• 한국산학기술학회논문지
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• 제12권9호
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• pp.4257-4260
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• 2011

온천수는 땅 표면에 자연 용출되거나 인공적으로 시추하여 끌어올린 지하수로서 수온이 그 지역의 연평균 기온 또는 그 지역의 얕은 지층의 지하수 수온보다 높아야 한다. 우리나라는 섭씨 25도 이상을 온천으로 규정하고 있다. 온천수는 일반적으로 혈액순환, 진통완화, 진정작용, 피부미용에 효과가 있는 것으로 널리 알려져 있으며 이것의 효능은 일반적으로 수온과 물속에 포함되어 있는 다양한 미네랄 성분의(Na, Si, Mg 등) 작용으로 알려져 있다. 온양 온천은 우리나라에서 가장 오래된 온천지구로 우리나라의 가장 대표적인 온천중에 하나이다. 본 연구에서는 온천수를 화장품 제형에 적용하여 피부자극테스트를 통하여 피부자극이 없는 것으로 나타났으며, 온양온천수를 이용한 제품에서 8.56%의 경피 수분함유량의 증가와 -67.74%의 상대 경피 수분증발량 감소가 나타나 온양온천수를 활용한 화장품의 피부개선 효과가 나타나는 것을 알 수 있었다.

• 대한화장품학회지
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• 제47권2호
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• pp.171-178
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• 2021

본 연구에서는 프로바이오틱스 유래 엑소좀 유사 나노베지클을 분리하고, 피부에 대한 여러 가지 생리활성을 평가했다. 프로바이오틱스의 한 종인 Lactococcus lactis subsp. lactis (LL)를 배양하고 고압균질기와 한외여과를 통해 70 ~ 200 nm 크기를 갖는 LL 유래 엑소좀 유사 나노베지클(LVs)을 분리했다. 나노입자추적분석 결과 1.81 × 10¹¹ particles/mL로 나타났다. LVs를 섬유아세포와 피부각질세포에 처리하여 피부 주름과 장벽 개선과 관련된 효능을 확인했다. 우선 섬유아세포에서 fibrillin (FBN1) 유전자 발현량이 23%, 피부각질세포에서 fibronectin (FN1)과 filaggrin (FGN) 유전자 발현량이 각각 65%, 400% 증가했다. 그리고 각질형성능은 대조군 대비 30% 증가함을 확인할 수 있었다. 또한, UV 조사한 피부각질세포에 LVs를 처리했을 때 collagen type I alpha 1 (COL1A1)이 대조군 대비 약 83% 증가하는 결과를 보여주었다. 이로써 프로바이오틱스 유래 엑소좀 유사 나노베지클은 장벽 개선과 관련하여 화장품 및 의약품 소재로 이용할 수 있음을 확인했다.

• 대한본초학회지
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• 제38권4호
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• pp.45-52
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• 2023

Objectives : Fine dust caused by environmental pollution cause oxidative damage and skin aging. In this study, The possibility of using the Codium fragile extract (CFE) as an anti-aging product for skin improvement was evaluated by confirming the protective effect of skin cells from PM10 (particulate matter 10) through inhibition of ROS and MMPs. Methods : In this study, elastase and collagenase inhibitory activities were evaluated. Cell viability was evaluated by treating keratinocytes (HaCaT cell line) with CFE at various concentrations. The cytoprotective effect from PM10 in keratinocyteswas evaluated using the 3-[4,5-dimethylthiazol]-2-yl]-2,5-diphenyl-tetrazoliumbromide (MTT) assay. ROS (reactive oxygen species) was measured in keratinocytes damaged by PM10 using DCF-DA (2′,7′-dichlorofluorescin diacetate) fluorescence staining. As an anti-aging effect of CFE, MMP-1 (matrix metalloproteinase-1) and MMP-1 (matrix metalloproteinase-9) inhibitory activities were evaluated. Results : As a result, CFE decreased the activity of elastase and collagenase. As a result of evaluating the toxicity of CFE, it is non-toxic at a concentration of 10 to 80 ㎍/㎖. Although cell viability of HaCaT cells treated with PM10 decreased, cell viability increased by 38% when treated with CFE 80 ㎍/㎖. Also, ROS decreased by 8.4%, and MMP-1 and MMP-9 decreased at CFE 80 ㎍/㎖. Conclusions : CFE showed excellent cell protection effect, and it is considered that it can be used in anti-aging products for skin improvement by effectively inhibiting ROS and MMPs from keratinocyte damage caused by fine dust.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.146-149
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• 2009

실시간 영상에서 사람의 얼굴 검출은 얼굴 인식분야에 있어서 주요한 관심 분야 중의 하나이다. 본 논문에서는 실시간 입력되는 영상에서 피부 색상과 Haar-like feature를 이용한 얼굴 검출 및 추적 알고리듬을 제안한다. 제안된 알고리듬은 컬러 색 공간에서 피부색상과 특징점을 가지고 얼굴 영역 및 추적하였다. 실험 결과 실시간 영상에 대해 조명 변화 및 가림 현상에서 강건한 추적 결과를 얻을 수 있었다.

• 대한화장품학회지
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• 제16권1호
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• pp.18-29
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• 1990

In this report, the variation of skin surface between before treatment and after treatment was investigated by skin image analyzer. The 30 volunteers were applied cream and lotion on the forearm Inside for 4 weeks, and the measurement parameter of skirl surface was adopted peak, length, height, and width. The results were as follows ; 1. variation trends of parameters was showed that number of peaks were increased, but length, height and width were decreased. 2. The order of improvement for skin surface are as follow ; height > length > peak > width. 3. And also disclosed that the number of peak has a correlation with width, and length has a correlation with height.

• 대한화장품학회지
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• 제27권1호
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• pp.83-98
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• 2001

Inositol, is a water-soluble crystalline compound. It helps with people’s metabolism and decreases cholesterol levels. It is also known to have anti-cancer results. In order to find out the affects of Inositol on the skin, Inositol skin lotion was produced with each amount of Inisitol: 0, 0.5, 1.0, 2.0, 3.0 wt% and tested on the faces and the arm areas of women in all ages for 7 weeks. The moisture, sebum, change in elasticity, and improvement of wrinkles were measured. Corneometer, Sebumeter, Cutometer, and an image analyzer were used as measuring equipments. There are subtle differences in the subjects when 1-2% of Inositol is used the moisture of the skin improved 19%, elasticity by 17%, and the amount of sebum for dry and oily skin types adjusted to the amount of sebum of the neutral skin types. This influenced the length, width, the number of peak, and the height of the wrinkles to improve 12.4%. It is thought that Inositol would be an effective new raw material in cosmetics.

• The Journal of Korean Physical Therapy
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• 제22권1호
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• pp.61-66
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• 2010

Purpose: The purpose of this study was to investigate the change in sympathetic nervous system responses of healthy adult women with changes in stimulus intensity of high frequency transcutaneous electrical nerve stimulation. Methods: Twenty-four healthy subjects (women) received high frequency electrical stimulation of the forearm. The subjects were randomly assigned to one of two groups; a low intensity stimulation group (n=12) and a high intensity stimulation group (n=12). The electrode attachment was arranged on the forearm of the dominant arm and the electricity stimulus time was 20 minutes. Measured items included skin conductance, pulse rate, skin temperature, and respiration rate. Each was measured at 4 times. Results: Skin conductance and skin temperature showed significant group by time interactions, though there were no significant group and time effects. There were no significant differences according to time, group effect, and a group by time interaction in pulse and respiration rates. Conclusion: High frequency and high intensity electrical stimulation may be helpful for the improvement of sudomotor function through the activation of the sympathetic nervous system. Also, high frequency and low intensity electrical stimulation may be helpful for the reduction of sudomotor function via inhibition of the sympathetic nervous system.

• Natural Product Sciences
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• 제27권4호
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• pp.300-306
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• 2021

Chronic ultraviolet (UV) radiation causes photoaging, which represents skin damage, disrupts skin barrier function, and promotes wrinkle formation. We investigated that the polysaccharide extract of an edible basidiomycetous white jelly mushroom, Tremella fuciformis, (TF-Glucan^®) exhibited statistically photoprotective activity by inhibiting matrix metalloproteases (MMPs) and increasing collagen synthesis, and an anti-inflammatory activity by inhibiting nitric oxide and pro-inflammatory cytokines at the concentrations of less than 1000 ㎍/ml, which is not cytotoxic (p < 0.05). Additionally, TF-Glucan^® increased the expression of involucrin and filaggrin to prevent the disruption of UVB-induced barrier function (p < 0.05). TF-Glucan^® was assessed as a safe material by the human primary skin irritation (1, 3, 5%), human repeated insult patch test (no sensitization at 5%), 3T3 NRU phototoxicity assay (no phototoxicity, PIF < 2, MPE < 0.1), eye irritation test test by BCOP (no category, IVIS ≤ 3) and local lymph node assay (negative at 10, 25, 50%) for identifying potential skin sensitizing. These results suggest that TF-Glucan^® may be useful as an anti-photoaging ingredient for developing cosmeceuticals.

• 예술인문사회 융합 멀티미디어 논문지
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• 제7권10호
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• pp.703-711
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• 2017

Today, men's appearance is an important part of the global fashion industry, including Korea, with such fashion concepts as the Metrosexual and Ubersexual. Domestic and overseas beauty and cosmetics related organizations are using this phenomenon for marketing and researching to improve the function of cosmetics. The purpose of this study was to investigate the effect of Prunus persica L. Batsch leaf extract on the skin condition after clinical application to male subjects with oily skin to determine the possibility of functional cosmetics utilizing this extract. The cleansing bars were prepared by the MP method and the cleansing packs were prepared using natural ingredients. After 8 weeks of application, moisture, oil, erythema, melanin, pH, elasticity and tactile sensation were measured using MPA5. The results showed that there was a statistically significant difference in T-zone moisture and T-zone oil after using the natural cleansing bar, but there was no significant difference between the two groups for other items. However, the statistically significant changes were found in the individual skin condition change items of the subjects in each group, and it was judged that the two kinds of formulations could be used at the same time to have a higher skin improvement effect. Thus, Prunus persica L. Batsch leaf extract demonstrates potential to be used as a functional cosmetics item.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.940-948
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• 2024

Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on anti-inflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon- gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.