• 대한교통학회지
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• 제34권1호
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• pp.81-94
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• 2016

교통신호를 가변 운영하는 실시간신호제어시스템은 방향별 움직임 포화도 추정을 위해 이론 기반 모형을 활용하나, 현장구축 실무에선 지침 부재로 모형에 고려되지 않은 운영상황에도 시스템을 설치하여 왔다. 본 연구는 서울시 실시간신호제어시스템 서버 운영 이력자료를 활용하여 교통조건, 기하구조 조건, 검지기 설치위치 등 현장여건에 따른 실시간신호제어시스템 포화도 모형의 포화도 추정 패턴을 진단한다. 총 476,505 신호주기 이력자료를 분석하여 직진 움직임 포화도를 진단한 결과 (1) 검지기가 모든 직진차로에 설치될 때 일부차로에 표본 설치되는 상황보다 포화도 추정이 안정적으로 판단되고, (2) 가로변버스전용차로가 존재하는 경우는 오히려 검지기를 일부 차로 표본 설치하는 것이 안정적으로 분석되며, (3) 공유차로 포함 차로군 검지기가 활용되는 경우 차량간섭으로 인해 포화도 추정이 정상적이지 않은 것으로 분석되고, (4) 검지기가 전용차로에 설치되더라도 공유차로에 인접한 경우도 차량간섭에 지속 영향 받아 포화도 추정이 어렵고, (5) 하루 24시간 중 특정시간은 교통흐름 속성에 따라 포화도 추정이 안정적이지 않을 수 있다는 내용이 진단되었다. 이러한 진단결과를 종합하여 향후 포화도 추정모형 개발단계 및 시스템 현장구축 단계에서 참조 가능한 기술발전 방향을 제언한다.

• 대한치과교정학회지
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• 제25권6호
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• pp.715-722
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• 1995

Orthodontic tooth movement in response to orthodontic force results from actions of osteoclasts and osteeoblasts in the cell level. Convincing evidence has now been provided to support the view that osteoclasts are derived from mononuclear cells that originate in the bone marrow or other hematopoietic organs and they migrate to the bones via vascular routes. Nitric oxide(NO), which accounts for the biological properties of endothelium-derived relaxing factor(EDRF), is the endogenous stimulator of soluble guanylate cylase. The discovery of the formation of nitric oxide(NO) from L-arginine in mammalian tissues and its biological roles has, in the last 7 years, thrown new light onto many areas of research. Data from experiments in vitro showed that N-metyl-L-arginine(L-NMA) and L-nitro-L- arginine(L-NAME) are competitive inhibitors of nitric oxide synthase. This study suggest that the multinucleated cells in our culture have characteristics of osteoclasts and that the potential bone cell activity of nitric oxide in vitro may be mediated in part by stimulation of marrow mononuclear cells to form osteoclast-like cells. Bone marrow cells were obtaineed from tibia of 19-days old chick embryo. After sacrifice, tibia was quickly dissected and the bone were then split to expose the medullary bone. The cells were attached for 4 hours and the nonadherent cells were collected. Marrow cells weere cultured in 96-well plate in medium 199. To examine the number of TRAP-positive multinucleated cells(MNCs), $10^{-8}\;M\;Vit=D_3$ and various concentration of L-NMA and L-NAME weere added at the beginning of cultures and with each medium change. After 7 days of culture. tartrate-resistant acid phosphatase(TRAP) staining was performed for microscopic evaluation. Cells haying more than three nuclei per cell were counted as MNCs. The obsrved results were as follows;1. 1,25-dihydroxyvitamine $D_3$ stimulated the osteoclast-like multinucleated cells in cultures of chick embryo bone marrow. 2. Nitric oxide synthase inhibitors(NOSI ; N-NMA, N-NAME) stimulated the osteoclast-like cells in cultures of chick embry bone marrow. 3. 1,25-dihydroxyvitamine$D_3$ and nitric oxide synthase inhibitors did not appear to have additive effect on the generation of TRAP-positive MNCs. These results suggest that nitric oxide synthase inhibitors may stimulate the osteoclast-like multinucleated cell formation and fusion in cultures of chick bone marrow.

• 재무관리연구
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• 제24권1호
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• pp.1-27
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• 2007

본 연구에서는 1998년부터 2002년 동안 주식분할을 실시한 과거 거래소 상장기업을 대상으로 장기성과를 분석하였다. 장기성과는 Event-time 포트폴리오 접근방식으로 측정되어지는 BHAR과 CAAR을 이용하였고 또한 Calendar-time 포트폴리오 접근방식으로 1요인 CAPM 모형과 3요인 모형을 이용하였다. 분석결과 주식분할의 공시월 부근에서 유의적인 양(+)의 초과수익률을 발견할 수 있었다. 이러한 결과는 기존 국내 연구들에서 밝혀진 바와 같이 주식분할의 공시효과가 존재한다는 것을 재확인 한 것이다. 하지만 이후 기간별 BHAR과 CAAR 모두 유의적인 음(-)의 초과수익률이 나타났으며, 이러한 결과는 Calendar-time 포트폴리오 접근방식인 1요인 CAPM 모형과 3요인 모형에서도 재확인 할 수 있었다. 분할비율에 따른 BHAR과 CAAR을 분석한 결과 분할비율이 높은 기업군도 주식분할 이후 여전히 음(-)의 초과수익률이 나타났으며 주식분할 이전 보다 이후에 영업성과가 더 악화되는 것으로 나타났다. 따라서 주식분할이 기업의 수익성이 개선된다는 신호로 보기에는 무리가 있었다. 배당성향의 증감에 따라 표본을 분류하여 장기성과를 분석한 결과에서 두 표본 간에 뚜렷한 차이를 발견할 수 없었다. 본 연구의 결과를 통하여 볼 때 주식분할은 한국 주식시장에서 단기적으로는 주가에 양(+)의 영향을 미치고 있지만 장기적으로는 주식분할이 주가에 미치는 영향은 없는 것으로 판단된다.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2001년도 발생공학 국제심포지움 및 학술대회 발표자료집
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• pp.37-43
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• 2001

1. About fifty thousand of cattle embryos were transferred and 16000 ET-calves were born in 1999. Eighty percents of embryos were collected from Japanese Black beef donors and transferred to dairy Holstein heifers and cows. Since 1985, we have achieved in bovine in vitro fertilization using immature oocytes collected from ovaries of slaughterhouse. Now over 8000 embryos fertilized by Japanese Black bull, as Kitaguni 7~8 or Mitsufuku, famousbulls as high marbling score of progeny tests were sold to dairy farmers and transferred to their dairy cattle every year. 2. Embryo splitting for identical twins is demonstrated an useful tool to supply a bull for semen collection and a steer for beef performance test. According to the data of Dr. Hashiyada(2001), 296 pairs of split-half embryos were transferred to recipients and 98 gave births of 112 calves (23 pairs of identical twins and 66 singletons). 3. A blastomere-nuclear-transferred cloned calf was born in 1990 by a joint research with Drs. Tsunoda, National Institute of Animal Industry (NIAI) and Ushijima, Chiba Prefectural Farm Animal Center. The fruits of this technology were applied to the production of a calf from a cell of long-term-cultured inner cell mass (1988, Itoh et al, ZEN-NOH Central Research Institute for Feed and Livestock) and a cloned calf from three-successive-cloning (1997, Tsunoda et al.). According to the survey of MAFF of Japan, over 500 calves were born until this year and a glaf of them were already brought to the market for beef. 4. After the report of "Dolly", in February 1997, the first somatic cell clone female calves were born in July 1998 as the fruits of the joint research organized by Dr. Tsunoda in Kinki University (Kato et al, 2000). The male calves were born in August and September 1998 by the collaboration with NIAI and Kagoshima Prefecture. Then 244 calves, four pigs and a kid of goat were now born in 36 institutes of Japan. 5. Somatic cell cloning in farm animal production will bring us as effective reproductive method of elite-dairy- cows, super-cows and excellent bulls. The effect of making copy farm animal is also related to the reservation of genetic resources and re-creation of a male bull from a castrated steer of excellent marbling beef. Cloning of genetically modified animals is most promising to making pig organs transplant to people and providing protein drugs in milk of pig, goat and cattle. 6. Farm animal cloning is one of the most dreamful technologies of 21th century. It is necessary to develop this technology more efficient and stable as realistic technology of the farm animal production. We are making researches related to the best condition of donor cells for high productivity of cloning, genetic analysis of cloned animals, growth and performance abilities of clone cattle and pathological and genetical analysis of high rates of abortion and stillbirth of clone calves (about 30% of periparutum mortality). 7. It is requested in the report of Ministry of Health, labor and Welfare to make clear that carbon-copy cattle(somatic cell clone cattle) are safe and heathy for a commercial market since the somatic cell cloning is a completely new technology. Fattened beef steers (well-proved normal growth) and milking cows(shown a good fertility) are now provided for the assessment of food safety.

• Archives of Plastic Surgery
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• 제35권3호
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• pp.261-266
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• 2008

Purpose: The incidence of skin cancer is increasing throughout the world including Asian countries such as Korea. Still there are only limited reports of the clinical features of skin cancer in Korea, especially in the fields of plastic surgery. This study is to demonstrate the recent clinical trends of skin cancer and the treatment of skin cancer in Korea by analyzing a single institution's experience. Methods: During a 11-year period, 370 patients visited our department for the excision of skin cancer. Data of the patients such as histopathologic diagnosis, primary site of the tumor, age and sex of the patient, operative methods were reviewed retrospectively. Results: We had 370 patients, 215 men and 155 women. The ages ranged from 10 to 95 years with a mean of 58.8 years. A total of 143 patients were diagnosed as basal cell carcinoma, while 100 were malignant melanoma, 80 were squamous cell carcinoma, 17 were dermatofibrosarcoma protuberans, and 30 were other miscellaneous skin cancers. Local flaps were the most frequently used reconstructive method after wide excision of the cancer, which was followed by primary closure, split-thickness skin graft, free flap and full-thickness skin graft. Conclusion: There was a gradual increase in the incidence of skin cancer after the year 2000. Basal cell carcinoma had the highest incidence which frequently involved the sun-exposed regions in the old ages. Malignant melanoma showed a relatively high incidence compared with other previous studies in Korea. The extremities were the most frequent location for malignant melanoma. Clinical features of other various skin cancers were also reported in this study. The reconstructive method highly depends on the primary site of the cancer, while local flaps were the mostly used operative technique.

• 아시안잔디학회지
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• 제26권2호
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• pp.135-139
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• 2012

Creeping bentgrass 는 골프장의 티나 퍼팅그린 그리고 경기장과 같이 집중관리가 요구되는 곳에 가장 많이 사용되는 잔디의 종류중 하나이다. 골프장에서 계속해서 발생하는 디봇과 같은 피해는 골프장을 관리하는데 있어서 가장 큰 장애요인중 하나이다. 디봇피해를 회복하기 위한 많은 연구결가가 선행 되었음에도 불구하고, 질소의 유형에 따른 디봇피해의 회복에 대해서는 그 연구결과가 제한적이다. 본 연구는 creeping bentgrass 에 발생한 디봇 피해에 대한 질소의 유형별 효과에 대해 알아보기 위해서 수행되었다. 11가지 질소가 creeping bentgrass 'Penncross' 에 시비되었다. 첫번째 시비처리 이전에 일정한 단위규격당 디봇피해가 만들어 졌으며 피해가 생긴 빈자리에 원토양이 채워졌다. 실험기간동안 잔디의 색과 질이 평가되었다. 질소의 분해속도에 따른 효과는 디봇피해를 회복시키거나 creeping bentgrass 생육에 대해 영향을 미치지는 않았다. 총 4번에 걸쳐 시비한 urea 처리구는 질소가 시비되지 않은 대조구와 비교했을때 디봇의 회복이나 creeping bentgrass 생육에 대해 차이가 나타나지 않았다. 디봇피해에 대한 회복과 creeping bentgrass 생육에 대해 polyon 제품군, 특히 polyon mini (41-0-0)가 가장 좋은 효과를 보여 주었다. 본 실험결과 입자의 지름이 작은 완효성질소가 입자의 지름이 큰 완효성질소나 속효성질소 보다 creeping bentgrass 에 발생한 디봇피해의 회복에 좋은 효과를 나타냈다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.5011-5017
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• 2016

Background: Cervical cancer is a major public health problem worldwide. There have been several studies indicating that risk is associated with geographic location and that the incidence of cervical cancer has changed over time. In Thailand, incidence rates have also been found to be different in each region. Methods: Participants were women living or having lived in upper Northern Thailand and subjected to cervical screening at Maharaj Nakorn Chiang Mai Hospital between January 2010 and December 2014. Generalized additive models with Loess smooth curve fitting were applied to estimate the risk of cervical cancer. For the spatial analysis, Google Maps were employed to find the geographical locations of the participants' addresses. The Quantum Geographic Information System was used to make a map of cervical cancer risk. Two univariate smooths: x equal to the residency duration was used in the temporal analysis of residency duration, and x equal to the calendar year that participants moved to upper Northern Thailand or birth year for participants already living there, were used in the temporal analysis of the earliest year. The spatial-temporal analysis was conducted in the same way as the spatial analysis except that the data were split into overlapping calendar years. Results: In the spatial analysis, the risk of cervical cancer was shown to be highest in the Eastern sector of upper Northern Thailand (p-value <0.001). In the temporal analysis of residency duration, the risk was shown to be steadily increasing (p-value =0.008), and in the temporal analysis of the earliest year, the risk was observed to be steadily decreasing (p-value=0.016). In the spatial-temporal analysis, the risk was stably higher in Chiang Rai and Nan provinces compared to Chiang Mai province. According to the display movement over time, the odds of developing cervical cancer declined in all provinces. Conclusions: The risk of cervical cancer has decreased over time but, in some areas, there is a higher risk than in the major province of Chiang Mai. Therefore, we should promote cervical cancer screening coverage in all areas, especially where access is difficult and/or to women of lower socioeconomic status.

• 대한교통학회지
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• 제10권1호
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• pp.55-62
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• 1992

교통수요는 교통정책 및 교통시설 계획의 수립 및 평가에 중요한 영향을 미치게 되므로 교통수요의 예측은 교통연구에서 중요한 부문을 차지하고 있다. 도로밑에 설치된 전자차량감지기(Electronic Vehicle Detector)로부터 자동 수집된 링크 교통량 자료(Traffic Counts)를 주요 입력자료로 이용하여 계획지역의 기종점 통행표(Origin Destination Trip Matrix)를 작성할 수 있는 기법 들이 최근 수년동안 많이 발달하게 되었다. 이러한 새로운 기법들은 가구조사(Home Inteview), 노변면접조사(Road-Side Interview)등을 토하여 조사된 자료를 기초로하는 전통적은 4단계 교통수요추정방법(Conventional 4-Stage Estimation Method)-통행발생(Generation), 통행분포(Distribution), 수단선택(Modal Split), 교통배분(Assignment)-과 비교하여 첫째로 정확도가 높은 링크 교통량 자료를 별도의 조사를 거치지 않고서도 수집이 가능하기 때문에 조사비용이 거의 들지 않아도 되어 경제적이고, 둘째로 전통적인 수요예측방법들에서 요구되어지는 복잡한 모형수립 및 계수조정(Parameter Calibration)이 필요하지 않아 간편하고 셋째로 오래전에 작성된 기종점 통행표를 단순히 링크 교통량 자료만을 이용하여 쉽게 보완할 수 있어 지속적인 자료의 축적(Data Age-ing)이 가능하며 더 나아 가서 소위 연속적인 교통 계획 및 교통시설관리(Continuous Transport Planning and Management)를 가능케 하는 등의 여러 장점 때문에 많은 주목을 받아 오고 최근 몇 년이 꾸준히 실무에 유용하게 적용이 되고 있는 실정이다. 본 연구는 링크 교통량자료를 이용하여 기종점 통행표를 작성하기 위하여 개발된 기존의 여러 기법들 가운데 특히 용량제약조건(Capacity-Restrained Condition)하에서 기존의 방법들을 상호 검토한 후 Wardrop의 교통망 평형원칙(Wardrop's First Network Equilibrium Principle)을 만족하는 새로운 추정기법을 제의하고 이의 시험결과를 논의하는 것을 주요내용으로 한다. 링크 교통량 자료를 이용하여 기종점 통행표를 작성하는 기법들의 근본 목표는 조사된 링크 교통량(Ob-served Traffic Counts)에 가장 근접한 교통망 통행 배정 링크 교통량(Assigned Link Volumes)을 재현(Re-producing)할 수 있는 기종점 통행표들 중에서 최적의 기종점 통행표를 발견하는 것이다. 따라서 교통망에서 통행자의 여행 경로 배정을 가장 잘 반영할 수 있는 현실적인(Realistic) 교통망 통행 배정 모형(Net-work Traffic Assignment Model)의 선택은 중요한 요소가 되며 특히 교통망에 교통체증(Traffic Conges-tion)이 심할 경우 교통망 통행자 평형조건(Network Traffic Equilibrium Condition)을 고려하기 위한 특별한 처리가 요구되어진다. 본 연구는 Whllumsen(Hall, Van Vliet and Willumsen, 1980)에 의하여 개발된 ME2(Maximum Entropy Matrix Estimation)기법에서 반복식 추정방법(Sequential Estimation Method)을 사용할 경우 Wardrop의 평형조건을 만족하는 기종점 통행표를 구할 수 없다는 단점을 극복하기 위한 방안으로서 엔트로피 극대화문제와 교통망 평형 조건(Entropy Maximisation and Network Equilibrium Condition)의 두 문제를 동시에 해결할 수 있는 새로운 수식모형과 이를 풀기 위한 알고리즘(Simultaneous Solution Algorithm)을 제의하였다. 제의된 수식모형과 알고리즘을 예제 교통망(Example Network)을 이용한 시험하고 그 결과를 ME2 의 반복식 추정 방법으로부터 구한 기종점 통행표와 비교 검토하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8573-8578
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• 2016

Background: This study was guided by principles of the theoretical system of evidence-based medicine. In particular, when searching for evidence of breast cancer, a measuring scale is an instrument for evaluating curative effects in accordance with the laws and characteristics of medicine and exploring the establishment of a system for medically assessing curative effects. At present, there exist few tools for evaluating curative effects. Patient-reported outcomes (PROs) refer to outcomes directly reported by patients (without input or explanations from doctors or other intermediaries) with respect to all aspects of their health. Data obtained from PROs provide evidence of treatment effects. Materials and Methods: In accordance with the tenets of theoretical medicine and ancient medical theory regarding breast cancer, principles for developing a PRO scale were established, and a theoretical model was developed and a literature review was performed, items from this pool were combined and split, and an initial scale was constructed. After a pilot survey and additional modifications, a pre-questionnaire scale was formed and used in a field investigation. After the application of statistical methods, the item pool was used to create a formal scale. The reliability, validity and feasibility of this formal scale were then assessed. Results: In a clinical investigation, 479 responses were recovered, with an acceptance rate of 95%. a combination of various methods was employed, and the items that were selected by all methods or more than half of the methods were employed in the questionnaire. In these cases, the screening methods were combined with certain features of the item, A total of four domains and 38 items were reserved. The reliability analysis indicated that the PRO scale was relatively reliable. Conclusions: Scientific assessment proved that the proposed scale exhibited good reliability and validity. This scale was readily accepted and could be used to assess the curative effects of medical therapy. However, given the limited scope of this investigation, the capacity for adapting this scale to incorporate other theories could not be determined.

• Journal of Plant Biology
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• 제13권1호
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• pp.33-46
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• 1970

Pinus densiflora stands are common secondary forest communities on infertile soils in Korea. The stands are results of long severe past biotic pressure such as cutting, burning and grazing. These could be regarded as biotic climax in Korea. Because of their prevalent occurrence, relatively simple species and age composition, and their domestic economic importance, study of their distributional patterns may give some basic knowledge for better utilization of land resources in Korea. To detect distributional patterns and interspecific associations ten pine stands, each of which was homogenious with respect to topography and physiognomy, were subjectively selected from pine stands in Kyunggi Province near Seoul in 1969 and were made object of this study. Four contiguous systematic samples of count for trees, shrubs and seedlings from belt transects were collected from homogeneous areas within ten natural pine stands. The belt transect was 64m or 128m in length, and 1m, 2m or 4m in width. Basic units within the transect ranged from 64 to 256. The data from the contiguous transects were analysed in terms of multiple split-plot experiment. Departure from randomness of stem distribution, i.e., pattern, was tested in terms of variance mean ratio. For the detection of association between species, correlation coefficient was calculated for different block sizes. The values of ${\gamma}$ were tested by the usual t-test. Fine trees within one of the stands showed significant regular distribution through out the blocks. Within other eight stands pines were randomly distributed at basic unit with 4$\times$4m, 2$\times$2m, 2$\times$1m and 1$\times$1m. One significantly clumped distribution at basic unit 2$\times$2m, however, was observed from one of the pine stands. These randomly distributed groups were themselves significantly regularly distributed throughout the blocks for four pine stands. For the other four pine stands, in addition to the random distribution at the basie unit(the primary random group), randomly distributed groups with 32m dimension(the secondary random groups) were also observed. Both the primary and the secondary random groups were significantly regularly distributed at the rest of blocks. Pine seedlings were not distributed randomly thoughout the blocks. Within three of the ten stands they were contagiously distributed. Important shrub species underneath pines such as Querus serrata, Q. acutissima, Leapedeza intermedia, Rhododendron Yedoense var. poukhanenae, Juniperus utilis, Rhododendron mucronulatum var. ciliatum shnwed consistently similar distributional pattern with the pine at each stand. The shrub species pairs; Rhododendron Yedoense var. poukhanenae/Quercus serrata, Rhododendron mucronulatum var. ciliatum/Lespedeza intermedia were significantly negatively associated from 1m to 4m dimensional block sizes but became significantly positively associated from 8m sized blocks on. On the other hand the shrub species pairs; Lespedeza intermedia/Robinia Pseudoacacia, and Lespedeza bicolor var, japonica/Lespedeza intermedia were also significnalty negatively associated from 1m to 8m sized blocks but became significantly positively associated from 16m sized blocks on. The associational pattern between Rhododendron mucronul tun var. poukhanenae and Lespedeza intermedia was not consistent throughout the stands. In some stands negative associations were observed throughout the blocks except NS 32. From these observatons micro-edaphic variation within the pine stands seems not to be great enough to cause distributinal difference of pine trees within the ten pine stands. Among each species and pine seedings, however, the edaphic variation within the pine stands may be great enought to cause distributional variation.