• Title/Summary/Keyword: spot exposure

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Optical Stimulation and Pacing of the Embryonic Chicken Heart via Thulium Laser Irradiation

  • Chung, Hong;Chung, Euiheon
    • Current Optics and Photonics
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    • v.3 no.1
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    • pp.1-7
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    • 2019
  • Optical stimulation provides a promising alternative to electrical stimulation to selectively modulate tissue. However, developing noninvasive techniques to directly stimulate excitable tissue without introducing genetic modifications and minimizing cellular stress remains an ongoing challenge. Infrared (IR) light has been used to achieve optical pacing for electrophysiological studies in embryonic quail and mammalian hearts. Here, we demonstrate optical stimulation and pacing of the embryonic chicken heart using a pulsed infrared thulium laser with a wavelength of 1927 nm. By recording stereomicroscope outputs and quantifying heart rates and movements through video processing, we found that heart rate increases instantly following irradiation with a large spot size and high radiant exposure. Targeting the atrium using a smaller spot size and lower radiant exposure achieved pacing, as the heart rate synchronized with the laser to 2 Hz. This study demonstrates the viability of using the 1927 nm thulium laser for cardiac stimulation and optical pacing, expanding the optical parameters and IR lasers that can be used to modulate cardiac dynamics.

Assessment of Di (2-ethylhexyl) Phthalate Exposure by Urinary Metabolites as a Function of Sampling Time

  • Park, Moon-Seo;Yang, Yun-Jung;Hong, Yeon-Pyo;Kim, Sang-Yon;Lee, Yong-Pil
    • Journal of Preventive Medicine and Public Health
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    • v.43 no.4
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    • pp.301-308
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    • 2010
  • Objectives: In most DEHP exposure assessment studies, single spot urine sample was used. It could not compare the exposure level among studies. Therefore, we are going to represent the necessity of selection of proper sampling time of spot urine for assessing the environmental DEHP exposure, and the association urinary DEHP metabolites with steroid hormones. Methods: We collected urine and plasma from 25 men. The urine sampling times were at the end of the shift (post-shift) and the next morning before the beginning of the shift (pre-shift). Three metabolites of DEHP {mono(2-ethylhexyl) phthalate [MEHP], mono-(2-ethyl-5-hydroxyhexyl)phthalate [MEHHP], and mono(2-ethyl-5-oxohexyl)phthalate [MEOHP]} in urine were analyzed by HPLC/MS/MS. Plasma luteinzing hormone, follicle stimulating hormone, testosterone, and $17{\beta}$- estradiol were measured at pre-shift using a ELISA kit. A log-transformed creatinine-adjusted urinary MEHP, MEHHP, and MEOHP concentration were compared between the post- and pre-shift. The Pearson’s correlation was calculated to assess the relationships between log-transformed urinary MEHP concentrations in pre-shift urine and hormone levels. Results: The three urinary metabolite concentrations at post-shift were significantly higher than the concentrations in the pre-shift (p<0.0001). The plasma hormones were not significantly correlated with log-transformed creatinine - adjusted DEHP metabolites. Conclusions: To assess the environmental DEHP exposure, it is necessary to select the urine sampling time according to the study object. There were no correlation between the concentration of urinary DEHP metabolites and serum hormone levels.

The Study on Clinical Conditions and Skin Dose of Upper-Gastrointestinal X-ray Fluoroscopy (위장 X선 투시검사에 따른 실태 및 선량에 관한 연구)

  • Kim, Sung-Chul;Ahn, Sung-Min;Jang, Sang-Sup
    • Journal of radiological science and technology
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    • v.30 no.1
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    • pp.7-12
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    • 2007
  • This study examined present conditions of upper-gastrointestinal X-ray fluoroscopy and patient skin dose. The authors elected 21 equipments to check the X-ray equipment and exposure factor of fluoroscopy & spot exposure in university hospitals, hospitals, and clinics where perform upper-gastrointestinal X-ray fluoroscopy more than five times every day in Incheon areas. The amount of patient's skin dose during upper-gastrointestinal X-ray fluoroscopy was measured by ionization chamber.

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Application of a Wire code in Domestic Residential EMF Studies (국내 거주환경에서의 전자기장 노출평가를 위한 Wire code의 타당성에 관한 연구)

  • Tak, Sang-Woo;Kim, Hyun;Kim, Rohko
    • Journal of Environmental Health Sciences
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    • v.26 no.3
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    • pp.55-60
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    • 2000
  • Wire codes, introduced by Wertheimer and Leeper, are interesting largely because several case-control studies have reported associations between them and certain types of cancers, including childhood leukemia. This paper is concerned with the reliability of wire codes as a surrogate for residential electric and magnetic field, divided into four categories based on the electrical wiring within 40m of homes. To examine the correlation between spot measurements and wire codes, EMF was measured by using HI-3604 and classified by wire codes. The correlation between long-transformed RMS of magnetic field and wire codes was 0.81. But the correlation between log-transformed RMS of electric field and wire codes was 0.27. The results led us to determine a four category from of the Wertheimer and Leeper code that 1) may be useful in domestic epidemiological studies and 2) is not suitable for electric field exposure. Thus, the critical point of exposure assessment in residential magnetic field is to classify a wire code precisely.

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A Characteristics of Temperature of the Local Tissue in the Human Body under Local Exposure of Electromagnetic Wave (전자파(電磁波)에 노출(露出)된 생체(生體)의 국소부위(局所部位)의 온도(溫度) 특성(特性))

  • Park, Ju-Tae
    • Journal of the Korean Society of Industry Convergence
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    • v.5 no.4
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    • pp.321-327
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    • 2002
  • There has been an increase in the public concern about possible health risks by electromagnetic exposure from mobile phones. Recently, increase in the use among young children of portable telephones public concern regarding potential health hazards due to a hot spot appearing inside the infant head, has been growing. Since the biological hazards due to RF exposure are caused mainly by a temperature-rise in tissue, the effect of localized SAR for portable telephones should also be related to the temperature-rise in the human head. In this paper, it was measured that in the actual use of portable telephone the temperature of the local tissue in the human-head change. As a result, it should be noted that the mean temperature of human-body and localized tissue is rising from beginning call. However the temperature variation of localized tissue is recovered rapidly as normal temperature, although the mean temperature of human-body rising continuously at ending call of portable telephone.

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An Evaluative Study on ESD(Entrance Surface Dose) by Posture Changes for Fluoroscopy (투시 검사 시 체위 변화에 따른 입사표면선량의 평가 연구)

  • Yang, Hae-Doo;Hong, Seon-Sook;Park, Eun-Seong;Seong, Min-Sook;Ha, Dong-Yoon
    • Korean Journal of Digital Imaging in Medicine
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    • v.13 no.4
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    • pp.177-183
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    • 2011
  • This study intends to investigate patients' exact exposure doses by comparatively measuring ESD (Entrance Surface Dose) with the DAP meter, which excludes scattered rays, and ESD with the Xi multifunction meter, which includes scattered rays, by posture changes for Esophagography test and UGI test. The materialwere examined through Sonialvision-SafireII SPEC overtube system. ESD was measured by using the DAP meter, and as a tool to measure ESD including scattered rays on the plane of incidence of human phantom, the Xi multifunction meter was used. The average fluoroscopic time of Esophagography test was 4.192 minutes and the average number of images was 47.7, while the average fluoroscopic time of UGI test was 6.881 minutes and the average number of images was 37.8. The ratios of the incident dose of DAP meter and the ESD of Xi meter were calculated bydividing the fluoroscopic time and the number of images by each posture change. As for Esophagography test, the dose increased by 21.6~55.5% in the fluoroscopic test and by 4.8~24.7% in the spot test. In the front spot test, however, the does increased by as little as 5.3%. As for UGI test, the dose increased by 21.1~49.5% in the fluoroscopic test and by 10.1~34.9% in the spot test. It is expected that measuring doses in consideration of scattered rays by posture changes will be an important index in evaluating and managing patients' exact exposure doses for each test above. Furthermore, it is judged that this sort of study is inevitable and desirable to reduce patients' exposure doses after all.

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Real-time Beam Exposure Time Control of Holographic Data Storage (홀로그래픽 저장장치의 실시간 광 노출시간 제어)

  • Han, Cho-Lok;Kim, Nak-Yeong;Song, Hee-Chan;Lim, Sung-Yong;Park, No-Cheol;Park, Young-Pil;Yang, Hyun-Seok
    • Transactions of the Society of Information Storage Systems
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    • v.6 no.2
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    • pp.63-67
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    • 2010
  • Holographic data storage system is one of next generation high density optical memories. Thereby storing multiple data pages using multiplexing method in one spot, we can achieve high store density and fast access time. However, for uniform writing, we must control exposure time properly by the change of writing material characteristics. Many studies have been investigated about exposure time scheduling. However, once it is decided, we cannot change the scheduled time. Therefore, it is hard to obtain uniform data intensity. In this study, we propose exposure time control method using additional red beam as the monitoring signal. Through reconstructed red beam intensity in real time, we can adjust exposure time by the writing condition change. We construct compensation method mathematically and verify the feasibility of proposed method through the experiments.

The investigation of the exposure dose reduction of the Staff according to the Lead Curtain installation in EVAR(Endovascular Aneurysm Repair) surgical operation using C-arm (C-arm을 이용한 EVAR(Endovascular Aneurysm Repair) 시술시 Lead Curtain 설치에 따른 Staff의 피폭선량 감소에 대한 연구)

  • Yoo, In Woung;Chung, Jea Yeon;Lee, Kwan Seob
    • Korean Journal of Digital Imaging in Medicine
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    • v.14 no.2
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    • pp.33-38
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    • 2012
  • In EVAR procedure using long time C-arm, we studied exposure dose reduction and effeciency through measuring surgical staff's ESD by installing lead curtain operating table next to. The height 3 the spot (50cm, 100cm, 150cm) dose was measured on 2 locations for 600sec in the X-ray radiation considering the surgical staff's movement. To install the curtains, we compared before and after the dose. As a result, it can confirm that dose of the installation former of 50cm height and after is reduced about 75% and 91% in 2 locations. In 100cm height, the reduction of the dose was a bit confirmed. There as to dose value, measured on 150cm height the installation former and after was nearly no change. This research examined the exposure dose about the radiation of the surgical staff during EVAR procedure in which the operation time is the long time. It was implemented in the object that it reduces the radiation exposure. It could confirm the certain effect of the experimental result exposure dose reduction In EVAR procedure using long time C-arm, we studied exposure dose reduction and effeciency through measuring surgical staff's ESD by installing lead curtain operating table next to. The height 3 the spot (50cm, 100cm, 150cm) dose was measured on 2 locations for 600sec in the X-ray radiation considering the surgical staff's movement. To install the curtains, we compared before and after the dose. As a result, it can confirm that dose of the installation former of 50cm height and after is reduced about 75% and 91% in 2 locations. In 100cm height, the reduction of the dose was a bit confirmed. There as to dose value, measured on 150cm height the installation former and after was nearly no change. This research examined the exposure dose about the radiation of the surgical staff during EVAR procedure in which the operation time is the long time. It was implemented in the object that it reduces the radiation exposure. It could confirm the certain effect of the experimental result exposure dose reduction.

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Proteomics Analysis of Early Salt-Responsive Proteins in Ginseng (Panax ginseng C. A. Meyer) Leaves (초기 염류 스트레스 반응 인삼 잎 단백질체 분석)

  • Kim, So Wun;Min, Chul Woo;Gupta, Ravi;Jo, Ick Hyun;Bang, Kyong Hwan;Kim, Young-Chang;Kim, Kee-Hong;Kim, Sun Tae
    • Korean Journal of Medicinal Crop Science
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    • v.22 no.5
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    • pp.398-404
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    • 2014
  • Salt stress is one of the major abiotic stresses affecting the yield of ginseng (Panax ginseng C. A. Meyer). The objective of this study was to identify bio-marker, which is early responsive in salt stress in ginseng, using proteomics approach. Ginseng plants were exposed to 5 ds/m salt concentration and samples were harvested at 0, 6, 12 and 18 hours after exposure. Total proteins were extracted from ginseng leaves treated with salt stress using Mg/NP-40 buffer and were separated on high resolution 2-DE. Approximately $1003{\pm}240$ (0 h), $992{\pm}166$ (6 h), $1051{\pm}51$ (12 h) and $990{\pm}160$ (18 h) spots were detected in colloidal CBB stained 2D maps. Among these, 8 spots were differentially expressed and were identified by using MALDI-TOF/TOF MS or/and LC-MS/MS. Ethylene response sensor-1 (spot GL 1), nucleotide binding protein (spot GL 2), carbonic anhydrase-1 (spot GL 3), thylakoid lumenal 17.9 kDa protein (spot GL 4) and Chlorophyll a/b binding protein (spot GL 5, GL 6) were up-regulated at the 12 and 18 hour, while RuBisCO activase B (spot GL 7) and DNA helicase (spot GL 8) were down-regulated. Thus, we suggest that these proteins might participate in the early response to salt stress in ginseng leaves.

A Study on the Central Bank's Foreign Exchange Market Intervention Strategies with OTC Currency Option Market (중앙은행의 OTC 통화옵션시장을 활용한 외환시장 개입 전략에 관한 연구)

  • Jae-Kwan Park
    • Korea Trade Review
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    • v.47 no.2
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    • pp.103-120
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    • 2022
  • This paper studies the possibility of options as an instrument for central bank to intervene foreign exchange market. As opposed to spot transaction or forward transaction, which impacts spot exchange rate only once, currency options can continuously resist a directional speculative pressure on spot market due to the dynamic delta hedging of OTC currency options market maker. This research also analyzes whether and how central banks can use currency options to lower exchange rate volatility and maintain (implicit) target zones in foreign exchange markets. It argues that short position rather than long position in options will result in market makers dynamically hedging their long option exposure in a stabilizing manner, consistent with the first objective. Selling a "Strangle" allows a central bank to increase the credibility of its commitment to a target zone, and could have a lower expected cost than spot market interventions. However, this strategy also exposes the central bank to an unlimited loss potential. Therefore these kinds of intervention strategies must be used in the short run and temporarily.