• 산업공학
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• 제11권3호
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• pp.89-101
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• 1998

The randomness of the input variables in simulation experiments produce output responses which are also realizations of random variables. The random responses make necessary the use of statistical inferences to adequately describe the stochastic nature of the output. The analysis of the simulation output of non-terminating simulations is frequently complicated by the autocorrelation of the output data and the effect of the initial conditions that produces biased estimates. The regenerative method has been developed to deal with some of the problems created by the random nature of the simulation experiments. It provides a simple solution to some tactical problems and can produce valid statistical results. However, not all processes can he modeled using the regenerative method. Other processes modeled as regenerative may not return to a given demarcating state frequently enough to allow for adequate statistical analysis. This paper shows how the state transformation concept was successfully used in a queueing model and a job shop model. Although the first example can be analyzed using the regenerative method. it has the problem of too few recurrences under certain conditions. The second model has the problem of no recurrences. In both cases, the state transformation increase the frequency of the demarcating state. It was shown that time state transformations are regenerative and produce more cycles than the best typical discrete demarcating state in a given run length.

• 설비공학논문집
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• 제20권7호
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• pp.447-454
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• 2008

The regenerative evaporative cooler(REC) is to cool a stream of air using evaporative cooling effect without an increase in the humidity ratio. In the regenerative evaporative cooler, the air can be cooled down to a temperature lower than its inlet wet-bulb temperature. Besides the cooling performance, for practical application of the regenerative evaporative cooler, the compactness of the system is also a very important factor to be considered. In this respect, three different configurations, i.e., the flat plate type, the corrugated plate type, and the finned channel type are investigated and compared for the most compact configuration. The optimal structure of each configuration is obtained individually to minimize the volume for a given effectiveness within a limit of the pressure drop. Comparing the three optimal structures, the finned channel type is found to give the most compact structure among the considered configurations. The volume of the regenerative cooler can be reduced to 1/8 by adopting the finned channel type as compared to that of the flat plate type.

• 한국항공우주학회지
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• 제37권12호
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• pp.1201-1208
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• 2009

액체로켓 연소기의 재생냉각 챔버의 제작에 사용되는 구리합금의 성형성을 돔 장출 시험과 인장시험을 수행하여 평가하였다. 성형성 평가에 사용된 시편은 열처리 유무와 재료의 방향성을 고려하여 제작하여 고온 열처리와 재료의 방향성이 성형성에 미치는 영향을 평가하였다. 시험 결과 열처리 후 구리합금 재료의 성형한계 값은 열처리 전 시편의 성형한계 값에 비하여 증가하였으나, 시편의 제작 방향에 따른 성형성의 차이는 열처리 영향에 비하여 작게 나타났다. 그리고 성형성 평가 시험방법에 따라 성형한계 값이 다르게 나타났다. 이러한 결과 들로부터 연소기 재생냉각 챔버의 내측구조물에서 실린더 형상의 구조물을 벌징 공정으로 네킹이나 파손 없이 노즐 형상으로 성공적으로 성형하기 위해서는 벌징 전 재료에 대한 고온열처리가 매우 중요함을 확인하였다. 또한 시험방법이 성형성 평가에 크게 영향을 미치는 것을 확인하였다. 본 연구를 통하여 얻은 구리합금의 성형한계도는 이 재료를 사용하여 제작하는 연소기 재생냉각 챔버 노즐의 구조설계를 위한 데이터로 활용할 예정이다.

• 대한기계학회논문집B
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• 제23권6호
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• pp.769-777
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• 1999

This paper presents models for the dynamic simulation of a regenerative gas turbine and describes dynamic behaviors of a small regenerative engine. A quasi-steady model is introduced where the inertia of the working fluid is assumed to be negligible compared with the mechanical inertia of the rotating shaft. Based on this quasi-steady model, the transient model for the heat exchanger is employed to simulate the unsteady heat exchange in the recuperator. The effect of the thermal inertia of the recuperator metal on transient behaviors is analyzed by comparing the predicted results of the transient and steady state heat exchanger models. For several load change modes such as sudden increase, decrease and periodic variation, engine dynamic characteristics are investigated by applying a fuel control logic for the constant shaft speed. It is found that the thermal inertia of the recuperator metal has a dominant effect on the whole engine dynamic behavior.

• 한국연소학회지
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• 제8권1호
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• pp.17-24
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• 2003

The conventional regenerative system has a high thermal efficiency as well as energy saving using the high preheated combustion air. in spite of these advantages, it can not avoid high nitric oxide emissions. Recently, flameless combustion has received much attention to solve these problems. In this research, numerical analysis is performed for flow-combustion phenomena in the self regenerative burner. In this analysis we used Fluent 6.0 code. the that is developed for commercial use, Methane gas is used as a fuel and two-step reaction model for methane and Zeldovich mechanism for NO generation are used. the velocity of the preheated combustion air is used as a parameter and we analyze the characteristics of flow-field, temperature distributions and NO emissions. Due to the increased recirculation rate, the maximum temperature of flame is significantly increased and NOx emissions is reduced.

• 한국연소학회지
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• 제5권1호
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• pp.99-108
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• 2000

Regenerative burner is a product of new combustion technology for realizing higher thermal efficiency and lower emissions, moreover utilizing very high preheated air temperature up to $1,000^{\circ}C$. In this study the experimental study was carried out to find out a combustion characteristics breaking the old combustion concept. From the variation of configuration of gas nozzle and hot test on the temperature distribution and NOx, CO, it was found out that the performance of regenerative burner was better than that of existing burner, mainly due to the effect of internal gas recirculation.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2002년도 제25회 KOSCI SYMPOSIUM 논문집
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• pp.97-104
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• 2002

The conventional regenerative system has a high thermal efficiency as well as energy saving using the high preheated combustion air. in spite of these advantages, it can not avoid high nitric oxide emissions. Recently, flameless combustion has received much attention to solve these problems. In this research, numerical analysis is performed for flow-combustion phenomena in the self regenerative burner. In this analysis we used Fluent 6.0 code. the that is developed for commercial use, Methane gas is used as a fuel and two-step reaction model for methane and Zeldovich mechanism for NO generation are used. the velocity of the preheated combustion air is used as a parameter and we analyze the characteristics of flow-field, temperature distributions and NO emissions. Due to the increased recirculation rate, the maximum temperature of flame is significantly increased and NOx emissions is reduced

• Medical Lasers
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• 제9권2호
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• pp.134-141
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• 2020

The use of stem cell therapy to treat various diseases has become a promising approach. The ability of stem cells to self-renew and differentiate can contribute significantly to the success of regenerative medical treatments. In line with these expectations, there is a great need for an efficient research methodology to differentiate stem cells into their specific targets. Photobiomodulation (PBM), formerly known as low-level laser therapy (LLLT), is a relatively non-invasive technique that has a therapeutic effect on damaged tissue or cells. Recent advances in adapting PBM to stem cell therapy showed that stem cells and progenitor cells respond favorably to light. PBM stimulates different types of stem cells to enhance their migration, proliferation, and differentiation in vitro and in vivo. This review summarizes the effects of PBM on targeted differentiation across multiple stem cell lineages. The analytical expertise gained can help better understand the current state and the latest findings in PBM and stem cell therapy.

• Biomolecules & Therapeutics
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• 제28권5호
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• pp.423-430
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• 2020

Telmisartan is an angiotensin-II receptor blocker and acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ). Several studies have demonstrated that telmisartan ameliorates depression and memory dysfunction and reduces brain inflammation. We hypothesized that the beneficial effects of telmisartan on brain could be due to modulation of the blood-brain barrier (BBB) function. Here, we examined the effect of telmisartan on tumor necrosis factor alpha (TNF-α)-induced expression of intercellular adhesion molecule 1 (ICAM-1) which plays an important role in leukocyte transcytosis through the BBB. Telmisartan blocked TNF-α-induced ICAM-1 expression and leukocyte adhesion in U87MG human glioma cells but showed no effect on human brain microvascular endothelial cells. In U87MG cells, a PPAR antagonist, GW9662 did not block the effect of telmisartan on ICAM1 expression but rather potentiated. Moreover, GW9662 caused no change in TNF-α-induced ICAM-1 expression, suggesting no implication of PPARγ in the telmisartan effect. Further studies showed that telmisartan blocked TNF-α-induced activation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and nuclear factorkappa B (NF-κB). In contrast, inhibitors of JNK, ERK1/2 and NF-κB but not p38, blocked ICAM-1 expression induced by TNF-α. Thus, our findings suggest that the beneficial effect of telmisartan is likely due to the reduction of astrocytic ICAM1 expression and leukocytes adhesion to astrocytes, and that this response was mediated by the inhibition of JNK/ERK1/2/NF-κB activation and in the PPAR-independent manner. In conclusion, this study enhances our understanding of the mechanism by which telmisartan exerts the beneficial brain function.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2008년도 춘계학술대회 논문집
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• pp.154-156
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• 2008

A prototype of the desiccant cooling system with a regenerative evaporative cooler was built and tested for the performance evaluation. The regenerative evaporative cooler is to cool a stream of air using evaporative cooling effect without an inc6rease in the humidity ratio. It is comprised of multiple pairs of dry and wet channels and the evaporation water is supplied only to the wet channels. By redirecting a portion of the air flown out of the dry channel into the wet channel, the air can be cooled down to a temperature lower than its inlet wet-bulb temperature at the outlet end of the dry channels. Incorporating a regenerative evaporative cooler eliminates the need for deep dehumidification in the desiccant rotor that is necessary to achieve low air temperature in the system with a direct evaporative cooler. Subsequently, the regenerative evaporative cooler enables the use of low temperature heat source to regenerate the dehumidifier permitting the desiccant cooling system more beneficial compared with other thermal driven air conditioners. At the ARI condition with the regeneration temperature of $60^{\circ}C$, the prototype showed the cooling capacity of 4.4 kW and COP of 0.75.