• 인간식물환경학회지
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• 제22권3호
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• pp.321-332
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• 2019

The purpose of this study is to investigate the changes of sensory and visual perception of children with intellectual disabilities by conducting psychomotorik (psychomotor activity) in the forest and indoor treatment rooms. Accordingly, this study divided 18 children with intellectual disabilities living in the facility for persons with disabilities located in Seoul into three groups: the experimental group participating in psychomotorik in the forest, the comparative group participating in psychomotorik in the treatment room, and the control group without any treatment at all. The program was conducted for 32 weeks, 4 hours a month. The results showed that psychomotorik promoted the sensory and visual development of children with disabilities. Psychomotorik in the forest showed significant effects on touch and activity level, form constancy and eye-hand coordination. Psychomotorik in the treatment room showed significant improvement in figure-ground with reduced motion. This suggests that psychomotorik in the forest as well as indoors is a positive factor for sensory adaptation reaction and visual development of children with intellectual disabilities.

• ETRI Journal
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• 제45권6호
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• pp.1046-1055
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• 2023

We introduce a display for virtual-reality (VR) fire training. Firefighters prefer to wear and operate a real breathing apparatus while experiencing full visual immersion in a VR fire space. Thus, we used a thin head-mounted display (HMD) with a light field and folded optical system, aiming to both minimize the volume for integration in front of the face into a breathing apparatus and maintain adequate visibility, including a wide viewing angle and resolution similar to that of commercial displays. We developed the optical system testing modules and prototypes of the integrated breathing apparatus. Through iterative testing, the thickness of the output optical module in front of the eyes was reduced from 50 mm to 60 mm to less than 20 mm while maintaining a viewing angle of 103°. In addition, the resolution and image quality degradation of the light field in the display was mitigated. Hence, we obtained a display with a structure consistent with the needs of firefighters in the field. In future work, we will conduct user evaluation regarding fire scene reproducibility by combining immersive VR fire training and real firefighting equipment.

• 한국전자파학회논문지
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• 제22권10호
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• pp.1012-1015
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• 2011

눈 모형이 열린 경우 간결하고 좋은 수렴 특성을 갖는 결정-지향 자력 등화 알고리듬이 자주 사용된다. 그러나 눈 모형이 닫힌 채널에서 결정-지향 알고리듬의 수렴은 보장되지 않는다. 이러한 문제를 해결하기 위하여 무기억 비선형 함수로 hyperbolic tangent 함수를 사용하는 수정된 Bussgang 알고리듬의 적용이 Filho 등에 의하여 제안되었다. 그러나 이 알고리듬의 적용은 hyperbolic tangent 함수 그리고 이의 미분에 대한 계산 및 채널의 변화에 따른 룩업 테이블을 위한 많은 메모리를 필요로 한다. 따라서 본 논문에서는 Filho 등이 제안한 알고리듬의 계산량 또는 하드웨어 복잡도를 줄이기 위하여 결정-지향 알고리듬을 위한 개선된 기법을 제안한다. 무기억 비선형 함수를 signum 함수로 설정하고, 이의 미분인 디락 델타 함수(Dirac delta function)를 협소한 사각 펄스로 근사화하여 결정-지향 알고리듬에 적용하면 Filho가 제안한 알고리듬의 수렴 및 정상 상태 성능은 유지하면서 계산 복잡도를 크게 줄일 수 있다.

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.27-36
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• 2017

Angelicae Gigantis Radix (AGR, Angelica gigas) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbital-induced sleeping behaviors via the activation of $GABA_A$-ergic systems in animals. Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also prolonged sleeping time, and decreased the sleep latency by pentobarbital (42 mg/kg), in a dose-dependent manner, similar to muscimol, both at the hypnotic (42 mg/kg) and sub-hypnotic (28 mg/kg) dosages. Especially, DCA increased the number of sleeping animals in the sub-hypnotic dosage. DCA (50 mg/kg, p.o.) itself modulated sleep architectures; DCA reduced the counts of sleep/wake cycles. At the same time, DCA increased total sleep time, but not non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. In the molecular experiments. DCA (0.001, 0.01 and $0.1{\mu}g/ml$) increased intracellular Cl- influx level in hypothalamic primary cultured neuronal cells of rats. In addition, DCA increased the protein expression of glutamic acid decarboxylase ($GAD_{65/67}$) and $GABA_A$ receptors subtypes. Taken together, these results suggest that DCA potentiates pentobarbital-induced sleeping behaviors through the activation of $GABA_A$-ergic systems, and can be useful in the treatment of insomnia.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.189-191
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• 2002

In the proton therapy using a gantry system, periodical verification of iso-center position is very important to assure precision of patient positioning system at any gantry angles in proton treatment. In the gantry system, there are three different types of iso-center; 1) in a geometrical view, 2) in an X-ray beam's eye view, 3) in a proton beam's eye view. Idealistically, they would be an identical point. They could, however, be different points. It may be a source of errors in patient positioning. At PMRC, we have established a system of verification for iso-center positions using a stainless ball of 2-cm in diameter and an imaging plate. This system provides the relation among a center of a patient target position, a center of proton irradiation field, and/or a center of X-ray field in accuracy of 50$\square$m in the 2) and 3) views, as images of a center of the stainless ball and a center of a 100 mm${\times}$100 mm-aperture brass collimator recorded on the imaging plate, which is setup at 1-cm behind the ball. In addition, it provides simultaneously the images of the ball and the collimator on an imaging intensifier (II), which is setup downstream of the proton or X-ray beam. We present a method of quality assurance (QA) for calibration of iso-center position in a rotation gantry system at PMRC and the performance of this system. A proton beam position on the 1$\^$st/ scatterer in the nozzle of the gantry affects less sensitive (reduced by a factor of 1/5) to the results of the iso-center position. The effect is systematically correctable. The effect of the nozzle (or the collimator) position is less than 0.5 mm at the maximum extraction (390 mm).

• Asian-Australasian Journal of Animal Sciences
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• 제15권1호
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• pp.72-78
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• 2002

The effects of housing and nutrition on the performance of growing gilts of the Nepalese Pakhribas breed were investigated. A total of 36 pigs were allocated according to a factorial design with 3 levels of nutrition, provided to achieve a target growth rate of 200, 300 or 400 g/day, and two types of housing, traditional or improved. The growth rate and body composition were monitored during the growing period and subsequent pregnancy. There was a significantly higher growth rate (p<0.01), greater $P_2$ backfat thickness (p<0.01), and greater eye muscle depth (p<0.01) at service in pigs given the higher level of nutrition. Similarly, there was a significantly higher growth rate (p<0.05), and greater eye muscle depth (p<0.10) with improved housing but no significant difference in $P_2$ backfat thickness. The conception rate was 90% at first service, with no difference between treatments. Gilts from the high plane of rearing produced a mean litter size of one piglet greater than those on the low plane, but this was not significant with the limited numbers. However, both improved plane of nutrition and reduced climatic penalty by improving housing resulted in increased birthweight of piglets (p<0.05). It is concluded that improvement in housing can give benefits equivalent to at least a 7% improvement in efficiency of feed use under traditional Nepalese circumstances for pig rearing.

• Archives of Plastic Surgery
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• 제33권4호
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• pp.449-453
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• 2006

Purpose: Perceiving the experience that $MRD_1$ is increased after small-incision double-eyelid operation, it has been statistically verified the improvement of $MRD_1$ retrospectively. Therefore, we suggest new interpretation for Korean-specific small eye and more definite classification for ptosis. Methods: In operation, we made 3 small incisions according to the line designed on upper eyelid and removed some soft tissues including connective tissues. Then, figure-of-8 continuous buried ligation was performed through the incision windows. This study is a retrospective study, measures $MRD_1$ changes and excursion distance change of eyelid margine and eyebrow using pre-and post-operative photos of 14 patients. Results: Postoperative photos were taken on the 4th day and all of 14 patients had an improvement in $MRD_1$ statistically. The excursion distance of upper eyelid was improved in half of patients, though not in the range of statistical verification. It was statistically confirmed that the movement of eyebrow was reduced after operation. Conclusion: It is thought that $MRD_1$ improvement without any operation on levator complex means that soft tissue including connective tissue eliminated in operation restricts the movement of upper eyelid. It is defined such factors as burden factors and such phenomenon as burdened eyelid. It is thougt that Korean's small eye is mainly burdened eyelid and cosmetic improvement may be obtaind even by removing such burden factors.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4853-4858
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• 2013

Objectives: To investigate whether hypoxia has an effect on regulation of multidrug resistance (MDR) to chemotherapeutic drugs in laryngeal carcinoma cells and explore the role of hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$). Methods: Laryngeal cancer cells were cultured under normoxic and hypoxic conditions. The sensitivity of the cells to multiple drugs and levels of apoptosis induced by paclitaxel were determined by MTT assay and annexin-V/propidium iodide staining analysis, respectively. HIF-$1{\alpha}$ expression was blocked by RNA interference. The expression of HIF-$1{\alpha}$ gene was detected by real-time quantitative RT-PCR and Western blotting. The value of fluorescence intensity of intracellular adriamycin accumulation and retention in cells was evaluated by flow cytometry. Results: The sensitivity to multiple chemotherapy agents and induction of apoptosis by paclitaxel could be reduced by hypoxia (P<0.05). A the same time, the adriamycin releasing index of cells was increased (P<0.05). However, resistance acquisition subject to hypoxia in vitro was suppressed by down-regulating HIF-$1{\alpha}$ expression. Conclusion: HIF-$1{\alpha}$ could be considered as a key regulator for mediating hypoxia-induced MDR in laryngeal cancer cells via inhibition of drug-induced apoptosis and decrease in intracellular drug accumulation.

• 한국의학물리학회지:의학물리
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• 제13권2호
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• pp.104-108
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• 2002

세기조절방사선치료(Intensity Modulated Radiation Therapy, IMRT)는 기존의 방사선치료에 비해 암조직에는 더 많은 선량을 조사하면서, 주위 정상조직과 중요 장기에는 더 적은 선량이 조사되게 하는 가장 이상적인 치료법 중 하나로 알려져 있다. 뇌종양에서 치료계획자의 의도대로 세기조절방사선치료계획을 시행하여 4 MV, 6 MV, 15 MV의 에너지에 따른 선량분포 특성과 DVH를 살펴보았다. 종양 표적이 있는 오른쪽 뇌간에서 최대 조사선량은 4 MV, 6 MV, 15 MV에서 4 MV에 대해 10.1％, 8.4％의 차이를, 오른쪽 눈에서는 5.2％, 2.7％의 차이를 나타내고 있지만, 왼쪽 뇌간과 눈, 그리고 시신경 교차와 뇌간은 1.7％에서 5.2％의 차이를 나타내었다. 뇌종양에서 세기조절방사선치료계획을 수행한 결과 4 MV, 6 MV, 15 MV의 에너지의 차이에 따른 선량분포특성과 DVH를 비교검토 해본 결과 PTV와 특정 장기에 조사되는 방사선량이 1.7％에서 10.1％ 까지 차이를 나타내었지만, 이것은 한 지점에 조사되는 선량이며, 전체적인 비교에서 본다면 세기방사선치료계획을 시행한 9문 조사에서 에너지의 의존성이 없는 것으로 사료된다.

• 한국물환경학회지
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• 제22권2호
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• pp.364-369
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• 2006

파라치온에 노출된 붕어의 뇌, 안구, 근육 및 혈청의 AChE 활성 변화를 조사한 결과 파라치온 $63{\mu}g/L$ 농도 이상에서 유의하게 감소하는 경향을 보였다. 실험종료 시 AChE 활성은 뇌에서 79.1~92.4%, 안구에서 76.0~91.5%, 근육에서 89.7~97.6% 및 혈청에서 68.9~78.0% 감소하였다. 실험기간동안 유의한 생존율 변화는 관찰되지 않았으나, 유영이상 및 경련을 보였다. 또한 파라치온에 노출된 붕어의 형태변화는 척추측만(scoliosis)이 관찰되었는데 이러한 변화는 파라치온 $190{\mu}g/L$ 농도는 15%, $380{\mu}g/L$에서는 75%로 관찰되었다. 따라서 붕어의 AChE 활성과 그 밖의 행동 및 형태적 특성은 자연수계에서 파라치온 오염을 추정할 수 있는 생물학적 모니터닝 도구로 활용할 수 있다.