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Keratinization of Lung Squamous Cell Carcinoma Is Associated with Poor Clinical Outcome

  • Park, Hye Jung;Cha, Yoon-Jin;Kim, Seong Han;Kim, Arum;Kim, Eun Young;Chang, Yoon Soo
    • Tuberculosis and Respiratory Diseases
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    • v.80 no.2
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    • pp.179-186
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    • 2017
  • Background: Although the World Health Organization (WHO) classification of lung squamous cell carcinoma (SCC) was revised in 2015, its clinical implications for lung SCC subsets remain unclear. We investigated whether the morphologic characteristics of lung SCC, including keratinization, were associated with clinical parameters and clinical outcome of patients. Methods: A total of 81 patients who underwent curative surgical resection of diagnosed lung SCC, were enrolled in this study. Attributes such as keratinization, tumor budding, single cell invasion, and nuclear size within the tumor, as well as immunohistochemistry of Bcl-xL and pS6 expressions, were evaluated. Results: The keratinizing and nonkeratinizing subtypes did not differ with respect to age, sex, TNM stage, and morphologic parameters such as nuclear diameter, tumor budding, and single cell invasion at the tumor edge. Most patients with the keratinizing subtype (98.0%) had a history of smoking, whereas the nonkeratinizing group had a relatively higher proportion of never-smokers relative to the keratinizing group (24.0% vs. 2.0%; p=0.008, chi-square test). Expression of pS6 (a surrogate marker of mammalian target of rapamycin complex 1 [mTORC1] signaling that regulates keratinocyte differentiation), and Bcl-xL (a key anti-apoptotic molecule that may inhibit keratinization), did not correlate significantly with the presence of keratinization. Patients with the keratinizing subtype had a significantly shorter overall survival (85.2 months vs. 135.7 months, p=0.010, log-rank test), and a multivariate analysis showed that keratinization was an independent, poor prognostic factor (hazard ratio, 2.389; 95% confidence interval, 1.090-5.233; p=0.030). Conclusion: In lung SCC, keratinization is associated with a poor prognosis, and might be associated with smoking.

Variance components estimation for farrowing traits of three purebred pigs in Korea

  • Lopez, Bryan Irvine;Kim, Tae Hun;Makumbe, Milton Tinashe;Song, Chol Won;Seo, Kang Seok
    • Asian-Australasian Journal of Animal Sciences
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    • v.30 no.9
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    • pp.1239-1244
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    • 2017
  • Objective: This study was conducted to estimate breed-specific variance components for total number born (TNB), number born alive (NBA) and mortality rate from birth through weaning including stillbirths (MORT) of three main swine breeds in Korea. In addition, the importance of including maternal genetic and service sire effects in estimation models was evaluated. Methods: Records of farrowing traits from 6,412 Duroc, 18,020 Landrace, and 54,254 Yorkshire sows collected from January 2001 to September 2016 from different farms in Korea were used in the analysis. Animal models and the restricted maximum likelihood method were used to estimate variances in animal genetic, permanent environmental, maternal genetic, service sire and residuals. Results: The heritability estimates ranged from 0.072 to 0.102, 0.090 to 0.099, and 0.109 to 0.121 for TNB; 0.087 to 0.110, 0.088 to 0.100, and 0.099 to 0.107 for NBA; and 0.027 to 0.031, 0.050 to 0.053, and 0.073 to 0.081 for MORT in the Duroc, Landrace and Yorkshire breeds, respectively. The proportion of the total variation due to permanent environmental effects, maternal genetic effects, and service sire effects ranged from 0.042 to 0.088, 0.001 to 0.031, and 0.001 to 0.021, respectively. Spearman rank correlations among models ranged from 0.98 to 0.99, demonstrating that the maternal genetic and service sire effects have small effects on the precision of the breeding value. Conclusion: Models that include additive genetic and permanent environmental effects are suitable for farrowing traits in Duroc, Landrace, and Yorkshire populations in Korea. This breed-specific variance components estimates for litter traits can be utilized for pig improvement programs in Korea.

Comparison of clinical and histological characteristics of orthodontic tooth movement into recent and healed extraction sites combined with corticotomy in rats

  • Samruajbenjakun, Bancha;Kanokpongsak, Kaviya;Leethanakul, Chidchanok
    • The korean journal of orthodontics
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    • v.48 no.6
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    • pp.405-411
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    • 2018
  • Objective: This study was performed to investigate the rate of tooth movement and histological characteristics of extraction sockets those were subjected to corticotomy. Methods: A split-mouth randomized controlled trial experiment was designed. Thirty-two adult, male Wistar rats were divided into 2 groups: healing extraction socket (H) and recent extraction socket (R); these groups were randomly classified into 4 subgroups (0/7/21/60 days). The first maxillary molar was extracted on 1 side and 2 months were allowed for complete bone healing; then, the corresponding molar was extracted on the other side and surgical intervention was performed at the mid-alveolar point of the first maxillary molar. Ten grams of continuous force was applied. The outcomes measured were rate of tooth movement, percentage of periodontal space and histological evaluation. The rate of tooth movement was calculated as the measured distance divided by the duration of molar movement. Histomorphometric evaluations were performed on the second and third maxillary molars. The Wilcoxon signed rank test was used to compare differences between the two groups. Results: There were no significant differences in the rates of tooth movement between H and R groups at any of the 4 time points. The histological appearance and percentage of periodontal space between the R and H groups also demonstrated no significant differences. Conclusions: The rates of orthodontic tooth movement into recent and healed socket sites did not differ between the groups. Histological analysis of tooth movement revealed regional acceleration during every time period.

The Effect of Mechanical Horseback-Riding Training according to Velocity on Trunk Muscles Thickness in Healthy Adult

  • Lim, Jae-Heon;Cho, Woon-Su;Park, Jang-Sung
    • The Journal of Korean Physical Therapy
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    • v.27 no.5
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    • pp.281-286
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    • 2015
  • Purpose: The study was to determine whether mechanical horseback-riding training according to velocity may improve trunk muscles thickness in healthy adults. Methods: Twenty healthy adults participated in this study. The subjects were divided into 2 groups as follows: 10 subjects in high velocity mechanical horseback-riding training (MHRT) and 10 subjects in low velocity MHRT. Subjects in all groups performed a total of 18 sessions 3 times a day for 20 minutes and this experiment lasted for 6 weeks. Mann-Whitney and Wilcoxon Signed Rank test were used in analysis the results of trunk muscle thickness. Ultrasonography was performed to evaluate for thickness of rectus abdominis (RA), external oblique (EO), internal oblique (IO), transverse abdominis (TrA), erector spine (ES), and multifidus (MF) in trunk muscles. Results: Results on the changes of EO, IO, and ES of high velocity MHRT showed a significant increase after 6 weeks (p<0.05). Regarding the changes of EO, IO, ES, TrA, and MF of low velocity MHRT, a significant increase was observed after 6 weeks (p<0.05). The differences in change of trunk muscle thickness before training, after 6-week training between groups, TrA and MF of low velocity MHRT were significantly higher (p<0.05). Conclusion: Based on the results of the current study, the velocity of MHRT was shown to affect change of trunk muscle thickness in healthy adults. In particular, low velocity MHRT may serve as a useful method to provide for TrA, MF thickness improvement related to trunk stabilizers.

Influence of Achievement Goal Orientation and Grit on the Military Cadets' Physical Strength Growth (사관생도의 성취목표지향성과 그릿이 체력변화에 미치는 영향)

  • Jung, Byong-Sam
    • Journal of the Korea Convergence Society
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    • v.11 no.4
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    • pp.287-294
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    • 2020
  • The purpose of this study was to analyze the influence of the achievement goal orientation of military cadets and grit on the military cadets' certification of physical fitness rank and on the improvement of the grade. To accomplish the research purpose, a survey was conducted to 350 cadets of the Korea Military Academy in December 2019, and 322 valid responses were analyzed by applying the path analyses. As a result, among the sub-factors of achievement goal orientation, the direct effect of task goal orientation on the two sub-factors of the grit was statistically significant. In addition, the effect of task goal orientation on grade physical certification was statistically significant, with the use of grit(maintaining interest) and grit(continuing effort) as meditating variables. In addition, task goal orientation had a significant effect on the improvement of physical strength grade via two sub-factors of Grit as meditating variables.

Syntaxonomical Reconsideration of the Rosetalia rugosae (해당화군목의 군락분류학적 재고)

  • Jung, Yong-Kyoo;Kim, Woen
    • The Korean Journal of Ecology
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    • v.24 no.5
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    • pp.267-271
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    • 2001
  • A phytosociological study on the hierarchical classification system of the Rosetalia rugosae, developed at the coastal dunes in the cool-temperate region of Northeast Asia, was carried out. Currently, the Rosetalia rugosae is subordinated to the Rosetea multiflorae which is the highest rank of the mantle vegetation in Northeast Asia, however its hierarchical system is somewhat ambiguous. This study was accomplished by using the syntaxa and hierarchical system of the Rosetalia rugosae and Rosetea multiflorae, and by also using 197 homogeneous relevns of the Rosetalia rugosae in South Korea and Japan in terms of the Zbrich-Montpellier School. For the hierarchical analysis of the Rosetalia rugosae, the constancy, the frequency and the net contribution degree were evaluated. It is estimated that the Rosetalia rugosae and the Rosetea multiflorae are hardly related to reciprocally. Thus, the subordination of the Rosetalia rugosae to the Rosetea multiflorae is comparatively irrational. Accordingly, the syntaxonomical hierarchy of the Rosetalia rugosae must be reconsidered that is correspond to the Viticetea rotundifoliae of the warm-temperate coastal dune shrub vegetation.

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Development of Preliminary Hazard Ranking System for Underground Storage Tanks Using Geographic Information System (GIS) (GIS를 이용한 지하저장탱크의 위해성 예비평가체계 개발)

  • 황상일;이상훈;이동수
    • Journal of the Korean Society of Groundwater Environment
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    • v.4 no.3
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    • pp.122-129
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    • 1997
  • Spills or leaks of hazardous organic. compounds from underground storage tanks (USTs) are common contaminant sources of soil and groundwater. It would aid in managing USTs to assess and rank the potential environmental hazard posed by the USTs. Therefore, a preliminary hazard ranking system of USTs is developed in this study. The system is combined with GIS and consists of five steps: 1) selection of significant factors, 2) determination of the hierarchy of the factors. 3) determination of the weights, 4) calculation of the potential hazard, and 5) hazard assessment. The system is applied to the gas stations in Kwanak-gu, Seoul. The results indicate that the gas stations can be categorized in three groups as highly hazardous, less highly hazardous, and weakly hazardous. Seven gas stations belong to the highly hazardous group. Through the sensitivity analysis, four stations appear to possess high hazard potentials regardless of weights assigned to the factors. It appears that a user can make flexible application of the hazard ranking system with the user's experience and particular purposes. However, the system still needs validations against field survey data.

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Improvement Effect of Water Quality along the Water Discharged Area by Water Dispersion from the Sewage Disposal Plant (하수처리장 분산방류에 의한 방류수역의 수질개선효과)

  • Kim, Dong-Soo;Park, Jong-Tae;Kim, Yong-Gu;Park, Sung-Chun
    • Journal of Environmental Science International
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    • v.17 no.1
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    • pp.113-118
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    • 2008
  • [ $6{\sim}13mg/L$ ] base water concentration on monthly BOD has been kept at the Geukrak bridge point for this research target and it indicates the water quality under the existed rank. Due to this present condition of water quality, the demage of ecology from the upper stream to the lower one of the bridge could be conjectured. Moreover, nonstructural extinction of the ecology seems to have gotten worse between both the streams of Yeoungsan River. On this research, eco-corridor between the upper stream and the lower stream of the river should be ensured, the ecological demage needs to be cut off, a dispersed discharge method which the existed method of the 1st sewage plant in Gwangju was enhanced to should be inducted for the procuring of various water ecosystem, and the conditions by the scenario suggested from this research could be applied to a water quality model. then, analysis the improvement effect of the water quality adjacent the river. From the test result, Case3-Type1 scenario is thought to be the best one. From the test result with Case3-Type1 when the concentrated discharge was never done, 0.07 mg/L of BOD concentration was increased at the lower stream where Yeoungbon B point (Haksan Bridge) is but the water improvement effect of $0.24{\sim}2.87mg/L$ is thought to have been done at the area of water deterioration.

A Study on the Costume of the Ruling Classes in the Three Kingdoms Period (삼국시대 지배계층 복식문화 연구)

  • 이선재;양경애
    • Journal of the Korean Society of Costume
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    • v.39
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    • pp.181-196
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    • 1998
  • This study is about the similarities and the individualties of the traditional costumes in the ruling classes of Koguryo(高句麗), Bakjae(百濟), and Shilla(新羅). The analysis is based on the views of historical reformation on$\boxDr$Sam-gooksagi(三國史記)$\boxUl$Bongi(本紀). The costumes that were worn by the governing classes are categorized by the following, official duties, wars, ceremonies, and recreations(hunting). Up to the present time, there has been a great tendency to emphasize the similarities of the Three Kingdoms' costumes among most of academic researchers. However, the conceptions of individualities of the costumes among the Three Kingdoms were conceived by the facts that geological environments, political systems, social traditions, social aspects, and foreign affairs. The Three Kingdoms had different official rank systems along with official costume systems. Monopolization of official positions of the ruling parties tried to show their dignity and authority through styles of their costumes. The costumes of Koguryo were greatly differentiated by geographical regions ; One direct example is cheak of Pyoungyang and Anak regiona was named as official hats of rulling parties of Kokuryo. However, in this study, the cheak was viewed as a product of influences of Chinese costume. Further-more, the laguan was named as mooguan. Costumes of ceremonial occasions were heavily decorated to symbolize dignity and auth-ority. Metal ornament of headgear and belt, metal shoes were con-sidered as ceremonial costumes. the tight hunting costumes of Koguryo shown in mural pain-ting costumes of Koguryo shown in mural pain-tings were presumed to be spring and autumn clothing. Excavated from Neungasnlee, the hunting costumes inscribed in the gold incense burnner were confirmed as hunting costumes of Bakjae. The individuality of the costumes of the Three Kingdoms could also be supported by the fact that they had different climates. The temperature difference between Gipan region and Kyoungjoo(慶州) region was emphasized. Especially winter clothing would have had a big difference in style than the summer clothing. Through the research summarized above, this study was able to confirm that each of the Three Kingdoms had developed individualized costumes based on their geographical, cultural and environmental factors. Furthermore, through this study, it was possible to find out the difference as well as the similarities of their costumes according to each of their people's sociopolitical status, awareness of indepen-dence, andunique historical and traditional charactoristics.

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A Trend Analysis of Market Structure in the Korean Daily Newspaper Industry (타일지수와 이동지표를 활용한 미디어 시장구조 분석 전국종합일간지 시장을 중심으로)

  • Oh, Jeongho
    • Korean journal of communication and information
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    • v.78
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    • pp.141-176
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    • 2016
  • This study investigates changes of market structure from 2001 to 2015 in the Korean daily newspaper industry using concentration and mobility measures. The main empirical results are as follows. First, the industry's total asset shows a U-shaped trend, despite the downward trend of the industry's total sales revenue. Second, the market concentration, measured in terms of assets, shows the trend of an inverted-U shape. The relatively small firms, measured in terms of assets, have on average gained in market share while the relatively large firm have lost. Third, market concentration, measured in terms of sales revenues, shows a U-shaped trend. the relatively small firms, measured in terms of sales revenues, have on average gained in market share while the relatively large firm have lost. My central argument has been that it is desirable to supplement traditional concentration measures with mobility statistics and trend analyses in investigating and regulating market structure.

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