• Nuclear Engineering and Technology
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• 제51권3호
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• pp.746-754
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• 2019

Vitrification of radioactive liquid waste (RLW) provides a feasible solution for isolating radionuclides from the biosphere for an extended period. In vitrification, base glass and radioactive waste are added simultaneously into the melter. Determination of heat and mass transfer rates is necessary for rational design and sizing of melter. For obtaining an assured product quality, knowledge of reaction kinetics associated with the thermal decomposition of waste constituents is essential. In this study Thermogravimetry (TG) - Differential Thermogravimetry (DTG) of eight kinds of nitrates and two oxides, which are major components of RLW, is investigated in the temperature range of 298-1273 K in the presence of base glasses of five component (5C) and seven component (7C). Studies on thermal behavior of constituents in RLW were carried out at heating rates ranging from 10 to $40\;K\;min^{-1}$ using TG - DTG. Thermal behavior and related kinetic parameters of waste constituents, in the presence of 5C and 7C base glass compositions were also investigated. The activation energy, pre-exponential factor and order of the reaction for the thermal decomposition of 24% waste oxide loaded glasses were estimated using Kissinger method.

• Bulletin of the Korean Chemical Society
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• 제17권3호
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• pp.257-262
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• 1996

p-(2-Vinyloxyethoxy)benzylidenemalononitrile 2 and methyl p-(2-vinyloxyethoxy)benzylidenecyanoacetate 3 was prepared by the condensation of p-(2-vinyloxyethoxy)benzaldehyde 1 with malononitrile or methyl cyanoacetate, respectively. Vinyl ether monomers 2 and 3 polymerized quantitatively with radical initiators in γ-butyrolactone solution at 65 ℃. The trisubstituted terminal double bond participated in the vinyl polymerization and radical polymerization of 2 and 3 led to swelling polymers 4 and 5 that were not soluble in common solvents due to cross-linking. Under the same polymerization conditions ethylvinyl ether polymerized well with model compounds of p-methoxybenzylidenemalononitrile 6 and methyl p-methoxybenzylidenecyanoacetate 7, respectively, to give 1:1 alternating copolymers 8 and 9 in high yields. Polymers 4 and 5 showed a thermal stability up to 300 ℃ without any characteristic Tg peaks in DSC thermograms. Alternating copolymers 8 and 9 were soluble in common solvents such as acetone and DMSO, and the inherent viscosities of the polymers were in the range of 0.36-0.74 dL/g. Films cast from acetone solution were cloudy and tough and Tg values obtained from DSC thermograms were in the range of 59-60 ℃.

• 대한간호학회지
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• 제52권2호
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• pp.214-227
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• 2022

Purpose: This study was aimed at investigating the incidence and risk factors of dyslipidemia in menopausal women using a Korean community-based longitudinal study. Methods: The subjects were 245 postmenopausal women without dyslipidemia who had participated in the Ansan-Ansung cohort study from 2001~2002 (baseline) to 2015~2016 (seventh follow-up visit). The dyslipidemia incidence was measured as incidence proportion (%) and incidence rate per 100 person-years. The predictors of developing dyslipidemia were analyzed with Cox's proportional hazard model. Results: The incidence of new dyslipidemia during the follow-up period was 78.4% (192 patients), and 11.9 per 100 person-years. Mean duration from menopause to developing dyslipidemia was 5.3 years in new dyslipidemia cases. The triglyceride/high density lipoprotein (TG/HDL-C) ratio at baseline (hazard ratio = 2.20; 95% confidence interval = 1.39~3.48) was independently associated with developing dyslipidemia. Conclusion: Dyslipidemia occurs frequently in postmenopausal women, principally within five years after menopause. Therefore, steps must be taken to prevent dyslipidemia immediately after menopause, particularly in women with a high TG/HDL-C ratio at the start of menopause.

• 대한치과보철학회지
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• 제47권4호
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• pp.394-405
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• 2009

연구목적: 임플란트 경부의 치은관통부 형상이 주위골 응력분포에 미치는 영향에 대해 조사하고자 한다. 연구재료 및 방법: 높이 2.8 mm, 상부 직경 4 mm, 하부 직경 2.7 mm 인 직선형 치은관통부를 가지는 ITI의 일체형(one piece) 임플란트 (Straumann, Waldenburg, Switzerland)를 Base Model로 사용하여, 치은관통부 외형에 함몰부를 부여하여 곡선형으로 수정한 4개의 해석 모델 (Model-1, -2, -3, -4)을 설정하였다. Base Model을 포함, 모두 5개의 경우에 대해 축대칭 유한요소모델링을 통해 임플란트 장축에 평행인 수직 방향과 임플란트 장축에 $30^{\circ}$ 경사진 방향으로 각각 50 N의 힘이 작용할 때 발생되는 임플란트 주위골의 응력을 해석하여 비교하였다. 체계적인 응력비교를 위해 임플란트 주위에 19개의 절점을 응력 관찰점으로 선정하였으며, 경부 치밀골에 설정된 5개 관찰점의 응력으로부터 회귀분석법으로 임플란트/골 사이에서 생기는 최대응력값을 추정하여 정량적인 비교를 실행하였다. 결과: 최대 골응력은 치은관통부가 직선인 기본모델에서 가장 컸으며, 치은 관통부를 곡선으로 설계한 경우 응력이 감소되었다. 치은 함몰부가 클수록 응력감소 정도가 커졌으며 함몰부의 수직위치가 몸체부에 가장 가까운 Model-4에서 응력감소 정도가 전체의 약5%로 가장 컸다. 결론: 임플란트의 경부 형상은 골응력에 영향을 미치며, 이를 곡선형으로 함으로써 또한 그 함몰부를 몸체부에 근접하게 함으로써 경부골 응력감소를 효과적으로 도모할 수 있다.

• 한국의학물리학회지:의학물리
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• 제28권4호
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• pp.190-196
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• 2017

For the $ViewRay^{(R)}$ system (ViewRay Inc., Cleveland, OH, USA) which is representative of magnetic resonance (MR) guided radiotherapy machine, it is important to evaluate effectiveness of AAPM's TG-51 protocol and the effect of the magnetic field on absolute dosimetry. In order to measure the absolute dose, MR-compatible chamber and water phantom system manufactured in this study were used. The materials of the water phantom system were plastic of polymethyl methacrylate (PMMA) and non-ferrous materials. Due to the inherent feature of the $ViewRay^{(R)}$, all Co-60 sources are not located at gantry angle of $0^{\circ}$ while being located at gantry angle of $90^{\circ}$. For this reason, absolute dosimetry was performed based on the measurements in solid water phantom (SWP) and water which determine the SWP to water correction factor. For evaluation of output constancy with gantry angle, measurements were made with ionization chamber inserted in cylindrical water-equivalent phantom. For measured doses in water, the values of dose deviation according to a reference dose of 200 cGy for Head 1, Head 2 and Head 3 were -0.27%, -0.45% and -0.22%, respectively. For measured doses in SWP, the values of dose deviation according to a reference dose of 200 cGy for Head 1, Head 2 and Head 3 were -1.91%, -2.07% and -1.84%, respectively. All values of dose measured in SWP tended to be less than those measured in water by -1.63%. With the reference gantry angles of $0^{\circ}$ and $90^{\circ}$, the maximum values of deviation for Head 1, Head 2 and Head 3 were 0.48%, 1.06% and 0.40%, respectively. The measurement agreement is within the range of results obtainable for conventional treatment machines. The low strength of the magnetic field does not affect dose measurements. Using the SWP to water correction factor, absolute doses for $ViewRay^{(R)}$ system can be measured.

• 한국양식학회지
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• 제21권1호
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• pp.41-46
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• 2008

본 연구의 목적은 rotifer Brachionus rotundiformis의 수온과 염분농도의 변화에 따른 이들의 소화효소 활성을 파악하고, 소화효소 활성을 기초로 적정 영양강화 조건을 찾는 것이다. 다른 온도에서 24시간 배양된 rotifer 밀도는 $32^{\circ}C$에서 1,453 개체/mL로 가장 높았다(P<0.05). 그리고 배양온도 $28^{\circ}C$에서 염분농도에 따른 rotifer 밀도는 15 에서 2,147 개체/mL로 가장 높게 나타났다(P<0.05). 배양환경에 따른 rotifer의 소화효소 활성에서 TAP 개체당 활성은 $24-32^{\circ}C$에서 유의적으로 높게 나타났으며(P<0.05), 단백질 비활성은 $32-36^{\circ}C$에서 높게 조사되었다(P<0.05). 그리고 TG-lipase 활성에서는 개체당 활성과 단백질 비활성 모두 $20^{\circ}C$에서 가장 높은 활성을 보였다(P<0.05). 또한 염분별 실험에서 TAP와 TG-lipase 활성은 32 psu에서 가장 높은 활성을 보였다(P<0.05). 32 psu에서 온도별 영양강화한 rotifer의 methionine 함량(% in protein), 지질 함량과 지방산 불포화도이 $20^{\circ}C$에서 유의적으로 높게 나타났다. 특히, DHA와 DHA/EPA 비가 $20^{\circ}C$ 실험구에서 12.6%와 12.5의 비로 각각 높았다(P<0.05). 따라서 rotifer B. rotundiformis의 지질 영양강화는 특히 TGlipase 활성을 높여 줄 수 있는 32 psu, $20^{\circ}C$에서 실시하는 것이 지방산 불포화도, DHA 및 DHA/EPA 비를 높여 줄 수 있는 효과적인 방법이라고 판단된다.

• Nutrition Research and Practice
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• 제18권1호
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• pp.1-18
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• 2024

BACKGROUND/OBJECTIVES: Endoplasmic reticulum (ER) stress in adipose tissue causes an inflammatory response and leads to metabolic diseases. However, the association between vitamin D and adipose ER stress remains poorly understood. In this study, we investigated whether 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) alleviates ER stress in adipocytes. MATERIALS/METHODS: 3T3-L1 cells were treated with different concentrations (i.e., 10-100 nM) of 1,25(OH)₂D₃ after or during differentiation (i.e., on day 0-7, 3-7, or 7). They were then incubated with thapsigargin (TG, 500 nM) for an additional 24 h to induce ER stress. Next, we measured the mRNA and protein levels of genes involved in unfold protein response (UPR) and adipogenesis using real-time polymerase chain reaction and western blotting and quantified the secreted protein levels of pro-inflammatory cytokines. Finally, the mRNA levels of UPR pathway genes were measured in adipocytes transfected with siRNA-targeting Vdr. RESULTS: Treatment with 1,25(OH)₂D₃ during various stages of adipocyte differentiation significantly inhibited ER stress induced by TG. In fully differentiated 3T3-L1 adipocytes, 1,25(OH)₂D₃ treatment suppressed mRNA levels of Ddit3, sXbp1, and Atf4 and decreased the secretion of monocyte chemoattractant protein-1, interleukin-6, and tumor necrosis factor-α. However, downregulation of the mRNA levels of Ddit3, sXbp1, and Atf4 following 1,25(OH)₂D₃ administration was not observed in Vdr-knockdown adipocytes. In addition, exposure of 3T3-L1 preadipocytes to 1,25(OH)₂D₃ inhibited transcription of Ddit3, sXbp1, Atf4, Bip, and Atf6 and reduced the p-alpha subunit of translation initiation factor 2 (eIF2α)/eIF2α and p-protein kinase RNA-like ER kinase (PERK)/PERK protein ratios. Furthermore, 1,25(OH)₂D₃ treatment before adipocyte differentiation reduced adipogenesis and the mRNA levels of adipogenic genes. CONCLUSIONS: Our data suggest that 1,25(OH)₂D₃ prevents TG-induced ER stress and inflammatory responses in mature adipocytes by downregulating UPR signaling via binding with Vdr. In addition, the inhibition of adipogenesis by vitamin D may contribute to the reduction of ER stress in adipocytes.

• 한국방사선학회논문지
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• 제8권5호
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• pp.241-248
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• 2014

본 연구는 미만성 $^{18}F-FDG$ 갑상선 섭취를 보이는 PET/CT 영상에서 최대 표준섭취계수($SUV_{max}$)와 갑상선 자가 항체(anti-TPO Ab, anti-TG Ab, TSH)들 사이의 임상적 상관관계를 하시모토 갑상선염과 그레이브스병 중심으로 분석하였다. 이를 위하여 2010년 5월부터 2013년 4월까지 건강검진에서 PET/CT 검사를 시행한 환자 1,097명을 대상으로 미만성 FDG 갑상선 섭취 여부를 분석하여 갑상선 기능 검사와 초음파 검사를 추가적으로 시행하였다. 결과적으로 미만성 $^{18}F-FDG$ 갑상선 섭취를 보이는 자가 면역 갑상선 질환 환자는 39명(3.6%)이 발견되었으며 하시모토 갑상선염은 43.6%, 그레이브스병은 23.1% 이었다. 하시모토 갑상선염은 anti-TPO Ab와 anti-TG 수준이 높은 역가의 양성 반응을 보였으며 $SUV_{max}$와 anti-TPO Ab간 상관계수가 통계적으로 유의하였다(r>0.4, p<0.05). 또한 그레이브스병은 대부분의 갑상선 자가 항체의 수준이 높은 역가의 양성 반응을 보였으며 $SUV_{max}$와 TSH간 상관계수가 통계적으로 유의하였다(r>0.5, p<0.01). 따라서 미만성 18F-FDG 갑상선 섭취 증가에 따른 $SUV_{max}$ 수준이 높을수록 하시모토 갑상선염은 anti-TPO Ab 수준이, 그레이브스병은 TSH 수준이 비례적으로 증가됨을 알 수 있었고 이러한 상관관계는 자가 면역 갑상선 질환에 대한 부대 징후를 판단할 수 있는 가장 영향력 있는 척도로서 임상적 적용이 가능할 것으로 판단하였다.

• 한국응용과학기술학회지
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• 제8권2호
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• pp.169-174
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• 1991

These studies were carried out to investigate the effects of Korean Job's tears on increasing control of body weight and organ and lipid in rats which were devided into control group, 10% Job's tears group(A), 20% Job's tears group(B), 30% Job's tears group(C), 60% Job's tears group(D) during 10 week administration after 3 week adaption before the experiment. 1. Food intake amount and food efficiency ratio decreased much better Job's tears amount in diet controled of body weight increasing. 2. The organ weight in 100g body weight heavier better 60% Job's tears group(D) then control group. 3. Serum lipid level are rowed Total cholesterol, Free-cholesterol levels in 60% Job's tears group, showed highed of HDL-cholesterol, TG levels.

• Nutritional Sciences
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• 제4권2호
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• pp.85-90
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• 2001

The purpose of this study was to evaluate the antioxidative potential of Korean wild leaf vegetables in vivo as well as in vitro. The antloxidative activities of Pleurospemum kamtschaticum, Aderophora remotiflor and Aster gfheni were evaluated as a reference for Spinacia oleracea. Fifty rats were find either a control diet or one of several vegetable diets for 4 weeks. The level of thiobarbituric acid reactive substance (TBARS) and the activity of catalase and superoxide dismutase (SOD) in the liver were compared. The levels of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG) in plasma were also compared. Also, the contents of $\beta$-carotene, vitamin C, vitamin E and total phenolic compound, including flavonoid and thiobarbituric acid (TBA) value using linoleic acid model system, were measured in Korean wind leaf vegetables. The TBARS values of Aderophora remotiflor and Aster giheni tended to be lower than that of Spinacia olerncea. The SOD activity of Artrr glheffi was significantly higher than that of Spinacia oleracea and reached 265% that of the control animals, whereas there was no difference between the control animals and the vegetable diet animals in terms of catalase activity. Compared to the control animals, TG and TC levels were significantly solver and showed a lower artheriosclerotic index. TBA values of Pleurospemum Kamschaticum and Aderophora remptiflor were only 18% of control value. TBA value of Spinacia olerucra was 41% of control value. These results suggest that Aderophora remotinor and Aster glheni could have antioxidative potency in vivo as well as in vitro and potential value far functional flood to improve the plasma lipid profile. flavonoid and phenolic compounds could be the major contributing factor in the antioxidative potential of Aderophora remotiflor and Aster glheni.