• Asian Oncology Nursing
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• v.10 no.1
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• pp.10-18
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• 2010

Purpose: This study was intended to identify the patterns of fatigue and its related factors in patients with stomach cancer during chemotherapy. Methods: Thirty participants (24 males and 6 females) were recruited for this study which utilized a longitudinal and descriptive approach. The research instruments included the Revised Piper Fatigue Scale, Symptom Distress Scale, and Linear Analogue Self Assessment Scale. The participants received 5-FU and Adriamycin at the first week and 5-FU only at the second and third week. The instruments were measured six times in total. The data were analyzed using SPSS 17.0. Results: It was found that fatigue scores in patients with stomach cancer, receiving 5-FU and Adriamycin (FA) regimen, reached the highest level on the third day (F=9.37, p=.024) after the initial infusion, and decreased gradually afterward. The symptom and psychological distress scores illustrated very similar pattern. The concept of multidimensionality of fatigue in patients with stomach cancer was supported in this study, showing that all four dimensions of the scale were positively correlated. Conclusion: The results of this study provided useful information of patients with stomach cancer on fatigue and other related symptoms which they experienced during weekly scheduled chemotherapy with FA regimen.

• Journal of Pharmaceutical Investigation
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• v.38 no.3
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• pp.151-155
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• 2008

Circadian variations of acebutolol and its main metabolite, diacetolol pharmacokinetics were studied after a single oral administration of acebutolol (10 mg/kg) to eight rabbits at 10 : 00 AM (in the morning) and 10 : 00 PM (at night). The plasma concentration profiles of acebutolol were significantly different (P<0.05) between 10 : 00 AM and 22 : 00 PM, suggesting circadian variations of pharmacokinetic behaviors. A significant circadian rhythm of pharmacokinetic parameters was noted in rabbits, showing higher total body clearance (CL/F), and lower the area under the plasma concentration-time curves (AUC) of acebutolol than that at night. The half-life ($t_{1/2}$) of acebutolol and diacetolol were also significantly shorter in the morning than at night (P<0.05). Metabolite-parent AUC ratio at night significantly decreased compared to in the morning, implying that night time could inhibit acebutolol metabolism than in the morning. From this study there was an administration-time difference of acebutolol pharmacokinetics in the rabbits. The optimized dosing regimen of acebutolol can be decided by considering circadian rhythm so that the effective therapies are established for patients.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9763-9766
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• 2014

Background: This systemic analysis was conducted to evaluate the efficacy and safety of an ifosfamide-containing regimen in treating patients with osteosarcoma. Methods: Clinical studies evaluating the efficacy and safety of Ifosfamide-containing regimen on response and safety for patients with osteosarcoma were identified by using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: When ifosfamide-containing regimens were evaluated, 4 clinical studies which including 134 patients with osteosarcoma were considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 44.8% (60/134) in ifosfamide-containing regimens. Major adverse effects were neutropenia, leukopenia, and fatigue inIfosfamide-containing regimens; No treatment related death occurred in cantharidin combined regimens. Conclusion: This systemic analysis suggests that ifosfamide-containing regimens are associated with good response rate and acceptable toxicity in treating patients with osteosarcoma, but this result should be confirmed by randomized clinical trials.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.2
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• pp.146-160
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• 2006

Background and Aim : As one of the World Cultural Heritage, Joseonwangjosillok is a history book including general state affair, social affair, economy, astronomical and atmospheric phenomena, art, music, eat. as well as the very private life of the king. With Joseonwangjosillok, we will look into health and death of the king and apply it to the regimen and recommended life-style of the aged. Materials and Method : With the archive of Joseonwangjosillok and medical text books such as Donguibogam Huang Di Nei Jing as reference, we tried to inquire the work and life of the kings of the Joseon dynasty, find connection with the regimen recommended life-style, and suggest medical guidelines for the aged as geriatric society is coming. Result : The Kings of the Joseon dynasty had omnipotent power, so that they lived quite much better lift than common people. But their average lifetime is estimated to be no better than that of ethers. Probably overwork, mental stress, rich fatty diet and lack of exercise took healthy life from them. Conclusion : Even if they had unlimited power, the state-of-the-art medical treatment hardly helped the Kings live better and longer life than common people. To keep and promote healthy lift for the aged, they need moderate exercise, appropriate rest, balanced diet, seen dissolving with reasonable environment.

• Journal of East-West Nursing Research
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• v.18 no.1
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• pp.31-39
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• 2012

Purpose: The purpose of this study was to investigate the relationship between happiness and Yangsaeng in university students of the Republic of Korea. Yangsaeng is a traditional health care regimen that incorporates specific principles and methods with the purpose of improving the health and longevity of life. Methods: The subjects of this study were 358 university students in Korea. Data were collected by using a self-reported questionnaire. Data were analyzed using descriptive statistics, Pearson correlation coefficient, independent t-test, one-way ANOVA, Scheffe test, hierarchial multiple regression, and Cronbach's alpha. Results: Practicing Yangsaeng yielded a statistically significant difference depending on the subject's satisfaction with his/her major, monthly household income, and smoking tendencies. In comparison, the statistical degree of happiness depended on the subject's satisfaction with the his/her major, monthly household income, and boyfriend or girlfriend situations. Yangsaeng was positively correlated with happiness (r=.66, p<.001). Hierarchial multiple regression showed that the Yangsaeng explained 43% of happiness, and if major satisfaction, monthly household income, and boyfriend or girlfriend situations were also considered, this model explained 56% of happiness. Conclusion: The Yangsaeng oriental health care regimen could produce a higher happiness level. Therefore, Yangsaeng could be recommended as a useful means of promoting health and happiness.

• Journal of Korean Academy of Nursing
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• v.48 no.3
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• pp.279-288
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• 2018

Purpose: The purpose of this study was to examine the effects of breathing exercises performed using panflutes in elderly patients undergoing spinal surgery. Methods: The study design was a nonequivalent control group non-synchronized pre-post test. The study included 24 patients in both the experimental group and the control group. The experimental group completed a daily breathing exercise regimen using panflutes for 30minutes after meals, whereas the control group was provided standard preoperative education, including breathing exercises using incentive spirometers. After the exercise regimen, breathing exercise compliance, pulmonary infections, and life satisfaction were measured in both groups, and the data were analyzed using the SPSS/WIN program. Results: The compliance rate of breathing exercises was significantly higher in the experimental group. The experimental group presented no pulmonary infections in the later period, whereas the control group presented higher pulmonary infection rates in the same period. In addition, the life satisfaction score in the experimental group significantly increased. Conclusion: The breathing exercise program using panflutes for elderly patients undergoing spinal surgery enhanced their breathing exercise compliance and their daily life satisfaction in addition to reducing their pulmonary infection rates.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1841-1846
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• 2013

Anti-angiogenic agents have played crucial roles in the treatment of ovarian cancer in recent years, but potential benefits of endostatin have been largely unexplored. The present retrospective study evaluated its efficacy and toxicity with two cohorts of patients with platinum-resistant recurrent ovarian cancer. One cohort received gemcitabine plus endostar (rh-endostatin), and the second cohort received gemcitabine regimen alone, with totals of 31 and 27 patients, respectively. The main endpoints were disease control rate (DCR), PFS, overall survival (OS) and safety. There were statistically significant differences in DCR (70.9% vs. 40.7%; P = 0.02) and PFS (6.3 months vs. 3.2 months, P = 0.001) between the two cohorts. Though the endostar cohort also improved median OS by 2.1 months, there was no statistically significant difference compared with gemcitabine alone cohort in this case (12.5 months vs. 10.4 months, P = 0.201). Treatment was well tolerated for most patients, and toxicity of endostar was negligible. Gemcitabine plus endostar significantly improved the prognosis in patients with platinum-resistant recurrent ovarian cancer, especially in those with malignant effusion. The endostar-containing regimen is recommended in this setting.

• The Journal of Korean Academic Society of Nursing Education
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• v.15 no.2
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• pp.241-250
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• 2009

Purpose: The purpose of this study was to investigate the relationship of stress, perceived health status and Yangsaeng in Korean part-time college students. Yangsaeng is a traditional health care regimen that incorporates specific principles and methods to promote health and prevent illness, with the aim of improving the health and longevity of life. Method: The subjects of this study were 158 part-time college students in Korea. Data were collected by using a self-reported questionnaire on-line. Analysis of data included descriptive statistics, Pearson's correlation coefficient, t-test, ANOVA and Cronbach's $\alpha$. Result: Statistically significant differences were evident in stress according to age, spouse, job, and income. Statistically significant differences were evident in perceived health status according to gender and job. Statistically significant differences were evident in Yangsaeng according to age, job, and income. Yangsaeng positively related to perceived health status and negatively related to stress. Conclusion: The Yangsaeng oriental health care regimen could lower stress levels and maintain a good health perception. Therefore, Yangsaeng could be recommended as a means of health promotion in Korean part-time college students.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3969-3972
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• 2015

Background: This analysis was conducted to evaluate the efficacy and safety of lenalidomide based regimen in treating patients with castration-resistant prostate cancer. Materials and Methods: Clinical studies evaluating the efficacy and safety of lenalidomide based regimens on response and safety for patients with castration-resistant prostate cancer were identified using a predefined search strategy. A pooled response rate (rate of PSA level decline of ${\geq}50%$) to treatment was calculated. Results: In lenalidomide based regimen, 3 clinical studies which including 98 patients with castration-resistant prostate cancer were considered eligible for inclusion. These lenalidomide based regimens included cisplatin, doxorubicin, or GM-CSF. Pooled analysis suggested that, in all patients, the pooled PSA level decline of ${\geq}50%$ was 13.3% (13/98) in lenalidomide based regimens. Fatigue, nausea and vomitting were the main side effects. No grade III or IV renal or liver toxicity were observed. No treatment related death occurred in patients with lenalidomide based regimens. Conclusions: This evidence based analysis suggests that lenalidomide based regimens are associated with mild response rate and acceptable toxicities for treating patients with castration-resistant prostate cancer.

• Korean Journal of Clinical Pharmacy
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• v.6 no.2
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• pp.1-6
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• 1996

Carcadian rhythm dependence of vancomycin pharmacokinetics was evaluated in 5 normal volunteers receiving a single intravenous 1.0 g dose of vancomycin at 8 o'clock in the morning and another occasion at 8 o'clock in the evening in a crossover manner. The serum data were subjected to simultaneous computer nonlinear least squares regression analysis using a two-compartment pbarmacokinetic model. The mean half-life of vancomycin was $4.78\pm0.81$ hr in the morning and $4.25\pm0.51$ hr in the evening. The mean total body clearance of vancomycin was $1.29\pm0.58$ hr in the morning and $5.58\pm0.48$ hr in the evening. No circadian rhythm was found to be apparent in normal volunteers. The mean in intrasubject difference in the half-life between 8 A.M. and 8 P.M. was $15.4\%$ with fluctuations ranging from $10.4\sim33.8\%$, It is reasonable to consider individual circadian rhythm for effective dosage regimen of vancomycin in clinical chronotherapeutics.