• Clinical and Experimental Pediatrics
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• v.48 no.6
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• pp.580-587
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• 2005

New evidence is emerging that airway smooth muscle(ASM) may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, polypeptide growth factors, extracellular matrix proteins, cell adhesion receptors and co-stimulatory molecules. ASM can promote the formation of the interstitial extracellular matrix, and potentially contribute to the alterations within the extracellular matrix in asthma. In addition, extracellular matrix components can alter the proliferative, survival, and cytoskeletal synthetic function of ASM cells through integrin-directed signaling. Increased ASM mass is one of the most important features of the airway wall remodeling process in asthma. Three different mechanisms may contribute to the increased ASM mass : cell proliferation, increased migration and decreased rate of apoptosis. The major signaling pathways of cell proliferation activated by ASM mitogens are those dependent on extracellular signal-regulated kinase and phosphoinositide 3'-kinase. The key signaling mechanisms of cell migration have been identified as the p38 mitogen-activated protein kinase and the p21-activated kinase 1 pathways. ASM cells contain ${\beta}2$-adrenergic receptors and glucocorticoid receptors. They may represent a key target for ${\beta}2$-adrenergic receptor agonist/corticosteroid interactions which have antiproliferative activity against a broad spectrum of mitogens.

• Bulletin of the Korean Mathematical Society
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• v.31 no.1
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• pp.15-23
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• 1994

Throughout this paper, we are working on the complex number field C. The aim of this paper is to explain the applications of Theorem 2 in .cint. 1. In the surface theory, the adjoint linear system has played important roles and many tools have been developed to understand it. In the cases of higher dimensional varieties, we don't have any useful tools so far. Theorem 2 implies that it is enough to compute the dimension of the adjoint linear system to check the birationality. We can compute, somehow, the dimension of the adjoint linear system. For example, we can get an information about $h^{0}$ (X, $O_{x}$( $K_{x}$ + D)) from Euler characteristic of vertical bar $K_{X}$ + D vertical bar and some vanishing theorems. We are going to show the applications of Theorem 2 to smooth three-folds and smooth fourfold, specially, of general type with a nef canonical divisor, smooth Fano variety, and Calabi-Yau manifold. Our main results are Theorem A and Theorem B. Most of birationality problems in Theorem A and Theorem B have been studied. (see Ando [1] and Matsuki [4] for the detail matters.) But Theorem 2 gives short and easy proofs in the cases of dimension 3 and improves the previously known results in the cases of dimension 4.4. 4.4.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.4
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• pp.333-338
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• 2000

We have examined whether bile acids can affect the electrical and mechanical activities of circular smooth muscle of canine colon and ileum, using isometric tension measurement or patch clamp technique. It was found that a dilution of canine bile $(0.03{\sim}2%\;by\;volume)$ enhanced or inhibited the amplitude of spontaneous contractions. An individual component of bile, deoxycholic acid (DCA) enhanced the frequency and amplitude of the spontaneous contractile activity at $10^{-6}\;M,$ while DCA at $10^{-4}\;M$ inhibited the contraction. Similarly, the response to cholic acid was excitatory at $10^{-5}\;M$ and inhibitory at $3{\times}10^{-4}\;M.$ Taurocholic acid at $10^{-4}\;M$ enhanced the amplitude of muscle contraction. Electrically, canine bile at 1% reversibly depolarized the colonic myocytes under current clamp mode. Bile acids also elicited non-selective cation currents under voltage clamp studies, where $K^+$ currents were blocked and the $Cl^-$ gradient was adjusted so that $E_{Cl}^-$ was equal to -70 mV, a holding potential. The non-selective cation current might explain the depolarization caused by bile acids in intact muscles. Furthermore, the bile acid regulation of electrical and mechanical activities of intestinal smooth muscle may explain some of the pathophysiological conditions accompanying defects in bile reabsorption.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.2
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• pp.193-201
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• 2018

Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner. AGE-induced CTGF expression was mediated via ERK1/2, JNK, and Egr-1 pathways, but not p38; consequently, cell proliferation and migration and ECM accumulation were regulated by CTGF signaling pathway. AGE-stimulated VSMC proliferation, migration, and ECM accumulation were blocked by fluvastatin. However, the inhibitory effect of fluvastatin was restored by administration of CTGF recombinant protein. AGE-induced VSMC proliferation was dependent on cell cycle arrest, thereby increasing G1/G0 phase. Fluvastatin repressed cell cycle regulatory genes cyclin D1 and Cdk4 and augmented cyclin-dependent kinase inhibitors p27 and p21 in AGE-induced VSMCs. Taken together, fluvastatin suppressed AGE-induced VSMC proliferation, migration, and ECM accumulation by targeting CTGF signaling mechanism. These findings might be evidence for CTGF as a potential therapeutic target in diabetic vasculature complication.

• Journal of the Korean Society of Combustion
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• v.1 no.1
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• pp.19-29
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• 1996

This study is to investigate the characteristics of heat transfer of a horizontal tube, with radial fins of various configuration, immersed in a high temperature fluidized bed. The experimental heat transfer variation is compared with that of a smooth tube. The finned tubes and smooth tube, with outside and inside diameter of 48.6mm and 30.6mm, are made of steel tubes. The depth of the fin is 5mm, the rake angles of fin are $25^{\circ},\;35^{\circ},\;45^{\circ}$ and the widthes of fin for each rake angle are 0mm, 1mm, 2mm and 3mm. A bed temperature is fixed at $880\;{\pm}\;10^{\circ}C$. A granular refractory(silica sand) is used as a bed material with mean particle diameters of 1.22mm and 1.54mm. The maximum heat transfer coefficient is achieved with the rake angle of $25^{\circ}$ and the width of 0mm for the mean particle size 1.22mm. The coefficient is 2.14 times larger than that for a smooth tube. The rake angle for the maximum heat transfer coefficient depends on the particle size of bed material. Also the transfer coefficient decreases as the width of fin increases.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.10 no.6
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• pp.743-752
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• 1998

Experiments were performed to characterize single-phase heat transfer behavior of submerged liquid jet with multiple nozzle normally impinging on the smooth and extended surfaces. Arrays of 9 and 36 nozzles were used, with diameters of 0.5 to 2.0mm providing nozzle area ratio (AR) from 0.05 to 0.2. The square pin fin arrays were chosen as extended surfaces and the effects of geometrical parameters such as fin height, the ratio of fin width to channel width on heat transfer enhancement were examined. Single nozzle characteristics were also evaluated for comparison. The results clearly showed that heat transfer enhancement could be realized by using multiple nozzles at the constant volume flow rate. The average Nusselt number of multiple nozzle impingement on the smooth surface was correlated by the following equation : Nu/$Pr\frac{1}{3}=0.94 Re^{0.56}N^{-0.12}AR^{0.50}$The average heat transfer coefficients of multiple nozzle impingement on the extended surfaces decreased with increasing fin height and the ratio of fin width to channel width. The effectiveness of ex-tended surfaces ranged from 1.5 to 3.5 depending on the fin height, the ratio of fin width to channel width of pin fin arrays, nozzle number and nozzle area ratio.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.12
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• pp.1124-1132
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• 2011

This paper deals with smooth path generation using B-spline for fixed-wing unmanned aerial vehicles manuevering in 2D environment. Hexagonal cell representation is employed to model the 2D environment, which features increased connectivity among cells over square cell representation. Subsequently, hexagonal cell representation enables smoother path generation based on a discrete sequence of path from the path planner. In addition, we present an on-line path smoothing algorithm incorporating B-spline path templates. The path templates are computed off-line by taking into account all possible path sequences within finite horizon. During on-line implementation, the B-spline curves from the templates are stitched together repeatedly to come up with a reference trajectory for UAVs. This method is an effective way of generating smooth path with reduced on-line computation requirement, hence it can be implemented on a small low-cost autopilot that has limited computational resources.

• Advances in nano research
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• v.2 no.2
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• pp.99-109
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• 2014

Experiments are performed to investigate the single-phase flow heat transfer augmentation of MWCNT/HT-B Oil in both smooth and micro-fin helical tubes with constant wall temperature. The tests in laminar regime were carried out in helical tubes with three curvature ratios of 2R/d=22.1, 26.3 and 30.4. Flow Reynolds number varied from 170 to 1800 resulting in laminar flow regime. The effect of some parameters such as the nanoparticles concentration, the dimensionless curvature radius (2R/d) and the Reynolds number on heat transfer was investigated for the laminar flow regime. The weight fraction of nanoparticles in base fluid was less than 0.4%. Within the applied range of Reynolds number, results indicated that for smooth helical tube the addition of nanoparticles to the base fluid enhanced heat transfer remarkably. However, compared to the smooth helical tube, the average heat transfer augmentation ratio for finned tube was small and about 17%. Also, by increasing the weight fraction of nanoparticles in micro-fin helical tubes, no substantial changes were observed in the rate of heat transfer enhancement.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.9
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• pp.809-815
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• 2004

Researches on mobile robots have been mainly focused on the autonomous navigation and a lot of interesting results have been published so far. Most of applications are, however, fancy, unpractical, and very expensive to be used for 'UN-expensive' purpose. Well-known soccer robot may be an example of unpractical application. Un-autonomous mobile robot has, however, potential for a lot of practical applications. Especially, tele-operation of the un-autonomous mobile robot may the central issue of research. Major research topics for the tele-operated un-autonomous mobile robot include development of a force reflecting joystick for tele-operation and development of a sophisticated algorithm for smooth tele-operation. A new concept named fuzzy command smoothing algorithm is proposed in this paper in order to provide smooth motion to a tele-operated mobile robot. It gives smooth motion command to the mobile robot from possibly abrupt quick turn motion command of the joystick using fuzzy logic. Simulation results verify the usefulness of the proposed algorithm.

• The Journal of Korean Academy of Prosthodontics
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• v.38 no.1
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• pp.108-115
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• 2000

This study was designed to compare the effect of polishing on surface roughness of composite resin. We used Z100(3M) composite resin and placed the composite resin in the hole (4mm thick and 4mm in diameter) of vinyl plate and polymerized it under manufacturer's instructions. Samples were divided into 5 groups by polishing methods. Group 1 was control: resin was polymerized under glass plate, Group 2: resin was polymerized without any polishing procedure, Group 3: resin was polymerized with a polishing procedure of abrasive disc, Group 4: bonding agent was applyed in thin layer and polymerized on the polished polymerized resin surface. Group 5: resin was polymerized under transparent celluloid strip. The surface roughness of each specimen was measured with Sufacoder SEF-30D (Kosaka lab. Ltd) under 0.08mm cut off, 0.05mm/s stylus speed, ${\times}40$ horizontal magnification, ${\times}5000$ vertical magnification. The results were as follows : 1. Group 1 showed the most smooth surface in this study. 2. Group 3 showed more rough surface than Group 2. Considering the surface roughness, it would be better to make the shape completely before polymerize the resin. To finish and polish after the polymerization of resin makes less smooth surface. 3. When we use the transparent celluloid strip, minimum finishing procedures are recommended. Any polishing procedure could not recover the smooth resin surface of celluloid strip. 4. Application and polymerization of the thin layer of bonding agent on the polished surface showed the minimum surface smoothing effect.