• Biomolecules & Therapeutics
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• v.20 no.4
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• pp.418-424
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• 2012

Repeated stress induces corticosterone release. However, it is not clear that stress results in further elevation of corticosterone levels, and the roles of released corticosterone to aggravate stress-related symptoms are also not clear. This study investigated whether neuronal modulation was induced in the amygdala after two kinds of stress, that is, such as electric shock and corticosterone injection. It was found that stress by electric shock decreased the expression of tyrosine hydoroxylase (TH) in the amygdala while the expression of pERK was increased. However, there is no difference in the expressions of TH and pERK in the frontal cortex compared with those of the control group. The level of corticosterone was significantly increased in the serum after stress. To determine the effect of corticosterone on the induction of anxiety and the expression of TH, the rats received corticosterone (20 mg or 40 mg/kg i.p.) for 1 day, 1 week, 2 weeks and 3 weeks, respectively. The spent time in open arms of the EPM (elevated plus maze) test was significantly decreased after 1 week, 2 weeks and 3 weeks. The time spent in open arms of the EPM test after repeated injections of corticosterone was significantly decreased in a dose-dependent manner. The expression of TH in the amygdala was reduced after following repeated corticosterone treatment for 2 weeks and 3 weeks. Collectively, this study suggests that corticosterone has a major role in the induction of anxiety and the modulation of TH expression, at least, in the amygdala.

• Geomechanics and Engineering
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• v.24 no.3
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• pp.253-266
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• 2021

The sufficient early strength of primary support is crucial for stabilizing the surroundings, especially for the tunnels constructed in soil. This paper introduces the Steel-Concrete Composite Support System (SCCS), a new support with high bearing capacity and flexible, rapid construction. The bearing characteristics and construction performance of SCCS were systematically studied using a three-dimensional numerical model. A sensitivity analysis was also performed. It was found that the stress of a π-shaped steel arch decreased with an increase in the thickness of the wall, and increased linearly with an increase in the rate of stress release. In the horizontal direction of the arch section, the nodal stresses of the crown and the shoulder gradually increased in longitudinally, and in the vertical direction, the nodal stresses gradually decreased from top to bottom. The stress distribution at the waist, however, was opposite to that at the crown and the shoulder. By analyzing the stress of the arch section under different installation gaps, the sectional stress evolution was found to have a step-growth trend at the crown and shoulder. The stress evolution at the waist is more likely to have a two-stage growth trend: a slow growth stage and a fast growth stage. The maximum tensile and compressive stresses of the secondary lining supported by SCCS were reduced on average by 38.0% and 49.0%, respectively, compared with the traditional support. The findings can provide a reference for the supporting technology in tunnels driven in loess.

• Transactions of Materials Processing
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• v.8 no.4
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• pp.384-392
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• 1999

In metal forming, there are problems with recurrent geometric characteristics without explicitly prescibed boundary conditions. In such problems, so-called recurrent boundary conditions must be introduced. In this paper, as a practical application of the proposed method, the precision cold forging of a helical gear has been simulated by a three-dimensional rigid-plastic finite element method and compared with the experiment. The application of recurrent boundary conditions to helical gear forging analysis is proved to be effective and valid. the elastic stress analysis of the die for helical gear forging has been calculated by using the nodal force at the final stage obtained from the rigid-plastic finite element analysis. In order to obtain more precise gear products, the elastic analysis of the die after release of punch and the elastic spring-back analysis of product after ejection have been performed, and the final dimension of the computational product has been in good agreement with that of the experimental product.

• Biomedical Science Letters
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• v.16 no.1
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• pp.65-67
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• 2010

The endoplasmic reticulum (ER) is a multifunctional intercellular organelle in which several posttranslational modification steps occurred such as protein folding, lipid biosynthesis, calcium storage and release. Perturbations that disrupt ER homeostasis lead to the misfolding of proteins in the ER lumen and up-regulation of ER signaling pathway called the unfolded protein response (UPR). Here, we have demonstrated that ageing changes the expression of ER chaperone and associated ER membrane kinases of IRE1, ATF6 and PERK.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.05a
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• pp.47-52
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• 2004

Springback comes from the release of residual stress after forming. The control of phenomenon is especially important in the sheet metal forming since there are no other practical methods available to correct the dimensional inaccuracy from springback. Therefore the accurate predication before the die machining has been a long goal in the Held of sheet metal forming. The aim of the present study is to enhance the prediction capability of finite element(FE) analysis for the springback phenomenon. For this purpose FE analysis for V-bending has been carried out with the commercial programs, LS-DYNA. The FE analysis results have been validated through the comparison of experimental. The experimental results measured directly by the strain gauge have given the confidence to FEA.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1998.03a
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• pp.179-184
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• 1998

Semi-solid forging can be applied in industry only with enough knowledge of the effects of the forming parameters related with the process and their exact control which can be obtained by empirical or numerical methods. In the current study, the effects of process variables on semi-solid forging are discussed based on mainly numerical results. Die preheating temperature, initial solid fraction of the workpiece, and die velocity were selected as process variables, and numerical analyses using a rigid-thermoviscoplastic finite element approach that considered the release of latent heat due to phase change were carried out. In the analyses, a proposed flow stress material characterization and a solid fraction updating algorithm were employed. The obtained results from numerical analysis are discussed and are compared with some experimental observations.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1999.03b
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• pp.237-240
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• 1999

The elastic stress analysis of the die for helical gear forging has been calculated by using the nodal force at the final stage obtained from the rigid-plastic finite element analysis. In order to obtain more precise gear products. the elastic analysis of the die after release of punch and the elastic spring-back analysis of product after ejection have been performed and the final dimension of the computational product has been in good agreement with that of the experimental product.

• Progress in Superconductivity and Cryogenics
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• v.2 no.2
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• pp.20-25
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• 2000

A CICC type superconducting bus-line electrically connecting a superconducting magnet to a power supply is cooled down to low temperature under the external magnetic field during operation. The thermal contraction during the cooling may be constrained by the supports which are installed to protect the bus-line from Lorenz magnetic forces. This constrained contraction causes thermal stresses in the bus-line to release thermal contraction. The minimum stress conditions in the bus-line may be optimized by controlling the supporting arrangement considering the thermal contraction and the external field. The analytical method to find optimal supports arrangement was suggested by using the beam theory, and numerical calculation using commercial code was performed to verify the suggested analytical optimization method.

• International Journal of Precision Engineering and Manufacturing
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• v.9 no.4
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• pp.66-70
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• 2008

The propagation of a mixed-mode crack in soda-lime silica glass is modeled by movable cellular automata (MCA). In this model, a special fracture criterion is used to describe the process of crack initiation and propagation. The results obtained using the MCA criterion are compared to those obtained from other crack initiation criteria, The crack resistance curves and bifurcation angles are determined for various loading angles. The MCA results are in close agreement with results obtained using the maximum circumferential tensile stress criterion.

• KCI Concrete Journal
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• v.12 no.1
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• pp.113-120
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• 2000

This paper presents the behavior and strengthening effect of reinforced concrete rectangular beams strengthened using CFRP sheets with different strengthening level. In general, normally strengthened beams are failed by interfacial shear failure (delamination) within concrete, instead of by tensile failure of the CFRP sheets. The delamination occurred suddenly and the concrete cover cracked vertically by flexure was spalled off due to the release energy. The strengthened beams were stiffer than the control beam before and after reinforcement yielding. The ultimate load considerably increased with an increase of strengthening level, while the ultimate deflection significantly decreased. The tensile force of CFRP sheets and average shear stress of concrete at delamination failure were curvilinearly proportional to the strengthening level. Therefore, the increment of ultimate load obtained by strengthening was curvilinearly proportional to the strengthening level. The averaged horizontal shear stress of concrete at the interface ranges between (equation omitted) and (equation omitted) (in kg/$\textrm{cm}^2$) depending on strengthening level.