• Clinical and Experimental Reproductive Medicine
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• v.46 no.4
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• pp.173-177
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• 2019

Objective: We investigated the clinical characteristics of men with testosterone replacement therapy (TRT)-induced hypogonadism and its effect on assisted reproductive technology (ART) in infertile couples. Methods: This study examined the records of 20 consecutive male patients diagnosed with azoospermia or severe oligozoospermia (< 5 × 10⁶/mL) who visited a single infertility center from January 2008 to July 2018. All patients were treated at a primary clinic for erectile dysfunction or androgen deficiency symptoms combined with low serum testosterone. All men received a phosphodiesterase 5 inhibitor and TRT with testosterone undecanoate (Nebido^®) or testosterone enanthate (Jenasteron^®). Patients older than 50 years or with a chronic medical disease such as diabetes were excluded. Results: The mean age of patients was 37 years and the mean duration of infertility was 16.3 ± 11.6 months. At the initial presentation, eight patients had azoospermia, nine had cryptozoospermia, and three had severe oligozoospermia. Serum follicle-stimulating hormone levels were below 1.0 mIU/mL in most patients. Three ongoing ART programs with female factor infertility were cancelled due to male spermatogenic dysfunction; two of these men had normal semen parameters in the previous cycle. After withholding TRT, serum hormone levels and sperm concentrations returned to normal range after a median duration of 8 months. Conclusion: TRT with high-dose testosterone can cause spermatogenic dysfunction due to suppression of the hypothalamic-pituitary-testicular axis, with adverse effects on infertility treatment programs. TRT is therefore contraindicated for infertile couples attempting to conceive, and the patient's desire for fertility must be considered before initiation of TRT in a hypogonadal man.

• Journal of Life Science
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• v.25 no.1
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• pp.113-120
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• 2015

Osteoporosis is a major bone disorder defined as having bone mineral density (BMD) of 2.5 standard deviations or more below the peak bone mass. Osteoporosis will increasingly be a major disorder that faces the aging mankind. It is the result of an imbalance in the bone remodeling system, where bone constantly undergoes a cycle of resorption by osteoclasts and formation by osteoblasts. Estrogen deficiency in women following menopause is identified as the predominant reason that causes disparity in this system. Current medical treatments for osteoporosis include hormone replacement therapy (HRT), biphosphonates, and teriparatide, but have various side effects that raise questions concerning their medical safety and practicality. Alternative treatments involving natural product sources are under study to find a safer therapy. Many natural sources including lactoferrin and isoflavones and numerous traditional herbal medicines exhibit anti-resorptive or anabolic effects on bone and thus show promises to provide therapeutic agents in treating osteoporosis. Unfortunately, the majority of natural product treatments are still in its preliminary stages to prove their efficacy even though the development pace of treatment for osteoporosis is astounding in the past few decades. Further progress in pre-clinical studies and the subsequent clinical studies will someday lead to a breakthrough that takes us another step forward in science.

• Journal of Korean Society for Atmospheric Environment
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• v.19 no.6
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• pp.689-699
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• 2003

This study was to examine characteristics of treating toluene vapor, which gets to be problematic due to its harmful carcinogenicity and mass generation from various sources, through a biological treatment facility which is environment-friendly and adopts a high-efficient and low-cost clean technology. In order to identify whether Alnus Firma Fruit (AFF) can be used as a media for a bioreactor, its utility and basic operating factors, a study was conducted on pressure drop, supply of nutrient substances and retention time which are operating factors of a biofilter, and eliminating characteristics were compared between AFF and the conventional biological activatedcarbon (BAC) widely used as filter media. In the case of AFF, the initial microbial deposits was 2.3${\times}$10$^{7}$ CFU/g dry AFF, which represents the initial microbial density higher than the case of BAC showing 5.5${\times}$10$^{6}$ CFU/g dry BAC And it took about 2 weeks to acclimate until its eliminating rate got to be increased over 90%. As a result of comparing pressure loss taking place with the lapse of time between BAC and AFF, after 130 days passed at SV 25h$^{-1}$ , BAC showed that its eliminating efficiency had a tendency to drop greatly due to a great pressure loss (0.53\longrightarrow54.7 mm$H_2O$/m) caused by an excess of biomass as accumulated. On the other hand. AFF showed that the pressure drop was 0.53 mm$H_2O$/m, about 2 times as much as the initial pressure loss of 0.4 mm$H_2O$/m, which represents no great change in the pressure loss, and its eliminating efficiency was also shown to be continuously high. Therefore, when AFF was used as a filler for a biological treatment facility, a biological filter enabling improvement of the purifying efficiency to be promoted could be provided, and moreover, the pressure loss was so small that the filler replacement cycle or the back flushing cycle could be extended. So, even in terms of the operating cost, it was identified to be an economical filler When an inorganic material was used as a filler, the biofilters performance acted sensitively on whether nutrient substances were supplied or not. In the case of AFF with low adsorptivity, addition of ethyl-alcohol increased the solubility of toluene, and consequently, biodegradation got to be actively made by microbes, and thus, its eliminating rate could be increased. As the flow velocity and the inflow concentration got to be more increased, its eliminating rate got to be lower, and particularly, an increase in the flow velocity made its eliminating rate drop more greatly than an increase in the concentration.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.6
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• pp.2639-2644
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• 2013

The renewal cycle, which newly decorates stores, has been shortened, as the marketing competition between telecommunication companies has been extended to the stores, due to the rapid increase of mobile phone users and fast replacement cycle of products. The store renewal made by major telecommunication companies, including signboard, has been pushed in order for telecommunication companies to give strong impression about their own brand identity to consumers. Consumers want stores not only to sell cheap and high quality products but also to provide customer experience, by which customers can feel store, product and service and accept them. Especially, since the competition between telecommunication companies is getting tough, it is the current trend that the number of stores is increasing much, and telecommunication companies are recently renewing their stores, with the concept of SI(Store Identity), which changes store image into the incorporated image including interior and exterior, rather than just replacing CI(Corporate Identity), when they renew stores. It can be said that SI(Store Identity) is an important factor, by which companies consistently design visual factors such as interior and sign, and then apply them to the interior and exterior of the stores, and thereby give good store image to consumers, and ultimately have great effect on the increase of sales volume. This kind of activity can be image-controlled by companies' Identity Management, and it can be a very important factor in terms of marketing. In this study, it has an objective to compare and analyze SI of domestic telecommunication companies and foreign telecommunication companies, and then suggest effective SI direction.

• Journal of Korean Neurosurgical Society
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• v.29 no.4
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• pp.471-476
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• 2000

Objective : p16/INK4a, a kind of tumor suppressor genes, encodes a specific inhibitor of the cyclin D-dependent kinases CDK4 and CDK6. This prevents the association of CDK4 with cyclin D1, and subsequently inhibits phosphorylation of retinoblastoma tumor suppressor protein(pRb), thus preventing exit from the G1 phase. According to previous reports, over 50% of glioma tissue and 80% of glioma cell lines have been demonstrated inactivation of p16/INK4a gene. The purpose of this study was to determine whether recombinant adenovirus-p16 virus is a suitable candidate for gene replacement therapy in cases of glioma. Methods : Three human glioma cell lines(U251MG, U87MG and U373MG) that express mutant p16 protein were used. Replication-deficient adenovirus was utilized as an expression vector to transfer exogenous p16 cDNA into the cells ; control cells were infected with the Ad-${\beta}$-gal expressing ${\beta}$-galactosidase. To monitor gene transfer and the expression of exogenous genes, we used Western Blotting analysis. Flow cytometry studies of cellular DNA content were performed to determine the cell cycle phenotype of the glioma cells before and after treatment. Results : We showed here that restoration of p16/INK4a expression in p16 negative U87MG, U251MG and partially deleted U373MG by Ad-CMV-p16 induced growth suppression in vitro. Flow cytometric study revealed that Ad-CMV-p16 infected U87MG cells were arrested during the G0-G1 phase of the cell cycle. Expression of p16 transferred by Ad-CMV-p16 in glioma cells was highly efficient and maintained for more than seven days. Conclusions : Our results suggest that Ad-CMV-p16 gene therapy strategy is potentially useful and warrants further clinical investigation for the treatment of gliomas.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.18 no.2
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• pp.55-61
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• 2018

Orinithine transcarbamylase (OTC) deficiency is the most common inborn error of the urea cycle with resulting hyperammonemia, which is medical emergency in newborns.We recently had a case of a boy that presented with lethargy, seizure, hyperammonemia and hypocalcemia in neonatal period. He was diagnosed with OTC deficiency by two consequent ways which are initial biochemical phenotype including hyperammonemia and an increased orotic acid in his urine and genetic analysis of the OTC gene. The OTC gene showed a novel hemizygous mutation c.913C>T (p.Pro305Ser). He was treated by low protein intake, sodium benzoate, phenylbutyrate sodium, L-arginine, and continuous renal replacement therapy (CRRT). After discharge, he has a relatively good prognosis without notable developmental delay. For good prognosis, the duration of hyperammonemia should be shorten. And it can be reached by an early diagnosis. For early detection of OTC deficiency, targeted exome sequencing will be a important role as well as biochemical tests.

• Cross-Cultural Studies
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• v.42
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• pp.165-203
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• 2016

This study attempted to reconsider the existing viewpoint on the history of Pansori transmission and suggested a new viewpoint on lostPansori transmission. Untill now, lost seven songs have been criticized for failure in Pansory's transmission history because it ceased to satirize negativity of abnormal character without creating a bearer of new value goals in the new age this paper resulted in another conclusion which extends Pansori history's process to modern times in the point of succession and duration of Pansori esthetics. Currently the above reason creats a problem ofcomplete nonmention that confront Pansori's twelve songs which does not apply to lost seven songs. If the evaluation standard of literary history used for lost seven songs is applied to inherited five songs, The inherited five songs also failed in the esthetic cultural history of present times. To resolve this issue, this study suggested a new viewpoint to replace the existing viewpoint that label Pansori's history as a historical structure consisting of success of inherited five songs and failure of lost seven songs repetitive replacement cycle of float and flow. This study provided constructive on lost Pansory of premodern times and presented entire Pansori as a flowing state. This paper futher identified the stages of decline the lost seven songs since the 20thcentury but sets the stage or finding a new qualitative possibility. This new theory was suggested through extant aspects of the movie that was a reproduction of in the present media age.

• Journal of Digital Convergence
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• v.12 no.9
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• pp.93-99
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• 2014

This study aims to explore and analyze smartphone users' characteristics from the two perspectives (purchase vs. use characteristics) on the two operating systems (iOS and Android). The results of the study on purchase characteristics show that smartphones choice priority and the gender ratio are found to be significantly different between the two operating system users. However, the replacement cycle is not statistically different from iOS and Android users. The results of study on use characteristics show that the number of the applications and the registered SNS(social network service), the average monthly smartphone bill, and satisfaction are significantly different between iOS and Android users. However, the average Internet usage time is not different between the two operating system users. The findings provide useful implications for operating developers, smartphone manufacturers, and application developers.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.11
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• pp.2347-2352
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• 2011

driver for safety always check the status of their vehicle, and it is essential to understand. But if you want to know the status of the driver of the vehicle in specialist referral time and money because it costs the operator shall be paid.IT technoligy with the development of the various features of your phone to check the status of the vehicle was able to do. However, the car' existing phone system, car diagnostic expertise must be learned because it will reveal the status of the vehicle do not have the expertise to not highlight the need for diagnostic. To reflect these points in smartphone users to easily use their own vehicles at a time to determine the status of a system that is required. In this paper, OBD-II protocol conversion WiFi OBD-II connector, retrieving information from the driver of the vehicle replacement cycle of consumables required vehicle inspection, vehicle problems in real-time diagnostic information to the user ease of use shows the iPhone implementation in the automotive supply was implemented based on the smartphone.

• Korean Journal of Construction Engineering and Management
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• v.18 no.2
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• pp.3-11
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• 2017

Aging buildings over 15 years reaches about 74% of 177 thousand buildings in Domestic public buildings. Due to the aging building, the energy loss is a serious problem. In order to reduce the energy usage through improving the energy efficiency on the existing buildings, the government & the local autonomous entity conduct the energy efficiency projects through the remodeling, repairing & equipment replacement on the existing buildings. The green remodeling is applied to the existing public buildings in recently revised the act on the creation and support of green building. However, the standard is not obvious that the work scope of green remodeling, financing and project delivery method. This paper propose is to suggest project delivery system for vitalizing the green remodeling. Green remodeling is defined on basis of the occurring work under project life cycle based on the existing building process and the financing method for owners and companies and the project delivery system according to work scope of green remodeling are proposed in this paper