• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 C
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• pp.1373-1375
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• 1999

High impedance fault (HIF) is defined as fault the general overcurrent relay can not detect or interrupt. Especially when HIF occur in residential areas, energized high voltage conductor results in fire hazard, equiment damage or personal threat. This paper proposes the model of HIF in transmission line using the ZnO arrester and resistance to be implemented within EMTP. Wavelet transform is efficient and useful for the detection of HIF in power system, because it uses variable windows according to frequency. HIF detection method using wavelet transform can distinguish HIF from similar phenomena like arcfurance load, capacitor bank switching and line switching.

• 한국생산제조학회지
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• 제8권6호
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• pp.71-77
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• 1999

Monitoring of Cutting tool wear is a critical issue in automated machining system and has been extensively studied for many years. An austempered ductile iron(ADI) exhibits the excellent mechanical properties and the wear resistance. ADI has generally the poor machinability due to the characteristic. This paper presents the in-process detection of flank wear of cutting tools using the acoustic emission sensor and the digital oscilloscope. The amplitude level of AE signal(AErms) is mainly affected by cutting speed and it is proportional to cutting speed. There have been the relationship of direct proportion between the amplitude level of AE signals and the flank wear width of cutting tool. The flank wear with corresponding to the tool life is successfully detected with the monitor-ing system used in this study.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2011년도 추계학술대회 초록집
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• pp.139.1-139.1
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• 2011

Electric vehicle use independent electricity of high voltage. if isolation of electricity is destructed, devices and people are considerably damaged. Therefore, detection of ground fault is necessary for electric vehicle. As the existing detection method of ground fault can not detect ground fault when isolation of both positive side and negative side of electricity is destructed, and change of voltage of electricity. This paper proposed detection method for ground fault of both two sides of electricity and change of voltage. The proposed method is verified by analysis of equivalent circuit.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8883-8886
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• 2014

Background: Tetracycline is an antibiotic widely used for the treatment of Helicobacter pylori infection, but its effectiveness is decreasing due to increasing bacterial resistance. The aim of this study was to investigate the occurrence of 16S rRNA mutations associated with resistance or reduced susceptibility to tetracycline ofHelicobacter pylori by real-time PCR (RT-PCR) assays from culture. Materials and Methods: Tetracycline susceptibility and minimal inhibition concentration (MIC) was determined by the Epsilometer test (Etest) method. A LightCycler assay developed to detect these mutations was applied to DNA extracted from culture. The 16S rRNA of these isolates was sequenced and resistance-associated mutations were identified. From 104 isolates of H. pylori examined, 11 showed resistance to tetracycline. Results: LightCycler assay was applied to DNA extracted from 11 tetracycline-susceptible and 11 tetracycline resistance H. pylori isolates. In our study the sequencing of the H. pylori wild types in 16 s rRNA gene were AGA 926-928 with MIC (0.016 to $0.5{\mu}g/ml$), while the sequencing and MIC for resistant were GGA and AGC, (0.75 to $1.5{\mu}g/ml$), respectively. Also we found a novel mutation in 2 strains with $84^{\circ}C$ as their melting temperatures and exhibition of an A939C mutation. Conclusions: We conclude that real-time PCR is an excellent method for determination of H. pylori tetracycline resistance related mutations that could be used directly on biopsy specimens.

• 대한미생물학회지
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• 제35권2호
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• pp.181-190
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• 2000

To investigate resistance to lamivudine (3TC), we examined the incidence of M184V in 20 HIV-1 patients treated with 3TC for $13.1{\pm}9$ months. Fourteen of 20 patients had been exposed to zidovudine (ZDV) or didanosine (ddI) prior to 3TC therapy. Nested PCR targeting to reverse transcriptase (RT) and direct sequencing were performed for peripheral blood mononuclear cells sampled serially. There were resistance mutations to ZDV in at least 9 patients at baseline, although there was no resistance mutation to 3TC. We could detect M184V in 6 (30%) out of 20 patients. The incidence of M184V increased as the duration of therapy prolongs (13% in samples <12 months; 47% in samples ${\ge}12$ months). The frequency of mutation M184V was higher in patients with previous mutation to ZDV than in patients with wild type. Resistance mutation was not detected in 7 patients. This study shows that resistance to 3TC tends to develop rapidly in patients with baseline mutations or two drugs combination therapy than in those treated simultaneously with triple drugs. This report is the first on resistance to 3TC in Korean AIDS patients.

• BMB Reports
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• 제42권2호
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• pp.81-85
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• 2009

Early and accurate detection of drug resistant Mycobacterium tuberculosis can improve both the treatment outcome and public health control of tuberculosis. A number of molecular-based techniques have been developed including ones using probe molecules that target drug resistance-related mutations. Although these techniques are highly specific and sensitive, mixed signals can be obtained when the drug resistant isolates are mixed with drug susceptible isolates. In order to overcome this problem, we developed a new drug susceptibility test (DST) for one of the most effective anti-tuberculosis drug, isoniazid. This technique employed a microplate hybridization assay that quantified signals from each probe molecule, and was evaluated using clinical isolates. The evaluation analysis clearly showed that the microplate hybridization assay was an accurate and rapid method that overcame the limitations of DST based on conventional molecular techniques.

• Tuberculosis and Respiratory Diseases
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• 제77권4호
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• pp.161-166
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• 2014

Since tuberculosis (TB) remains a major global health concern and the incidence of multi-drug resistant (MDR)-TB is increasing globally, new modalities for the detection of TB and drug resistant TB are needed to improve TB control. The Xpert MTB/RIF test can be a valuable new tool for early detection of TB and rifampicin resistance, with a high sensitivity and specificity. Late-generation fluoroquinolones, levofloxacin, and moxifloxacin, which are the principal drugs for the treatment of MDR-TB, show equally high efficacy and safety. Systemic steroids may reduce the overall TB mortality attributable to all forms of TB across all organ systems, although inhaled corticosteroids can increase the risk of TB development. Although fixed dose combinations were expected to reduce the risk of drug resistance and increase drug compliance, a recent meta-analysis found that they might actually increase the risk of relapse and treatment failure. Regarding treatment duration, patients with cavitation and culture positivity at 2 months of TB treatment may require more than 6 months of standard treatment. New anti-TB drugs, such as linezolid, bedaquiline, and delamanid, could improve the outcomes in drug-resistant TB. Nontuberculous mycobacterial lung disease has typical clinical and immunological phenotypes. Mycobacterial genotyping may predict disease progression, and whole genome sequencing may reveal the transmission of Mycobacterium abscessus. In refractory Mycobacterium avium complex lung disease, a moxifloxacin-containing regimen was expected to improve the treatment outcome.

• 센서학회지
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• 제17권4호
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• pp.250-255
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• 2008

A vanadium pentoxide ($V_2O_5$)-based bolometric infrared (IR) sensor has been designed and fabricated using micro electro mechanical systems (MEMS) technology for glucose detection and its resistive characteristics has been illustrated. The proposed bolometric infrared sensor is composed of the vanadium pentoxide array that shows superior temperature coefficient of resistance (TCR) and standard silicon micromachining compatibility. In order to achieve the best performance, deposited $V_2O_5$ thin film is optimized by adequate rapid thermal annealing (RTA) process. Annealed vanadium oxide thin film has demonstrated a linear characteristic and relatively high TCR value (${-4}%/^{\circ}C$). The resistance of vanadium oxide is changed by IR intensity based on glucose concentration.

• 전자공학회논문지T
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• 제36T권4호
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• pp.88-93
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• 1999

본 논문에서는 한방의료에서 인체 전신의 상태를 파악하는데 주요한 요소인 맥파를 과학적으로 관찰하고자 스트레인 게이지를 이용하여 맥파를 검출하는 새로운 시스템을 구성하였다. 스트레인 게이지는 센서의 변형에 대해 선형적으로 고유한 저항값이 변화되므로 손목에서 맥의 변화는 스트레인 게이지를 이용하여 맥파의 파형으로 검출할 수 있다. 맥파 검출 시스템의 구성에서 스트레인 게이지로부터 발생된 저항변화값을 검출하기 위해 정밀 브리지회로와 고감도 증폭회로를 설계, 제작하였으며 이 시스템으로 미세한 맥의 변화를 상응하는 전압파형으로 출력시킨다. 구성된 시스템을 이용하여 6인의 맥을 직접 검출하고 시간영역과 주파수 영역에서 맥의 특성을 관찰하므로써 본 연구에서 구성된 맥파 검출 시스템의 과학적인 효용성을 입증하였다.

• Journal of Microbiology and Biotechnology
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• 제17권4호
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• pp.673-676
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• 2007

A two-step triplex PCR assay targeting the mecA, femA, and nuc genes was developed for the detection of methicillin resistance genes harbored by some Staphylococcus aureus isolates and for the simultaneous identification of such isolates at the species level. The triplex PCR revealed the presence of the femA and nuc genes in all the S. aureus isolates examined (n=105). Forty-four clinical isolates were mecA positive and no foodborne isolates were mecA positive. The PCR results had a 98 or 99% correlation with the results of PBP2a latex agglutination tests or oxacillin susceptibility tests, respectively.