Expressional Variation of Endoplasmic Reticulum Stress Signaling Factors in Mouse Tissues by Aging

  • Han, Song-Yi (Department of Anatomy, School of Medicine, Chungnam National University) ;
  • Jin, Cho-Yi (Department of Anatomy, School of Medicine, Chungnam National University) ;
  • Kwon, Ki-Sang (Department of Anatomy, School of Medicine, Chungnam National University) ;
  • Yun, Eun-Young (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
  • Goo, Tae-Won (Department of Sericulture and Entomology, National Institute of Agriculture Science and Technology, R.D.A.) ;
  • Kim, Seung-Whan (Department of Emergency Medicine, Chungnam National University Hospital) ;
  • Kwon, O-Yu (Department of Anatomy, School of Medicine, Chungnam National University)
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  • 권오유 (충남대학교 의학전문대학원 해부학교실)
  • Received : 2010.01.22
  • Accepted : 2010.02.14
  • Published : 2010.03.31

Abstract

The endoplasmic reticulum (ER) is a multifunctional intercellular organelle in which several posttranslational modification steps occurred such as protein folding, lipid biosynthesis, calcium storage and release. Perturbations that disrupt ER homeostasis lead to the misfolding of proteins in the ER lumen and up-regulation of ER signaling pathway called the unfolded protein response (UPR). Here, we have demonstrated that ageing changes the expression of ER chaperone and associated ER membrane kinases of IRE1, ATF6 and PERK.

Keywords

References

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