• Title/Summary/Keyword: safety coefficient

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Residue and risk assessment of veterinary antibiotics in manure-based composts and agricultural soils (가축분뇨 유래 퇴비 및 농경지 중 축산용 항생제의 잔류 및 위해성 평가)

  • Paik, Min-Kyoung;Ryu, Song-Hee;Kim, Sung-Chul;Hong, Young-Kyu;Kim, Jin-Wook;Kim, Jeong-Gyu;Kwon, Oh-Kyung
    • Journal of Applied Biological Chemistry
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    • v.64 no.2
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    • pp.177-184
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    • 2021
  • While veterinary antibiotics are used only in a part of the dose administered, the rest are excreted as urine or feces. Residual antibiotics enter the adjacent agricultural environments by spraying manure-based composts on farmlands and lead to secondary pollution. Therefore, it is necessary to develop the technique for post management such as regulatory levels of antibiotics in the agricultural environments. This study was conducted to compare by different matrices the amount of residual antibiotics such as tetracyclines and sulfonamides, which are known to be frequently used in Korea and to practice risk assessment by different antibiotics in soils before and after application of composts. Pre-treatment with modified typical method using buffer and solid phase extraction showed the recovery of composts and soils was more than 70% at ppb level and the limits of detection were 0.13-0.46 and 0.05-0.25 ㎍/kg, respectively. Analysis of manure-based composts revealed concentrations from 5.38 to 196.0 ㎍/kg for tetracyclines, from below the detection of limit (BDL) to 259.0 ㎍/kg for sulfonamides. In case of agricultural soils, residual concentrations of selected veterinary antibiotics were ranged 0.30-53.3 ㎍/kg, BDL-4.16 ㎍/kg respectively and the concentration level of tetracyclines, which had higher soil distribution coefficient (Kd) values, was higher than that of sulfonamides. There was a difference in human risk assessment by different antibiotics in soil before and after application of composts. But, it was indicated that detection values of all of 5 antibiotics were very safe on the basis that Hazard Quotient was safe below 1.

A Study on Optical Design Factors by Artificial Recharge Performance (인공함양 주입성능평가에 의한 설계요소 산정 연구)

  • Won, Kyoung-Sik;Lee, Yeoung-Dong;Shin, Dong-Min;Kim, Byeong-Jun;Kim, Gyoo-Bum
    • The Journal of Engineering Geology
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    • v.30 no.4
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    • pp.603-615
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    • 2020
  • The design factors of artificial recharge are determined by considering the hydrogeological characteristics of the aquifer. The optimal design factors for artificial recharge were derived after performing the injection tests step by step for each injection type (vertical well, ditch and mixed type), which were built in the test site of the study area. It was analyzed that the difference in the injection effect according to the diameter of the injection well was not large, and the 100 mm well was evaluated as appropriate in consideration of the availability and economy of land use. Since the injection effect was well maintained even in the upper rock, the depth of the injection well was proposed for the alluvial layer and the upper rock layer. On the other hand, in four cases of filter media in the ditch, it was analyzed that the penetration efficiency and the hydraulic interference effect indicated excellent injection performance when a filter medium of 10 to 30 mm diameter was filled in the ditch. In addition, the proper spacing of the injection wells was analyzed as 9~12 m considering the interference efficiency. The interference efficiency attenuation coefficient per 1 m of hole spacing was calculated to be 1.75% in this area. In the future study, the artificial recharge design factors obtained in this stage are applied and verified on site construction and operation. Also it is expected to contribute to securing water in areas where there is always a lack of water.

Development and Validation of a Questionnaire on the Feasibility of a Mobile Dietary Self-Monitoring Application (식습관 관리 애플리케이션의 적용 가능성에 대한 설문지 개발 및 타당성 연구)

  • Lee, Heejin;Ahn, Jeong Sun;Lee, Jung Eun
    • Korean Journal of Community Nutrition
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    • v.27 no.2
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    • pp.146-157
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    • 2022
  • Objectives: This study aimed to develop and assess the content validity and internal consistency of a questionnaire on the feasibility of mobile dietary self-monitoring applications. Methods: We developed a feasibility questionnaire to assess the overall usage, convenience, usefulness, and satisfaction of mobile dietary applications. The initial draft of the questionnaire contained 17 items with yes/no, multiple-choice, and open-ended questions and 52 items on 5-point Likert scales. To validate the content, ten experts evaluated the relevance of the items for each subscale using a 5-point scale. We calculated the item-level content validity index (I-CVI) and scale-level content validity index (S-CVI). A total of 102 adults answered the questionnaires which reflected the experts' reviews. We conducted an exploratory factor analysis to determine the underlying structure of responses and categorized convenience, usefulness, and satisfaction. We also calculated Cronbach's alpha coefficient to examine the internal consistency of items in each subscale. Results: The S-CVI score of the items was 0.86, and we removed items with an I-CVI score of < 0.80. We combined, revised, or separated some remaining items and added one item as per the experts' comments. As a result, we included 16 items about overall usage and 42 sub-questions. Based on the responses of the 102 adults, we performed exploratory factor analysis using the principal axis method. We retained items with a factor loading of > 0.40, resulting in a final set of 35 questions (convenience: 15, usefulness: 12, satisfaction: 8 items). The Cronbach's alpha values of the three scales were 0.93, 0.91, and 0.91 for 1) usefulness, 2) convenience, and 3) satisfaction, respectively. Conclusions: We developed a feasibility questionnaire for mobile dietary self-monitoring applications and examined its content validity and internal consistency. Our questionnaire has the potential to measure the feasibility of mobile dietary self-monitoring applications.

Mediating effect of Resilience for Life care in the Relationship between Stress Coping and Job Stress of 119 Emergency Medical Technicians (119 구급대원의 라이프 케어를 위한 스트레스 대처와 직무스트레스 간의 관계에서 극복력의 매개효과)

  • Kang, Da-Yeon;Lee, Hyo-Cheol;Ko, Dae-Sik
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.3
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    • pp.463-473
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    • 2020
  • This study was conducted to provide basic data to find measures to alleviate the job stress of 119 Emergency Medical Technicians by identifying the mediating effect of resilience for life care in the relationship between stress coping and job stress of 119 Emergency Medical Technicians. The data for this study were collected from October 5, 2019, to October 31, 2019. The subject was 205 119 Emergency Medical Technicians working in 119 safety centers located in G Metropolitan City. The collected data were analyzed by independent t-test, ANOVA, Scheffé test, Pearson's correlation coefficients, hierarchical multiple regression analysis, and Sobel test using the SPSS Statistics 21.0 program. As a result oh the study, The mediation effect of resilience was not statistically significant in the relationship between stress coping of seeking social support type and job stress; the mediation effect of resilience was not statistically significant in the relationship between stress coping of seeking positive thinking type and job stress. but, resilience was revealed that resilience completely mediates the relationship between problem-solving type and job stress, and partially mediates the relationship between avoidance type and job stress. The measures to reduce the job stress of 119 Emergency Medical Technicians derived from the above results are as follows. First, among the 119 Emergency Medical Technicians, problem-solving stress coping type 119 Emergency Medical Technicians need to reduce job stress through resilience improvement program. Second, avoidance stress coping type 119 Emergency Medical Technicians should take part in education programs that can reduce job stress in parallel with resilience improvement program.

Evaluation on the Performance of Relief Wells Using Geosynthetics Blanket Length as a Parameter in an Agricultural Reservoir Embankment (농업용 저수지 제방에서 토목섬유 블랭킷의 길이에 따른 감압정의 성능 평가)

  • Ryu, Jeonyong;Kim, Seungwook;Chang, Yongchai
    • Journal of the Korean GEO-environmental Society
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    • v.23 no.6
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    • pp.5-17
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    • 2022
  • The performance of the relief wells installed for the purpose of controlling seepage of the dam embankment is affected by various parameters such as diameter, spacing, penetration rate, permeability coefficient of the ground, thickness of the foundation layer. Therefore, when the relief wells are adopted for the purpose of reducing seepage pressure, these parameters should be sufficiently reviewed to determine the installation specifications of the relief wells. This study evaluated the effect of the length of the geosynthetics blanket on the performance of the relief wells installed in the downstream part of the dam embankment with blankets in the upstream and downstream part of the dam embankment as countermeasure methods to control seepage of the dam embankment. In the relationship between the length of the upstream and downstream blanket and the discharge, the discharge of the relief wells decreases as the length of the upstream blanket increases, and on the other hand, the discharge of the relief wells decreases as the length of the downstream blanket increases. In the upper and lower blanket length-spacing relationship, as the length of the upstream blanket increases, the spacing of the relief wells increases and as the length of the downstream blanket increases, the spacing of the relief wells decreases. Therefore, when installing the relief wells in parallel with the blanket, it was found that increasing the length of the upstream blanket is more efficient than increasing the length of the downstream blanket in order to minimize the discharge of seepage discharge and to ensure economic feasibility by wider installation of the relief wells.

Analytical Method of Multi-Preservatives in Cosmetics using High Performance Liquid Chromatography (HPLC 를 이용한 화장품 중 살균보존제 다성분 동시분석법 연구)

  • Min-Jeong, Lee;Seong-Soo, Kim;Yun-Jeong, Lee;Byeong-Chul, Lee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.48 no.4
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    • pp.321-330
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    • 2022
  • This study attempted to establish an optimal multi-compound simultaneous analysis method that can secure reliable results for 15 - preservatives, 2 - sun screens and 1 - antioxidants of cosmetics using HPLC-PDA. Since the potential of hydrogen (pH) in the mobile phase affects the acid dissociation constant (pKa) of the preservatives, and the peak retention time shift and area change were observed. The peak separation condition was established by adjusting the pH to 0.1% H3PO4 addition (mL) when preparing the mobile phase. As a results of method validation, the linearity correlation coefficient (R2) of above 0.999 were obtained, and accuracy 87.9 ~ 101.1%, 0.1 ~ 7.6% precision for two types of cosmetics (cream and shampoo). It was found that the limit of detection (LOD) was 0.1 ~ 0.2 mg/kg and the limit of quantitation (LOQ) was 2.0 ~ 4.0 mg/kg. In addition, it was possible to simultaneously separate p-anisic acid, a natural compound that was difficult to separate in HPLC due to the small difference from methylparaben, a synthetic preservatives. Through this study, it will be effectively used to secure quality control and safety for compound that need restrictions on use cosmetics.

Seismic Performance Evaluation of Mechanically Jointed PE Pipeline by Response Displacement Method (기계식 이음 PE관의 응답변위법 기반 내진성능평가 요령)

  • DongSoon Park
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.27 no.4
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    • pp.23-32
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    • 2023
  • The seismic performance of buried PE pipes is reported to be favorable due to their exceptional elongation capacity at break. Although a seismic performance evaluation procedure based on the response displacement method has been summarized in Korea for fusion-bonded PE pipes, there is currently no procedure available for mechanically jointed PE pipes. This article aims to present a seismic performance evaluation procedure based on the response displacement method specifically designed for mechanically jointed PE pipes in Korea. When employing the mechanical joining method for PE pipes, it is recommended to adhere to the evaluation procedure established for segment-type pipes. This involves assessing the stress induced by the pipe, the expansion and contraction strain of the joint, and the bending angle of the pipe joint. Furthermore, the coefficient of inhomogeneity of the soil, which is necessary for estimating the axial strain of the ground, is introduced. Additionally, a computation method for determining lateral displacement and reconsolidation settlement in soil susceptible to liquefaction is proposed. As a result of the sensitivity analysis considering the typical soil condition in Korea, the mechanically jointed PE pipe with a certain quality was shown to have good structural seismic safety when soil liquefaction was not considered. This procedure serves as a valuable tool for seismic design and evaluating the seismic performance of mechanically joined buried PE pipes, which are primarily utilized for connecting small-diameter pipes.

Influence of Rainfall Intensity and Saturated Permeability on Slope Stability during Rainfall Infiltration (강우침투시 강우강도와 포화투수계수가 안전율에 미치는 영향)

  • Lee, Seung-Rae;Oh, Tae-Kyu;Kim, Yun-Ki;Kim, Hee-Chul
    • Journal of the Korean Geotechnical Society
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    • v.25 no.1
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    • pp.65-76
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    • 2009
  • The unsaturated characteristics of Korean weathered granite soils have been studied to investigate the influence of saturated permeability, rainfall intensity and soil-water characteristic curve (SWCC) on the slope stability. The upper, average and lower SWCCs were estimated from the publication and experimental results using the statistical concept. The roughly estimated SWCC can be used for the soils without experimental results by relating SWCC with the particle size distribution curve. An appropriate ratio between the saturated permeability and the rainfall intensity ($k_s$/i) was also suggested for practical use in designing the slopes by investigating the time-dependent variation of slope instability during the rainfall. The slope stability was deteriorated from the initiation of rainfall and recovered again after the factor of safety reached the critical value. The FS of the slope decreased at first and then increased after reaching the critical value during the rainfall. As a result, the slope instability was not related with an absolute rainfall intensity but with the ratio between the saturated permeability and the rainfall intensity. In case of the upper SWCC, the critical condition occurred when the ratio between the saturated permeability and the rainfall intensity was in the range of $1.0{\sim}2.0$.

Development of LC-MS/MS analytical methods for metalaxyl in Atractylodes macrocephala Koidzumi and Achyranthes japonica Nakai (LC-MS/MS를 이용한 생약 백출 및 우슬 중 Metalaxyl 잔류분석법 개발)

  • Yun, Myung-Sub;Yang, Seung-Hyun;Choi, Hoon
    • Journal of Applied Biological Chemistry
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    • v.65 no.1
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    • pp.17-21
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    • 2022
  • A new rapid and simple method for metalaxyl in Atractylodes macrocephala Koidzumi and Achyranthes japonica Nakai has been developed and validated. This study was conducted to develop a method for analyzing metalaxyl by a method based on QuEChERS using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Samples were extracted with acetonitrile and purified using amino-propyl (NH2) Solid Phase Extraction cartridge. The method limit of quantitation (MLOQ) was 0.01 mg/kg. The linearity of matrix-matched calibration curve (r2) was ≥0.99 at the calibration range of 0.001-0.05 mg/kg. For recovery test, Atractylodes macrocephala Koidzumi or Achyranthes japonica Nakai was treated with standard solutions at MLOQ and 10MLOQ levels. Recovery rates were in the range of 88.1-109.1% with <5.5% coefficient of variation. This established analytical method was fully validated. Based on these results, it can contribute to improving the safety of residual pesticides in Atractylodes macrocephala Koidzumi and Achyranthes japonica Nakai.

An Empirical Study on the Effects of Entrepreneurship on Entrepreneurial Intention: Focusing on Moderating Effects of Fear of Entrepreneurial Failure (기업가정신이 창업의지에 미치는 영향에 관한 연구 - 창업실패두려움의 조절효과를 중심으로)

  • Kim, Young Hee;Yang, Dong Woo
    • Korean small business review
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    • v.41 no.4
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    • pp.65-86
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    • 2019
  • This study empirically analyzed how the elements of entrepreneurship and the fear of entrepreneurial failure influence entrepreneurial intention with each other in a situation that encourages startups. In particular, the moderating effect of fear of entrepreneurial failure was verified by dividing the fear of entrepreneurial failure into three sub-variables: fear of financial loss, fear of psychological loss, and fear of career loss. As a result, it was found that proactiveness and risk-taking had a positive effect on entrepreneurial intention, but innovativeness did not. Fear of entrepreneurial failure(all of sub-variables) was found to have no significantly moderating effect on the relationship between entrepreneurship and entrepreneurial intention. Therefore it seemed to have a negative effect as a independent variable. However, considering the regression coefficient(β) is positive or negative depending on the interaction terms of the sub-variables of fear of entrepreneurial failure and the entrepreneurship, it could be inferred that the moderating effect could be positive or negative. Based on this research results, a sophisticated entrepreneurship education program to inspire entrepreneurship and lower the fear of failure is needed in order to promote startups. And at the same time, a social safety net construction plan to reduce the fear of entrepreneurial failure needs to be prepared.