• Asian Pacific Journal of Cancer Prevention
• /
• 제15권8호
• /
• pp.3359-3362
• /
• 2014

Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of the activation or repression of target genes and proteins in response to various stimuli and of how they are assembled during signal transduction in cancer cells. Detailed mechanistic insights have unveiled new maps of linear and integrated signal transduction cascades, but the multifaceted nature of the pathways remains unclear. Although new layers of information are being added regarding mechanisms underlying ovarian cancer and how polymorphisms in VDR gene influence its development, the findings of this research must be sequentially collected and re-interpreted. We divide this multi-component review into different segments: how vitamin D modulates molecular network in ovarian cancer cells, how ovarian cancer is controlled by tumor suppressors and oncogenic miRNAs and finally how vitamin D signaling regulates miRNA expression. Intra/inter-population variability is insufficiently studied and a better understanding of genetics of population will be helpful in getting a step closer to personalized medicine.

• IMMUNE NETWORK
• /
• 제21권3호
• /
• pp.18.1-18.13
• /
• 2021

TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune response. In recent years it has become apparent that several different TLRs regulate the function of lymphocytes as well, albeit to a lesser degree compared to innate immunity. TLR2 heterodimerizes with either TLR1 or TLR6 to broadly recognize bacterial lipopeptides as well as several danger-associated molecular patterns. In general, TLR2 signaling promotes immune cell activation leading to tissue inflammation, which is advantageous for combating an infection. Conversely, inappropriate or dysfunctional TLR2 signaling leading to an overactive inflammatory response could be detrimental during sterile inflammation and autoimmune disease. This review will highlight and discuss recent research advances linking TLR2 engagement to autoimmune inflammation.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권8호
• /
• pp.3905-3909
• /
• 2012

Ovarian cancer is the fifth leading cause of cancer death in women aged 35 to 74 years. Although there are several popular hypothesis of ovarian cancer pathogenesis, the genetic mechanisms are far from being clear. Recently, systems biology approaches such as network-based methods have been successfully applied to elucidate the mechanisms of diseases. In this study, we constructed a crosstalk network among ovarian cancer related pathways by integrating protein-protein interactions and KEGG pathway information. Several significant pathways were identified to crosstalk with each other in ovarian cancer, such as the chemokine, Notch, Wnt and NOD-like receptor signaling pathways. Results from these studies will provide the groundwork for a combination therapy approach targeting multiple pathways which will likely be more effective than targeting one pathway alone.

• 한국시뮬레이션학회논문지
• /
• 제8권4호
• /
• pp.125-136
• /
• 1999

In the forthcoming public ATM/B-ISDN, the efficient resource management with pre-planned transit networking which public domain NNI signaling is essential to maintain high network utilization and to assure QoS to the multimedia service users. For this purpose the transit networks must be managed according to the bearer service capability which is defined by ATM Forum and ITU-T. In this paper, we introduce an implementation of ATM transit networking with ATM VP-XC(Virtual Path cross-connect) and US(Network Management System). The functions of ATM VP-XC and NMS have been simulated with OPNET 6.1 modules. We implemented the F4 OAM functions of ATM VP connection according to the ITU-T 1.610 recommendation. Also, the ATM VP transit networking is managed by the NMS according to the connection management architecture of the TWN(Telecommunications Management Network) /TINA ( Telecommunications Information Networking Architecture).

• BMB Reports
• /
• 제50권1호
• /
• pp.12-19
• /
• 2017

Traditionally, biologists have devoted their careers to studying individual biological entities of their own interest, partly due to lack of available data regarding that entity. Large, high-throughput data, too complex for conventional processing methods (i.e., "big data"), has accumulated in cancer biology, which is freely available in public data repositories. Such challenges urge biologists to inspect their biological entities of interest using novel approaches, firstly including repository data retrieval. Essentially, these revolutionary changes demand new interpretations of huge datasets at a systems-level, by so called "systems biology". One of the representative applications of systems biology is to generate a biological network from high-throughput big data, providing a global map of molecular events associated with specific phenotype changes. In this review, we introduce the repositories of cancer big data and cutting-edge systems biology tools for network generation, and improved identification of therapeutic targets.

• 한국통신학회논문지
• /
• 제28권6B호
• /
• pp.563-572
• /
• 2003

차세대 이동 통신망 환경에 Mobile IP 방식을 적용하였을 경우 빈번히 발생하는 핸드오프로 인한 재등록 과정의 오버헤드 증가와 등록 시의 지연으로 인한 패킷 손실 증가 등의 마이크로 이동성(micro-mobility) 문제가 발생할 수 있다. 본 논문에서는 이 문제의 해결을 위해 IP 기반 무선 액세스 망에서 마이크로 이동성을 효율적으로 지원하는 ANMM(Access Network Mobility Management) 방식을 제안한다. ANMM 방식은 액세스 망 내에서 노드가 이동할 때 발생하는 핸드오프 등록 과정을 액세스 망 자체적으로 처리하여 등록 지연과 시그널링 오버헤드를 감소시킨다. 또한 핸드오프 시의 무선 구간에서의 시그널링을 최소화하여 무선 자원의 낭비를 줄일 수 있다.

• PNF and Movement
• /
• 제6권2호
• /
• pp.51-57
• /
• 2008

Purpose : Mechanical stress activates signaling cascades and leading to a specific response of a network of signaling pathways. The purpose of this study is to review the effect of mechanical stress-induced adaptation in skeletal muscle involves a biological mechanisms. Methods : This is literature study with Pubmed, Medline and books. Results : Skeletal muscle tissue demonstrates a malleability and may adjust its metabilic response, vascularization and neuromuscular characteristic makeup in response to alteration in functional demands. The adaptation in skeletal muscle involoves a multitude of signalling mechanisms related with insuline-like growth factor, vascular endothelial growth factor, neurotrophins. Conclusions : The identification of the basic relationships underlying the malleability of skeletal muscle tissue is likely to be of relevance for our understanding with PNF technique.

• 한국조명전기설비학회:학술대회논문집
• /
• 한국조명전기설비학회 2001년도 학술대회논문집
• /
• pp.157-162
• /
• 2001

There are many economic and operational reasons to integrate fire alarm signaling system with other building automation system. Integration of this requires communication standard and careful design practices. The important point for this is also the development of intelligent control modules for replacing the conventional zone adapter in fire system. Therefore, this paper proposes an new conceptual design of the distributed fire alarm signaling system and a new intelligent control modules with LonTalk protocol. Newly proposed additions to LonWorks network make it very well suited for integrating fire systems with other building automation systems. Additionally, it is very important that best design practices, test procedures and building codes need to be modernized to accommodate Integrated building systems.

• 한국정보과학회:학술대회논문집
• /
• 한국정보과학회 2008년도 한국컴퓨터종합학술대회논문집 Vol.35 No.1 (D)
• /
• pp.110-115
• /
• 2008

음성 데이터를 IP기반의 패킷망을 통해 전송하는 기술인 VoIP(Voice over Internet Protocol) 기술은 음성 데이터를 기존의 PSTN(Public Switched Telephone Network)망을 통해 전송하는 방식에 비해 비용 절감 등의 장점을 가지고 있다. 그러나 VoIP가 기존의 PSTN망을 대체하기 위해서는 QoS(Quality of Service)의 보장과 보안이 제공되어야 한다는 문제점을 가지고 있다. VoIP망에서 보안을 위해서는 사용자간에 전송되는 음성 데이터에 대한 보안과 초기의 세션 연결 시 사용자를 인증하는 과정이 고려되어져야 한다. 실질적인 대화 내용인 음성 데이터의 보안도 중요한 부분이지만 대화에 참여하는 사용자를 인증하는 과정이 선행되어야 한다. VoIP에서는 세션 연결 설정을 위해 H.323과 SIP를 사용하고 있으며, 최근에는 H.323에 비해 간단한 SIP가 주목을 받고 있다. RFC3261에서는 SIP를 이용해 세션 연결을 하는 과정에서 사용자를 인증하기 위한 몇 가지 인증 메커니즘을 제시하고 있다. 본 논문에서는 SIP를 이용하여 세션을 연결하는 과정에서 사용자의 인증을 위해 사용되는 인증 메커니즘 중 한 가지인 HTTP Digest Authentication의 취약점을 분석하고, 이를 보완하기 위한 새로운 인증 메커니즘을 제시한다.

• 한국정보통신학회:학술대회논문집
• /
• 한국해양정보통신학회 1998년도 추계종합학술대회
• /
• pp.340-343
• /
• 1998

사설 ATM 스위치에서 인터넷이나 프레임 릴레이 등과 같은 이 기종 망 접속 장비들을 접속하기 위한 망 인터워킹 서비스를 수행하기 위하여 이들의 신호 및 연결 제어를 수행하기 위한 PSA(Proxy Signaling Agent)의 기능을 정의하고, PSA 신호 기능을 수행하기 위한 사설 ATM 스위치에서 수용 가능한 두 가지의 하드웨어 구조를 제안한다. 그리고 이 제안된 하드웨어 구조 상에서 PSA 기능을 수행하기 위한 신호 메시지 전달 방법을 알아보고, non-ATM 망 상의 서비스 이용자를 수용하기 위하여 PSA 기능을 수행하기 위한 ATM 주소 번역 기능, 서비스 대역 폭 할당 및 준비, 트래픽과 QoS 협상 등을 수행하는 PSA를 이용한 호 연결 설정 절차에 대하여 자세히 기술하고자 한다.