• Title/Summary/Keyword: s (PPI)

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A Method for Protein Functional Flow Configuration and Validation (단백질 기능 흐름 모델 구성 및 평가 기법)

  • Jang, Woo-Hyuk;Jung, Suk-Hoon;Han, Dong-Soo
    • Journal of KIISE:Computing Practices and Letters
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    • v.15 no.4
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    • pp.284-288
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    • 2009
  • With explosively growing PPI databases, the computational approach for a prediction and configuration of PPI network has been a big stream in the bioinformatics area. Recent researches gradually consider physicochemical properties of proteins and support high resolution results with integration of experimental results. With regard to current research trend, it is very close future to complete a PPI network configuration of each organism. However, direct applying the PPI network to real field is complicated problem because PPI network is only a set of co-expressive proteins or gene products, and its network link means simple physical binding rather than in-depth knowledge of biological process. In this paper, we suggest a protein functional flow model which is a directed network based on a protein functions' relation of signaling transduction pathway. The vertex of the suggested model is a molecular function annotated by gene ontology, and the relations among the vertex are considered as edges. Thus, it is easy to trace a specific function's transition, and it can be a constraint to extract a meaningful sub-path from whole PPI network. To evaluate the model, 11 functional flow models of Homo sapiens were built from KEGG, and Cronbach's alpha values were measured (alpha=0.67). Among 1023 functional flows, 765 functional flows showed 0.6 or higher alpha values.

A Time Study of Nursing Activities by Home Care Nurses for Non-Cancer Terminal Patients (가정전문간호사의 비암성 말기환자 간호행위 시간 분석)

  • Lee, Hanul;Lee, Jong-Eun
    • Journal of Home Health Care Nursing
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    • v.26 no.2
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    • pp.180-188
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    • 2019
  • Purpose: To investigate the duration of each nursing activity performed by home care nurses for non-cancer patients and the relationship between patients' palliative prognostic index (PPI) and duration of each nursing activity. Methods: Nursing activities performed for six non-cancer terminal patients were timed using a stopwatch, and 18 parameters were measured by visiting each patient thrice. The mean and standard deviations of duration for each category of nursing activities were computed. The relationship between category-specific duration of nursing activities and PPI was analyzed with Spearman's correlation and multiple regression analysis. Results: Among nursing activities, the highest greatest duration of time was spent on traffic time (11.91 min), followed by urinary catheter management (10.65 min) and insertion and management of nasogastric tube (9.03 min). In terms of nursing categories, after excluding movement time, the greatest duration of time was spent on excretion care (5.48 min), nutrition care (5.40 min), and medication (3.82 min). PPI correlated with hygiene care, excretion care, and patient and information management. Multiple regression analysis revealed that PPI increased with increasing duration of hygiene care. Conclusion: These study findings provide grounds for the increased nursing time of hygiene care for people reaching the end of life.

Study on the Hydraulic and Thermal Characteristics of Metallic Porous Medium (다공성 금속의 수력 및 열 교환 특성에 관한 연구)

  • Jin, M.H.;Kim, P.H.;Lee, Y.H.;Chung, H.S.;Jeong, H.M.
    • Journal of Power System Engineering
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    • v.12 no.5
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    • pp.54-58
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    • 2008
  • 최근 열교환기의 향상을 위해 발포다공성매체의 적용이 증가하고 있다. 열교환기의 적용에 있어서 발포다공성매체의 이점을 살펴보기 위해 본 연구에서는 2가지 실험을 수행하였다. 첫 번째는 수력의 관점에서 투과계수 및 내부계수를 결정하는 것이고, 두 번째는 열교환의 관점에서 다공성매체의 유효전도율을 측정하는 것이다. 본 실험에서는 기공도는 거의 같으나 기공의 크기가 각각 20 ppi와 40 ppi인 구리 다공성매체를 사용하였다. 실험의 결과는 40 ppi 크기의 다공성매체가 수력과 열교환, 두가지 관점 모두에서 보다 높은 저항 효율을 나타낸다는 것을 보여준다.

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Efficacy of Dairy Free Diet and 6-Food Elimination Diet as Initial Therapy for Pediatric Eosinophilic Esophagitis: A Retrospective Single-Center Study

  • Wong, Jonathan;Goodine, Sue;Samela, Kate;Vance, Katherine S.;Chatfield, Beth;Wang, Zhu;Sayej, Wael N.
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.23 no.1
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    • pp.79-88
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    • 2020
  • Purpose: Management of eosinophilic esophagitis (EoE) varies from center to center. In this study, we evaluated the effectiveness of a dairy-free diet (DFD) and the 6-Food Elimination Diet (SFED) as initial therapies for the treatment of EoE in our practice. Methods: This was a retrospective study of children who had been treated for EoE at Connecticut Children's Medical Center, Hartford, CT, USA. Pre- and post-treatment endoscopy findings and histology results of patients treated with DFD or SFED were examined. Results: One hundred fifty-two patients (age 9.2±5.2 years, 76.3% male, 69.7% caucasian) met the inclusion criteria for initial treatment with DFD (n=102) or SFED (n=50). Response for DFD was 56.9% and for SFED was 52.0%. Response based on treatment duration (<10, 10-12, and >12 weeks) were 81.8%, 50.0%, and 55.1% for DFD, and 68.8%, 50.0%, and 40.0% for SFED. Response based on age (<6, 6-12, and >12 years) were 59.3%, 42.9%, and 67.5% for DFD, and 36.4%, 58.8%, and 72.7% for SFED. In patients treated with DFD, concomitant proton pump inhibitor (PPI) administration resulted in improved outcomes (p=0.0177). Bivariate regression analysis showed that PPI with diet is the only predictor of response (p=0.0491), however, there were no significant predictors on multiple regression analysis. Conclusion: DFD and SFED are effective first line therapies for EoE. DFD should be tried first before extensive elimination diets. Concomitant therapy with PPI's may be helpful.

A Study on the Evaluation of Value for Money in Private Provided Infrastructure with a Focus on BTO Projects (BTO 민간투자사업의 화폐적 투자가치 평가)

  • Baek, Seong-Jun
    • Journal of Korean Society of Transportation
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    • v.25 no.1 s.94
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    • pp.49-59
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    • 2007
  • This study has examined the allocation of risk in Korea's private provided Infrastructure(PPI) with the following contents (1) Developing a quantitative risk allocation model for Korea's PPI and (2) examining the implication of changes in the minimum revenue guarantees (MRG) clause of government legislation using the developed empirical model. The model of this study adopts and extends H. Yamaguchi's model developed in 2002. To investigate Korea's actual risk allocation deals, the author incorporated the MRG framework. The payment related to the MRG is indeterminable. Hence. the average MRG rate was calculated using probabilistic risk analysis. The risk allocation model is applied to the two eases to validate the model and evaluate the project's VFM(Value for Money). As the revenue guarantee rate is lowered, the government subsidies are increased. This in turn worsens VFM. The same relationship is true when the revenue guarantee Period is shortened.

Design of the timing controller for automatic magnetizing system

  • Yi Jae Young;Arit Thammano;Yi Cheon Hee
    • Proceedings of the IEEK Conference
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    • 2004.08c
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    • pp.468-472
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    • 2004
  • In this paper a VLSI design for the automatic magnetizing system has been presented. This is the design of a peripheral controller, which magnetizes CRTs and computers monitors and controls the automatic inspection system. We implemented a programmable peripheral interface(PPI) circuit of the control and protocol module for the magnetizer controller by using a O.8um CMOS SOG(Sea of Gate) technology of ETRI. Most of the PPI functions has been confirmed. In the conventional method, the propagation/ramp delay model was used to predict the delay of cells, but used to model on only a single cell. Later, a modified "apos;Linear delay predict model"apos; was suggested in the LODECAP(LOgic Design Capture) by adding some factors to the prior model. But this has not a full model on the delay chain. In this paper a new "apos;delay predict equationapos;" for the design of the timing control block in PPI system has been suggested. We have described the detail method on a design of delay chain block according to the extracted equation and applied this method to the timing control block design.

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Functional recovery after radical prostatectomy for prostate cancer

  • Ko, Young Hwii
    • Journal of Yeungnam Medical Science
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    • v.35 no.2
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    • pp.141-149
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    • 2018
  • With the enthusiasm regarding robotic application in radical prostatectomy in accordance with the widespread use of serum prostate-specific antigen as a screening test, the number of surgeries performed for complete removal of the gland is increasing continuously. However, owing to the adjacent anatomical location of the prostate to the nerve and urethral sphincter complex, functional recovery, namely improvement from post-prostatectomy incontinence (PPI) and post-prostatectomy erectile dysfunction, still remains a main problem for patients who are reluctant to undergo surgery and tend to choose alternative ways instead. Since the late 1980s, the introduction of radical prostatectomy by open surgical modalities, the depth of the anatomical understanding of the structure surrounding the prostate is getting tremendous, which leads to the development of new surgical modalities and techniques that are consequently aimed at reducing the incidences of PPI and erectile dysfunction. Briefly, recent data from robotic radical prostatectomy, particularly on PPI, are quite acceptable, but by contrast, the reported potency regain rate still remains <20%, which indicates the need for advanced surgical modification to overcome it. In this review, the authors summarized the recent findings on the anatomy and surgical techniques reported up to now.

The relation among narcissistic personality, depression, and psychopathy: Focus on gender differences (대학생의 자기애, 우울과 정신병질 성향과의 관계: 성차를 중심으로)

  • Kim, Young Youn;Lee, Eunjin;Kim, Beom Jun
    • The Korean Journal of Woman Psychology
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    • v.16 no.1
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    • pp.97-113
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    • 2011
  • The current study was conducted to explore the relations among college students' narcissistic personality, depression, and psychopathy. This study investigated how narcissistic personality and depression variables relate to psychopathy variables. For this purpose, an assessment battery consisting of Narcissistic Personality Inventory(NPI), Narcissistic Personality Disorder Scale: NPDS), BDI, Self-Reported Psychopathy Scale(SRPS), and Psychopathic Personality Inventory-Revised. PPI-R was administered to 1003 college students (501 males and 502 females). For comparison with the levels of pathological narcissism, the participants were devided two groups( above 33%, below 33% ) based on their scores of the NPDS, According to the results, males had more overt narcissistic personality, and females felt more depressive and psychopathic. The higher level group on the NPDS had higher scores on the NPI, BDI, SRPS and PPI-R. The students' narcissistic personality had relations to depression and psychopathy, but the results were different according to the kind of inventories(PPI-R or SRPS, NPI or NPDS). The implications and limitations of this study, as well as some suggestions for future research, were suggested.

The Effect of Remedial Precepted Video Review on Clinical Performance Examination Scores (재교육으로서 비디오를 이용한 피드백이 임상수행평가 성적에 미치는 영향)

  • Kim, Jong Hoon
    • Korean Medical Education Review
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    • v.14 no.1
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    • pp.51-56
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    • 2012
  • Purpose: Precepted video review (PVR) has been considered one of the methods for the remediation of clinical performance examinations (CPX). This study quantified the effect of brief PVR on CPX scores. Methods: For two years, final-year students (61 students in the 1st year's cohort and 54 in the 2nd year's cohort) participated in CPXs. The scores on the initial CPX were announced to the students shortly after that CPX administration. There was no PVR after the initial CPX in the 1st year. All participants of the 2nd year were notified of the opportunity to voluntarily receive brief PVR after the initial CPX. Several months after the initial CPX, the students took the latter CPX in both years. The differences of scores between initial and latter CPX were compared in good performers and poor performers of the initial CPX. Results: Thirteen poor performers and 8 good performers received PVR in the 2nd year. In the 1st year, history taking (Hx), physical examination, and patient physician interaction (PPI) scores of the good performers of the initial CPX were significantly decreased on the latter CPX. In the 2nd year, the Hx and PPI scores of the good performers of the initial CPX, who received PVR, were significantly decreased at the latter CPX. The Hx and PPI scores of the poor performers of the initial CPX were significantly increased at the latter CPX in both years regardless of PVR. Conclusion: The changes in CPX scores according to PVR did not show any consistent trend. Brief PVR appears to be not sufficient for improving CPX scores.

470 x 235ppi poly-Si TFT LCD for High-Resolution 2D and 3D Autostereoscopic Display

  • Uehara, Shin-Ichi;Ikeda, Naoyasu;Takanashi, Nobuaki;Iriguchi, Masao;Sugimoto, Mitsuhiro;Matsuzaki, Tadahiro;Asada, Hideki
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.783-786
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    • 2004
  • We have developed a 470 x 235ppi poly-Si TFT LCD with a novel pixel arrangement, called HDDP (Horizontally Double-Density Pixels), for high-resolution 2D and 3D autostereoscopic display. 3D image quality is especially high in a lenticular-lens-equipped 3D mode because both horizontal resolution and vertical resolution are high, and because these resolutions are equal. 3D and 2D images can be displayed simultaneously in the same picture. In addition, 3D images can be displayed anywhere and 2D characters can be made to appear at different depths with perfect legibility. No switching of 2D/3D modes is necessary, and the design's thin and uncomplicated structure makes it especially suitable for mobile terminals.

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