• 생물정신의학
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• 제19권3호
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• pp.121-127
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• 2012

Objectives : The multimodal telepresence systems have been adopted in a variety of applications, such as telemedicine, space or underwater teleoperation and videoconference. Multimedia, one of the telepresence systems, has been used in various fields including entertainment, education and communication. The degree of subjective telepresence is defined as the probability that a person perceives to be physically in the remote place when he/she experiences a multisensory feedback from the multimedia. The current study aimed to explore the neural mechanism of telepresence related to multisensory feedback in patients with schizophrenia. Methods : Brain activity was measured using functional magnetic resonance imaging while fifteen healthy controls and fifteen patients with schizophrenia were experiencing filmed referential conversation at various distances (1 m, 5 m and 10 m). Correlations between the image contrast values and the telepresence scores were analyzed. Results : Subjective telepresence was not significantly different between the two groups. Some significant correlations of brain activities with the telepresence scores were found in the left postcentral gyrus, bilateral inferior frontal gyri, right fusiform gyrus, and left superior temporal sulcus. There were no main effects of group and distance. Conclusion : These results suggest that patients with schizophrenia experience telepresence as appropriately as healthy people do when exposed to multimedia. Therefore, patients with schizophrenia would have no difficulty in immersing themselves in multimedia which may be used in clinical training therapies.

• Journal of Korean Neurosurgical Society
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• 제46권2호
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• pp.136-143
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• 2009

Objective: Remote cerebellar hemorrhage (RCH) is one of the rare complications occurring after supratentorial surgery, and its pathomechanism is poorly understood. We report 10 cases of RCH from our institution and review 154 cases from a database in order to delineate incidence, common presentation, risk factors, and outcomes of this complication. In addition, the means of prevention are discussed. Methods: We reviewed the medical records of 10 patients who experienced RCH after undergoing supratentorial surgery at our institution between 2001 and 2008. A database search in Medline revealed 154 cases of RCH in the English literature. Characteristic features were analyzed and compared. Results: There were 10 cases of RCH among 3307 supratentorial surgery cases, indicating a 0.3% incidence. All patients had characteristic imaging features of RCH, namely a streaky bleeding pattern in the superior folia of the cerebellum. Seven patients had a history of preoperative hypertension. Four cases were related to cerebral aneurysms, and other four developed after the removal of brain tumors. Cerebrospinal fluid (CSF) drainage apparatuses were installed postoperatively in all cases. Outcomes according to modified Rankin scale (mRS) were good in 7 patients, with 1 fatal case. Conclusion: RCH is a rare complication after supratentorial surgery, and the exact etiology still remains uncertain. Hypertension and perioperative loss of CSF seem positively correlated with RCH, but no single risk factor is totally responsible. Patients with RCH should be closely observed to improve their prognosis.

• 디자인학연구
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• 제17권2호
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• pp.413-424
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• 2004

텔레프레즌스는 '현상체가 현실세계를 떠나 가상세계로 이동함에 따라 가상세계의 사물과 인물에 대해 마치 현실세계의 사물과 인물에 대해 반응하는 것과 유사한 심리적, 행동적 반응을 보이는 현상'이며 '커뮤니케이션 매체를 통해 제공된 환경에 존재한다고 지각하는 경험'이다. 텔레프레즌스는 매체를 수단으로 경험하게 되는 것으로, 매체의 특성은 매개된(mediated) 환경에 직접적인 영향을 끼친다. 하나의 매개된 환경이 사용자에게 텔레프레즌스의 경험을 불러일으킬 것인지 아닐지는 환경에 사용된 감각자극들의 조합, 사용자가 환경과 상호 작용할 수 있는 방법들 그리고 그 환경을 경험하는 사용자 개인들의 특성들에 의해 결정된다. 텔레프레즌스 아트는 네트워크로 연결된 사이버 공간(cyber space)에서 서로 다른 지역에 있는 사람들을 텔레커뮤니케이션 시스템(telecommunication system)을 이용해 연결하고 그들로 하여금 가상현실(virtual reality)의 감각적 정보를 기반으로 상호작용하게 함으로써 텔레프레즌스(telepresence)를 경험하도록 하는 예술 활동을 말한다. 텔레프레즌스 아트의 특징은 원거리 통제(remote control), 원거리 영상(remote vision), 원거리 운동(telekinesis), 실시간 시청각 정보의 교환(real-time exchange of audiovisual information)이라 할 수 있다. 본 연구는 텔레프레즌스의 결정요인을 감각적 몰입도(sensory immersion), 감각적 충실도(sensory fidelity), 인지적 충실도(cognitive fidelity), 사용자의 개인적 특성들(personal factors)로 분류하고 이 네 가지 결정요인이 적용된 텔레프레즌스 아트의 사례분석을 통해 뉴미디어 아트를 위한 미학적 접근과 디자인 방법론을 모색하고 있다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2007년도 Proceedings of ISRS 2007
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• pp.37-40
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• 2007

Satellite altimetric data from 1993 to 2006 are used to study sea level variations in the long tenn in the East Sea. The trend of sea level in the East Sea is rising 4.16 mm/yr and indicate that it rose 5.82 cm in 2006 against to 1993. The South Ses is the fastest in the study areas (4.89 mm/yr, 6.84cm) and the Yellow Sea is 4.10 mm/yr and 5.75cm, respectively. The both of Mokho coast and Ulleung island are minimal sea level in March to May and maximal sea level in September to November. For periods above 20.9days, coherences are found to be higher than 95% confidence level, and the phase differences are near zero.

• BioChip Journal
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• 제16권
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• pp.280-290
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• 2020

Considerable attention is given to drug delivery technology that efficiently delivers appropriate levels of drug molecules to diseased sites with significant therapeutic efficacy. Nanotechnology has been used to develop various strategies for targeted drug delivery, while controlling the release of drugs because of its many benefits. Here, a delivery system was designed to control drug release by external magnetic fields using porous silica and magnetic nanoparticles. Magnetic nanochains (MNs) of various lengths (MN-1: 1.4 ± 0.8 ㎛, MN-2: 2.2 ± 1.1 ㎛, and MN-3: 5.3 ± 2.0 ㎛) were synthesized by controlling the exposure time of the external magnetic force in magnetic nanoaggregates (MNCs). Mesoporous silica-coated magnetic nanochains (MSMNs) (MSMN-1, MSMN-2, and MSMN-3) were prepared by forming a porous silica layer through sol-gel polymerization. These MSMNs could load the drug doxorubicin (DOX) into the silica layer (DOX-MSMNs) and control the release behavior of the DOX through an external rotating magnetic field. Simulations and experiments were used to verify the motion and drug release behavior of the MSMNs. Furthermore, a bio-receptor (aptamer, Ap) was introduced onto the surface of the DOX-MSMNs (Ap-DOX-MSMNs) that could recognize specific cancer cells. The Ap-DOX-MSMNs demonstrated a strong therapeutic effect on cancer cells that was superior to that of the free DOX. The potent ability of these MSMNs as an external stimulus-responsive drug delivery system was proven.

• 한국실내디자인학회논문집
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• 제19권2호
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• pp.234-242
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• 2010

The twenty seven houses at Incheon city, were remodeled in 2009 for the physically handicapped people. This research had been done the analysis of the itemized questionnaire by the needs of the physically handicapped for their better living environment and suggested the following remodeling devices. First of all, there was the priority for the remodeling of their living facilities. According to their priority, they wanted to remodel their bathroom, kitchen & dining room, veranda, living room, and hall way. These were based on their needs of movement, personal hygiene, convenient closet, and cabinet usage. In particular, their demands were shown as followings. The wheelchair using handicapped people required safe doorknobs, unslippery floor materials, removal of step levels, and heights adjustable washing stand for their bathroom. They also requested washboard, non-threshold, and automatic door locks. Otherwise, the disabled in critical condition who could not move anything preferred the remodeling of inner structure of living spaces and automatic door system. The slight disabled and the families those who have the disabled demanded the remodeling of kitchen & dining room, and preferred the reorganization of closet, cabinets, floor tiles, and turncock. The remodeling of bedroom was mostly requested by the disabled women, people with the brain disorder, and disabled people in critical condition who could not move anything. They wanted the remote controlled lightings.

• 대한물리치료과학회지
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• 제9권3호
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• pp.107-119
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• 2002

Astrocyte, which shares the greatest part of the brain (about 25%), is a land of glial cell that composes the central nervous system along with microglia, ependymal cell and oligodendroglia. It has 7-9nm of fibers in its cytoplasma, which are composed of glial fibrillary acidic protein (GFAP) and vimentin. As for the functions of the astrocyte, it has, so far, been supposed that the astrocyte will play a cytoskeletal role in maintaining the structure of the cerebrum, play a role as a blood-brain barrier so that it can induce migration of the neuron in its development and substances in the blood cannot go into the nervous tissue, and a role of immunology and phagocytosis. However, it was revealed today that it will be a role in preventing expansion of injury by attaching itself to the connective tissue such as the vessel and the pia mater when the nervous tissue or the arachnoid is injured. Microcurrent stimulation can control current, on the basis of A unit. That is, with such devices using it, it is possible to sense, from the outside, the injured current(wound current) of the lesion and to change it into the normal current, thereby promoting the restoration of the cells. In order to examine the effects of microcurrent stimulation on the injured astrocytes in the rabbits, this study was conducted with 24 New Zealand White Rabbit as its subjects, which were divided into 8 animals of the experiment group and 16 animals of the control group. After the animals in the experiment group were fixed to the stereotaxic apparatus, their hair was removed and their premotor area(association area) perforated by the micro-drill for skull-perforation with the depth of 8mm from the scalp. In one week after the injury, 4 animals in the control group and 8 animals in the experiment group were sacrificed and examined with immunohistochemical method. And in three weeks, the remaining 4 animals in the control group and 8 animals in the experiment group were also sacrificed and examined with the same way. The conclusion has been drawn as follows : In the control group sacrificed in one week after the injury, the astrocytes somewhat increased, compared with the normal animals, and in the group sacrificed in three weeks after the injury, they increased more (p < 0.05). The experiment group A in one week showed a little increase, but there was no significant differences, but the experiment group in three weeks showed more increase, compared with the experiment group in one week (p < 0.05). The experiment group B in one week showed more increase than the control group or the experiment group A, and the experiment group in three weeks showed more increase than the experiment group in one week (p < 0.05). Among the astrocytes, fibrous astrocytes were mostly observed, increasing as they are close to the lesion, and decreasing as they are remote from it. The findings show that microcurrent can cause the astrocytes to proliferate and that it will be more effective to stimulate the cervical part somewhat remote from the lesion rather than to directly stimulate the part of the lesion. Thus, microcurrent stimulation can be one of the methods that can activate the reaction of astrocytes, which is one of the mechanism for treating cerebral injury with hemorrhage. Therefore, this study will be used as basic research data for promoting restoration of functions in the patient with injury in the central nervous system.

• Tuberculosis and Respiratory Diseases
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• 제70권2호
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• pp.160-164
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• 2011

Paraneoplastic neurologic syndrome is a group of assorted disorders resulting from damage to the nervous system in cancer, remote from primary site, and not related to metastasis, infection, or metabolic disorder associated with cancer. Patient with small cell lung cancer sometimes shows various neurological syndromes, but patient with non-small cell lung cancer rarely shows neurologic syndromes and few antineuronal antibodies have been found. Here, we report a case of 53-year-old male patient who developed ptosis and extraocular muscular limitation of left eye due to third and forth cranial nerve palsy in non-small cell lung cancer without brain metastasis. These neurologic symptoms improved after lobectomy without any other treatment immunotherapy.

• Clinical and Experimental Pediatrics
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• 제53권4호
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• pp.603-606
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• 2010

부신생물 변연계뇌염(paraneoplastic limbic encephalitis)은 신경계의 전이가 없이 종양의 원격 작용에 의해 발생하는 질환으로 소아에서는 드물게 보고되고 있다. 저자들은 사춘기 여아에서 발생한 성숙 난소기형종에 동반된 부신생물 변연뇌염을 경험하고 보고하고자 한다. 15세 여자 환자가 신경정신증상, 기억력 저하, 경련, 의식 저하를 주소로 내원하였다. 뇌척수액 검사, 뇌 MRI는 정상이었으나, 뇌 SPECT 검사에서 양측 측두엽의 저관류가 관찰되었다. 복부 초음파와 MRI에서 좌측 난소의 낭성 종양이 발견되었다. 종양의 수술적 제거 후 성숙 난소기형종으로 확인되었으며, 종양 제거 및 면역글로불린 정맥 투여로 완전한 인지 기능의 회복을 보였다.

• Biomolecules & Therapeutics
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• 제19권4호
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• pp.431-437
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• 2011

Aberrant activation of microglia has been reported to cause neuronal damages by releasing a variety of pro-inflammatory cytokines. Besides where microglia become active, damages have been also observed in remote places, which is considered due to the migration of activated microglia. Therefore, an agent that could suppress abnormal activation of microglia and their subsequent migration might be valuable in activated microglia-related brain pathologies. The objective of the present study was to evaluate anti-inflammatory effects of betulinic acid on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Pretreatment of betulinic acid significantly attenuated LPS-induced NO production and protein expression of iNOS. Betulinic acid also significantly suppressed LPS-induced release and expression of cytokines such as TNF-${\alpha}$ and IL-$1{\beta}$. Furthermore, betulinic acid significantly uppressed LPS-induced MMP-9 expression, which has been suggested to play an important role in the migration of activated microglia. In order to understand the possible mechanism by which betulinic acid suppresses LPS-induced cytokine production and migration of microglia, the role of NF-kB, a major pro-inflammatory transcription factor, was examined. Betulinic acid significantly suppressed LPS-induced degradation of IKB, which retains NF-kB in the cytoplasm. Therefore, nuclear translocation of NF-kB upon LPS stimulation was significantly suppressed with betulinic acid. Taken together, the present study for the first time demonstrates that betulinic acid possesses anti-inflammatory activity through the suppression of nuclear translocation of NF-kB in BV2 microglial cells.