• Journal of Microbiology and Biotechnology
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• v.30 no.2
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• pp.306-312
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• 2020

Despite the importance of brown adipocytes as a therapeutic target for the prevention and treatment of obesity, the molecular mechanism underlying brown adipocyte differentiation is not fully understood. In particular, the role of post-translational modifications in brown adipocyte differentiation has not been extensively studied. Histidine phosphorylation is increasingly recognized an important process for protein post-translational modifications. In this study, we show that histidine phosphorylation patterns change during brown adipocyte differentiation. In addition, the expression level of protein histidine phosphatase 1 (PHPT1), a major mammalian phosphohistidine phosphatase, is reduced rapidly at the early phase of differentiation and recovers at the later phase. During white adipocyte differentiation of 3T3-L1 preadipocytes, however, the expression level of PHPT1 do not significantly change. Knockdown of PHPT1 promotes brown adipocyte differentiation, whereas ectopic expression of PHPT1 suppresses brown adipocyte differentiation. These results collectively suggest that histidine phosphorylation is closely linked to brown adipocyte differentiation and could be a therapeutic target for obesity and related metabolic diseases.

• Journal of IKEEE
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• v.26 no.3
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• pp.462-467
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• 2022

The feedback buffer structure is proposed to alleviate the overshoot and undershoot phenomenon and the regulation of the output voltage. The conventional LDO regulator undergoes a regulation voltage change caused by a constant load current change. An LDO regulator with a feedback voltage sensing structure operates in the input voltage range of 3.3 to 4.5 V and has a load current of up to 150 mA at output voltage of 3 V. According to the simulation results, a regulation value of 6.2 mV was ensured when the load current uniformly changed to 150 mA.

• Journal of Korea Technology Innovation Society
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• v.20 no.4
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• pp.939-969
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• 2017

The interest in social regulation and its influence on innovation are increasing as the society concerns more for environment and safety. There have been plenty of literature about the impact of social regulation on innovation and its mechanism. Majority of research have been influenced by or based on the famous Porter's hypothesis. However, majority of the literature focus on internal factors such as expected benefits from change of regulations, and it is hard to find one studying social regulation's influence on innovation through external factors such as market or industrial structure. This study addresses this issue of the impact of social regulation on innovation by analyzing the case of fire-retardant coating material for steel structure industry in Korea. It scrutinizes the impact of social regulation which affects competition and innovation on substitute competing market, and tries to reveal that there might exist the other path to innovation, besides the way that the expected benefit from compliance of regulation directly drives innovation. As a result of the case study, we have found that changes in social regulation may act like economic regulation and restructure the market segment and this effect may lead to innovation. It can be explained by the fact that expected benefits from compliance of regulation can be a direct source of innovation, as Porter suggested, but the change of industry structure and competitive strength caused by the change in social regulation can also act as a driving force of innovation.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.14
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• pp.349-370
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• 2000

The environmental problems such as global climate change, global waming, ozone depletion, environmental pollution have been caused by the rapid economic growth, increasing in use of fossil fuels for industrialization and scientific technology development. Especially human activities are significantly altering the atomosphere's composition and its radiative properties. To Stabilize greenhouse gas concentrations in the atmosphere at a level that would prevent dangerous anthropogenic interference with the climate system, the international community adopted the UN Framework Convention on Climate Change in 1992 and Kyoto protocol in 1997. Also to protect ozone layer the international community adopted the Vienna Convention for the Protection of the Ozone Layer in 1985, and the Montreal Protocol on Substances that Deplete the Ozone Layer in 1987. To achieve global environmental objectives, some multilateral environmental agreements includes trade regulation. For example, Montreal Protocol includes the provisions to regulate the world trade of the sudstances which might destroy ozone layer. However Kyoto Protocol has no provisions to regulate trade and is not in force yet. Although there is no trade regulation article in Kyoto Protocol, the international world trade will be influenced by limitation and reduction of CO2 and strengthening the CO2 emission standard for import good. For example Korean car industy agreed with EU to reduce CO2 emission from new passenger car and Korean Semiconductor industry agreed with WSC(World Semiconductor Council) to reduce PFCs in 1999.

• Proceedings of the KIEE Conference
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• 1999.07b
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• pp.743-745
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• 1999

In these days, pumped storaged power plants are under operations mainly for load regulation in power system. After we investigated the governor related electrical circuit of a pumped storaged power plant, we measured speed regulation and dead time of both the governor and the hydraulic system according to the change of variables of the governor during generation. After that the measured speed regulation improved much.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.7
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• pp.1405-1414
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• 2011

This paper analyzes the impact of the change in telecommunication regulation on network investment such as the integration of telecommunication service. The integration of telecommunication service plays a role of separating the behavior regulation from entrance regulation and reducing a entrance constraints. Therefore, it is expected that the market spill over effect is high through the improvement of behavior regulation such as interconnection regulation, facilities provisions, retail price regulation, bundling, number portability of VoIP. This paper discusses the critical factor affecting the decision making process in respect of the firm level and analyzes the impact path guiding investment and innovation. Finally, the paper proposes the guideline for telecommunications policy.

• Journal of Educational Research in Mathematics
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• v.12 no.3
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• pp.371-388
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• 2002

The purpose of this study is to analyze the effects of interaction based on contingent regulation between teacher and underachiever in elementary mathematics. For this purpose, research questions are established as follows; (1) Is there any difference between contingent regulation and natural regulation in mathematics achievement\ulcorner (2) Is there any difference between contingent regulation and natural regulation in affectionate perspective\ulcorner (3) Is there any difference between contingent regulation and natural regulation in adult regulation\ulcorner Two classes of fifth grade Children(10 children) were sampled from an elementary school in city of Daegu. One of them was assigned to the contingent regulation group and the other to natural regulation group. An experiment was conducted for 7 weeks. Two kinds of test instruments were used : pre-test and post-test. The pre-test scores guaranteed that both groups were homogeneous. Post-test was used to identify two effects(research questions (1) & (2)) and the post-test scores were analyzed by t-test. The results were as follows. (1) There was significant difference between contingent regulation and natural regulation in mathematics achievement. This means that experiment group was higher than control group and the interaction effect of contingent regulation was higher in post-test. The self-control indicated in experiment group. (2) There was slightly significant difference between contingent regulation and natural regulation in affectionate perspective. This means that experiment group turned to slightly positioner in post-test. (3) There was significant difference between contingent regulation and natural regulation in adult regulation. In other words, level of contingent regulation changed depending on underachievers' ability but level of natural regulation didn't change. Therefore, I suggest that contingent regulation based on Vygotsky theory would provide effective mathematics education for underachievers in elementary mathematics.

• Journal of Digital Convergence
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• v.16 no.1
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• pp.117-124
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• 2018

The purpose of this study was to evaluate the effects of PAIR leadership program which can make one's own for solving problems of conflicts through understanding of self and the environmental. For this, the PAIR leadership were administered in 10 sessions for 60 minutes with 16 of the adjustment soldiers and 20 of the maladjustment soldiers of the military alternative social workers. The pre-post on the behavioral change will, interpersonal efficacy and the self-regulation level were assessed. The results were as the PAIR he maladjustment soldiers group reported significantly higher score on level of the behavioral change will, interpersonal efficacy and the self-regulation. Also the adjustment soldiers reported significantly on interpersonal efficacy and the self-regulation. This results suggest that the PAIR readership program can be applied effectively for promotion of the behavioral change will, the self-regulation.

• Journal of Korean Society on Water Environment
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• v.25 no.6
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• pp.855-862
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• 2009

This paper pointed out major problems of land use regulation policy surrounding Paldang Lake as follows: (1) inefficient management system, (2) inconsistent administrative management, (3) illogical selection of regulated area, (4) contradictory present system, and (5) controversial discharge control. Several regulation laws for the land-use surrounding Paldang Lake caused confusion of application and inefficiency of management. Amendment of regulation laws made it possible that the regulated area was developed, which resulted in the deterioration of water quality. In addition, successive regulations without scientific implementation overexpanded regulated area and focus on the discharge concentration of contaminated sources stimulated development of small size sources. To overcome these problems, we suggested reestablishment of regulated area, differentiation of regulation amendments, and flexibility in the application of regulation. It is necessary to arrange regulated area based on the efficient land use management and scientific implementation and then to mitigate land use regulation under the sustainable development. For the flexible application of regulation, it is required to amend the rule in response to the change of environmental condition and development of environmental techniques.

• Proceedings of the Safety Management and Science Conference
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• 2006.04a
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• pp.385-390
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• 2006

Air pollution problem has been one of the most urgent global environmental problems since UN Framework Convention on Climate Change accepted in Rio Conference, 1992. International environmental regulations of global community to reduce the green house gases have influenced the domestic environmental policies. International trends of environmental regulation are introduced in this paper.