• 한국임상약학회지
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• 제30권1호
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• pp.1-10
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• 2020

Objective: The aim of the study was to perform a meta-analysis of randomized clinical trials to compare the clinical efficacy and safety between combination of cyclin-dependent kinase (CDK) 4/6 inhibitors with aromatase inhibitors (AIs) and AIs alone in patients with hormone receptor+/human epidermal growth factor receptor type2-(HR+/HER2-) advanced breast cancer. Methods: Published clinical studies were identified through electronic database searches until February 2019. Literature qualities were assessed by the Scottish Intercollegiate Guidelines Network Checklist. Key endpoints of efficacy were progression-free survival (PFS), objective response rate (ORR), and clinical benefit (CB). Endpoints of safety were adverse events (AEs) (neutropenia, leukopenia, any grade 3/4 AEs, and serious AEs) and on-treatment death. Meta-analysis was performed using the RevMan 5.3 software. Results: The selected five studies were evaluated as "good" in quality assessment. Compared to AIs alone, the combination therapy significantly improved PFS (pooled hazard ratio=0.55; 95% confidence interval (CI) 0.49-0.62), ORR (odds ratio=1.78; 95% CI=1.49-2.13), and CB (odds ratio=1.86; 95% CI=1.51-2.28). The prevalence of AEs was significantly higher in the combination group than in the AIs alone group. On-treatment death was greater in the combination group than in the AIs alone group, although insignificant. Conclusion: The combination therapy of CDK4/6 inhibitors with AIs was more effective for the treatment of HR+/HER2- advanced breast cancer, but less safe than AIs alone. The combination therapy should be effectively managed through patient monitoring, and further studies are needed to reduce AEs in the combination therapy of CDK4/6 inhibitors with AIs.

• 해양환경안전학회지
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• 제13권4호
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• pp.71-78
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• 2007

예부선은 항만 개발 및 매립, 해상교량 건설, 항로 준설 등 우리나라 해양 산업 건설에 핵심적인 공헌과 역할을 수행하여 왔다. 또한 국내 등록 척수로는 가장 많은 비중을 차지하고 있고, 부선의 경우 전용화와 대형화가 꾸준히 진행되어 일반 상선과 등급의 부선이 운항되고 있다. 이로 인한 해양사고의 증가에도 불구하고 예부선에 대한 국가적인 차원에서의 안전운항 대책이 미흡한 실정이다. 본 연구는 최근 빈번하게 발생하고 있는 해상교량과 관련된 예부선의 사고에 대한 안전 운항 대책을 제안하고자 한 것으로, 해양사고의 통계 자료와 사례 분석, 예부선 운항 실태를 운송계약 측면과 인원 구성을 검토하여 해상교량의 안전 통항을 위해 선학 자체적으로 점검해야 하는 항해계획과 운항점검표를 일례로 제시하고, 예부선의 안전운항 향상을 위한 전자차트시스템 기반의 안전항행지원시스템을 제안한다.

• 한국안전학회지
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• 제25권6호
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• pp.169-179
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• 2010

The aim of this study was to investigate occupational and individual risk factors and working conditions in relation to musculoskeletal symptoms in street cleaners. Investigation was conducted through a survey of 395 male street cleaners employed by the government office in Seoul, Gyeonggi and Chung-Nam from July to August of 2009. The control group was comprised of 143 male drivers and security guards. Risk factors for musculoskeletal symptoms in street cleaners were investigated by multiple logistic regression analysis and also evaluated ergonomic risk factors by assessing working conditions of 4 street cleaners. As a result of symptom questionnaires, all of the prevalent rates of musculoskeletal symptoms in street cleaners had significantly higher results than those of the control group(p<0.05). On binary logistic regression analysis of musculoskeletal symptoms, street cleaners showed significant higher odds ratio as 18.84(95%CI: 6.56-54.12) in the arm/elbow, 10.49(95%CI: 4.29-25.65) in the hand/wrist compared to the control group. Both absence of rest breaks and exposure to ergonomic risk factors showed to be important internal risk factors of musculoskeletal symptoms among street cleaners. The exposure levels of QEC(Quick exposures checklist) in street cleaners were revealed to be higher on the shoulder/arm, wrist/hand, and neck than back, or from stress. The findings appear to show that street cleaners were high-risk group of work-related musculoskeletal disorders. Therefore street cleaners require a holistic interventional strategy, including adequate arrangement of rest breaks, improvement of working tools and control of individual risk factors such as obesity and smoking.

• 한국건축시공학회지
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• 제18권6호
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• pp.611-619
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• 2018

현재까지의 건설 안전관리와 리스크에 관한 연구들은 건설현장 내부(근로자)에 한정되어 있어 건설현장 외부(제 3자)에 대한 연구는 미비한 실정이다. 그 결과, 건설현장 주변의 일반인들이 피해를 받고 있으며 산재 다발이라는 부정적인 이미지로 언론이나 일반 대중들에게 투영되고 있다. 일반 대중들에게 부정적인 이미지를 탈피하기 위해서는 건설현장 내부(공종, 건축물)에만 집중되어있는 기존의 안전관리가 아닌 건설 현장 외부(제 3자)에 대해서도 고려된 종합적 안전관리체계를 구축해야 한다. 이에 본 연구에서는 건설 현장 외부(제 3자)의 인명사고 리스크를 정량화하고 몬테카를로 시뮬레이션을 활용하여 리스크가 어떻게 변화할 것인지 예측하고자 한다. 이를 위하여 첫째, 선행연구를 고찰하여 불안전한 상태와 인명사고 발생형태를 정의한다. 둘째, 14년 간 건설현장 외부에서 발생한 제 3자 인명 손해배상액 데이터를 수집한다. 셋째, 수집된 데이터의 사고내용을 분석하여 사고 발생분석 모델을 설정한다. 넷째, 리스크 정량화 모델을 구축하고 불안전한 상태, 인명사고 발생형태별 사고발생확률과 손해배상액 확률분포를 제시한다. 마지막으로 몬테카를로 시뮬레이션을 통해 도출된 사고 형태별 분포결과를 분석한다. 본 연구의 결과는 향후 건설현장 내 외부 안전관리 체크리스트 개발 및 인명사고 예측 관리 시스템 개발의 참고 자료로 활용될 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9767-9771
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• 2014

Background: Social support is an important factor in psycho-social well-being of cancer survivors. There is little information about level of social support and its predictors among cancer survivors in Iran or other Middle Eastern countries. The aims of present study were to determine the social support and its prediction factors among Iranian cancer survivors. Materials and Methods: In this descriptive-correlational study 187 cancer patients in one educational center and one private oncology office in northwest of Iran participated using a convenient sampling method. The data collection tool consisted of a researcher-prepared checklist and the Multidimensional Scale of Perceived Social Support Assessment (MSPSS). Data analysis was performed using SPSS statistical software with descriptive statistics and multiple linear regression analysis. Results: The total score of MSPSS was 68 from a possible score between 7 and 84. Participants believed that they received a high level of support from their family members and significant others. Multiple linear regression analysis showed that single and depressed cancer survivors and participants with lower levels of physical activity believed that they received lower levels of social support. Conclusions: Iranian cancer survivors receive high levels of social support and family members are the most important source of this support. In planning any supportive care program for Iranian cancer survivors this strength should be considered. Especially, single and depressed and patients with lower levels of physical activity need more attention.

• 부모자녀건강학회지
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• 제6권1호
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• pp.31-45
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• 2003

This study is designed to produce basic data on the nursing intervention between infants and mothers after discharge from hospitals. This research is carried by investigating the nursing intervention during their after-delivery staying in the hospitals located in Pusan. The object of this study includes the neonatal wards of 51 hospitals. Data collection was carried from the 3rd of September, 2001 to the 4th of October in the same year. Tools for measurement using in this research is the nursing checklist designed by these researchers. The data were analyzed by using SPSS and the output was produced in frequency and percentage considering general characteristics and nursing activities. On the course of investigation, it was revealed that the average number of items checked are as follows; total beds in one hospital came up to 360.1, the beds in each newborn infant ward came up to 36.1, in each ward the numbers of incubators came up to 9.2 and intensive care unit to 1.7. In each ward 8.4 nurses and 2.9 nurse aids were working at that time. In each hospital, secure of air way, physical examination, eye care, umbilical cord care, maintenance of body temperature, identification of infant, nutritive condition, safety and danger management, infection management, mother-infantile interaction, medical assistant to doctor, medication and discharge education were comparatively well done. But, in case of emotional, social and cognitive aspect of nursing activities through interactions between newborn infants and nurses as substitutes are not reached to the adequate level. In the end, this study hereby suggests that further investigation on the device to facilitate the interaction between newborn infant and nurse as a nursing intervention of high quality.

• 동의신경정신과학회지
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• 제31권2호
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• pp.63-76
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• 2020

Objectives: The purpose of this study was to verify the clinical effects of herbal medicines on patients with depressive disorder. Methods: A prospective observational study on patients with depressive disorder was conducted. The patients were treated with herbal medicines for eight weeks. The Korean Hamilton Depression Rating Scale (K-HDRS) was evaluated as the primary outcome and the Korean Beck's Depression Inventory (K-BDI), Instrument on Pattern Identification for Depression, Korean Symptom Checklist-95 (KSCL-95), Insomnia Severity Index (ISI), Korean State-Trait Anxiety Inventory (STAI-K), Korean State-Trait Anger Expression Inventory (STAXI-K), EuroQol five-dimensional Questionnaire (EQ-5D), Minnesota Multiphasic Personality Inventory-2 (MMPI-2), Heart Rate Variability (HRV) were measured as the secondary outcome. Adverse events were assessed for safety. Results: A total of 35 participants were observed for 12 weeks. The K-HDRS improved significantly in four, eight, and 12 weeks and the K-BDI showed significant differences in four, and eight weeks. There were no significant improvements in other evaluation scales. Gyejibongnyeong-hwan was the most frequently and continuously prescribed, showing significant improvements of K-HDRS after eight weeks of treatment. Conclusions: In our observational study, herbal medicine was effective for relieving the depression of patients with depressive disorder and Gyejibongnyeong-hwan showed the most significant effectiveness.

• 한국항행학회논문지
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• 제19권1호
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• pp.33-40
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• 2015

A-SMGCS는 모든 기상조건에서 공항 이동지역 내 요구되는 안전수준을 확보하는 동시에 정해진 지상이동률을 유지하기 위하여 항공기와 차량에게 경로, 안내, 감시, 통제기능을 제공하는 시스템이다. 본 연구에서는 A-SMGCS 적합성 검증방안을 개발하기 위해 시스템 엔지니어링을 도입하였다. A-SMGCS 운용개념을 통해 레벨 IV급 A-SMGCS에 대한 요구사항을 정의하였으며, 기능분석과 할당을 통해 시스템 아키텍처와 시스템 규격을 도출하였다. A-SMGCS 개발을 위한 WBS와 IMS를 수립하였으며, 마지막으로 시스템에 대한 확인 및 검증을 위한 CCL과 TEMP를 개발하였다.

• 한국산업정보학회논문지
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• 제22권6호
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• pp.95-105
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• 2017

본 연구는 중소기업들의 경쟁력을 증대하기 위하여 평가진단 체크시트 모델을 개발하는 것이다. 평가진단 체크시트 개발 절차는 사전조사(주력기업 조사, 업종특징 분석. 핵심기능 선정 등), 연구개발(핵심기능 체크시트 개발, 핵심기능 향상도구 개발)순으로 진행하였다. 평가모델은 5개 부문(비전과 전략체계, 품질보증과 제품안전, 현장관리 수준, 통계적 공정관리, 개선활동)으로 대별한 후, 각 부문별로 1)인식, 2)체계, 3)운영, 4)검토 및 보완의 4가지 내용으로 구분하여 구성하였다. 본 평가모델은 특히 지방자치단체 내에 산재해 있는 중소기업 중에서 주력 중소기업을 선정하여 집중 육성하는데 많은 기여를 하게 될 것으로 기대되며, 이를 통해 해당 중소기업의 경쟁력이 향상될 것으로 판단된다.

• 한국응급구조학회지
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• 제23권2호
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• pp.43-59
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• 2019

Purpose: The purpose of this study was to assess 119 emergency medical technicians' perception of child abuse, attitudes towards mandatory reporting, and perceptions of mandatory reporting system, and to promote early reporting. Methods: The questionnaire was filled out by one hundred ninety 119 EMTs with paramedic or nurse licenses. The questionnaire consisted of 53 items with responses based on a five-point scale. Data were collected from July 10 to July 31, 2018, and were analyzed using IBM SPSS version 24.0 software. Results: The average score for 119 EMT's perception of child abuse was 3.76. The average score for positive attitude towards mandatory reporting was 3.63, and the average score for negative attitude towards mandatory reporting was 2.63. The average score for perceptions of the mandatory reporting system was 3.50. There was a significant positive correlation between perception of child abuse and positive attitude towards mandatory reporting (r=.244, p=.001), between perception of child abuse and perceptions of the mandatory reporting system (r=.209, p=.004), and between positive attitude towards mandatory reporting and perceptions of mandatory reporting system (r=.336, p=.000). Conclusion: Systemic educational programs for 119 EMTs on perception of child abuse and reporting are needed. It is very important to establish institutional strategies such as the use of checklist for suspicion of child abuse, procedural simplicity after reporting, and protection of reporter information.