Medical Lasers

Korean Society for Laser Medicine and Surgery (대한의학레이저학회)
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Effects of Photobiomodulation on Stem Cells Important for Regenerative Medicine

  • Chang, So-Young (Beckman Laser Institute Korea, Dankook University) ;
  • Carpena, Nathaniel T. (Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University) ;
  • Kang, Bong Jin (Department of Anesthesia and Pain medicine, College of Medicine, Dankook University) ;
  • Lee, Min Young (Beckman Laser Institute Korea, Dankook University)
  • Received : 2020.08.04
  • Accepted : 2020.10.05
  • Published : 2020.12.31
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Abstract

The use of stem cell therapy to treat various diseases has become a promising approach. The ability of stem cells to self-renew and differentiate can contribute significantly to the success of regenerative medical treatments. In line with these expectations, there is a great need for an efficient research methodology to differentiate stem cells into their specific targets. Photobiomodulation (PBM), formerly known as low-level laser therapy (LLLT), is a relatively non-invasive technique that has a therapeutic effect on damaged tissue or cells. Recent advances in adapting PBM to stem cell therapy showed that stem cells and progenitor cells respond favorably to light. PBM stimulates different types of stem cells to enhance their migration, proliferation, and differentiation in vitro and in vivo. This review summarizes the effects of PBM on targeted differentiation across multiple stem cell lineages. The analytical expertise gained can help better understand the current state and the latest findings in PBM and stem cell therapy.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2020R1C1C1009695).

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