• Journal of the Optical Society of Korea
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• 제10권1호
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• pp.16-22
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• 2006

Wavefront sensing using a Shack-Hartmann sensor has been widely used for estimating wavefront errors or distortions. The sensor combines the local slopes, which are estimated from the centroids of each lenslet image, to give the overall wavefront reconstruction. It was previously shown that the pupil-plane irradiance profile effects the centroid estimation. Furthermore, a previous study reported that the reconstructed wavefront from a planar wavefront with a Gaussian pupil irradiance profile contains large focus and spherical aberration terms when there is a focus error. However, it has not been reported yet how seriously the pupil irradiance profiles, which can occur in practical applications, effect the sensing errors. This paper considered two cases when the irradiance profiles are not uniform: 1) when the light source is Gaussian and 2) when there is a partial interference due to a double reflection by a beam splitting element. The images formed by a Shack-Hartmann sensor were simulated through fast Fourier transform and were then supposed to be detected by a noiseless CCD camera. The simulations found that sensing errors, due to the Gaussian irradiance profile and the partial interference, were found to be smaller than RMS ${\lambda}/50$ when ${\lambda}$ is $0.6328\;{\mu}m$, which can be ignored in most practical cases where the reference and test beams have the same irradiance profiles.

• 제어로봇시스템학회논문지
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• 제19권12호
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• pp.1145-1151
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• 2013

Kinematic modeling is a prerequisite for motion planning and the control of mobile robots. In this paper, we proposed a new method of kinematic modeling for a type of mobile robot based on differential motion transformation. The differential motion implies a small translation and rotation in three-dimensional space in a small time interval. Thus, transformation of the differential motion gives the velocity relationship, i.e., Jacobian between two coordinate frames. Since the theory of the differential motion transformation is well-developed, it is useful for the systematic velocity kinematic modeling of mobile robots. In order to show the validity for application of the differential motion transformation, we obtained velocity kinematic models for a type of exemplar mobile robot including spherical ballbots.

• 전기전자학회논문지
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• 제21권3호
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• pp.320-330
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• 2017

Porous nanosilica (PNS) has been identified as a potential candidate for controlled drug delivery. However, unmodified PNS-based carriers exhibited an initial release of loaded bioactive agents, which may limit their potential clinical applications. In this study, the surface of PNS was functionalized with adamantylamine (ADA) via disulfide bonds (-S-S-), PNS-S-S-ADA, which was then modified with cyclodextrin (CD)-heparin (Hep) (CD-Hep), PNS-S-S-CDH, for redox triggered rhodamine B (RhB) delivery. The obtained samples were then characterized by proton nuclear magnetic resonance ($^{1}H\;NMR$), Fourier transform infrared (FTIR), and transmission electron microscope (TEM). These results showed that PNS-S-S-CDH was successfully formed with spherical shape and average diameter of $45.64{\pm}2.33nm$. In addition, RhB was relatively encapsulated in the PNS-S-S-CDH (RhB@PNS-S-S-CDH) and slowly released up to 3 days. The release of RhB, in particular, was triggered due to the cleavage of -S-S- in the presence of dithiothreitol (DTT). It might be anticipated that the modified PNS can be used as redox-responsive drug delivery system in cancer therapy.

• Bulletin of the Korean Chemical Society
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• 제34권5호
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• pp.1333-1338
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• 2013

Chitosan-based nanoparticles (CSNP) were prepared through ionic cross-linking and gelation of chitosan (CS) by tripolyphosphate (TPP). CS properties such as molecular weight, and preparation conditions were screened and the resulting nanoparticles were examined by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The obtained particles were consistently spherical with an overall diameter of approximately $107{\pm}20$ nm. They were successfully used as a carrier for Zidovudine, an anti-human immunodeficiency virus (HIV) which, to our knowledge, is novel. The encapsulation ability, loading capacity, and controlled release behavior for these CSNP was evaluated. Results indicated that their intrinsic properties were strongly affected by properties inherent to CS such as molecular weight, and by the preparation condition, such as cross-linking density, which depends on the concentration of the cross-linker. In vitro release tests for the entrapped zidovudine showed that the CNNP provided a continuous release that can last upwards 20 h.

• 한국의학물리학회지:의학물리
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• 제32권2호
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• pp.50-58
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• 2021

Purpose: In this study, we investigated the relationship between the noise characteristics and the number of projected images in tomosynthesis using a digital phantom. Methods: The digital phantom consisted of a columnar phantom in the center of the image and a spherical phantom with a diameter of 80 pixels. A virtual scan was performed, and 128 projected images (Tomo_w/o) of the phantoms were obtained. The image noise according to the Poisson distribution was added to the projected images (Tomo_×1). Furthermore, another projected image with additional noise was prepared (Tomo_×1/2). For each dataset, we created datasets with 64 (half) and 32 (quarter) projections by removing the even-numbered images twice from the 128 (fully) projected images. Tomosynthesis images were reconstructed by filtered back projection (FBP). The modulation transfer function (MTF) was estimated using the sphere method, and the noise power spectrum (NPS) was estimated using the two-dimensional Fourier transform method. Results: The MTFs did not change between datasets, and the NPSs improved as the number of projected images increased. The noise characteristics of the Tomo_×1_half images were the same as those of the Tomo_×1/2_full. Conclusions: To achieve a reduction in the patient dose in tomosynthesis acquisition, we recommend reducing the number of projected images rather than reducing the dose per projection.

• Journal of the Korean Physical Society
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• 제73권9호
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• pp.1334-1339
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• 2018

Spherical nickel ferrite nanoparticles were synthesized using the thermal decomposition method and coated with cetyl trimethyl ammonium bromide (CTAB) after the synthesis. Transmission electron microscopy images showed that the average diameter of the particles was 9.40 nm. The status of the CTAB-coating on the surface of the particles was checked using Fourier-transform infrared spectroscopy. Their hysteresis curve showed that the particles exhibited a superparamagnetic behavior. The $T_1$ and the $T_2$ relaxations of the nuclear spins were observed in aqueous solutions of the particles with different particles concentrations by using a magnetic resonance imaging (MRI) scanner, which showed that the $T_1$ and the $T_2$ relaxivities of the particles in water were $0.57mM^{-1}{\cdot}s^{-1}$ and $10.42mM^{-1}{\cdot}s^{-1}$, respectively. In addition, using an induction heating system, we evaluated their potentials for magnetic hyperthermia applications. The aqueous solution of the particles with a moderate concentration (smaller than 6.5 mg/mL) showed a saturation temperature larger than the hyperthermia target temperature of $42^{\circ}C$. These findings show that the CTAB-coated nickel ferrite particles are suitable for applications as $T_2$ contrast agents in MRI and heat generators in magnetic hyperthermia.

• 한국측량학회지
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• 제26권5호
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• pp.513-518
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• 2008

지구 중력장의 경년변화 관측을 통한 전 지구 차원에서의 대규모 질량이동 및 그 변화에 대한 연구는 지속적으로 진행되고 있다. 여기에는 지구의 편평 정도를 나타내는 $J_2$(또는 지구 중력장모델의 $C_{20}$)에 대한 연구도 포함되며, 최근에는 GRACE를 비롯한 위성중력기술의 개발로 기존의 SLR 등 우주관측기술의 관측결과와 비교분석을 수행할 수 있게 되었다. 본 연구에서는 2002년 4월부터 2008년 5월사이의 GRACE 월별 중력장모델(CSR RL04)을 이용하여 저차항 중력장 구면조화 계수 $C_{20}$의 시계열 변화를 구하고 SLR 관측 자료로부터 얻어진 $C_{20}$ 값과 비교분석을 수행하였다.시계열 데이터의 분석에는 웨이블릿 변환 신호분석기법을 사용하였으며,구체적으로 연속 웨이블릿 변환,직교 웨이블릿 변환 및 웨이블릿 상관간계 분석을 수행하였다.분석 결과, GRACE와 SLR의 $C_{20}$ 결과는 모두 감소하는 추세를 나타내었으며, 1년 주기를 나타내는 SLR과는 달리 GRACE는 반년 주기에서 더욱 높은 강도를 보였다.또한,GRACE는SLR와의 직교 웨이블릿 스펙트럼 및 상관관계 분석에서도1년 주기에서 매우 강한 상관관계를 보여주었다.

• Journal of Periodontal and Implant Science
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• 제36권4호
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• pp.797-808
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• 2006

Objective : The purpose of this study was to evaluate the physicochemical properties and cytocompatibility of microporous, spherical biphasic calcium phosphate(BCP) ceramics with a 60/40 $hydroxyapatite/{\beta}$ -tricalcium phosphate weight ratio for application as a bone graft substitute. Materials and Methods : Microporous, spherical BCP granules(MGSB) were prepared and their basic characteristics were compared with commercially available BCP(MBCP; Biomatlante, France) and deproteinized bovine bone mineral(Bio-Oss; GBistlich-Pharma, Switzerland, BBP; Oscotec. Korea), Their physicochemical properties were evaluated by scanning electron microscopy, X-ray diffractometry, Fourier-transform infrared spectroscopy, inductively coupled plasma atomic emission spectrometer, and Brunauer-Emmett-Teller method. Cell viability and proliferation of MC3T3-El cells on different graft materials were evaluated. Results : MGSB granules showed a chemical composition and crystallinity similar with those in MBCP, they showed surface structure characteristic of three dimensionally, well-interconnected micropores. The results of MTT assay showed increases in cell viablity with increasing incubation times. At 4d of incubation, MGSB, MBCP and BBP showed similar values in optical density, but Bio-Oss exhibited significantly lower optical density compared to other bone substitutes(p <0,05). MGSB showed significantly greater cell number compared to other bone substitutes at 3, 5, and 7d of incubation(p <0,05), which were similar with those in polystyrene culture plates. Conclusion: These results indicated the suitable physicochemical properties of MGSB granules for application as an effective bone graft substitute. which provided compatible environment for osteoblast cell growth. However, further detailed studies are needed to confirm its biological effects on bone formation in vivo.

• 정보과학회 논문지
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• 제41권11호
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• pp.927-934
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• 2014

본 논문에서는 Kinect와 같은 RGB-D 센서를 이용하여 사람의 3차원 신체 포즈 스트림 데이터를 생성하고, 이로부터 사람의 일상 행위를 효과적으로 인식하는 방법을 제안한다. Kinect SDK나 OpenNI에서 제공하는 실시간 신체 포즈 데이터는 Kinect 중심의 3차원 데카르트 좌표계로 표현되기 때문에, 시점 변화 문제와 크기 변화 문제를 겪을 가능성이 높다. 이러한 문제를 해결하고 시점 및 크기 불변인 특징을 얻기 위해, 본 논문에서는 신체 포즈 데이터를 실험자의 골반을 원점으로 하는 구면 좌표계로 변환하고 실험자의 팔 길이를 이용한 크기 정규화를 수행한다. 또한, 본 논문에서는 확률 그래프 모델 중 하나인 은닉 조건부 랜덤 필드를 이용하여, 고수준의 일상 행위들이 내포하는 다양한 내부 구조를 효과적으로 표현한다. 두 가지 데이터 집합 KAD-70과 CAD-60을 이용한 실험을 통해, 본 논문에서 제안한 행위 인식 방법과 구현 시스템의 높은 인식 성능을 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제30권6호
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• pp.920-925
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• 2020

In India, nanotechnology has been used in therapeutic applications for several millennia. One example of a traditional nanomedicine is Rajath Bhasma (also called calcined silver ash), which is used as an antimicrobial and for the treatment of various ailments and conditions such as memory loss, eye diseases, and dehydration. In this study, we aimed to characterize the physical composition and morphology of Rajath Bhasma and its suitability for use as a non-toxic antimicrobial agent. First, Rajath Bhasma was physically characterized via i) Fourier-transform infrared spectroscopy to analyze the surface functional groups, ii) scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy to observe the morphology and elemental composition, and iii) X-ray diffraction to determine the crystalline phases. Thereafter, functional characterization was performed through toxicity screening using zebrafish embryos and through antimicrobial activity assessment against gram-positive (Staphylococcus epidermidis) and gram-negative (Escherichia coli) bacteria. Rajath Bhasma was found to harbor alkene, hydroxyl, aldehyde, and amide functional groups originating from biological components on its surface. The main component of Rajath Bhasma is silver, with particle size of 170-210 nm, and existing in the form of spherical aggregates with pure crystalline silver structures. Furthermore, Rajath Bhasma did not exert toxic effects on zebrafish embryos at concentrations below 5 ㎍/ml and exhibited effective antimicrobial activity against both gram-positive and gram-negative bacteria. The present results indicate that Rajath Bhasma is a potentially effective antimicrobial agent without toxicity when used at concentrations below 5 ㎍/ml.