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Distinct Features of Brain-Resident Macrophages: Microglia and Non-Parenchymal Brain Macrophages

  • Lee, Eunju;Eo, Jun-Cheol;Lee, Changjun;Yu, Je-Wook
    • Molecules and Cells
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    • v.44 no.5
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    • pp.281-291
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    • 2021
  • Tissue-resident macrophages play an important role in maintaining tissue homeostasis and innate immune defense against invading microbial pathogens. Brain-resident macrophages can be classified into microglia in the brain parenchyma and non-parenchymal brain macrophages, also known as central nervous system-associated or border-associated macrophages, in the brain-circulation interface. Microglia and non-parenchymal brain macrophages, including meningeal, perivascular, and choroid plexus macrophages, are mostly produced during embryonic development, and maintained their population by self-renewal. Microglia have gained much attention for their dual roles in the maintenance of brain homeostasis and the induction of neuroinflammation. In particular, diverse phenotypes of microglia have been increasingly identified under pathological conditions. Single-cell phenotypic analysis revealed that microglia are highly heterogenous and plastic, thus it is difficult to define the status of microglia as M1/M2 or resting/activated state due to complex nature of microglia. Meanwhile, physiological function of non-parenchymal brain macrophages remain to be fully demonstrated. In this review, we have summarized the origin and signatures of brain-resident macrophages and discussed the unique features of microglia, particularly, their phenotypic polarization, diversity of subtypes, and inflammasome responses related to neurodegenerative diseases.

Flexible Energy Harvesting Device Based on Porous Piezoelectric Sponge (다공성 압전 스펀지를 이용한 플렉서블 에너지 하베스팅 소자 개발)

  • Dong Hun, Heo;Dong Yeol, Hyeon;Sung Cheol, Park;Kwi-Il, Park
    • Korean Journal of Materials Research
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    • v.32 no.11
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    • pp.508-514
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    • 2022
  • Piezoelectric composite films which are enabled by inorganic piezoelectric nanomaterials-embedded polymer, have attracted enormous attention as a sustainable power source for low powered electronics, because of their ease of fabrication and flexible nature. However, the absorption of applied stress by the soft polymeric matrices is a major issue that must be solved to expand the fields of piezoelectric composite applications. Herein, a flexible and porous piezoelectric composite (piezoelectric sponge) comprised of BaTiO3 nanoparticles and polydimethylsiloxane was developed using template method to enhance the energy conversion efficiency by minimizing the stress that vanishes into the polymer matrix. In the porous structure, effective stress transfer can occur between the piezoelectric active materials in compression mode due to direct contact between the ceramic particles embedded in the pore-polymer interface. The piezoelectric sponge with 30 wt% of BaTiO3 particles generated an open-circuit voltage of ~12 V and a short-circuit current of ~150 nA. A finite element method-based simulation was conducted to theoretically back up that the piezoelectric output performance was effectively improved by introducing the sponge structure. Furthermore, to demonstrate the feasibility of pressure detecting applications using the BaTiO3 particles-embedded piezoelectric sponge, the composite was arranged in a 3 × 3 array and integrated into a single pressure sensor. The fabricated sensor array successfully detected the shape of the applied pressure. This work can provide a cost-effective, biocompatible, and structural strategy for realizing piezoelectric composite-based energy harvesters and self-powered sensors with improved energy conversion efficiency.

A Study on the Formative Characteristics of Vyshyvanka Embroidery Expressed in Apparel Elements (의복구성요소에 표현된 비쉬반카 자수의 조형적 특성 연구)

  • Song, A-ra;Lee, Jin-Hee
    • Journal of the Korea Fashion and Costume Design Association
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    • v.24 no.1
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    • pp.59-69
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    • 2022
  • Vyshyvanka, the embroidered folk costume shirt of Ukraine, originated during the early reign of the Slavs, and currently, it is also called Ukrainian embroidery. In cases of Vyshyvanka embroidery expressed in apparel elements, it is necessary to research formative characteristics for expanding the visual aspect through the diversification of techniques, but also the aspect of the psychological meaning to Ukrainians. This study aims to consider Vyshyvanka as a unique embroidery technique, and also analyze the formative characteristics expressed in apparel elements. The study of Vyshyvanka embroidery expressed in apparel elements can present meaning to understanding the Ukrainian fashion. The image materials for the analysis of Vyshyvanka design, included work photos contained in literary materials and foreign online visual materials. The results of formatively analyzing the Vyshyvanka embroidery expressed in apparel are as follows. First, the Vyshyvanka embroidery expressed in apparel elements held an incantatory meaning, protecting wearers from getting easily invaded by evil spirits. Second, the Vyshyvanka patterns utilized symbolism that implied the incantatory meaning. Third, a single color was used for the embroidery. Lastly, materials like cotton, that are easy to embroider, were mostly used. The formative characteristics of Vyshyvanka embroidery expressed in apparel elements implied the community spirit, nature worship, and folk beliefs. As an attempt to understand the Ukrainian fashion, this study is significant in the aspect of expanding, widely utilizing, and expanding the range of understanding of Ukrainian fashion. Therefore, there should be more active researches on Ukrainian fashion, so Vyshyvanka can be more widely used as a design element.

Doppler Velocity-based Dynamic Object Tracking and Rejection for Increasing Reliability of Radar Ego-Motion Estimation (레이더 에고 모션 추정 신뢰성 향상을 위한 도플러 속도 기반 동적 물체 추적 및 제거)

  • Park, Yeong Sang;Min, Kyoung-Wook;Choi, Jeong Dan
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.21 no.5
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    • pp.218-232
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    • 2022
  • Researches are underway to use a radar sensor, a sensor used for object recognition in vehicles, for position estimation. In particular, a method of classifying dynamic and static objects using the Doppler velocity, the output from the radar sensor, and calculating ego-motion using only static objects has been researched recently. Also, for the existing dynamic object classification, several methods using RANSAC or robust filtering has been proposed. Still, a classification method with higher performance is needed due to the nature of the position estimation, in which even a single failure causes large effects. Hence, in this paper, we propose a method to improve the classification performance compared to existing methods through tracking and filtering of dynamic objects. Additionally, the method used a GMPHD filter to maximize tracking performance. In effect, the method showed higher performance in terms of classification accuracy compared to existing methods, and especially shows that the failure of the RANSAC could be prevented.

Exploring phoenix patterns - Dunhuang Mogao Grottoes and fashion design expressions - (봉황문양 탐구 - 둔황 막고굴과 패션디자인 표현기법 -)

  • Jingyi Zhang;Myung Hee Lee
    • The Research Journal of the Costume Culture
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    • v.31 no.4
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    • pp.504-518
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    • 2023
  • The objective of this study was to explore the symbolism associated with phoenix patterns in China and the temporal aesthetic characteristics of these patterns found in Dunhuang Mogao Grottoes. The study involved collecting examples of clothing designs featuring phoenix patterns from China Fashion Week and the Vogue website, spanning from spring and summer of 2016 to fall and winter of 2022. After collecting and organizing these examples, representative cases were selected for analysis. The objective was to identify effective techniques for incorporating phoenix patterns within the context of Dunhuang Mogao Grottoes and provided insights for future clothing design and textile pattern design research. Phoenix patterns boasted a lengthy history and were laden with symbolic meaning. Early renditions of phoenix patterns found at Mogao Grottoes in Dunhuang were relatively simplistic in design, mainly employing elements like rhythm, coordination, balance and symmetry to convey a sense of nature and gravity. Over time, these patterns evolved under the influence of the prevailing cultural backdrop, employing repeated emphasis to portray notions of abundance and tenacity. Furthermore, regarding the use of phoenix patterns in clothing, there were four prevalent expression techniques: embroidery, beading, printing, and knitting. Traditional techniques like embroidery and beadwork often prioritized aesthetic features like coordination, emphasis, and symmetry, thereby showcasing the opulent characteristics of phoenix patterns. On the other hand, printing and knitting techniques used a single phoenix pattern or a modified version to simplify designs by emphasizing or repeating aesthetic characteristics while adhering to a modern artistic approach.

An objective assessment of the impact of tendon retraction on sleep efficiency in patients with full-thickness rotator cuff tears: a prospective cohort study

  • Ashley E. MacConnell;William Davis;Rebecca Burr;Andrew Schneider;Lara R Dugas;Cara Joyce;Dane H. Salazar;Nickolas G. Garbis
    • Clinics in Shoulder and Elbow
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    • v.26 no.2
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    • pp.169-174
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    • 2023
  • Background: Sleep quality, quantity, and efficiency have all been demonstrated to be adversely affected by rotator cuff pathology. Previous measures of assessing the impact of rotator cuff pathology on sleep have been largely subjective in nature. This study was undertaken to objectively analyze this relationship through the use of activity monitors. Methods: Patients with full-thickness rotator cuff tears at a single institution were prospectively enrolled between 2018 and 2020. Waist-worn accelerometers were provided for the patients to use each night for 14 days. Sleep efficiency was calculated using the ratio of the time spent sleeping to the total amount of time that was spent in bed. Retraction of the rotator cuff tear was classified using the Patte staging system. Results: This study included 36 patients: 18 with Patte stage 1 disease, 14 with Patte stage 2 disease, and 4 patients with Patte stage 3 disease. During the study, 25 participants wore the monitor on multiple nights, and ultimately their data was used for the analysis. No difference in the median sleep efficiency was appreciated amongst these groups (P>0.1), with each cohort of patients demonstrating a generally high sleep efficiency. Conclusions: The severity of retraction of the rotator cuff tear did not appear to correlate with changes in sleep efficiency for patients (P>0.1). These findings can better inform providers on how to counsel their patients who present with complaints of poor sleep in the setting of full-thickness rotator cuff tears.

An Insight Into the Recycling of Waste Flexible Polyurethane Foam Using Glycolysis

  • Woo Seok Jin;Pranabesh Sahu;Gyuri Kim;Seongrok Jeong;Cheon Young Jeon;Tae Gyu Lee;Sang Ho Lee;Jeong Seok Oh
    • Elastomers and Composites
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    • v.58 no.1
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    • pp.32-43
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    • 2023
  • The worldwide use of polyurethane foam products generates large amounts of waste, which in turn has detrimental effects on the surroundings. Hence, finding an economical and environmentally friendly way to dispose of or recycle foam waste is an utmost priority for researchers to overcome this problem. In that sense, the glycolysis of waste flexible polyurethane foam (WFPF) from automotive seat cushions using different industrial-grade glycols and potassium hydroxide as a catalyst to produce recovered polyol was investigated. The effect of different molecular weight polyols, catalyst concentration, and material ratio (PU foam: Glycols) on the reaction conversion and viscosity of the recovered polyols was determined. The obtained recovered polyols are obtained as single or split-phase reaction products. Besides, the foaming characteristics and physical properties such as cell morphology, thermal stability, and compressive stress-strain nature of the regenerated flexible foams based on the recovered polyols were discussed. It was observed that the regenerated flexible foams displayed good seating comfort properties as a function of hardness, sag factor, and hysteresis loss compared to the reference virgin foam. With the growing demand for a sustainable and circular economy, a global valorization of glycolysis products from polyurethane scraps can be realized by transforming them into profitable substances.

Study of the Progressive Party Case Records through the Lens of Archival Science (진보당 형사사건기록에 대한 기록학적 고찰)

  • Lee, JuYoung;Jeon, HyunSoo
    • The Korean Journal of Archival Studies
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    • no.77
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    • pp.109-150
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    • 2023
  • Prior researchers interpreted the records of criminal cases involving the Progressive Party from a historical perspective. In marked contrast to existing trends, this study examines the Progressive Party case records through the lens of archival science. This study dissects the Progressive Party case records as a single and complete record group and at each stage of their life cycle from police investigation through criminal prosecution to trial. This approach enables a holistic analysis of archival characteristics of the records. This study begins with an appraisal of the nature and types of case records generated and maintained by the various agencies in light of the investigatory authorities delegated to each institution. This study then dissects the police, prosecution, and Counter Intelligence Corps records leading up to the indictment of Progressive Party members as well as the court records of the trial that followed. In particular, this study reveals the insufficiency and illegality of the evidence against the defendants in the Progressive Party case from an archival standpoint. Setting aside the admissibility or strength of the evidence under criminal law, the present study demonstrates that the records lack reliability, authenticity, and integrity-the fundamental attributes required for evidentiary efficacy of records from an archival standpoint.

Treatment of Multiple Gingival Recessions Using Vestibular Incision Subperiosteal Tunnel Access with Platelet-rich Fibrin: Two Cases Reports

  • Sung-Min Hwang;Jo-Young Suh
    • Journal of Korean Dental Science
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    • v.16 no.2
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    • pp.218-226
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    • 2023
  • Treatment of multiple gingival recession defects is usually more challenging than that of single gingival recession. Various techniques for the treatment of multiple gingival recession have been established. Recently, vestibular incision subperiosteal tunnel access (VISTA) technique has been considered to exhibit high predictive ability. Connective tissue graft (CTG) has also been considered a gold standard technique owing to its high predictability of root coverage. However, this technique requires a suitable donor site and has clinical disadvantages, such as additional pain. Thus, in this case presentation, platelet-rich fibrin (PRF) was used as an alternative material for CTG along with VISTA. We herein report cases of two patients with Miller's class I and III multiple gingival recession defects, respectively. These patients underwent VISTA along with the use of a PRF membrane. They were followed up for 12 months postoperatively, and their clinical parameters, including probing depth, depth of gingival recession, clinical attachment level, and width of attached gingiva at baseline and at 2, 6, and 12 months postoperatively, were assessed. The patient with class 1 recession defects exhibited a significant amount of root coverage, which remained stable during the follow-up period. Whereas the patient with class 3 recession defects had lesser amount of coverage compared to class 1 patient. The partial coverage observed may be attributed to not only anatomical factors but also the technique-sensitive nature of the procedure. Considering these results, the use of VISTA along with PRF is a viable option for treating gingival recession, as it does not cause discomfort to patients. However, various factors need to be considered during the surgical procedure.

Mechanical properties of sustainable green self-compacting concrete incorporating recycled waste PET: A state-of-the-art review

  • Shireen T. Saadullah;James H. Haido;Yaman S.S. Al-Kamaki
    • Advances in concrete construction
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    • v.16 no.1
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    • pp.35-57
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    • 2023
  • Majority of the plastic produced each year is being disposed in land after single-use, which becomes waste and takes up a lot of storage space. Therefore, there is an urgent need to find alternative solutions instead of disposal. Recycling and reusing the PET plastic waste as aggregate replacement and fiber in concrete production can be one of the eco- friendly methods as there is a great demand for concrete around the world, especially in developing countries by raising human awareness of the environment, the economy, and Carbon dioxide (CO2) emissions. Self-compacting concrete (SCC) is a key development in concrete technology that offers a number of attractive features over traditional concrete applications. Recently, in order to improve its durability and prevent such plastics from directly contacting the environment, various kinds of plastics have been added. This review article summarizes the latest evident on the performance of SCC containing recycled PET as eco-friendly aggregates and fiber. Moreover, it highlights the influence of substitution content, shape, length, and size on the fresh and properties of SCC incorporating PET plastic. Based on the findings of the articles that were reviewed for this study, it is observed that SCC made of PET plastic (PETSCC) can be employed in construction era owing to its acceptable mechanical and fresh properties. On the other hand, it is concluded that owing to the lightweight nature of plastic aggregate, Reusing PET waste in the construction application is an effective approach to reduces the earthquake risk of a building.