• 대한영상의학회지
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• 제82권1호
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• pp.261-266
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• 2021

가역적 뇌혈관 수축 증후군은 허혈성 뇌졸중을 야기할 수 있으며 다양한 질환이 원인이 된다. 하지만 빈혈과 가역적 뇌혈관 수축 증후군의 연관성을 나타내는 사례 보고는 거의 없다. 이에 저자들은 보존적 치료로 호전된 66세 여성의 허혈성 뇌졸중과 뇌혈관 수축을 동반한 중증 철결핍빈혈의 사례를 보고하고자 한다. 고해상도 혈관벽 자기공명영상 소견 및 뇌혈관 협착의 가역성을 토대로 가역적 뇌혈관 수축 증후군을 진단할 수 있었다. 가역적 뇌혈관 수축 증후군 및 허혈성 뇌졸중을 가진 환자에서 철결핍빈혈은 하나의 원인으로 고려되어야 하며 즉각적인 처치를 통해 질병의 진행 및 재발을 방지해야 한다.

• 한국수정란이식학회지
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• 제32권4호
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• pp.331-336
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• 2017

A 2-year-old female Maltese dog was presented with a history of anemia and vaginal hemorrhagic discharge. Physical examination revealed severe vaginal hemorrhagic discharge, abdominal pain, pale mucous membranes, low blood pressure and dehydration. Results of serum biochemistry, hematology, venous blood gas, and electrolyte canine C-reactive protein (CRP) test revealed severe normocytic normochromic anemia, severe neutropenia, a high level of CRP, hypoglycemia, and imbalanced electrolytes. Abdominal ultrasound examination showed focal hypoechoic defect with loss of layering in uterine horn wall. A laparotomy revealed a clear reddish fluid in the abdomen, the fistula of left and right uterine horn, the purulent discharge from fistula, and symptoms of septic peritonitis near by the fistula site. The bitch underwent ovariohysterectomy and recovered without complication. Histopathological diagnosis of the uterine fistula site was adenocarcinoma.

• 한국임상수의학회지
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• 제18권3호
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• pp.232-236
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• 2001

It has been known that garlic, one of the essential ingredient in korean food, has a hypotensive effect. and it is reported that they lower the level of triglycerides, cholesterol and glucose in blood. Especially, the sulfur containing amine acid and the derivatives of the garlic has the counteracting effect to heavy metals. Nowadays, the garlic is known for its efficiency for the various kinds of cancer, neoplasms, hypertension, arteriosclerosis and apoplexy. But, it is reported that the intake of the excessive amount of garlic causes hemolytic anemia recently. The hemolytic anemia is more severe especially in HK phenotype dogs which has a Na-K-ATPase activity. Therefore, this study was performed to examine the effect on the blood of the HK phenotype Jindo dogs when administered the excessive amount of garlic. HK phenotype group showed the significant decrease on RBC, WBC, PCV, Hb, MCV, MCHC, GSH, Met-Hb but LK phenotype group didn't show the significant decrease.

• 한국임상수의학회지
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• 제18권3호
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• pp.288-292
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• 2001

A 3-year-old, 4.0 kg, intact male shih-tzu dog with anorexia, depression, pale mucous membranes, tachypnea, tachycardia was referred to the Veterinary Medical Teaching Hospital. Autoagglutination was observed by naked eye when blood was collected in an EDTA-tube and many spherocytes were found on a Diff-Quik stained blood smear. PCV was 6% and indirect bilirubin was increased markedly. So the immune-mediated hemolytic anemia was diagnosed. Autoagglutination was too severe to perform cross-matching test. Blood was not transfused as it might accelerate or precipitate hemolytic crisis, and regeneration of erythrocytes was very good. Thus corticosteroid of immunosuppressive dose and fluid were administered and PCV was monitored. Although blood was not transfused, PCV increased from 6 to 15.9% in a day and to 30% 7 days later. Therapy for liver was concurrently conducted because liver enzyme activities were high. Corticosteroid tappering therapy was conducted for 75 days and PCV was recovered to 46% after 4 months form start of the treatment.

• Journal of Yeungnam Medical Science
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• 제38권4호
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• pp.366-370
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• 2021

Immune checkpoint inhibitors (ICIs) have become the main drugs for programmed cell death receptor-1 or ligand-1 expressing non-small cell lung cancer (NSCLC) combined with conventional chemotherapy. ICIs are generally more tolerable than cytotoxic chemotherapies in terms of toxicity, and ICI-related adverse events are mild and manageable. However, these drugs may lead to unexpected severe adverse events such as immune-related hematologic toxicities, which could be life-threatening. Here, a rare case of a pembrolizumab-related adverse event in a patient with NSCLC who showed early-onset hemolytic anemia and recovered by high-dose steroid and a series of plasma exchanges is reported.

• BMB Reports
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• 제56권12호
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• pp.669-674
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• 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to various clinical symptoms including anemia. Lipocalin-2 has various biological functions, including defense against bacterial infections through iron sequestration, and it serves as a biomarker for kidney injury. In a human protein array, we observed increased lipocalin-2 expression due to parental SARS-CoV-2 infection in the Calu-3 human lung cancer cell line. The secretion of lipocalin-2 was also elevated in response to parental SARS-CoV-2 infection, and the SARS-CoV-2 Alpha, Beta, and Delta variants similarly induced this phenomenon. In a Calu-3 implanted mouse xenograft model, parental SARSCoV-2 and Delta variant induced lipocalin-2 expression and secretion. Additionally, the iron concentration increased in the Calu-3 tumor tissues and decreased in the serum due to infection. In conclusion, SARS-CoV-2 infection induces the production and secretion of lipocalin-2, potentially resulting in a decrease in iron concentration in serum. Because the concentration of iron ions in the blood is associated with anemia, this phenomenon could contribute to developing anemia in COVID-19 patients.

• Tuberculosis and Respiratory Diseases
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• 제42권3호
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• pp.381-386
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• 1995

45세의 침윤형 흉선종 환자에서 혈색소는 6.2g/dl, 직접 및 간접 Coombs' test는 모두 양성인 심한 자가 면역 용혈성 빈혈이 동반되어 있었다. 흉선종 적출술과 부신피질호르몬제의 투여로 용혈성 빈혈의 호전이 보였으나 부신피질호르몬제를 중단한 2달후에 용혈성 빈혈이 재발되어 현재 prednisolone 15mg/day을 투여 중이며 국소재발이나 용혈성 빈혈의 소견없이 8개월째 경과관찰 중이다.

• Journal of Preventive Medicine and Public Health
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• 제25권2호
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• pp.162-171
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• 1992

The hematologic effect by low-concentration and repeated exposure to mixed organic solvent remains obscure. This study was performed to evaluate the hematologic effect by mixed organic solvent exposure, especially on the type of anemia by mean corpuscular volume(MCV) and red blood cell distribution width(RDW). The subject were 64 organic solvent workers(male 4, female 60) and 78 general workers(male 18, female 60) who showed anemic tendency in worker's health examination which carried out by Pusan Paik Hospital from January to December, 1988. The author gained some hematologic findings(hemoglobin, hematocrit, RBC, WBC, MCV, MCHC, platelet count, ESR, RDW) from auto-analysis method by coulter counter S plus IV, and compared the type of anemia by MCV and RDW. In the pilot study for estimating the prevalence of anemia according to the type of b, the prevalence rate was higher in organic solvent workers than in public officials as 10.9% and 4.1% respectively. There were statistical significance in the value of hemoglobin, hematocrit, MCV, MCHC, platelet count, ESR, RDW between the two study groups with more severe anemic tendency in organic solvent workers. The type of anemia in organic solvent workers was microcytic and anisocytic with the mean value of $68.28{\pm}8.3fL$ of MCV and $19.1{\pm}4.0%$ of RDW.

• 대한간호
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• 제23권2호통권125호
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• pp.29-36
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• 1984

Bone marrow transplantation has been recognized as one of the best methods in the treatment of patients with severe aplastic anemia, acute leukemia, chronic myelocytic leukemia, congenital immune deficiency syndrome and radiation exposure. While there are

• 대한수의학회지
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• 제10권2호
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• pp.81-87
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• 1970

This survey was conducted to observe the relationships between hematozoa and hematological values among cattle. The genus of hematozoa were Anaplasma spp., Babesia spp., Eperythrozoon spp. and Theileria spp. The anemia of dairy cattle was more severe than that of Korean native cattle.