• 제목/요약/키워드: site-response effect

검색결과 298건 처리시간 0.024초

도심지 내 복층 저소음포장 설치에 따른 소음저감 사례연구 (A Case Study on Noise Reduction Effect of Two-layer Porous Asphalt Pavement in an Urban Area)

  • 정종석;소정락;이수형;양홍석
    • 한국도로학회논문집
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    • 제18권5호
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    • pp.49-56
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    • 2016
  • PURPOSES : In this study, noise reduction effect of a two-layer porous asphalt pavement was investigated through site measurement and computer simulation. METHODS : To examine noise reduction effect, a 3 km long quiet pavement was installed by removing previous normal pavement, which had a rather low porosity. The studied site was a high-rise apartment building surrounded by the quiet pavement and Seoul ring road with heavy traffic volume, indicating relatively high background noise. RESULTS : The measurement result before and after installing the quiet pavement showed a noise reduction effect of 4.3 dB(A) at a distance of 7.5 m from the road. After validating the accuracy of simulation using SoundPLAN, the reduction in SPL(sound pressure level) at the facades by the quiet pavement was predicted by considering five different road conditions generating traffic noise from each road or in the combination of the quiet pavement and Seoul ring road. In the case of no noise from Seoul ring road, noise reduction at the facades was 4.2 dB(A) on average for 702 housing units. With background noise from Seoul ring road, however, the average SPL decreased to 2.0 dB(A). Regarding subjective response of noise, the number of housing units with a noise reduction of over 3 dB(A) was 229 out of 706 units (approximately 32%). For 77 housing units, the noise reduction was between 1~3 dB(A), while it was less than 1 dB(A) for 400 housing units. CONCLUSIONS : The overall result indicates that the quiet pavement is useful to reduce noise evenly at low and high floors compared to noise barriers, especially in the urban situation where background noise is low.

한국산 생약제들의 혈압강하작용에 대한 연구 II. 한국산 후박수피의 혈압강하 작용 (Pharmacological Action of Machilus Thunbergii Siebold Zuccarini)

  • 조병헌;김인호;이상복;조규철;이종화
    • 대한약리학회지
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    • 제15권1_2호
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    • pp.45-56
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    • 1979
  • With a view to searching after a new antihypertensive or hypotensive agents in the botanical crude plants, authors intended to reevaluate several natural products caltivated in Korea. This experiment was undertaken to compare pharmacogical actions of Machilus thunbergii Siebold et Zuccarini with those of Magnolia obovata Thunberg in anesthetized rats and in normal mice. Machilus thunbergii Sieb. et Zucc., a tree belonging to the Lauraceae family, is caltivated at Ull-ung Do, and their cortecies have been used as folk medicine mingled with those of Magnolia obovata Thunberg. These two cortecies have teen also applied in chinese medicine, it was advocated that these cortecies exerted good therapeutic effects on gastritis, convulsive abdominal pain, nausea, vomiting and urinary tract disorders. Therefore, we intended to determine the pharmacological action of two palnt of different family each other, especially their effects on blood pressure and heart rate, and also their mechanism of action were observed. We studied their action with extracts of hexane(MTHE), ether(MTEE), methanol(MTME) and water(MTWE) from Machilus thunhergii Sieb. et Zucc., and also fractionations of methanol(MOME), chloroform(MOCE) and water(MOWE) from Mapolia obovata Thunberg. The results of this experiment were as follows; 1) MTME, when intravenously administered to rats, elicited the significant hypotensive responses dependent on the administered dosage. 2) MOWE was also exhibited the hypotensive effect dependent on the treated dose. 3) Depressor effect of MTME was blocked by pretreatment with hexamethonium. 4) The hypotensive response of MOWE was blocked by pretreatment with hexamethonium or hrdralazine. 5) HTME and MOWE were also observed the anticonvulsive effect and sedative effect. These results suggested that MTME may induce the hypotensive response via central sympathetic effect, but the site of action in brain are not clarified, and the hypotensive effect of MOWE may be due to dual mechanism of central sympathetic action and direct vasodilation of blood vessel.

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설계용 탄성응답스펙트럼으로 규준화된 인공지진동과 기록지진동의 비선형 지진응답 (Nonlinear Seismic Estimates of Recorded and Simulated Ground Motions Normalized by the Seismic Design Spectrum)

  • 전대한;강병두;김재웅
    • 한국지진공학회논문집
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    • 제15권5호
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    • pp.25-33
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    • 2011
  • 비선형 시간이력응답해석에서 입력지진동은 구조물의 탄소성 지진응답을 결정짓는 중요한 요소이다. 시간이력해석에 사용되는 기록지진동파형은 지진발생 메카니즘, 전달경로, 지반의 성질에 따른 여러 가지 인자가 복잡하게 관련되어 있기 때문에 구조물의 지진응답해석에 사용될 일반성을 갖는 입력지진동을 선정하는 것은 매우 어려운 문제이다. 본 논문은 실무에서 내진설계용 지진동으로 가장 선호하지 않는 입력지진동을 선정하여 인공지진동파형을 작성하였다. 인공지진동은 기록지진동과 동일한 위상각을 가지며, 감쇠정수 h=5%일 때의 설계용 스펙트럼과 거의 일치하도록 작성되었다. 기록지지동과 인공지진동을 입력한 1자유도계의 탄성 및 탄소성 지진 응답해석을 수행하여 탄소성 응답스펙트럼 및 입력에너지 응답 특성을 분석하였다. 본 연구에서 작성된 인공지진동은 건축구조물의 탄소성 지진응답해석용 입력지진동으로 충분히 타당성이 있다고 사료된다.

요구스펙트럼의 비탄성이력특성 -완전탄소성모델을 중심으로- (Inelastic Hysteretic Characteristics of Demand Spectrum -Focused on Elasto Perfectly Plastic Model-)

  • 이현호
    • 한국지진공학회:학술대회논문집
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    • 한국지진공학회 2000년도 춘계 학술발표회 논문집 Proceedings of EESK Conference-Spring
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    • pp.367-374
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    • 2000
  • This study investigates the effect of hysteretic characteristics to the Inelastic Demand Spectrum (IDS) which was expressed by an acceleration(Sa) and a displacement response spectrum (Sd). Elasto Perfectly Plastic(EPP) model is used in this study and inelastic demand spectrum (Sa vs, Sd) are obtained from a given target ductility ratio. For a given target ductility ratio IDS can be obtained by using nonlinear time history analysis of single degree of system with forth five recorded earthquake ground motions for stiff soil site. The effect EPP model under demand spectrum is investigated by ductility factor and natural frequency. According to the results obtained in this study IDS has dependency on ductility factor and natural frequency.

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HWAW방법을 사용한 아스팔트 포장층의 온도에 따른 물성치 변화 결정 (Evaluation of Material Property of Asphalt Pavement with Temperature using HWAW method)

  • 박형춘;이미예
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2008년도 춘계 학술발표회 초청강연 및 논문집
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    • pp.1417-1421
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    • 2008
  • Temperature variation affect the response of asphalt pavement and should be considered in the evaluation of performance of the pavement. In this paper, HWAW method is applied to evaluate shear wave velocity(or shear modulus) of the asphalt pavement with temperature. HWAW method which is based on time-frequency analysis using harmonic wavelet transform have been developed to determine phase and group velocities of waves. This method minimize effect of noise and is not affected by mode jump effect which cause erroneous result when surface wave method is applied to pavement evaluation. In order to estimate the applicability of HWAW method, field tests were performed in 1 site and preliminary correlation between shear wave velocity(shear modulus) and asphalt pavement average temperature.

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세굴을 고려한 얕은 기초 교량의 동적거동 분석 및 지진 취약도 해석 (Dynamic Behavior and Seismic Fragility Analysis of Shallow Foundation Bridge Considering Scour)

  • 김나연;송종걸
    • 한국지진공학회논문집
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    • 제20권2호
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    • pp.79-89
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    • 2016
  • If scour is occurred at shallow foundation of bridge, seismic performance of the bridge will be reduced. In order to evaluate accurate seismic response of bridge according to scour depths, modeling of foundation reflecting scour effect is important. In this study, taking into account the effect of the reduction in embedment depth of the shallow foundation by scouring, the soil around the foundation is modelled as an equivalent soil spring with various stiffness. Seismic fragility analyses for 3 types of bridges subjected to 4 types of ground motions classified into Site Class A, B, C, D are evaluated according to several scour depths. From the fragility analysis results, it can be observed that the deeper the scour depth, the higher probability of exceeding damage states. Also, seismic failure probability of asymmetric bridge is higher than that of symmetric bridge.

Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy

  • Muto, Momotaro;Nakata, Hirotaka;Ishigaki, Kenichi;Tachibana, Shion;Yoshida, Moe;Muto, Mizue;Yanagawa, Nobuyuki;Okumura, Toshikatsu
    • Journal of Gastric Cancer
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    • 제21권3호
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    • pp.319-324
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    • 2021
  • The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with brain radiotherapy and anti-programmed death-1 (PD-1) therapy-induced abscopal effect. Although anti-PD-1 therapy alone could not prevent disease progression, the metastatic lesions in the brain and also in the abdominal lymph node showed a drastic response after brain radiotherapy and anti-PD-1 therapy. To our knowledge, this is the first reported case of successful treatment of advanced gastric cancer with multiple brain and abdominal lymph node metastases, possibly through anti-PD-1 therapy combined with brain radiotherapy-induced abscopal effect. We suggest that the combination of brain radiotherapy and anti-PD-1 therapy may be considered as a therapeutic option for advanced gastric cancer, especially when there is brain metastasis.

Application of Apoptogenic Pretreatment to Enhance Anti-tumor Immunity of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)-secreting CT26 Tumor Cells

  • Jun, Do-Youn;Jaffee, Elizabeth M;Kim, Young-Ho
    • IMMUNE NETWORK
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    • 제5권2호
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    • pp.110-116
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    • 2005
  • Background: As an attempt to develop a strategy to improve the protective immune response to GM-CSF-secreting CT26 (GM-CSF/CT26) tumor vaccine, we have investigated whether the apoptogenic treatment of GM-CSF/CT26 prior to vaccination enhances the induction of anti-tumor immune response in mouse model. Methods: A carcinogeninduced mouse colorectal tumor, CT26 was transfected with GM-CSF gene using a retroviral vector to generate GM-CSF-secreting CT26 (CT26/GM-CSF). The CT26/GM-CSF was treated with ${\gamma}$-irradiation or mitomycin C to induce apoptosis and vaccinated into BALB/c mice. After 7 days, the mice were injected with a lethal dose of challenge live CT26 cells to examine the protective effect of tumor vaccination in vivo. Results: Although both apoptotic and necrotic CT26/GM-CSF vaccines were able to enhance anti-tumor immune response, apoptotic CT26/GM-CSF induced by pretreatment with ${\gamma}$-irradiation (50,000 rads) was the most potent in generating the anti-tumor immunity, and thus 100% of mice vaccinated with the apoptotic cells remained tumor free for more than 60 days after tumor challenge. Conclusion: Apoptogenic pretreatment of GM-CSF-secreting CT26 tumor vaccine by ${\gamma}$-irradiation (50,000 rads) resulted in a significant enhancement in inducing the protective anti-tumor immunity. A rapid induction of apoptosis of CT26/GM-CSF tumor vaccine at the vaccine site might be critical for the enhancement in anti-tumor immune response to tumor vaccine.

지반의 비선형성을 고려한 암반지진에 의한 구조물의 수평방향 탄성거동 (Elastic Horizontal Response of a Structure to Bedrock Earthquake Considering the Nonlinearity of the Soil Layer)

  • 김용석
    • 한국지진공학회논문집
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    • 제6권3호
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    • pp.53-62
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    • 2002
  • 지반조건은 구조물의 지진거동에 매우 큰 영향을 미치고 성능에 기준한 내진설계에 중요한 요소이다. 이 논문에서는 지진에 의한 지반의 비선형성을 포함한 지반의 비선형성이 구조물의 탄성지진거동에 미치는 영향을 지반 구조물 일괄해석 유한요소법과 지반의 비선형성을 구현하기 위해 Ramberg-Osgood 토질모델에 대한 근사선형 반복해석법으로 연구하였다. 연구는 말뚝기초의 유무를 고려한 주기가 변하는 선형 단자유도계에 지표에서 기록된 1940년 EI Centre지진을 적용하여 수행하였다. 연구결과에 의하면 연약지반의 비선형 특성 영향이 구조물의 탄성 지진거동에 매우 중요하곡 성능에 기준한 지반의 비선형성을 고려한 구조물의 내진설계가 필요하다는 것을 잘 보여주고 있다.

Extracranial systemic antitumor response through the abscopal effect induced by brain radiation in a patient with metastatic melanoma

  • D'Andrea, Mark A.;Reddy, G.K.
    • Radiation Oncology Journal
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    • 제37권4호
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    • pp.302-308
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    • 2019
  • The abscopal effect is a term that has been used to describe the phenomenon in which localized radiation therapy treatment of a tumor lesion triggers a spontaneous regression of metastatic lesion(s) at a non-irradiated distant site(s). Radiation therapy induced abscopal effects are believed to be mediated by activation and stimulation of the immune system. However, due to the brain's distinctive immune microenvironment, extracranial abscopal responses following cranial radiation therapy have rarely been reported. In this report, we describe the case of 42-year-old female patient with metastatic melanoma who experienced an abscopal response following her cranial radiation therapy for her brain metastasis. The patient initially presented with a stage III melanoma of the right upper skin of her back. Approximately 5 years after her diagnosis, the patient developed a large metastatic lesion in her upper right pectoral region of her chest wall and axilla. Since the patient's tumor was positive for BRAF and MEK, targeted therapy with dabrafenib and trametinib was initiated. However, the patient experienced central nervous system (CNS) symptoms of headache and disequilibrium and developed brain metastases prior to the start of targeted therapy. The patient received radiation therapy to a dose of 30 Gy delivered in 15 fractions to her brain lesions while the patient was on dabrafenib and trametinib therapy. The patient's CNS metastases improved significantly within weeks of her therapy. The patient's non-irradiated large extracranial chest mass and axilla mass also shrank substantially demonstrating the abscopal effect during her CNS radiation therapy. Following radiation therapy of her residual chest lesions, the patient was disease free clinically and her CNS lesions had regressed. However, when the radiation therapy ended and the patient continued her targeted therapy alone, recurrence outside of her previously treated fields was noted. The disease recurrence could be due to the possibility of developing BRAF resistance clones to the BRAF targeted therapy. The patient died eventually due to wide spread systemic disease recurrence despite targeted therapy.