• The korean journal of orthodontics
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• v.43 no.6
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• pp.294-301
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• 2013

Objective: To determine the interleukin (IL)-6 levels in gingival crevicular fluid (GCF) of patients with severe root resorption after orthodontic treatment and investigate the effects of different static compressive forces (CFs) on IL-6 production by human periodontal ligament (hPDL) cells and the influence of IL-6 on osteoclastic activation from human osteoclastic precursor (hOCP) cells in vitro. Methods: IL-6 levels in GCF samples collected from 20 patients (15 and 5 subjects without and with radiographic evidence of severe root resorption, respectively) who had undergone orthodontic treatment were measured by ELISA. The levels of IL-6 mRNA in hPDL cells and IL-6 protein in conditioned medium after the application of different uniform CFs (0, 1.0, 2.0, or 4.0 $g/cm^2$ for up to 72 h) were measured by real-time PCR and ELISA, respectively. Finally, the influence of IL-6 on mature osteoclasts was investigated by using hOCP cells on dentin slices in a pit-formation assay. Results: Clinically, the IL-6 levels were significantly higher in the resorption group than in the control group. In vitro, IL-6 mRNA expression significantly increased with increasing CF. IL-6 protein secretion also increased in a time- and magnitude-dependent manner. Resorbed areas on dentin slices were significantly greater in the recombinant human IL-6-treated group and group cultured in hPDL cell-conditioned medium with CF application (4.0 $g/cm^2$) than in the group cultured in hPDL cell-conditioned medium without CF application. Conclusions: IL-6 may play an important role in inducing or facilitating orthodontically induced inflammatory root resorption.

• Korean Business Review
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• v.17
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• pp.185-214
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• 2004

This paper is focused on the e-business level in Kangwon Province by industries, volumes, employees comparing with nation wide survey output, and analysis of the tasks and problems of e-business in environment, infrastructure, process, manpower, effect. Poor level of Kangwon province was identified. It is important that role clarity and cooperation among central goverment, Kangwon province, large enterprises and small and medium enterprises. Local goverment and regional cities and counties should play a centripetal role of the regional enterprises, and faithfully execute the support policies of the central goverment, and make the unique supporting climate of coopration between the university and enterprises in consideration with situations of each regional characteristics. More specifically, there are widening the infrastructure of e-business for regional enterprises, strenthening educatin and public relation of the electronic commerce, supporting and utilizing the electronic ccommerce research center. Also, fund supporting for SOHO is desirable in consideration of the poor Kangwon land and population, and to enhence the electronic commerce technology of the Kangwon enterprises, relative importance of policy of it is incresing. In conclusion, indices of Kangwon province in all areas of the survey is appeared poor. So efficient and effective policies is needed in each central and regional goverment. To promote Kangwon enterprises, investment in e-business commerce should be expanded.

• Journal of Digital Convergence
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• v.13 no.10
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• pp.33-40
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• 2015

Today the computerization in overall civil life is globally progressing, and software plays a central role in all interdisciplinary areas of society. These changes of information environments lead to the change of values and paradigm shift, and the change of Korean educational policies is also happening. As human-machine interaction is becoming ubiquitous, code literacy is going to play an important role before long. Despite these transitions, information education in universities in Korea focuses on just driving application programs. In this paper, we explore overall educational system and curriculum of universities in Korea. And we present educational factors corresponding to educational levels and contents. Presented five factors coupling three educational contents and three educational levels may be dedicated to design curriculum.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.18 no.5
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• pp.49-59
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• 2015

In this research, the connectivity status between natural environment (forests and rivers) and urban parks in view of ecological networks in a city is evaluated and on the basis of these evaluation results, a future connectivity enhancing recommendations are suggested. As a result, the 96.8% of the connectivity role of the neighborhood parks were core or connected parks and as in terms of the ecological pattern on the outer park, 84.1% of the case neighborhood parks were connected to the ecological element at least one side. Therefore, it can be expected to play a role as corridor that enables the direct connection with the natural environment if the connection plan is well established. As a result of connectivity evaluation of the parks, inside of the parks had low ecological element overall and had low connectivity, outside of the parks had 1.5 times more of low connectivity parks than high connectivity parks, and had similar disconnections such as facilities(fence, soundproof walls, breast walls, etc.), developments(roads, apartment complexes, industrial complexes, etc.), or poor greens regardless of the neighborhood with the ecological elements. To increase the connectivity of ecological network, the cities already built shall secure primarily green territory where can connect with the isolated park due to the surrounding with the developing areas and when planning for new cities or residential complexes, it shall establish a connection plan with the nearby at the beginning.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.5009-5018
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• 2014

Introduction: Numerous countries have launched campaigns regarding sun protection in the last decades. Aim: The aim of the present study was to assess an intervention program aimed at higher knowledge and healthier attitudes regarding sun protection. Materials and Methods: The sample consisted of 4,133 students aged 8-12 years from a single Greek province. Results: In most items, knowledge levels after the intervention were found to be higher than those before ($2.8{\pm}0.9$ vs $3.3{\pm}0.9$), while knowledge about sun protection factors seems to have had the highest improvement (27.1% vs 56.6%). However, student attitudes did not appear to improve, with the exception of applying sunscreen with a higher SPF (29.7% vs 54.8%). Girls seemed to have healthier attitudes compared to boys, but gender played no role with regard to knowledge levels. Also, place of residence did not play any role regarding knowledge levels, although those living in semi-urban areas seemed to have more unhealthy attitudes. Logistic regression by correlating knowledge and attitudes established that higher knowledge levels are usually accompanied by healthier attitudes, albeit marginally. Conclusions: The intervention had a positive contribution to the student knowledge level regarding sun protection and also led to small improvements regarding some attitudes. Continuous similar interventions could lead to better results and the adoption of healthier attitudes.

• Journal of the Korean Institute of Landscape Architecture
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• v.31 no.5
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• pp.31-42
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• 2003

This study looked at worked on remaining landscapes in terms of landscape ecology. It presented some ways to conserve and to activate remaining landscapes with examples of agricultural lands in Hwa-won Gun, Ok-po Myun. The results are as follows: We investigated 20 remaining landscape types and 90 remaining landscapes, and classified them in terms of forest and water zones. To evaluate the investigated remaining landscapes, we produced a grading system using 8 criteria such as vitality, stability, field suitability, type of inner scenery formation, connection, recreation, and culture/tradition. Our evaluation of the vitality found that Grade I had the mast remaining landscapes; Grade II had 28, Grade III had 16, Grade V had four, and Grade IV had none. We evaluated the outer landscape influence using 3 criteria such as divisibility, vitality, and indication. We found from evaluating the type of inner scenery formation that most of the landscapes superior to Grade III were adjacent to water zones and that linear landscapes evaluated as Grade I, and II played an important role in this connection. We evaluated the recreation probability using marks, frequencies, and emergencies of peculiar types. Based on the results, we proposed some ways to conserve and to activate the remaining landscapes classified by grades using the results of the last evaluation. Additionally, we proposed some ways to activate the restoration of the linear axis of the green space function the formation of a buffer green space around matric space, the improvement of the axis of the green space center, and the formation of additional green tracts of land to play the role of stepping stones. We proposed the possibility of improving uniformed farm land structures. This study did not consider the weighting values of the evaluation index. Therefore a more objective study will be needed with an expert-survey in the future.

• Journal of the Korean Home Economics Association
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• v.42 no.12 s.202
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• pp.161-174
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• 2004

The primary objective of this study was to employ Darden's store patronage model in order to investigate the role that shopping orientation and store attributes play in store patronage. The study sample consisted of 340 female university students residing in Seoul. The data was analyzed by using path analysis and factor analysis. The recreational shopping orientation played a greater role in influencing the importance of store attributes than did the convenience shopping orientation. Recreational shoppers want a variety of brands and convenience shoppers can be attracted by a convenient location and availability of parking. Six important store attributes(variety of products and price level, proximity, variety of trendy brands, store decor, sales promotion, sales personnel) have a differential influence on store patronage. Shopping orientation was a direct predictor of patronage behavior and mediated the relationship between shopping orientation and store attribute importance. The finding indicated that both the recreational shopping orientation and convenience shopping orientation can be used effectively to position store patronage in such a way as to provide a strong means for shoppers to satisfy their needs. The findings of this study demonstrated that South Korean female shoppers with different shopping orientation have different store attribute preference and store patronage. The results provide a basis for building a successful strategy to attract shoppers and generate sales. The study focused on a specific product category, i.e., women's apparel. To meet the needs of female apparel shoppers, further research is needed to learn more about the distinctive characteristics of Korean consumers that could be applied to a variety of jobs, ages and living areas.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.11a
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• pp.99-113
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• 1996

Taurine, a ${\beta}$-amino acid, plays an important role as a neuromodulator and is necessary for the normal development of the brain. Since de novo synthesis of taurine in the brain is minimal and in vivo studies suggest that taurine does not cross the blood-brain barrier, the blood-cerebrospinal fluid (CSF) barrier is likely to play a role in taurine transport between the central nervous system and the systemic circulation. Therefore, we examined in vivo elimination of taurine from the CSF in the rat to characterize in vivo kinetics of elimination for taurine from the CSF is consistent with the in vitro study. Using a stereotaxic device, cannulaes were placed into the lateral ventricle and the cisterna magna of the rat. Radio-labelled taurine and inulin (a marker of CSF flow) were injected into the lateral ventricle, and the concentrations of the labelled compounds in the CSF were monitored for up to 3 hrs in the cisterna magna. The apparent clearance of taurine from CSF was greater than the estimated CSF flow (p<0.005), indicating that there is a clearance process in addition to the CSF flow. Taurine distribution into the choroid plexus was at least 10 fold higher than that found in other brain areas (e.g., cerebellum, olfactory bulb and cortex). When unlabelled taurine was co-administered with radio-labelled taurine, the apparent clearance of the labeled taurine was reduced (p<0.01), suggesting a saturable disposition of taurine from CSF. Distribution of taurine into the choroid plexus, cerebellum, olfactory bulb and cortex was similarly diminished, indicating that the saturable uptake of taurine into these tissues is responsible for the non-linear disposition. A pharmacokinetic model involving first order elimination and saturable distribution described these data adequately. The Michaelis-Menten rate constant estimated from in vivo elimination study is similar to that obtained in the in vitro uptake experiment Collectively, our results demonstrate that taurine is transported in the choroid plexus via a taurine is cleared from the CSF via a saturable process. This process may be functionally relevant to taurine homeostasis in the brain.

• Journal of the Korean association of regional geographers
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• v.19 no.3
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• pp.494-513
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• 2013

In this study, a transnational social space which emerges in a rural village of the northern Vietnam called 'Korean Village' is analyzed. The immigrant women of whom the spouses are Korean were forming transnational network with family members through which frequent and active communications took place. At the same time materialistic exchanges were occurring by means of remittance. Like most rural areas where up-to-date life patterns co-exist with outdated ones, the studied region was turning into a transnational social space under the influence of indigenous locallity, culture and other economic factors. Women were found to play a virtual role as resonator in practicing the transnational activity of migration. With the migration routes getting more and more solidified, the evolution of the transnational social space and the role of resonator, the form of transnational migration which makes involved young women look like a sacrifice is ceaselessly expanding around a specific region. This is noticeable because a rural village seemingly far away from internationalization is not only becoming the transnational social space but also a stage of its evolution.

• IMMUNE NETWORK
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• v.9 no.3
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• pp.90-97
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• 2009

Background: CD147, as a cellular receptor for cyclophilin A (CypA), is a multifunctional protein involved in tumor invasion, inflammation, tissue remodeling, neural function, and reproduction. Recent observations showing the expression of CD147 in leukocytes indicate that this molecule may have roles in inflammation. Methods: In order to investigate the role of CD147 and its ligand in the pathogenesis of atherosclerosis, human atherosclerotic plaques were analyzed for the expression pattern of CD147 and CypA. The cellular responses and signaling molecules activated by the stimulation of CD147 were then investigated in the human macrophage cell line, THP-1, which expresses high basal level of CD147 on the cell surface. Results: Staining of both CD147 and CypA was detected in endothelial cell layers facing the lumen and macrophage-rich areas. Stimulation of CD147 with its specific monoclonal antibody induced the expression of matrix metalloproteinase (MMP)-9 in THP-1 cells and it was suppressed by inhibitors of both ERK and NF-${\kappa}B$. Accordingly, the stimulation of CD147 was observed to induce phosphorylation of ERK, phosphorylation-associated degradation of $I{\kappa}B$, and nuclear translocation of NF-${\kappa}B$ p65 and p50 subunits. Conclusion: These results suggest that CD147 mediates the inflammatory activation of macrophages that leads to the induction of MMP-9 expression, which could play a role in the pathogenesis of inflammatory diseases such as atherosclerosis.