• Structural Engineering and Mechanics
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• 제68권4호
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• pp.459-473
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• 2018

Temperature fields and temperature deformations induced by time-varying solar radiation, shadow, and heat exchange are of great importance for the ride safety and quality of the maglev system. Accurate evaluations of their effects on the dynamic performances are necessary to avoid unexpected loss of service performance. This paper presents a numerical approach to determine temperature effects on the maglev train/guideway interaction system. Heat flux density and heat transfer coefficient of different components of a 25 m simply supported concrete guideway on Shanghai High-speed Maglev Commercial Operation Line is calculated, and an appropriate section mesh is used to consider the time-varying shadow on guideway surfaces. Based on the heat-stress coupled technology, temperature distributions and deformation fields of the guideway are then computed via Finite Element method. Combining guideway irregularities and thermal deformations as the external excitations, a numerical maglev train/guideway interaction model is proposed to analyze the temperature effect. The responses comparison including and excluding temperature effect indicates that the temperature deformation plays an important role in amplifying the response of a running maglev, and the parameter analysis results suggest that climatic and environmental factors significantly affect the temperature effects on the coupled maglev system.

• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.279-288
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• 2011

The Dexamethasone (DEX) loaded chitosan microspheres were prepared by thermal denaturation and chemical cross-linking method using a dierent concentration of glutaraldehyde as chemical cross-linking agent. The prepared microspheres were evaluated for the percentage of Drug Loading (DL), Encapsulation Efficiency (EE) and surface morphology by Scanning Electron Microscopy (SEM). DL and EE were found to be maximum range of 10.0 to 10.79 % and 58.19 to 64.73 % respectively. The SEM Photographs of the resultant microspheres exhibited fairly smooth surfaces and predominantly spherical in appearance. In addition, Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) shown that there was no interaction between the drug and polymer. In vitro and in vivo release studies revealed that the release of dexamethasone was sustained and extended up to 63 days and effectively controlled by the extent of cross-linking agent. Non-clinical parameters such as paw volume, hematological parameters like Erythrocyte Sedimentation Rate (ESR), Paced Cell Volume (PCV), Total Leucocytes Count (TLC), Hemoglobin (Hb), Differential Cell Count (DCC) were investigated in Fruend's Complete Adjuvant (FCA) induced arthritic rats. Radiology and histopathological studies were also performed in order to evaluate the therapeutic efficacy of the DEX-loaded microspheres in extenuating the rat arthritic model.

• 한국지반공학회논문집
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• 제19권5호
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• pp.163-173
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• 2003

본 연구에서는 억지말뚝으로 보강된 사면에서 한계평형 해석법과 3차원 해석 결과를 비교 분석하였다. 특히, 유한차분법을 이용한 FLAC 3D를 바탕으로 하는 커플링 해석에 주안점을 두었으며, FLAC을 이용하여 전단강도감소기법에 따른 보강사면의 안전율을 계산하기 위해 FLAC의 내장언어인 FISH를 이용하여 작성하였다. 커플링 해석에서 억지말뚝에 의한 안정화된 사면을 해석하기 위해 말뚝의 거동과 사면안정을 동시에 고려하였다. 따라서 본 연구에서는 이 두 방법을 적용하여 일렬 억지말뚝이 사면선단, 중앙부, 정부에 위치할 경우에 있어서 각각의 활동 파괴면 및 안전율을 비교 분석하였으며 강도정수 감소법을 적용한 해석기법의 적용성과 타당성에 대한 분석을 수행하였다.

• Molecules and Cells
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• 제22권2호
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• pp.175-181
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• 2006

Delivery of DNA vaccines to airway mucosa would be an ideal method for mucosal immunization. However, there have been few reports of a suitable gene delivery system. In this study we used a cationic emulsion to immunize mice via the intranasal route with pCMV-S coding for Hepatitis B virus surface antigen (HBsAg). Complexing pCMV-S with a cationic emulsion dramatically enhanced HBsAg expression in both nasal tissue and lung, and was associated with increases in the levels of HBs-specific Abs in serum and mucosal fluids, of cytotoxic T lymphocytes (CTL) in the spleen and cervical and iliac lymph nodes, and of delayed-type hypersensitivity (DTH) against HBsAg. In contrast, very weak humoral and cellular immunities were observed following immunization with naked DNA. In support of these observations, a higher proliferative response of spleenocytes was detected in the group immunized with the emulsion/pCMV-S complex than in the group immunized with naked pCMV-S. These findings may facilitate development of an emulsion-mediated gene vaccination technique for use against intracellular pathogens that invade mucosal surfaces.

• 제어로봇시스템학회논문지
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• 제16권3호
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• pp.249-255
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• 2010

The paper proposes a new type of robust speed control strategy for permanent magnet synchronous motor by using PD-sliding mode hybrid control. The PD control has a good performance in the transient region while the sliding mode controller provides the robustness against system uncertainties. Taking advantages of the two control strategies, the proposed control method utilizes the PD control in the approaching region to the sliding surface and the sliding mode control near at the sliding surfaces. The chattering problem of the sliding mode controller is eliminated by applying the saturation function for the switching function of the sliding mode control. The stability of the sliding mode control is verified by using Lyapunov function with the proper selection of variable gains. It is shown that with this simple switching algorithm, stability of the overall hybrid control system is ensured. Through the simulations, the PD-sliding mode algorithm is shown to have a good performance in the transient response as well as being robust against disturbances. The robustness of the PD-sliding mode algorithm is further demonstrated against various external disturbances in the real experiments of SPMSM motor control.

• Korean Chemical Engineering Research
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• 제53권3호
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• pp.321-326
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• 2015

Plackett-Burman (PB) and Box-Behnken (BB) experimental designs were used to optimize fermentation variables for the biotransformation of glycyrrhizin (GL) to monoglucuronyl-glycyrrhetinic acid (MGGA). The PB design was first used to screen the important factors among the medium variables. The steepest ascent method was used to approach the optimum range for each of these factors. The BB design was finally used to analyze the response surfaces of the screened factors for further optimization. The optimized conditions for this system were 0.7 g/L $MgSO_4{\cdot}7H_2O$, 1.19 g/L GL, and cultivation for six days. The biotransformation of GL to MGGA could reach up to 35.72%, which is a good result for this kind of transformation.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2007년도 하계학술대회 논문집 Vol.8
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• pp.378-378
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• 2007

In this study, liquid crystal (LC) aligning capabilities for homeotropic alignment on the $ZrO_x$ thin film by electron beam evaporation method were investigated. Also, the control of pretilt angles and thermal stabilities of the NLC treated on $ZrO_x$ thin film were investigated. The uniform LC alignment on the $ZrO_x$ thin film surfaces and good thermal stabilities with electron beam evaporation can be achieved. It is considerated that the LC alignment on the $ZrO_x$ thin film by electron beam evaporation is attributed to elastic interaction between LC molecules and micro-grooves at the $ZrO_x$ thin film surface created by evaporation. In addition, it can be achieved the good electro-optical (EO) properties of the VA-LCD on $ZrO_x$ thin film layer with. oblique electron beam evaporation.

• 한국기계가공학회지
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• 제18권3호
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• pp.74-81
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• 2019

Herein, we performed a comparative study on approximate multi-objective design optimization, to realize a structural design to improve the weight and vibration performances of the knuckle - a car suspension component - considering various load conditions and vibration characteristics. In the approximate multi-objective optimization process, a regression meta-model was generated using the response surfaces method (RSM), while Kriging and back-propagation neural network (BPN) methods were applied for interpolation meta-modeling. The Pareto solutions, multi-objective optimal solutions, were derived using the non-dominated sorting genetic algorithm (NSGA-II). In terms of the knuckle design considered in this study, the characteristics and influence of the meta-model on multi-objective optimization were reviewed through a comparison of the approximate optimization results with the meta-models and the actual optimization.

• 폴리머
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• 제30권6호
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• pp.471-477
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• 2006

이온성 고분자-금속 복합체(ionic polymer metal composite, IPMC)는 낮은 구동 전압에서도 비교적 빠른 응답 속도를 갖는 전기활성고분자(electro active polymer, EAP) 재료이다. IPMC는 인간의 근육과 유사한 인성 및 변형 특성을 나타내므로 최근 인공근육용 구동체 개발을 위한 많은 연구들이 진행되어 왔으며, 또한 우주항공, 센서 및 펌프 등의 다양한 분야에서 적용가능성이 조사되고 있다. 본 연구에서는 액상 내피온을 이용하여 용액 캐스팅 방법으로 다양한 두께의 내피온 막을 제조하는 방법을 도입하였다. IPMC 제조방법은 Oguro가 제안한 방법을 기초로 하여 도금온도를 변화시켜 무전해 도금법을 이용하여 내피온 내부로의 1차 전극을 형성시켰으며, 형성된 1차 전극의 안정성과 표면전기저항을 낮추기 위하여 이온빔보조증착법(ion beam assisted deposition, IBAD)을 도입하여 금과 이리듐을 1차 전극표면 위에 증착하여 2차 전극을 형성시켰다. 1, 2차 무전해 도금한 IPMC와 2차 IBAD 코팅한 IPMC 전극의 표면과 단면 형상을 SEM으로 관찰하였으며, 전압을 인가할 때 IPMC 내부의 수분증발 및 이온전도도의 변화를 조사하였다. 또한 다양한 두께의 IPMC를 제조하여 두께변화에 따른 변위와 구동력을 측정하였다.

• 대한기계학회논문집B
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• 제38권6호
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• pp.547-556
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• 2014

본 논문에서는 15,000 마력급 원심식 압축기 임펠러 블레이드에 대한 단방향 유체-구조 연성해석 및 응답표면법을 이용한 형상최적설계를 제시하였다. 임펠러 블레이드의 형상은 공력 성능에 영향을 미칠 뿐만 아니라, 유체의 압력과 원심력에 의한 임펠러의 구조적 안전성에도 큰 영향을 미치므로 유체-구조 연성해석을 함께 고려한 형상최적설계가 필요한 분야이다. 본 논문에서 유체-구조 연성해석의 유체영역과 구조영역을 ANSYS CFX와 Mechanical을 사용하여 각각 해석하였다. 실험계획법을 기반으로 유체 및 구조해석 결과에 대한 응답표면을 생성하여 구조적 안전성 및 압축비를 제한조건으로 하고 임펠러의 효율을 최대화하는 임펠러 블레이드의 형상최적설계를 수행하였다.