• Journal of Genetic Medicine
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• v.19 no.1
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• pp.1-6
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• 2022

Radiation therapy (RT) is a very important treatment for cancer that irradiates a large amount of radiation to lead cancer cells and tissues to death. The progression of RT in the aspect of personalized medicine has greatly advanced over the past few decades in the field of technical precision responding anatomical characteristics of each patient. However, the consideration of biological heterogeneity that makes different effect in individual patients has not actually applied to clinical practice. There have been numerous discovery and validation of biomarkers that can be applied to improve the efficiency of radiotherapy, among which those related to genomic information are very promising developments. These genome-based biomarkers can be applied to identify patients who can benefit most from altering their therapeutic dose and to select the best chemotherapy improving sensitivity to radiotherapy. The genomics-based biomarkers in radiation oncology focus on mutational changes, particularly oncogenes and DNA damage response pathways. Although few have translated into clinically viable tools, there are many promising candidates in this field. In this review the prominent mutation-based biomarkers and their potential for clinical translation will be discussed.

• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.3
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• pp.143-152
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• 2014

In this study, the sensor response and sensitivity is experimented and analyzed quantitatively by the line numbers of chlorine ion reaction type corrosion sensor that is developed. The sensor response of the developed corrosion sensor is verified with properties of chlorine ion. The multilineal sensor is shown a large resistance change more than the single line sensor by damage of the sensor. And, the resistance change of sensor is as large as high concentration of NaCl aqueous solution, the sensitivity of multilineal sensor is higher than single line sensor's, and the depth of sensor's location is as large as the increasing of resistance change time (cycle). These results suggest that, the developed corrosion sensor could sense corrosion reaction, sensor sensitivity and change of resistance for chloride ion. Especially, It was judged that 7 line sensor was the most superior for monitoring chloride ion immigration into concrete.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.5
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• pp.276-284
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• 2013

A stochastic expected cost model has been suggested by combining the nonlinear cumulative damage model with the expected cost model together which can be useful for doing the preventive optimal-maintenance of the armor units of rubble-mound breakwaters. The suggested model has been satisfactorily calibrated by comparison of the results from others models, also the sensitivity analysis has been carried out in detail under the variation of the associated parameters with the model. The optimal repair times can be directly evaluated by minimizing the expected cost rates that depend on the social importances, damage intensity functions and resistance limits. Finally, the present cost model has been straightforwardly applied to the armor units of rubble-mound breakwaters. Based on the assumption of turning the damaged structure back to the state as good as new after repairs, the required optimal repair times and magnitudes can be determined quantitatively in terms of the optimum balance between the costs and benefits on the preventive maintenance.

• Korean Journal of Veterinary Research
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• v.44 no.1
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• pp.41-47
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• 2004

The alkaline single-cell gel electrophoresis (SCGE) assay, called the comet assay, has been applied to detect DNA damage induced by a number of chemicals and biological factors in vivo and in vitro. The DNA damage was analysed by tail moment (TM) and tail length (TL), which were markers of DNA strand breaks in SCGE. Human, mouse and rat peripheral blood lymphocytes (PBLs) were irradiated with different doses of $^{60}Co$ ${\gamma}$-rays, e.g. 1, 2, 4, and 8 Gy at a dose rate of 1 Gy/min. A dose-dependent increase in TM (p<0.01) and TL (p<0.01) was obtained at all the radiation doses (1-8 Gy) in human, mouse and rat PBLs. Mouse PBLs were more sensitive than human PBLs which were in turn more sensitive than rat PBLs when the treated dosages were 1 and 2 Gy. However, human PBLs were more sensitive than mouse PBLs which were in turn more sensitive than rat PBLs when the irradiation dosages were 4 and 8 Gy. Data from all three species could be fitted to a linear-quadratic model. These results indicated that there may be inherent differences in the radio-sensitivity among PBLs of mammalian species.

• Journal of the Korea institute for structural maintenance and inspection
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• v.11 no.2
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• pp.134-144
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• 2007

In this study, a smart sensor unit is developed by using the smart sensor technology that is being rapidly developed in recent years for structural health monitoring system, and its performance is evaluated through various experiments, and also, damage detection experiment is performed on a model structure. This paper as the first half of this study contains the development and performance evaluation of the smart sensor. In the latter half of this study, structure damage detection experiment is performed for the application of verified smart sensor unit into structural health monitoring, and it is compared with a wire measurement system. The smart sensor is developed by using high-power wireless modem, MEMS Sensor and AVR microcontroller, and an embedded program is also developed for the control and operation of the sensor unit. To verify the performance of the smart sensor, many experiments are performed for sensitivity and resolution analysis tests, data acquisition by using cantilever beam and shaker, and on-site application using actual bridge. As a result, the smart sensor proves to be satisfactory in its performance.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1993.04b
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• pp.300-304
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• 1993

Chip formation control is an important problem in the automation of manufacturing process, since the continuous chip can cause catastrophic failures of the tooling and entangle the workpiece causing damage. However, it is impossible to predict chip form correctly due to the complex nature of cutting process. In order to detect the chip form for unmanned manufacturing, a new identification method is proposed. The feasibility of using acoustic emission signals from the sensing plate for identification of chip form is investigated. Experiments were conducted under the various cutting conditions. When the acoustic emission sensor is attached to the sensing plate, it turns out that the moving averaged AE signals correlated well with the collision of segmented chips with the plate. The sensitivity of moving averaged AE signals to chip congestions due to continuous chip formation is illustrated as well.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.1454-1458
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• 2007

The determination of feasible design flood is the most important to control flood damage in river management. Model parameters should be calibrated using observed discharge but due to deficiency of observed data the parameters have been adopted by engineer's empirical sense. Storage constant in the Clark unit hydrograph method mainly affects magnitude of peak flood. This study is to estimate the storage constant based on the observed rainfall-runoff data at the three stage stations in the Imjin river basin and the three stage stations in the Ansung river basin. In this study four methods have been proposed to estimate the storage constant from observed rainfall-runoff data. The HEC-HMS model has been adopted to execute the sensitivity of storage constant. A criteria has been proposed to determine storage constant based on the results of the observed hydrograph and the HEC-HMS model.

• Progress in Medical Physics
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• v.11 no.2
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• pp.157-165
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• 2000

Purpose: For estimation of yields of l)NA damages induced by radiation and enhanced by oxygen, a mathematical model was used and tested. Materials and Methods: Reactions of the products of water radiolysis were modeled as an ordinary time dependant equations. These reactions include formation of radicals, DNA damage, damage repair, restitution, and damage fixation by oxygen and H-radical. Several rate constants were obtained from literature while others were calculated by fitting an experimental data. Sensitivity studies were performed changing the chemical rate constant at a constant oxygen number density and varying the oxygen concentration. The effects of oxygen concentration as well as the damage fixation mechanism by oxygen were investigated. Oxygen enhancement ratio(OER) was calculated to compare the simulated data with experimental data. Results: Sensitivity studies with oxygen showed that DNA survival was a function of both oxygen concentration and the magnitude of chemical rate constants. There were no change in survival fraction as a function of dose while the oxygen concentration change from 0 to 1.0 x 10$^{7}$ . When the oxygen concentration change from 1.0 $\times$ 107 to 1.0 $\times$ 101o, there was significant decrease in cell survival. The OER values obtained from the simulation study were 2.32 at 10% cell survival level and 1.9 at 45% cell survival level. Conclusion: Sensitivity studies with oxygen demonstrated that the experimental data were reproduced with the effects being enhanced for the cases where the oxygen rate constants are largest and the oxygen concentration is increased. OER values obtained from the simulation study showed good agreement for a low level of cell survival. This indicated that the use of the semi-empirical model could predict the effect of oxygen in cell killing.

• Women's Health Nursing
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• v.7 no.3
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• pp.284-292
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• 2001

This study is an attempt to analyze concept of pain and to do it according to a series of concept development processes described by Walker and Avant. Based on the results of the study, the attributes, scope, precedences and consequences of pain were identified : 1. The attributes of pain were subjectivity, unpleasantness, expression, experience, response, and sensitivity. 2. The scope of pain were physical, psychological, and socio-cultural. 3. The following were precedences of pain : 1) Internal or external noxious stimuli 2) actual or potential injury or damage to body and/or mind 3) noxious stimulation or aversive sensation is perceived as pain 4. The following were consequences of pain : 1) physical, psychological, socio-cultural response 2) verbal and/or non-verbal communication 3) coping and self-preservation.

• Geomechanics and Engineering
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• v.2 no.1
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• pp.57-69
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• 2010

A major consideration in the design of tunnels in urban areas is the prediction of the ground movements and surface settlements associated with the tunneling operations. Excessive ground movements can damage adjacent building and utilities. In this paper, a neural network model is used to predict the maximum surface settlement, based on instrumented results from three separate EPB tunneling projects in Singapore. This paper demonstrates that by coupling the trained neural network model to a spreadsheet optimization technique, the reliability assessment of the settlement serviceability limit state can be carried out using the first-order reliability method. With this method, it is possible to carry out sensitivity studies to examine the effect of the level of uncertainty of each parameter uncertainty on the probability that the serviceability limit state has been exceeded.