Bragg grating in the superstructure configuration. The measured sensitivities for pressure and acceleration are found to be 0.21 pm/Pa and 6.49 nm/g respectively.

• Korean Journal of Metals and Materials
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• v.49 no.3
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• pp.211-220
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• 2011

To improve the low ductility and high strain-rate sensitivity in Sn-Bi based solder alloys, the influences of the minor additions of alloying elements (Ag, Mn, In) were investigated. The strain-stress curves of various Sn-40Bi(-X) alloys, including a pre-suggested Sn-40Bi-0.1Cu composition were measured using a tensile testing machine. As a result, the elongation and ultimate tensile strength (UTS) values were compared. The small addition (0.5 wt.%) of Ag significantly enhanced the ductility and high strain-rate sensitivity of the alloys at strain rates of $10^{-4}$ to $10^{-2}\;s^{-1}$ mainly due to the increase and refinement of eutectic lamellar structures. The microstructure change increased the area of grain boundaries, thus ameliorating the grain boundary sliding mode. It was also found that Mn is an effective element in enhancing the ductility, especially at the strain rates of $10^{-3}$ to $10^{-2}\;s^{-1}$ The enhancement is likely attributed to the fine and homogeneous microstructure in the alloys containing Mn.

• Geomechanics and Engineering
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• v.24 no.3
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• pp.295-305
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• 2021

In this study, design charts for estimating consolidation settlement are proposed according to finite strain consolidation theory using a nonlinear constitutive relationship equation. Results of parametric sensitivity analysis shows that the final settlement, initial height, and initial void ratio exerted the greatest effect, and the coefficients of the void ratio-effective-stress. Proposed design charts were analyzed for three regions using a representative constitutive relationship equation that enables major dredged-reclaimed construction sites in Korea. The regional design charts can be calculated accurately for the final settlement because it is applied directly to the numerical analysis results, except for reading errors. A general design chart applicable to all marine clays is proposed through correlation analysis of the main parameters. A final self-weight consolidation settlement with various initial void ratios and initial height conditions should be estimated easily using the general design chart and constitutive relationship. The estimated final settlement using the general design chart is similar to the results of numerical analysis obtained using finite strain consolidation theory. Under an overburden pressure condition, design charts for estimating consolidation settlement are proposed for three regions in Korea.

• Coupled systems mechanics
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• v.12 no.5
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• pp.429-444
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• 2023

The comprehension and structural modeling of masonry constructions is fundamental to safeguard the integrity of built cultural assets and intervene through adequate actions, especially in earthquake-prone regions. Despite the availability of several modeling strategies and modern computing power, modeling masonry remains a great challenge because of still demanding computational efforts, constraints in performing destructive or semi-destructive in-situ tests, and material uncertainties. This paper investigates the shear behavior of masonry walls by applying a plane-stress FE continuum model with the Modified Masonry-like Material (MMLM). Epistemic uncertainty affecting input parameters of the MMLM is considered in a probabilistic framework. After appointing a suitable probability density function to input quantities according to prior engineering knowledge, uncertainties are propagated to outputs relying on gPCE-based surrogate models to considerably speed up the forward problem-solving. The sensitivity of the response to input parameters is evaluated through the computation of Sobol' indices pointing out the parameters more worthy to be further investigated, when dealing with the seismic assessment of masonry buildings. Finally, masonry mechanical properties are calibrated in a probabilistic setting with the Bayesian approach to the inverse problem based on the available measurements obtained from the experimental load-displacement curves provided by shear compression in-situ tests.

• Journal of Microbiology and Biotechnology
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• v.34 no.7
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• pp.1443-1451
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• 2024

Weizmannia coagulans can be used as a starter strain in fermented foods or as a probiotic. However, it is salt-sensitive. Here, W. coagulans genomes were compared with the genomes of strains of Bacillus species (B. licheniformis, B. siamensis, B. subtilis, and B. velezensis) that were isolated from fermented foods and show salt tolerance, to identify the basis for the salt-sensitivity of W. coagulans. Osmoprotectant uptake (Opu) systems transport compatible solutes into cells to help them tolerate osmotic stress. B. siamensis, B. subtilis, and B. velezensis each possess five Opu systems (OpuA, OpuB, OpuC, OpuD, and OpuE); B. licheniformis has all except OpuB. However, W. coagulans only has the OpuC system. Based on these findings, the opuA and opuB operons, and the opuD and opuE genes, were amplified from B. velezensis. Expression of each of these systems, respectively, in W. coagulans increased salt-tolerance. W. coagulans expressing B. velezensis opuA, opuD, or opuE grew in 10.5% NaCl (w/v), whereas wild-type W. coagulans could not grow in 3.5% NaCl. The salt resistance of B. subtilis was also increased by overexpression of B. velezensis opuA, opuB, opuD, or opuE. These results indicate that the salt-susceptibility of W. coagulans arises because it is deficient in Opu systems.

• Science of Emotion and Sensibility
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• v.15 no.4
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• pp.527-540
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• 2012

We examined the effect of delayed and immediate rewards on short- and long-term memory performance depending on the level of stress. It has been demonstrated that delaying feedback during memory tasks could lead to better retention than presenting it immediately (a.k.a., feedback delay benefit or delay-retention effect). In this study, we manipulated stress level(high-stress or low-stress), reward-timing(delayed or immediate reward), reward-existence(500 or 0 won) and retrieval-timing(delayed or immediate memory test). On the high-stress learning condition, one week later, the number of correct answers with delayed-rewards were significantly more than that of delayed-no-rewards but there was not any difference between immediate-rewards and immediate-no-rewards. On the other hand, in the high-stressful immediate memory test, immediate-rewards only had a positive effect on memory performance. The results indicated that delayed rewards improved long-term memory performance by promoting memory consolidation and the sensitivity to rewards was higher under the high-stress condition.