• Journal of Environmental Science International
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• v.15 no.4
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• pp.319-324
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• 2006

Release rate is one of the important items for the environmental impact assessment caused by radioactive materials in case of an accidental release from the nuclear facilities. In this study, the uncertainty of the estimated release rate is evaluated using Monte Carlo method. Gaussian plume model and linear programming are used for estimating the release rate of a source material. Tracer experiment is performed at the Yeoung-Kwang nuclear site to understand the dispersion characteristics. The optimized release rate was 1.56 times rather than the released source as a result of the linear programming to minimize the sum of square errors between the observed concentrations of the experiment and the calculated ones using Gaussian plume model. In the mean time, 95% confidence interval of the estimated release rate was from 1.41 to 2.53 times compared with the released rate as a result of the Monte Carlo simulation considering input variations of the Gaussian plume model. We confirm that this kind of the uncertainty evaluation for the source rate can support decision making appropriately in case of the radiological emergencies.

• Archives of Pharmacal Research
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• v.28 no.11
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• pp.1275-1281
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• 2005

The $G_{q/11}$ protein-coupled receptors, such as muscarinic (M1 & M3) receptors, have been shown to regulate the release of a soluble amyloid precursor protein (sAPP$\alpha$) produced from $\alpha$-secretase processing. However, there is no direct evidence for the precise characteristics of G proteins, and the signaling mechanism for the regulation of $G_{q/11}$ protein-coupled receptor mediated sAPP$\alpha$ release is not clearly understood. This study examined whether the muscarinic receptor-mediated release of sAPP$\alpha$ is directly regulated by $G\alpha_{q/11}$ proteins. The HEK293 cells were transiently cotransfected with muscarinic M3 receptors and a dominant-negative minigene construct of the G protein $\alpha$ subunit. The sAPP$\alpha$ release in the media was measured using an antibody specific for sAPP. The sAPP$\alpha$ release enhancement induced by muscarinic receptor stimulation was decreased by a $G_{q/11}$ minigene construct, whereas it was not blocked by a control minigene construct (the G$\alpha$ carboxy peptide in random order, G$\alpha_{q}$R) or $G\alpha_{j}$ constructs. This indicated a direct role of the $G\alpha_{q/11}$ protein in the regulation of muscarinic M3 receptor-mediated sAPP$\alpha$ release. We also investigated whether the transactivation of the epidermal growth factor receptor (EGFR) by a muscarinic agonist could regulate the sAPP$\alpha$ release in SH-SY5Y cells. Pretreatment of a specific EGFR kinase inhibitor, tyrophostin AG1478 (250 nM), blocked the EGF-stimulated sAPP$\alpha$ release, but did not block the oxoM­stimulated sAPP$\alpha$ release. This demonstrated that the transactivation of the EGFR by muscarinic receptor activation was not involved in the muscarinic receptor-mediated sAPP$\alpha$ release.

• Archives of Pharmacal Research
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• v.18 no.3
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• pp.183-188
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• 1995

Polymeric reinforcement and coatings of alginate beads were carried out to control the release rate of drug from alginate beads. A poorly water-soluble ibuprofen (IPF) was selected as a model drug. A commercially available $Eudragit^{\circledR}$ RS100 was also used as a polymer. Effects of polymeric contents, the presence of plasticizers and amount of drug loading on the release rate of drug were investigated. The release rate of drug from alginate beads in the simulated gastric fluid did not occur within 2 h but released immediately when dissolution media were switched to the simulated intestinal fluid. No significant difference of release rate from polymer-reinforced alginate bead without plasticizers was observed when compared to plain (simple) beads. However, the release rate of drug from polymer-reinforced alginate beads was further sustained and retarded when aluminium tristearate (AT) as a plasticizer was added to polymer. However, polyethylene glycol 400 (PEG400) did not change the release rate of drug from alginate beads although PEG400 was used to improve dispersion of polymer and sodium alginate, and plasticize $Eudragit^{\circledR}$ RS100 polymer. The presence of plasticizer was crucial to reinforce alginate gel matrices using a polymer. As the amount of drug loading increased, the release rate of drug increased as a result of decreasing effects of polymer contents in matrices. The significantly sustained release of drug from polymer-coated alginate beads occurred as the amount of polymer increased because the thickness of coated membrane increased so that cracks and pores of the outer surface of alginate beads could be reduced. The sustained and retarded action of polymer-reinforced and coated beads may result from the disturbance of swelling and erosion (disintegration) of alginate beads. From these findings, polymeric-reinforcement and coatings of alginate gel beads can provide an advanced delivery system by retarding the release rate of various drugs.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2008.04a
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• pp.44-47
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• 2008

This paper evaluated the fire characteristics by using furniture calorimeter. Fire property assessment using the furniture calorimeter showed that the heat release rate is maximum 1,600 kW, maximum CO is 0.261%, maximum CO2 is 2.597%, while for the sofa for one person, the maximum heat release rate is approx. 531.5 kW, max. CO is 0.102%, and max. CO2 is 1.011%.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.4 no.3
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• pp.209-216
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• 2006

Characteristics of heat release process, while the Wigner energy was drawn off the graphite during DSC(Differential Scanning Calorimenter) measurement as an example of annealing process which is one of release methods of Wigner energy that is contained in the irradiated graphite, was studied. Linear temperature rise method in DSC operation was selected to estimate the total Wigner energy content and the heat release rate of each graphite samples, which were located in several positions in the thermal column in KRR-2 research reactor. As an annealing process in DSC operation Wigner energy of the irradiated graphite samples were totally released by heat supplying to the graphite from room temperature to $500^{\circ}C$, in DSC. Characteristics of Wigner energy release from the graphite sample was well correlated with the various activation energy model of the kinetic equation.

• Applied Chemistry for Engineering
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• v.30 no.2
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• pp.233-240
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• 2019

Molecular recognition technology has attracted considerable attention for improving the selectivity of a specific molecule by imprinting it on a polymer matrix. In this study, adsorption and release characteristics of chitosan based drug delivery films imprinted with sulindac (SLD) were investigated in terms of the plasticizer, temperature and pH and the results were also interpreted by the related mathematical models. The adsorption characteristics of target molecules on SLD-imprinted polymer films were better explained by the Freundlich and Sips equation than that of the Langmuir equation. The binding site energy distribution function was also useful for understanding the adsorption relationship between target molecules and polymer films. The drug release of SLD-imprinted polymer films followed the Fickian diffusion mechanism, whereas the drug release using artificial skin followed the non-Fickian diffusion behavior.

• Fire Science and Engineering
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• v.25 no.5
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• pp.62-68
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• 2011

A series of fire tests involving realistic solid combustible materials was conducted to quantify the heat release rate and investigate the fire growth characteristics during the initial fire growth stage. For these tests, single/double wood cribs, urethane cushion having polypropylene covers and wood crib on nylon carpet with urethane carpet padding were used as a fuel source. The fire growth coefficient of the solid combustible materials was quantified and the fire growth characteristics were compared with the $t^2$ fire scenario. The mean effective heat of combustion was evaluated by the total mass loss of fuel and total energy release concept and examined the effect of the ventilation and fire condition. The present study provides the practical information on the fire growth characteristics of solid combustible material to design to a set of fire scenarios for the fire risk analysis.

• Journal of the Korean Wood Science and Technology
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• v.30 no.3
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• pp.18-25
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• 2002

Research to discuss the fire performance of materials requires tools for measuring their burning characteristics and validated fire growth models to predict fire behavior of the materials under specific tire scenarios using the measured properties as input for the models. In this study, burning characteristics such as time to ignition, weight loss rate, flame spread, heat release rate, total heat evolved, and effective heat of combustion for four types of wood-based materials were evaluated using the cone calorimeter and inclined panel tests. Time to ignition was affected by not only surface condition and specific gravity of the tested materials but also the type and magnitude of heat source. Results of weight loss rate, measured by inclined panel tests, indicated that heat transfer from the contacted flame used as the heat source into the inner part of the specimen was inversely proportional to specific gravity of material. Flame spread was closely related with ignition time at the near part of burning zone. Under constant and severe external heat flux, there was little difference in weight loss rate and total heat evolved between four types of wood-based panels. More applied heat flux caused by longer ignition time induced a higher first peak value of heat release rate. Burning characteristics data measured in this study can be used effectively as input for fire growth models to predict the fire behavior of materials under specific fire scenarios.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.05a
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• pp.523-524
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• 2010

• 한국연소학회:학술대회논문집
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• 2003.05a
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• pp.7-12
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• 2003

The purpose of this work is to investigate the effect of premixing condition on the combustion and exhaust emission characteristics in a HCCI diesel engine. To form homogeneous charge before intake manifold, the premixed fuel is injected into premixed tank by GDI injection system and the premixed fuel is ignited by direct injected diesel fuel. But in the case of high intake air temperature, premixed fuel is auto-ignited before diesel combustion and soot emission is increased. In the case of light load condition, the BSFC is improved by intake air heating because increased air temperature promoted the combustion of premixed mixture. NOx and smoke concentration of exhaust emissions are reduced compared to conventional diesel engine. The combustion characteristics of the HCCI diesel engine such as combustion pressure, rate of heat release, and exhaust emission characteristics are discussed.