• The Journal of Internal Korean Medicine
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• v.29 no.4
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• pp.1100-1114
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• 2008

The aim of the study was to investigate recovery effects of Rehmannia, which has been used clinically for chronic renal failure therapy. Mice had 5/6 nephrectomy to induce chronic renal failure. The results were as follows: 1. The protein amount in urine per 24hrs of the Rehmannia-treated group was significantly reduced compared to the control. 2. The albumin amount in the blood of the Rehmannia-treated group significantly increased compared to the control. The creatinine. total-cholesterol, LDL-cholesterol and triglyceride levels in serum of the Rehmannia-treated group as compared to the control were significantly inhibited. 3. The structural change in kidney of the Rehrnannia-treated group was significantly inhibited compared to the control. 4. The factor (macrophage/monocyte antigen (ED-1), type IV collagen and angiotensin II type 1 ($AT_1$) receptor) of the Rehmanala-treated group was significantly inhibited compared to the control, which induced the structural change in kidneys. The above results suggest that Rehmannia partially improved kidney function.

• Journal of the Korea Institute of Building Construction
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• v.1 no.2
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• pp.154-164
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• 2001

This research is aiming to specify the requirement of the investment such as intial cost, running cost earning rate to make effective investment considering the purpose of remodeling and economical value of store building enough to meet the initial purpose of remodeling. The review of earning for economical evaluation was performed by the on-site auditing on the structure and function of the building and applying the assessment simulation program, which is to find the possible business model to identify the requirement of building owner through case study. After the research, the following results are obtained. First, it is important that many aspects should be carefully analysis and the best method should be selected as characteristics of remodeling can be defer each other in their implementations. Second, though the remodeling of exist building to promote the functions has been applied, no suitable assessment tool has bee developed for deciding the level of remodeling in the view of economical efficiency so far. Third, the economical benefit was evaluated by analysing annual earning rate which is applied by investment items and recovery period for the investment. More specific date base should be established to apply the suggested economic acessments in business enough ti forecast the future circumstances. More researches should be promoted on the area continuously as well as the integrated economic evaluation of remodeling on existing building.

• Journal of Korean Neurosurgical Society
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• v.45 no.2
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• pp.118-121
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• 2009

Pituitary apoplexy is a clinical syndrome caused by an acute ischemic or hemorrhagic vascular accident involving a pituitary adenoma or an adjacent pituitary gland. Pituitary apoplexy may be associated with a variety of neurological and endocrinological signs and symptoms. However, isolated third cranial nerve palsy with ptosis as the presenting sign of pituitary apoplexy is very rare. We describe two cases of pituitary apoplexy presenting as sudden-onset unilateral ptosis and diplopia. In one case, brain magnetic resonance imaging (MRI) revealed a mass in the pituitary fossa with signs of hemorrhage, upward displacement of the optic chiasm, erosion of the sellar floor and invasion of the right cavernous sinus. In the other case, MRI showed a large area of insufficient enhancement in the anterior pituitary consistent with pituitary infarction or Sheehan's syndrome. We performed neurosurgical decompression via a transsphenoidal approach. Both patients showed an uneventful recovery. Both cases of isolated third cranial nerve palsy with ptosis completely resolved during the early postoperative period. We suggest that pituitary apoplexy should be included in the differential diagnosis of patients presenting with isolated third cranial nerve palsy with ptosis and that prompt neurosurgical decompression should be considered for the preservation of third cranial nerve function.

• Korean Journal of Materials Research
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• v.13 no.5
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• pp.309-312
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• 2003

Tin dioxide($_SnO2$) thin films were deposited on alumina substrate by metal-organic chemical vapor deposition (MOCVD) as a function of temperature and time. Thin films were fabricated from di-n-butyltin diacetate as a precursor and oxygen as an oxidation. The microstructure of deposited films was characterized by X-ray diffraction and field emission scanning electron microscopy(FE-SEM). The thickness was linearly increased with deposition time and $SnO_2$structure was found from $375^{\circ}C$ for the deposition time of 32 min. The maximum sensitivity to 500ppm CO gas was observed for the specimens deposited at $375^{\circ}C$ for 2 min at the operating temperature of $350^{\circ}C$. Gas sensitivity to CO increased with decreasing the film thickness. The sensing properties of response time, recovery and sensitivity of CO were changed with variations of substrate temperature and time.

• Journal of Communications and Networks
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• v.9 no.3
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• pp.265-273
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• 2007

This paper expands an analytical performance model of 802.11 to accurately estimate throughput and energy demand of 802.11-based wireless sensor network (WSN) when sensor nodes employ Reed-Solomon (RS) codes, one of block forward error correction (FEC) techniques. This model evaluates these two metrics as a function of the channel bit error rate (BER) and the RS symbol size. Since the basic recovery unit of RS codes is a symbol not a bit, the symbol size affects the WSN performance even if each packet carries the same amount of FEC check bits. The larger size is more effective to recover long-lasting error bursts although it increases the computational complexity of encoding and decoding RS codes. For applying the extended model to WSNs, this paper collects traffic traces from a WSN consisting of two TIP50CM sensor nodes and measures its energy consumption for processing RS codes. Based on traces, it approximates WSN channels with Gilbert models. The computational analyses confirm that the adoption of RS codes in 802.11 significantly improves its throughput and energy efficiency of WSNs with a high BER. They also predict that the choice of an appropriate RS symbol size causes a lot of difference in throughput and power waste over short-term durations while the symbol size rarely affects the long-term average of these metrics.

• Advances in aircraft and spacecraft science
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• v.11 no.2
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• pp.177-194
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• 2024

The objective of this paper is to compute entire flow field over Apollo-II, Aerospace Reentry Demonstrator (ARD), Orbital Experiment (OREX) with sharp shoulder and rounded shape shoulder and Space Recovery Experiment (SRE) at different flare-cone half-angle of 20° and 35°. This paper addresses numerical solutions of the compressible three-dimensional Euler equations on hexahedral meshes for a freestream Mach 6 and at an angle of incidence 5°. Furthermore, spatial discretization is accomplished by a cell centred finite volume formulation solution and advanced in time by an explicit multi-stage Runge-Kutta method. The flow field characteristics, distribution of surface pressure coefficient and Mach number on fore-body and aft-body are presented as a function of the geometrical parameters of many reentry capsules. The surface pressure variation is numerically integrated to obtain the aerodynamic drag and compared well with impact theory. The present numerical study has observed the significant dependence of the blunt body and the aft-body geometry of the vehicle and can be used to study atmospheric conditions during re-entry trajectory. The numerical analysis reveals the significant influence of capsule geometry on the flow characteristics of the mechanism of upstream and structure of the flow near the wake region and aerodynamic drag coefficient.

• BMB Reports
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• v.51 no.9
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• pp.437-443
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• 2018

Non-homologous end joining (NHEJ), and to a lesser extent, the error-free pathway known as homology-directed repair (HDR) are cellular mechanisms for recovery from double-strand DNA breaks (DSB) induced by RNA-guided programmable nuclease CRISPR/Cas. Since NHEJ is equivalent to using a duck tape to stick two pieces of metals together, the outcome of this repair mechanism is prone to error. Any out-of-frame mutations or premature stop codons resulting from NHEJ repair mechanism are extremely handy for loss-of-function studies. Substitution of a mutation on the genome with the correct exogenous repair DNA requires coordination via an error-free HDR, for targeted transgenesis. However, several practical limitations exist in harnessing the potential of HDR to replace a faulty mutation for therapeutic purposes in all cell types and more so in somatic cells. In germ cells after the DSB, copying occurs from the homologous chromosome, which increases the chances of incorporation of exogenous DNA with some degree of homology into the genome compared with somatic cells where copying from the identical sister chromatid is always preferred. This review summarizes several strategies that have been implemented to increase the frequency of HDR with a focus on somatic cells. It also highlights the limitations of this technology in gene therapy and suggests specific solutions to circumvent those barriers.

• Korean Journal of Oriental Medicine
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• v.5 no.1
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• pp.17-25
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• 1999

To investigate recovery effects of Insambackhotang, which have been used clinically in diabetes therapny, on kidney failure of a diabetes-induced mouse by Alloxan administration, body and kidney weight changes of mice, BUN, creatinine, glucose and MDA level in serum, MDA level in kidney tissue. 1. A hyperglycemia(250-400mg/dl) mouse induced by Alloxan(75mg/kg) showed significant decline of kidney function: increase of BUN and creatinine in serum, excretion of glucose, protein, ketone in urine were observed at 4 days after the treatment. 2. Increase of the mouse body and kidney weight and a ratio of the kidney/body weight of Insambackhotang treated group as compared to the control group was significantly inhibited. 3. The BUN, creatinine level in serum of Insambackhotang treated group as compared to the control group were significantly inhibited. 4. The MDA level in serum and kidney tissue of Insambackhotang treated group as compared to the control group were significantly inhibited.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.17 no.1
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• pp.45-54
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• 2010

Purpose: The purpose of this study was to develop and test an explanatory model of dyspnea in patients with chronic lung disease (CLD). Methods: Participants were 181 patients with CLD, recruited from the outpatient pulmonary clinic of one university hospital in Korea. Data were collected using questionnaires, as well as measurement of 6-minute walking distance (6MWD), oxygen saturation ($SpO_2$), FEV1% predicted, and Body Mass Index (BMI). Results: The results indicated a good fit between the proposed dyspnea model and the collected data [$x^2$=91.27, p= .13, $x^2$/d.f.=1.17, Normal Fit Index= .934]. Oxygenation ($SpO_2$, = -.530), self-efficacy (= -.429), anxiety (= .253), depression (= .224), exercise endurance (6MWD, = -.211), and pulmonary function (FEV1% predicted, = -.178) had a direct effect on dyspnea (all p< .05) and these variables explained 74% of variance in dyspnea. BMI, smoking history, and social support had an indirect effect on dyspnea. Conclusion: The findings of this study suggest that comprehensive nursing interventions should focus on recovery of respiratory health and improvement of emotions, exercise ability, and nutritional status. From this perspective, pulmonary rehabilitation would be an effective strategy for managing dyspnea in patients with CLD.

• Nuclear Engineering and Technology
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• v.47 no.4
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• pp.443-453
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• 2015

A hybrid safety injection tank (H-SIT) can enhance the capability of an advanced power reactor plus (APR+) during a station black out (SBO) that is accompanied by a severe accident. It may a useful alternative to an electric motor. The operations strategy of the H-SIT has to be investigated to achieve maximum utilization of its function. In this study, the master logic diagram (i.e., an analysis for identifying the differences between an H-SIT and a safety injection pump) and an accident case classification were used to determine the parameters of the H-SIT operation. The conditions that require the use of an H-SIT were determined using a decision-making process. The proper timing for using an H-SIT was also analyzed by using the Multi-dimensional Analysis of Reactor Safety (MARS) 1.3 code (Korea Atomic Energy Research Institute, Daejeon, South Korea). The operation strategy analysis indicates that a H-SIT can mitigate five types of failure: (1) failure of the safety injection pump, (2) failure of the passive auxiliary feedwater system, (3) failure of the depressurization system, (4) failure of the shutdown cooling pump (SCP), and (5) failure of the recirculation system. The results of the MARS code demonstrate that the time allowed for recovery can be extended when using an H-SIT, compared with the same situation in which an H-SIT is not used. Based on the results, the use of an H-SIT is recommended, especially after the pilot-operated safety relief valve (POSRV) is opened.