• Journal of Korean Society for Atmospheric Environment
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• v.9 no.E
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• pp.390-396
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• 1993

An acid deposition Engineering Model was developed by parameterizing the role of organics in the photochemistry and by simplifying liquid phase processes. This Engineering Model concept was implemented onto the Sulfur Transport Eulerian Model II(STEM II). The Engineering Model version of the STEM(STEM-ENG) saves the CPU time over 50 times and produces the upper and lower limit values prodicted by the original STEM II. These limits obtained by the STEM-ENG can be used to estimate the importance of organics in acid and O3 production. The STEM-ENG with 30,000 grid points can be run on any recent PCs to give a quick assessment of air quality.

• International Journal of Stem Cells
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• v.15 no.3
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• pp.334-345
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• 2022

Background and Objectives: Flavonoids form the largest group of plant phenols and have various biological and pharmacological activities. In this study, we investigated the effect of a flavonoid, 3, 4'-dihydroxyflavone (3, 4'-DHF) on osteogenic differentiation of equine adipose-derived stromal cells (eADSCs). Methods and Results: Treatment of 3, 4'-DHF led to increased osteogenic differentiation of eADSCs by increasing phosphorylation of ERK and modulating Reactive Oxygen Species (ROS) generation. Although PD98059, an ERK inhibitor, suppressed osteogenic differentiation, another ERK inhibitor, U0126, apparently increased osteogenic differentiation of the 3, 4'-DHF-treated eADSCs, which may indicate that the effect of U0126 on bone morphogenetic protein signaling is involved in the regulation of 3, 4'-DHF in osteogenic differentiation of eADSCs. We revealed that 3, 4'-DHF could induce osteogenic differentiation of eADSCs by suppressing ROS generation and co-treatment of 3, 4'-DHF, U0126, and/or N-acetyl cysteine (NAC) resulted in the additive enhancement of osteogenic differentiation of eADSCs. Conclusions: Our results showed that co-treatment of 3, 4'-DHF, U0126, and/or NAC cumulatively regulated osteogenesis in eADSCs, suggesting that 3, 4'-DHF, a flavonoid, can provide a novel approach to the treatment of osteoporosis and can provide potential therapeutic applications in therapeutics and regenerative medicine for human and companion animals.

• Journal of Korean Institute of Industrial Engineers
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• v.41 no.5
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• pp.488-498
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• 2015

Research on stem cells can be divided into three categories : pluripotent stem cell, adult stem cell, and induced pluripotent stem cell. Technology life cycle (TLC) on research stage is analyzed for the three stem cell categories based on diffusion model. Three diffusion models-logistic, Bass, and Bass model with integration constant (BMIC)-are applied to the number of articles related to each stem cell category in SCOPUS lists. Two different parameter estimation methods is used for each of logistic and Bass model. Results show that (1) the current year, 2015, lies in growth period at pluripotent stem cell and adult stem cell, and lies in growth period or maturity period at induced pluripotent stem cell. (2) Model fitness is the highest at BMIC model. (3) Imitation effect works best at the research area of induced pluripotent stem cell.

• Journal of Engineering Education Research
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• v.11 no.2
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• pp.90-101
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• 2008

This study was conducted to develop pre-engineering educational program model based on STEM integration approach. To accomplish this purpose literature review and content validity ratio survey were carried out. The main results of this study were as follows: First, the conceptual model of STEM integration approach was constituted. Second, the conceptual model of pre-engineering educational program model based on STEM integration approach was proposed. Third, the formation steps of inquiry project activity, problem solving activity, and creative engineering design activity were developed to structure the educational program.

• BMB Reports
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• v.48 no.2
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• pp.68-80
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• 2015

G protein-coupled receptors (GPCRs) are a large class of transmembrane receptors categorized into five distinct families: rhodopsin, secretin, adhesion, glutamate, and frizzled. They bind and regulate 80% of all hormones and account for 20-50% of the pharmaceuticals currently on the market. Hundreds of GPCRs integrate and coordinate the functions of individual cells, mediating signaling between various organs. GPCRs are crucial players in tumor progression, adipogenesis, and inflammation. Several studies have also confirmed their central roles in embryonic development and stem cell maintenance. Recently, GPCRs have emerged as key players in the regulation of cell survival, proliferation, migration, and self-renewal in pluripotent (PSCs) and cancer stem cells (CSCs). Our study and other reports have revealed that the expression of many GPCRs is modulated during the generation of induced PSCs (iPSCs) or CSCs as well as during CSC sphere formation. These GPCRs may have crucial roles in the regulation of self-renewal and other biological properties of iPSCs and CSCs. This review addresses the current understanding of the role of GPCRs in stem cell maintenance and somatic reprogramming to PSCs or CSCs.

• Journal of Korean Society of Forest Science
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• v.89 no.5
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• pp.634-644
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• 2000

Sterba's theory that stem number maintaining maximum basal area per ha is maximum stem number of a stand, had been applied to data from 103 temporary plots in even-aged Pinus densiflora stands in Kangwon province, Korea and a maximum stem number and mortality model was prepared. DBH growth model which estimates dbh with the independent variables of stem number per ha and dominant height shows the good statistical performance, and explains well differences in dbh growth that would be caused by stem number per ha and dominant height. Basal area model derived from dbh growth model also explains well differences in basal area according to stem number per ha and dominant height. The maximum stem number curve, which is derived from stem number per ha at maximum basal area for dominant height and dbh, represents well the upper range of stem number per ha observed. And maximum stand density index derived from the maximum stem number model for dbh could be used for the index of maximum potential density of a stand. The maximum stem number model and maximum stand density index in this study were not based on stand data with maximum density but based on the temporary data from stands with various density. This maximum stem number model can be applied to the estimation of mortality and maximum potential volume.

• Journal of Korean Society of Forest Science
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• v.83 no.1
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• pp.63-74
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• 1994

One of the essential factors to estimate the stem and stand growth is to correctly portray a stem form (profile). It is also required to numerically approximate a stem form in order to dynamically grasp and represent a stand growth. A whole stem form seems to be a conical form but a stem outline at various positions tapers off differently. Accordingly it is difficult to model a whole stand form with single taper equation. A stem taper equation with different coefficients on each subinterval can be useful tools to accurately portray a stem form. This article presents the derivation method of individual stem taper curve using spline function. It is also in this paper aimed to study how a stand taper curve car, be derived from the population of single stem taper curve in a stand. These taper equations numerically formulated enable to dynamically represent and prognosticate the development process of a stand and prepare the foundation of variety on growth model study and rational forest planning model.

• BMB Reports
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• v.55 no.5
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• pp.205-212
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• 2022

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating chronic disorder characterized by suprapubic pain and urinary symptoms such as urgency, nocturia, and frequency. The prevalence of IC/BPS is increasing as diagnostic criteria become more comprehensive. Conventional pharmacotherapy against IC/BPS has shown suboptimal effects, and consequently, patients with end-stage IC/BPS are subjected to surgery. The novel treatment strategies should have two main functions, anti-inflammatory action and the regeneration of glycosaminoglycan and urothelium layers. Stem cell therapy has been shown to have dual functions. Mesenchymal stem cells (MSCs) are a promising therapeutic option for IC/BPS, but they come with several shortcomings, such as immune activation and tumorigenicity. MSC-derived extracellular vesicles (MSC-EVs) hold numerous therapeutic cargos and are thus a viable cell-free therapeutic option. In this review, we provide a brief overview of IC/BPS pathophysiology and limitations of the MSC-based therapies. Then we provide a detailed explanation and discussion of therapeutic applications of EVs in IC/BPS as well as the possible mechanisms. We believe our review will give an insight into the strengths and drawbacks of EV-mediated IC/BPS therapy and will provide a basis for further development.

• Journal of agriculture & life science
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• v.46 no.6
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• pp.43-49
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• 2012

This study was conducted to develop a stem volume table for the Robinia pseudoacacia using stem taper equations. Specifically, Kozak's model was used in the estimation of each model parameter. The fitness of the estimated model was statistically verified and results of the residual analysis were found significant. Therefore, this model is considered applicable in the preparation of stem volume table for R. pseudoacacia. Furthermore, volume with bark and without bark table were developed based on the bark thickness estimation equation. The bark thickness estimation equation was also statistically significant, The stem volume table developed for R. pseudoacacia, which was first in Korea, is vital in managing these forests.

• Journal of agriculture & life science
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• v.44 no.4
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• pp.1-7
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• 2010

Data was collected to develop equation for predicting stemp taper for Carpinus laxiflora in Jeju Experimental Forests. The Models tested for choosing the best-fit equations were Max & Burkhart's model, Kozak's model, and Lee's model. Performance of the equations in predicting stem diameter at a specific point along a stem was evaluated with fit and validation statistics and distribution of residuals on predicted values. In result, all the three models gave slightly better values of fitting statistics. In plotting residuals against predicted diameter, Max & Burkhart's model showed underestimation in predicting small diameter and Lee's Model did the same in predicting small diameter. Based on the above analysis of the three models in predicting stem taper, Kozak's model was chosen for the best-fit stem taper equations, and its parameters were given for C. laxiflora. Kozak's model was used to develop a stem volume table of outside bark for C. laxiflora.