• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1993년도 학술대회지
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• pp.127-131
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• 1993

The effects of total ginseng saponin. extracts of Panax ginseng C.A. Meyer, on the differentiation of F9 teratocarcinoma stem cells were studied. F9 stem cells cultured in the presence of ginseng saponin together with dibutyric cAMP became parietal endoderm - like cells. Moreover, the expressions of differentiation marker genes. laminin. type IV collagen. and retinoic acid $receptor-{\beta}(RAR{\beta})$ were increased after treatment of ginseng saponin. Among various ginsenosides purified from crude ginseng saponin, $Rh_1\;and\;Rh_2$ caused the differentiation of F9 cells most effectively. Since ginsenosides and steroid hormone show resemblance in chemical structure. we studied the possibility of the involvement of a steroid receptor in the differentiation process induced by ginsenosides. According to Southwestern blot analysis, a 94 kDa protein regarding as a steroid receptor was detected in F9 cells cultured in the medium containing ginseng saponin. Based on these data, we suggest that ginseng saponin, especially ginsenosides $Rh_1\;and\;Rh_2$ cause the differentiation of F9 cells and the effects of ginsenosides might be exerted via binding with a steroid receptor or its analogous nuclear receptor.

• 대한세포병리학회지
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• 제10권2호
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• pp.169-174
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• 1999

Spontaneous infarction of fibroadenoma of the breast is very uncommon and may lead to difficulties in clinical and pathological diagnosis. Most reported cases occured in young women during pregnancy or lactation. This report describes imprint cytologic features of an infarcted fibroadenoma in a 19-year-old young woman without evidence of pregnancy. The smears revealed many individually scattered degenerated or necrotic epithelial or spindle stromai cells and naked nuclei on dirty necrotic background. A few sheets of cohesive uniform epithelial cells and a few fragments of stromal cells were also present. Most of the epithelial cells had pyknotic and hyperchromatic nuclei, however, cellular atypism such as pleomorphism, prominent nucleoli or mitosis were not present. Though the necrotic ductular and glandular outline of this case may bear a superficial resemblance to adenocarcinoma, obvious cytologic atypia or mitosis, even in the necrotic areas were not present.

• 한국축산식품학회지
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• 제31권5호
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• pp.631-640
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• 2011

Milk oligosaccharides are the complex mixture of six monosaccharides namely, D-glucose, D-galactose, N-acetyl-glucosamine, N-acetyl-galactosamine, L-fucose, and N-acetyl-neuraminic acid. The mixture is categorized as neutral and acidic classes. Previously, 25 oligosaccharides in bovine milk and 115 oligosaccharides in human milk have been characterized. Because human intestine lacks the enzyme to hydrolyze the oligosaccharide structures, these substances can reach the colon without degradation and are known to have many health beneficial functions. It has been shown that this fraction of carbohydrate can increase the bifidobacterial population in the intestine and colon, resulting in a significant reduction of pathogenic bacteria. The role of milk oligosaccharides as a barrier against pathogens binding to the cell surface has recently been demonstrated. Milk oligosaccharides have the potential to produce immuno-modulation effects. It is also well known that oligosaccharides in milk have a significant influence on intestinal mineral absorption and in the formation of the brain and central nervous system. Due to its structural resemblance, bovine milk is considered to be the most potential source of oligosaccharides to produce the same effect of oligosaccharides present in human milk. This review describes the characteristics and potential health benefits of milk oligosaccharides as well as the prospects of oligosaccharides in bovine milk for use in functional foods.

• 산업기술연구
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• 제19권
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• pp.155-162
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• 1999

In the last few years the automatic classification of morpholgical landforms using GSIS and DEM was investigated. Particular emphasis has been put on the morphological point attribute approaches and the extraction of drainage basin variables from digital elevation models. The automated derivation of landforms has become a neccessity for quantitative analysis in geomorphology. Furthermore, the application of GSIS technologies has become an important tool for data management and numerical data analysis for purpose of geomorphological mapping. A process developed by Dikau et al, which automates Hanmond's manual process, was applied to the pyoung chang of the kangwon. Although it produced a classification that has good resemblance to the landforms in the area, it had some problems. For example, it produced a progressive zonation when landform changes from plains to mountains, it does not distinguish open valleys from a plains mountain interface, and it was affected by micro relief. Although automating existing quantitative manual processes is an important step in the evolution automation, definition may need to be calibrated since the attributes are oftem measured differently. A new process is presented that partly solves these problems.

• 한국게임학회 논문지
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• 제11권1호
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• pp.121-129
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• 2011

온라인 게임에서 오토 프로그램 또는 봇 프로그램으로 인하여 다양한 게임 서비스 피해사례가 발생하고 있다. 특히, 게임 머니 및 아이템의 비정상적인 수집은 게임이 가지는 본연의 재미를 잃어버리게 되고, 궁극적으로 게임 생명주기에 결정적 악영향을 미치게 된다. 본 논문은 게임 봇 감지를 위해 게임 행위 변화 패턴을 수집하고 분석하여 봇 탐지 방법에 적용한다. 인간의 게임 행위 변화 정보와 봇의 게임 행위 변화 정보를 이용하여 유사정도를 측정하고, 봇 탐지 기법에 활용하는 것이다. 실험에서는 서비스 중인 온라인 게임을 이용하여 사용자와 봇의 모델을 생성하고 유사성을 판별하였으며 적절한 결과를 확인하였다.

• Journal of Chest Surgery
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• 제14권2호
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• pp.127-130
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• 1981

A 39-year-old male was admitted to Dept. of Thoracic Cardiovasc. Surgery, Korea University Hospital with the chief complaints of progressively enlarged mass on right upper lung which revealed on routine chest P-A since 4 Years ago. Chest PA and tomography revealed well circumscribed huge mass of 7cm. in diameter without invasion on bronchus. so, right upper lobectomy was performed under impression of lung cancer. Postoperative pathologic examination revealed pulmonary blastoma. Pulmonary blastoma is accepted as a distinctive neoplasm recently. One case of typical pulmonary blastoma is reported, and the previous literature is reviewed. There are no specific clinical or radiologic feature of pulmonary blastoma. The presentation is can be that of any other pulmonary tumor although a peripheral situation is usual and a large size is often attained before detection. Pulmonary blastoma is a mixed tumor with malignant epithelial and connective tissue components with a distinctive resemblance to fetal lung. The treatment of choice is surgical excision but the overall prognosis is poor. There is no evidence of recurrence or metastasis on follow-up study during 6 months period after right upper lobectomy.

• 한국수학교육학회지시리즈A:수학교육
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• 제46권2호
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• pp.173-192
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• 2007

We define mathematical learning as a process of overcoming framing difference of teachers and students, two main subjects in a mathematics class. We have reached this definition to the effect that we can grasp a mathematical classroom per so and understand students' mathematical learning in the context. We could clearly understand the process in which the framing differences are overcome by analyzing mutual negotiation of informants in specific cultural models, both in its form as well as in its meaning. We review both of the direct and indirect forms of negotiation while keeping track of 'evolution of subject' in terms of content of negotiation. More specifically, we discuss direct negotiation briefly and review indirect negotiation from three distinct themes of (1) argument structure, (2) revoicing, and (3) development patterns and narrative structure of proof. In addition, we describe the content of negotiation under the title of 'Evolution of Subject.' We found that major modes of mutual negotiation are inter-reference and appropriation while the product of continued negotiation is inter-resemblance.

• 대한후두음성언어의학회지
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• 제28권1호
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• pp.48-51
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• 2017

Candida exists in the oral cavity as normal flora, which is cultured in 7% of the population. And the development of candidiasis is usually related to the systemic or local immunosuppressed status such as diabetes, long-term antibiotics, steroid, radiation therapy or chemotherapy. However, isolated laryngeal candidiasis in immunocompetent patients is a rare entity with fewer than 40 cases reported in the world. Symptoms of laryngeal candidiasis are variable such as hoarseness, dysphagia, or odynophagia according to its extent, but it has clinical importance because of its resemblance with laryngeal premalignant or malignant lesions. Diagnosis is made by biopsy under direct laryngoscopy with special staining to identify the hyphae. In this article, we report a case of laryngeal candidiasis presented as leukoplakia localized on vocal fold with literature reviews.

• 대한약침학회지
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• 제23권1호
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• pp.1-7
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• 2020

Nicotine, primary component of tobaco produces craving and withdrawal effect both in humans and animals. Nicotine shows a close resemblance to other addictive drugs in molecular, neuroanatomical and pharmacological, particularly the drugs which enhances the cognitive functions. Nicotine mainly shows its action through specific nicotinic acetylcholine receptors located in brain. It stimulates presynaptic acetylcholine receptors thereby enhancing Ach release and metabolism. Dopaminergic system is also stimulated by it, thus increasing the concentration of dopamine in nuclear accumbens. This property of nicotine according to various researchers is responsible for reinforcing behavioral change and dependence of nicotine. Various researchers have also depicted that some non dopaminergic systems are also involved for rewarding effect of nicotinic withdrawal. Neurological systems such as GABAergic, serotonergic, noradrenergic, and brain stem cholinergic may also be involved to mediate the actions of nicotine. Further, the neurobiological pathway to nicotine dependence might perhaps be appropriate to the attachment of nicotine to nicotinic acetylcholine receptors, peruse by stimulation of dopaminergic system and activation of general pharmacological changes that might be responsible for nicotine addiction. It is also suggested that MAO A and B both are restrained by nicotine. This enzyme helps in degradation dopamine, which is mainly responsible for nicotinic actions and dependence. Various questions remain uninsurable to nicotine mechanism and require more research. Also, various genetic methods united with modern instrumental analysis might result for more authentic information for nicotine addiction.

• 한국의류학회지
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• 제26권11호
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• pp.1547-1557
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• 2002

The purpose of this study is to find the profitable clothes design of middle-aged men by examining visual effects in physical design. The methode of study is experimentation. The sample of this study is people who live in Kwangiu, Korea and 20-50 age's 719. The difference of physical design effect by arrangement, pattern and the shape of body. There are partly resemblance difference in physical design visual effect by the shape of body and clothes design(arrangement and pattern)In weak type, single suit with striped pattern and double suit with check pattern make the upper body look short. Otherwise, double suit with striped pattern have man look tall. In standard type, single arrangement suit with striped pattern make the lower half of body long, so make man look tall. And double arrangement suit with striped pattern have man look tall. The suit without pattern have one's shoulder look wide. In pyknic type, striped pattern make the lower half of one's body look long. But single arrangement with striped pattern have the upper body look big. sing1e suit with striped pattern make lower half of body look long and check pattern make it look short. Totally, arrangement, and pattern are very important clothes due to give an effect on whole visual effect man's suit. Also, these dues were felt differently by each types of body. So, it is confirmed that the type of body is important fluent to make people perceive.