• Title/Summary/Keyword: sensitivity to damage

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Risk Screening of a BTX Plant Using FEDI Method (화재폭발손실지수법을 이용한 BTX 공장의 위험선별)

  • Kim Yong-Ha;Kim In-Tae;Kim In-Won;Kim Ku-Hwoi;Yoon En-Sup
    • Fire Science and Engineering
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    • v.19 no.1 s.57
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    • pp.20-28
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    • 2005
  • Major petrochemical companies in the USA and the EU map out the strategies step-by-step hazard evaluation for the efficient risk management. They adopted the risk screening methods, such as Dow fire & explosion index, as a preliminary phase to execute detailed evaluation such as QRA (Quantitative Risk Assessment). In this study, The FEDI (Fire & Explosion Damage Index), which a kind of risk screening method proposed by Khan and Abbasi, was applied to the BTX plant in Korea. We showed that the FEDI can be effectively used to classify the hazard potential by comparison of the result from the FEDI and the result from QRA. And we showed that the characteristics and the quantities of chemical are the factors which have a largest effect on fire and explosion by executing relative sensitivity analysis of the FEDI. In conclusion, if the FEDI was applied as a preliminary phase of HAZOP, more efficient hazard evaluation can be possible.

Cardamonin exerts a protective effect against autophagy and apoptosis in the testicles of diabetic male rats through the expression of Nrf2 via p62-mediated Keap-1 degradation

  • Samir, Shereen M.;Elalfy, Mahmoud;El Nashar, Eman Mohamad;Alghamdi, Mansour A.;Hamza, Eman;Serria, Mohamed Saad;Elhadidy, Mona G.
    • The Korean Journal of Physiology and Pharmacology
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    • v.25 no.4
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    • pp.341-354
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    • 2021
  • Cardamonin (CARD) is a chalconoid with anti-inflammatory and antioxidant properties, and it is present in several plants. We sought to explore whether CARD exerts any positive effects against hyperglycemia-induced testicular dysfunction caused by type 2 diabetes and aimed to identify its possible intracellular pathways. Adult male rats were subdivided into six groups: control, CARD, diabetic (DM), DM + glibenclamide (GLIB), DM + CARD and DM + GLIB + CARD. Type 2 DM induced a significant increase in blood glucose and insulin resistance, along with diminished serum insulin, testosterone and gonadotropins levels, which were associated with the impairment of key testicular androgenic enzymes and cellular redox balance. Administration of CARD at a dose of 80 mg/kg for 4 weeks effectively normalized all of these alterations, and the improvement was confirmed by epididymal sperm analysis. After treatment with CARD, the pathological changes in spermatogenic tubules were markedly improved. Significantly, CARD upregulated testicular glucose transporter-8 (GLUT-8) expression and had inhibitory effects on elevated autophagy markers and caspase-3 immunoreactive cells. Furthermore, our results revealed that CARD was able to attenuate damage via activation of Nrf2 through the p62-dependent degradation of testicular anti-Kelch-like ECH-associated protein-1 (Keap-1). In conclusion, this study suggests that CARD provides protection against diabetic stress-mediated testicular damage. The use of CARD with conventional anti-diabetic therapy was associated with improved efficacy compared with conventional therapy alone.

Characteristics of Corrosion Damages in Bottom Plate of Above Ground Tank by Acoustic Emission Signal (지상탱크 저판부의 부식손상 평가를 위한 음향방출 신호의 분석)

  • Kim, Sung-Dai;Jung, Woo-Gwang;Lee, Jong-O
    • Journal of the Korean Institute of Gas
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    • v.11 no.4
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    • pp.64-72
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    • 2007
  • Under the AE methods, the valid condition analysis and evaluation the leak etc, resulted by the AE signal pattern on the bottom plate of ground tank at full. In next more, the gradient of accumulation amplitude distribution analysis and comparison the energy, count, and duration time that noise of EMI signal were removed. EMI signal showed height-energy, count, and duration time, it also appeared great gradient of accumulation distribution. Then, with the pure remaining AE signals cluster analysis and location. It would possibly assume of damage with corrosion. Total cluster 20 and energy showed between the maximum 11,990 and 8,565 which is much lower than above figure and event number showed from 8 to 5. Even when it difficult to certify damage by open, as it is raised higher height-sensitivity and threshold by 60 dB. It would possibly presume of location source more accurately.

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Dependency of COD on ground motion intensity and stiffness distribution

  • Aschheim, Mark;Maurer, Edwin;Browning, JoAnn
    • Structural Engineering and Mechanics
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    • v.27 no.4
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    • pp.425-438
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    • 2007
  • Large changes in stiffness associated with cracking and yielding of reinforced concrete sections may be expected to occur during the dynamic response of reinforced concrete frames to earthquake ground shaking. These changes in stiffness in stories that experience cracking might be expected to cause relatively large peak interstory drift ratios. If so, accounting for such changes would add complexity to seismic design procedures. This study evaluates changes in an index parameter to establish whether this effect is significant. The index, known as the coefficient of distortion (COD), is defined as the ratio of peak interstory drift ratio and peak roof drift ratio. The sensitivity of the COD is evaluated statistically for five- and nine-story reinforced concrete frames having either uniform story heights or a tall first story. A suite of ten ground motion records was used; this suite was scaled to five intensity levels to cause varied degrees of damage to the concrete frame elements. Ground motion intensity was found to cause relatively small changes in mean CODs; the changes were most pronounced for changes in suite scale factor from 0.5 to 1 and from 1 to 4. While these changes were statistically significant in several cases, the magnitude of the change was sufficiently small that values of COD may be suggested for use in preliminary design that are independent of shaking intensity. Consequently, design limits on interstory drift ratio may be implemented by limiting the peak roof drift in preliminary design.

DEFECT EVALUATION IN RAILWAY WHEELSETS

  • Kwon, Seok-Jin;Lee, Dong-Hyong;Seo, Jung-Won;You, Won-Hee
    • Proceedings of the KSR Conference
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    • 2007.11a
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    • pp.1940-1945
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    • 2007
  • The wheelsets are one of most important component: damages in wheel tread and press fitted axle are a significant cost for railway industry. Since failure in railway wheelset can cause a disaster, regular inspection of defects in wheels and axles are mandatory. Ultrasonic testing, acoustic emission and eddy current testing method and so on regularly check railway wheelset in service. However, it is difficult to use this method because of its high viscosity and because its sensitivity is affected by temperature. Also, due to noise echoes it is difficult to detect defects initiation clearly with ultrasonic testing. It is necessary to develop a non-destructive technique that is superior to conventional NDT techniques in order to ensure the safety of railway wheelset. In the present paper, the new NDT technique is applied to the detection of surface defects for railway wheelset. To detect the defects for railway wheelset, the sensor for defect detection is optimized and the tests are carried out with respect to surface and internal defects each other. The results show that the surface crack depth of 1.5 mm in press fitted axle and internal crack in wheel could be detected by using the new method. The ICFPD method is useful to detect the defect that initiated in the tread of railway wheelset.

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Investigation of the Electromechanical Response of Smart Ultra-high Performance Fiber Reinforced Concretes Under Flexural (휨하중을 받는 스마트 초고강도 섬유보강 콘크리트의 전기역학적 거동 조사)

  • Kim, Tae-Uk;Kim, Min-Kyoung;Kim, Dong-Joo
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.26 no.5
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    • pp.57-65
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    • 2022
  • This study investigated the electromechanical response of smart ultra-high performance fiber reinforced concretes (S-UHPFRCs) under flexural loading to evaluate the self-sensing capacity of S-UHPFRCs in both tension and compression region. The electrical resistivity of S-UHPFRCs under flexural continuously changed even after first cracking due to the deflection-hardening behavior of S-UHPFRCs with the appearance of multiple microcracks. As the equivalent bending stress increased, the electrical resistivity of S-UHPFRCs decreased from 976.57 to 514.05 kΩ(47.0%) as the equivalent bending stress increased in compression region, and that did from 979.61 to 682.28 kΩ(30.4%) in tension region. The stress sensitivity coefficient of S-UHPFRCs in compression and tension region was 1.709 and 1.098 %/MPa, respectively. And, the deflection sensitivity coefficient of S-UHPFRCs in compression region(30.06 %/mm) was higher than that in tension region(19.72 %/mm). The initial deflection sensing capacity of S-UHPFRCs was almost 50% of each deflection sensitivity coefficient, and it was confirmed that it has an excellent sensing capacity for the initial deflection. Although both stress- and deflection-sensing capacity of S-UHPFRCs under flexural were higher in compression region than in tension region, S-UHPFRCs are sufficient as a self-sensing material to be applied to the construction field.

Biological Control Strategy of Uzi Fly in Sericulture

  • Singh, R.N.;Saratchandra, Beera
    • International Journal of Industrial Entomology and Biomaterials
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    • v.6 no.2
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    • pp.125-132
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    • 2003
  • Uzi fly (Exorista bombycis Louis) is one of the major larval endo-parasitoid of silkworm (Bombyx mori). It causes extensive damage to sericulture industry. The application of synthetic organic pesticides has tremendous impact on minimizing pest population but their overuse and frequent misuse and high sensitivity towards the silkworms, has forced the entomologists to search for alternatives to chemical control, which is safe to silkworm, environment and farm workers. Biological control continues to offer exciting possibilities for the control of fly pest population. It is environmentally safe alternative to chemical control and offering a long-term protection. Several potential hymenopteran parasitoids have been screened. Among successful natural enemies, Nesolynx thymus, Trichomalopsis apanteloctena, Trichopria sp., Brachymeria lasus, Pediobius sp., Spalangia sp., Spilomicrus karnatakensis and Dhirhinus sp. are important. It is essential to predict accurately the efficacy of these natural enemies in a new habitat prior to its introduction. The important desirable attributes of these potential parasitoids viz., host searching capacity, specificity, power of increase and fitness and adaptability of the parasitoid in new environment has been recorded. Results of the host parasitoid interaction indicate that the aging of the host function as a factor that influence the host finding efficiency of the parasitoid. It is highly scored with 15-20 hrs old pupa of the host. However, aging of the parasitoid does not significantly affect it. The sex ratio is female biased which is advantageous from biological control point of view, Biological suppression methods involving conservation and utilization of natural enemies have been discussed in detail.

Effectiveness of seismic isolation in a reinforced concrete structure with soft story

  • Hakan Ozturk;Esengul Cavdar;Gokhan Ozdemir
    • Structural Engineering and Mechanics
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    • v.87 no.5
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    • pp.405-418
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    • 2023
  • This study focused on the effectiveness of seismic isolation technique in case of a reinforced concrete structure with soft story defined as the stiffness irregularity between adjacent stories. In this context, a seismically isolated 3-story reinforced concrete structure was analyzed by gradually increasing the first story height (3.0, 4.5, and 6.0 m). The seismic isolation system of the structure is assumed to be composed of lead rubber bearings (LRB). In the analyses, isolators were modeled by both deteriorating (temperature-dependent analyses) and non-deteriorating (bounding analyses) hysteretic representations. The deterioration in strength of isolator is due to temperature rise in the lead core during cyclic motion. The ground motion pairs used in bi-directional nonlinear dynamic analyses were selected and scaled according to codified procedures. In the analyses, different isolation periods (Tiso) and characteristic strength to weight ratios (Q/W) were considered in order to determine the sensitivity of structural response to the isolator properties. Response quantities under consideration are floor accelerations, and interstory drift ratios. Analyses results are compared for both hysteretic representations of LRBs. Results are also used to assess the significance of the ratio between the horizontal stiffnesses of soft story and isolation system. It is revealed that seismic isolation is a viable method to reduce structural damage in structures with soft story.

Water Physiology of Panax ginseng. 1. Habitat observation. cultural experience, weather factors and characteristics of root and leaf (인삼의 수분생리 1. 자생지관찰.재배 경험.기상요인과 근 및 엽의 특성)

  • Park, Hoon
    • Journal of Ginseng Research
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    • v.4 no.2
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    • pp.197-221
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    • 1980
  • Habitat observation, cultural experience of old and present plantation, weather factors in relation to crop stand and water physiology of root and leaf were reviewed. According to habitat observation ginseng plants love water but plate wit talus well grow at drained place with high moisture content in air and soil while ginseng plants were not found in dry or wet place. According to cultivation experience ginseng plants require abundant water in nursery and main field but most old planters believe that ginseng plaints are draught-loving thus require little water. The experience that rain especially in summer i.e unfavorable might be due to mechanical damage of leaves arid leaf disease infection, or severe leaf fall which is caused by high air temperature and coinsided with rain. According to crop stand observation in relation to weather factors abunsant water increased each root weight but decreased total yield indicating tile increase of missing root rate. Rain in summer was unfavorable too. Though rain in June was favorable for high yield general experience that cloudy day and rain were unfavorable might be due to low light intensity under shade. Present leading planters also do loot consider the importance of water in main field. Water content is higher in top than in root and highest in central portion of root and in stem of top. For seedling the heavier the weight of root is tile higher the water content while it reveries from two years old. Water potential of intact root appeared to be -2.89 bar suggesting high sensitivity to water environment. Under water stress water content severly decreased only in leaf. Water content of leaf appeared to be 78% for optimum, below 72% for functional damage and 68% for perm anent wilting. Transpiration or curs Principally through stomata in lower side of leaf thus contribution of upper side transpiration decreased with the increase of intensity. Transpiration is greater in the leaves grown under high light intensity. Thus water content is lower with high light inte nsity under field condition indicating that light is probable cause of water stress in field. Transpiration reached maximum at 10K1ut The decrease of transpiration at higher temperature seems to be due to the decrease of stomata aperture caused by water stress. Severe decrease of photosynthesis under water stress seems to be principally due to functional damage which is not caused by high temperature and Partly due to poor CO2 supply. Water potential of leaf appeared to be -16.8 bar suggesting weakness in draught tolerance. Ginseng leaves absorb water under high humidity. Water free space of leaf disc is %mailer than that of soybean leaf and water uptake appears to be more than two steps.

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Combination Effects of 7β-Hydroxycholesterol and Radiation in Human Lung Cancer Cells

  • KANG Kyoung Ah;LEE Kyoung Hwa;CHAE Sungwook;KIM Dae Yong;PARK Moon Taek;LEE Su Jae;LEE Yun Sil;HYUN Jin Won
    • Biomolecules & Therapeutics
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    • v.13 no.4
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    • pp.220-226
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    • 2005
  • The present study was performed to evaluate combination effect of 7$\beta$-hydroxycholesterol (7$\beta$-OHC) and $\gamma$-radiation in NCI-H460 human lung cancer cells. 7$\beta$-OHC in combination with $\gamma$-irradiation has an enhanced effect in decreasing clonogenic survival and increasing cellular DNA damage. Pretreatment of cells with 7$\beta$-OHC enhanced radiation-induced apoptosis. Apoptosis of the cells by combined treatment of 7$\beta$-OHC and $\gamma$-irradiation was associated with reactive oxygen species generation and loss of mitochondrial membrane potential, resulting in the activation of caspase 9 and caspase 3. The combined treatment also resulted in an increased G1 cell cycle distribution. These results indicate that 7$\beta$-OHC shows the additive effect of radiation sensitivity in human lung carcinoma cells in vitro.