• 지역연구
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• 제6권1호
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• pp.69-89
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• 1990

• 대한지리학회지
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• 제36권1호
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• pp.52-65
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• 2001

1985-1997년 사이에 자가용 승용차는 소득수준이 높고 서비스업이 발달한 서울.부산.대수시 등 대도시등 서울시의 위성도시에서 보급이 먼저 이루어지고 점차 공업도시와 지상 중심도시로 확산하는 한편, 대도시에서의 보급률 증가는 둔화되었다. 이와 같은 현상은 1985년과 1991년 모두 금융, 보험, 부동산 및 사업 서비스업 종사율이 가장 크게 영향을 주었다 1997년에는 농업, 수렵업, 임업 및 어업 종사율이 새롭게 가장 큰 영향력을 미쳤다. 자가용 승용차 보급의 시.공간적 분포패턴은 1991년을 기준으로, 1985-1990년은 서울시나 그 위성도시 및 지방 중심도시에서 보급률이 높았고 보급률의 지역간 격차가 켰던 시기이며, 1991-1997년은 지역적 보급이 평준화되면서 수도권지역 및 지방 주요 도시에 보급률이 높았던 시기이다. 자가용 보급 지역 유형의 결정에 영향을 미친 중요한 요인은 대도시에서는 서비스업 종사율과 소득이, 군 지역에서의 서울시로부터의 거리와 인구규모이다.

• 한국경제지리학회지
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• 제6권1호
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• pp.171-191
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• 2003

21세기로의 진입과 함께 전 세계적으로 창의적 지식의 창출 및 기술혁신의 주체로서 대학의 역할이 크게 강조되고 있다. 특히 대학으로부터 이전된 지식과 기술은 국가 및 지역발전의 원동력으로 간주되고 있으며, 따라서 오늘날 많은 대학들은 대학의 기능을 다시 정립하는 동시에 지식 및 기술이전을 중심으로 지역사회와의 다양한 협력관계를 모색하고 있다. 이런 맥락에서 본 연구는 교육, 연구, 평생학습, 이전 등 대학의 다양한 기능 중 대학의 지식 및 기술이전이 지역발전에 어떻게 기여하는가를 우리나라 호남권의 대표적 국립대학의 하나인 전남대학을 사례로 실증적인 분석을 시도하였다. 이를 위해 본 연구는 전남대학이 교육 및 연구활동을 통해 창출한 지식, 기술, 정보, 노하우 등을 지역사회에 이전하는 방법과 이에 따라 지역발전에 미치는 영향, 즉 공간적 파급범위와 효과가 과연 어느 정도인가를 중점적으로 규명하고자 했다. 전남대학의 지식 및 기술이전이 지역발전에 미치는 영향은 이전의 형태에 따라 공간적으로 서로 다를 뿐만 아니라, 지역 내외의 경제구조로부터 적잖은 영향을 받는 것으로 밝혀졌다 그리고 지식 및 기술이전의 여러 형태 중 분사창업을 통한 이전이 특히 지역과의 높은 연계성을 보여주었다. 지식 및 기술이전에 의한 전남대학의 지역발전에의 기여는 전체적으로 다소 미흡한 것도 사실이지만, 대학의 노력 여하에 따라 장차 상당 부분 개선될 여지는 있다.

• Journal of Construction Engineering and Project Management
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• 제2권4호
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• pp.32-41
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• 2012

In recent times, multi-centralization and decentralization as well as large Capital area and suburbanization in the spatial structure of capital area. With rapid growth, urbanization and industrialization are unsystematic, and growth inequality between regions caused negative effects such as discordant centralization and decentralization, fluctuating land value, and gap between living conditions. Accordingly, this study analyzed urban spatial indexes by the self-governed body in the capital area such as Seoul, Incheon, and Gyeonggi province for the analysis of the regional inequality phenomenon. We examined the characteristics of temporal and spatial changes in urban spatial structure in the capital area by utilizing the distribution pattern and density of city indexes such as population, employment, etc, and then drew the commonality of those factors through factor analysis. We evaluated the drawn results through the city standard index by each city, conducted factor score analysis, and identified the interaction between each factor and Housing Purchase Price Composite Indices index, housing rent price index(Housing Jeonse Price Composite Indices), land price fluctuation rate, diffusion ratio of house, and financial independence.

• 한국수소및신에너지학회논문집
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• 제23권1호
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• pp.34-42
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• 2012

Gas diffusion layers (GDLs) of carbon composite type in polymer electrolyte fuel cells were prepared by simple and cheap manufacturing process. To obtain the carbon composite GDLs, carbon black with polymer binder was mixed in solvent, rolled to make sheet, and finally heat-treated at $340^{\circ}C$. The performance of fuel cell using composite GDLs was changed by PTFE content. The physical properties of composite GDLs for pore, conductivity and air permeability were analyzed to compare with the variation of fuel cell performance. The conductivity of composite GDLs was very similar to carbon paper as commercial GDL but pore properties and air flux were considerably different. The porosity, PTFE content and conductivity for composite GDLs did not have an influence on the cell performance much. The increase of pore diameter and air flux led to enhance cell performance.

• Journal of Ginseng Research
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• 제45권2호
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• pp.228-235
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• 2021

Backgroud: Ginsenoside compound K (GK) is a major metabolite of protopanaxadiol-type ginsenosides and has remarkable anticancer activities in vitro and in vivo. This work used an ionic cross-linking method to entrap GK within O-carboxymethyl chitosan (OCMC) nanoparticles (Nps) to form GK-loaded OCMC Nps (GK-OCMC Nps), which enhance the aqueous solubility and stability of GK. Methods: The GK-OCMC Nps were characterized using several physicochemical techniques, including x-ray diffraction, transmission electron microscopy, zeta potential analysis, and particle size analysis via dynamic light scattering. GK was released from GK-OCMC Nps and was conducted using the dialysis bag diffusion method. The effects of GK and GK-OCMC Nps on PC3 cell viability were measured by using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. Fluorescent technology based on Cy5.5-labeled probes was used to explore the cellular uptake of GK-OCMC Nps. Results: The GK-OCMC NPs had a suitable particle size and zeta potential; they were spherical with good dispersion. In vitro drug release from GK-OCMC NPs was pH dependent. Moreover, the in vitro cytotoxicity study and cellular uptake assays indicated that the GK-OCMC Nps significantly enhanced the cytotoxicity and cellular uptake of GK toward the PC3 cells. GK-OCMC Nps also significantly promoted the activities of both caspase-3 and caspase-9. Conclusion: GK-OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the antiproliferative effects of GK.

• Journal of Preventive Medicine and Public Health
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• 제36권4호
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• pp.359-366
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• 2003

Objectives : This study was conducted to review the diffusion process and factors affecting the adoption of the Health Center Information System (HIS). Methods : Data were collected from POSDATA (private company), MOHW, other Ministries and local governments. To specify the date of adoption, supplementary information was collected from 40 health centers. The following three kinds of factors were analyzed. Internal factors included type, size, and innovativeness of health centers. Community factors were composed of population sire, economic status, and level of education. Organizational environmental factors consisted of information score of the municipalities, financial support of the from central government, and the neighborhoodness of innovator health centers. Results : All health centers in the metropolitan cities of Seoul, Gwangju and Jeju adopted the HIS. The laggards were those in the metropolitan cities of Busan (18.8%), Incheon (20.0%) and Daejun (20.0%), and cities with population more than 300,000 (54.8%) and counties with health center hospitals (47.1%). Financially supported rural health centers adopted the HIS more rapidly than those not supported. The factors identified as being statistically significant (p<0.05), from a univariate analysis by Kaplan-Meier method, were: (1) internal factors of the type, size and innovativeness of health centers; (2) community factors of population size and economic status; (3) organizational environmental factors of the central government financial support and the neighborhoodness of innovator health centers. A multivariate analysis, using a Cox proportional hazard method, proved the innovativeness of health centers, central government financial support and the neighborhoodness of innovator health centers, were statistically significant (p<0.05). Conclusions : The innovativeness of health centers, financial support from central government and the neighborhoodness of innovator health centers, rather than community factors related to regional socioeconomic status, affected ffe adoption of the HIS in health centers. Further in-depth studies, modifying the MOHW's strategy to propagate the HIS to the laggard health confers, are recommended.

• 한국의학물리학회지:의학물리
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• 제21권2호
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• pp.153-164
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• 2010

혈관분포도(vascularity) 및 세포조밀도(cellularity)와 같은 종양의 생물학적 특성을 고려한 임상표적체적을 결정하기 위하여, 국부혈류용적영상(regional cerebral blood volume map, rCBV map)과 겉보기확산계수영상(apparent diffusion coefficient map, ADC map)의 종양 체적을 해부학적 영상 위에 맵핑 할 수 있는 소프트웨어를 개발하였다. 개발한 프로그램은 해부학적 영상 및 기능 영상 간 mutual information, affine transform, non-rigid registration을 이용한 영상 정합 기능을 제공한다. 영상 정합 후 기준 영상과 정합된 영상에서 획득한 각 segmented bone의 겹치는 체적 비율 및 contour 간 평균 거리를 이용하여 정합도 평가도 가능하다. 잔여 종양이 있는 악성신경아교종 환자의 영상을 이용하여 소프트웨어의 기능을 평가하였을 때, bone segmentation과 contour 간 평균 거리 차이를 이용한 정합도는 각각 약 74%와 2.3 mm였으며, 수동정합을 이용하여 2~5% 정도의 정합도를 향상 시킬 수 있었다. 종양의 생물학적 특성을 치료 계획에 반영할 수 있도록, color map을 이용하여 rCBV map을 분석하였으며, ADC map에서 설정한 관심 영역의 평균 확산 계수와 표준 편차 등을 계산하여 종양의 예후 인자 및 악성도를 평가하였다. 두 기능 영상이 공통적으로 나타내는 종양 체적에서 얻은 생물학적 인자를 평면 위에 맵핑하여 종양의 특성을 쉽게 파악할 수 있는 multi-functional parametric map을 구성하였다. 또한 각기능 인자에 대응되는 악성 종양의 임계값을 적용하여 주변 종양 세포에 비하여 혈관 분포도는 높으면서 확산 계수는 낮아 악성 종양 세포일 확률이 높은 영역을 구분할 수 있었다. 각 기능 영상 위에서 설정한 생물학적 종양 체적 및 악성도가 높은 국소 체적은 해부학적 영상 위에 표시하여 dicom 파일로 출력할 수 있었다. 개발한 소프트웨어는 기능적 다중영상을 이용하여 생물학적 종양 체적을 해부학적 영상 위에 맵핑하는데 적용할 수 있으며, 해부학적 영상에서 파악하기 어려운 종양의 특성 변화들을 치료 계획에 활용할 수 있다. 나아가 개발한 소프트웨어를 이용하여, 한 종류의 영상을 참고하여 종양 체적을 결정했을 때 발생할 수 있는 오류를 줄이고, 치료 전이나 치료 과정에서 나타나는 종양의 조직학적, 생리학적 특성을 치료 계획에 접목하는데 활용할 수 있다.

• 한국유기농업학회지
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• 제14권2호
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• pp.159-177
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• 2006

Governance systems are basically an autonomous cooperation type among the government, civil society and market, also a new paradigm for efficient and democratic administration of policies. The governance mainly consists of the central operating body, institutions, operating principles and so on. The constituents are the nation(government), civil society(NGO) and market(firm). Institutional conditions are a legitimate base, financial stability and independency. And as a operating principle, governance systems have common goals and issues from a national and social point of view. This governance has been recently emerged due to financial risk of government, diffusion of new liberalism going with the globalization, localization-decentralization, and development of civil society and information-oriented society. We have to grope fur the framework of participatory agri- policy confronting globalization and localization as well as developing our agriculture and rural village. This agri-policy governance should be theoretically focused on policy network or self-organizing network or multi-lateral governance (MLG) based on NPM. Also, it is proper to have connection of nation-central type and civil society-central type. And it is necessary to have a MLG type with local governance corresponding to localization and decentralization. Governance should have the type whose participants have authority and responsibility as well. Basic directions of environmentally friendly agri-policy governance are as follows : first, its purposes are constructing the democratic and efficient framework of participatory environmentally friendly agri-policy based on consensus of all the related groups, embodying environmentally friendly agri-policy adjusted to local field, raising farmer's real interest, and improving their position. Second, its form should have a council or an agreement system, not an advisory or a consultation organ. Thus, public sector(eg. government) and voluntary sector(eg. farmers' organization) jointly execute agricultural policy and are responsible together. Environmentally friendly agri-policy governance is mainly made up of farmers' organization, cooperative and civil society(NGO). And secondary bodies are agribusinesses and academic groups. Government interacts with the main bodies on administrative execution. And environmentally friendly agri-policy governance has MLG type with a central unit, province and county units. Environmentally friendly agri-policy governance has several main functions such as agri-policy partnership, speaking for farmer's rights and interests, investigation and research on domestic and foreign agricultural streams, and etc. Especially, local unit will play roles in activation for regional agriculture, consulting on technique and management, education and training services, services entrusted by government, and so on.

• Clinical and Experimental Pediatrics
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• 제62권4호
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• pp.131-137
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• 2019

Purpose: Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that present with seizures. Methods: We retrospectively reviewed the medical records of patients aged less than 15 years with laboratory-confirmed RSV infections and seizures between January 2011 and December 2016 in a regional hospital in South Korea. Results: During this period, 1,193 patients with laboratory-confirmed RSV infection were identified. Of these, 35 (35 of 1,193, 2.93%; boys, 19; girls, 16; mean age: $20.8{\pm}16.6months$) presented with seizure. Febrile seizure was the most common diagnosis (27 of 35, 77.1%); simple febrile seizures in 13 patients (13 of 27, 48.1%) and complex febrile seizures in 14 (14 of 27, 51.9%). Afebrile seizures without meningitis or encephalopathy were observed in 5 patients (5 of 35, 14.3%), seizures with meningitis in 2 (2 of 35, 5.7%), and seizure with encephalopathy in 1 (1 of 35, 2.9%) patient. Lower respiratory symptoms were not observed in 8 patients. In a patient with encephalopathy, brain diffusion-weighted magnetic resonance imaging revealed transient changes in white matter, suggesting cytotoxic edema as the mechanism underlying encephalopathy. Most patients recovered with general management, and progression to epilepsy was noted in only 1 patient. Conclusion: Although febrile seizures are the most common type of seizure associated with RSV infection, the proportion of patients with complex febrile seizures was higher than that of those with general febrile seizures. Transient cytotoxic edema may be a pathogenic mechanism in RSV-related encephalopathy with seizures.