• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3131-3137
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• 2013

Background: Visual inspection of cervix with acetic acid (VIA) is offered at 252 centers in 64 districts of Bangladesh. VIA+ve women are managed at colposcopy clinics of Bangabandhu Sheikh Mujib Medical University (BSMMU) and 14 Medical College Hospitals (MCHs). This research work has been supported by 'UICC Cancer Prevention Campaign' programme. Objectives: This study explored the role of print materials and electronic media to improve cervical cancer screening in the present socio-cultural context of Bangladesh. Methods: This study was performed from January to August 2011 at two upazilas of Bangladesh (Singair with screening facility and Sonargaon without screening facility). Data were collected by focus group discussion (FGD) with women, husbands and community people before and after intervention. Information on cervical cancer screening and VIA camps was disseminated using advertisement through local cable line of the television, microphone announcement, service providers and leaflet throughout the week prior to a VIA camp. Three-day VIA camps were organized at the upazila health complex (UHC) of both upazilas. Quantitative data was gathered from women at the camps on source of information on VIA and the best method of awareness creation. Results: The population was aware of "cancer" and a notable number knew about cervical cancer. Baseline awareness on prevention and VIA was low and it was negligible where screening services were unavailable. Awareness was increased fourfold in both upazilas after interventions and half of the women and the majority of the community people became aware of screening and available facilities. Cable line advertisement (25.5%), microphone announcement (21.4%), and discussion sessions (20.4%) were effective for awareness creation on VIA. Television was mentioned as the best method (37.4%) of awareness creation. Conclusion: Television should be used for nation-wide awareness creation. For local awareness creation, cable line advertisement, microphone announcements and health education at Uthan Baithaks/ EPI sessions can easily be adopted by the government.

• Nutrition Research and Practice
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• 제14권1호
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• pp.25-31
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• 2020

BACKGROUND/OBJECTIVES: To date, sodium intake has been evaluated based on spot urine instead of 24-hour (hr) urine collection. Nevertheless, the optimal method for assessing daily sodium intake remains unclear. SUBJECTS/METHODS: Fifteen male (age 32.7 ± 6.5 years) participants were offered 3 meals with a total of 9-10 g salt over 24 hours, and 24-hr urine was collected from the second-void urine of the first day to the first-void urine of the second day. Twenty-four-hr urinary sodium (24UNa) was estimated using Tanaka's equation and the Korean formula, and spot urine Na, potassium (K), chloride (Cl), urea nitrogen (UN), creatinine (Cr), specific gravity (SG) and osmolality (Osm) were measured. The ratios of urinary Na to other parameters were calculated, and correlations with total measured 24UNa were identified. RESULTS: Average 24-hr urine volume was 1,403 ± 475 mL, and measured 24UNa was 143.9 ± 42.1 mEq (range, 87.1-239.4 mEq). Measured 24UNa was significantly correlated with urinary Na/UN (r = 0.560, P < 0.01), urinary Na/Osm (r = 0.510, P < 0.01), urinary Na/Cr (r = 0.392, P < 0.01), urinary Na/K (r = 0.290, P < 0.01), 24UNa estimated using Tanaka's equation (r = 0.452, P < 0.01) and the Korean formula (r = 0.414, P < 0.01), age (r = 0.548, P < 0.01), weight (r = 0.497, P < 0.01), and height (r = 0.393, P < 0.01) in all spot urine samples. Estimated 24UNa based on the second-void spot urine of the first day tended to be more closely correlated with measured 24UNa than were estimates from the other spot urine samples. The significant parameters correlated with the second-void urine of the first day were urinary Na/K (r = 0.647, P < 0.01), urinary Na/Cr (r = 0.558, P < 0.05), and estimated 24UNa using Tanaka's equation (r = 0.616, P < 0.05) and the Korean formula (r = 0.588, P < 0.05). CONCLUSIONS: Second-void urine is more reliable than first-void urine for estimating 24UNa. Urinary Na/K in the second-void urine on the first day is significantly correlated with 24UNa. Further studies are needed to establish the most reliable index and the optimal time of urine sampling for predicting 24UNa.

• Asian-Australasian Journal of Animal Sciences
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• 제30권10호
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• pp.1471-1477
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• 2017

Objective: Since athletic performance is a most importance trait in horses, most research focused on physiological and physical studies of horse athletic abilities. In contrast, the molecular analysis as well as the regulatory pathway studies remain insufficient for evaluation and prediction of horse athletic abilities. In our previous study, we identified AXL receptor tyrosine kinase (AXL) gene which was expressed as alternative spliced isoforms in skeletal muscle during exercise. In the present study, we validated two AXL alternative splicing transcripts (named as AXLa for long form and AXLb for short form) in equine skeletal muscle to gain insight(s) into the role of each alternative transcript during exercise. Methods: We validated two isoforms of AXL transcripts in horse tissues by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned the transcripts to confirm the alternative locus and its sequences. Additionally, we examined the expression patterns of AXLa and AXLb transcripts in horse tissues by quantitative RT-PCR (qRT-PCR). Results: Both of AXLa and AXLb transcripts were expressed in horse skeletal muscle and the expression levels were significantly increased after exercise. The sequencing analysis showed that there was an alternative splicing event at exon 11 between AXLa and AXLb transcripts. 3-dimentional (3D) prediction of the alternative protein structures revealed that the structural distance of the connective region between fibronectin type 3 (FN3) and immunoglobin (Ig) domain was different between two alternative isoforms. Conclusion: It is assumed that the expression patterns of AXLa and AXLb transcripts would be involved in regulation of exercise-induced stress in horse muscle possibly through an $NF-{\kappa}B$ signaling pathway. Further study is necessary to uncover biological function(s) and significance of the alternative splicing isoforms in race horse skeletal muscle.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5927-5936
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• 2014

Introduction: Breast cancer is the most common cancer among Jordanians. Breast cancer patients suffer from several negative consequences after treatment and these include pain, fatigue, sexual problems, appearance and body image concerns, with psychological dysfunction. This could affect the patient quality of life and psychological well-being. To the best of our knowledge, there is no published quantitative data on the quality of life and psychological well-being of breast cancer patients in Jordan. The objective of this study was to obtain such data and assess predictors with calculated scores. Methods: In this cross-sectional study conducted among breast cancer patients in Jordan diagnosed in 2009 and 2010, assessment was performed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), the Breast Module (QLQ-BR23) and the Hospital Anxiety and Depression Scale (HADS). Clinical, demographic and psychosocial indicators that could predict patient quality of life scores were collected. Results: The number of patients interviewed was 236 (mean age=$50.7{\pm}10.7$ years). The mean Global Health score for the QLQ-C30 was $63.7{\pm}20.2$ SD. Among functional scales, "social functioning" scored the highest ($mean=78.1{\pm}28.6$ SD), whereas "emotional functioning" scored the lowest ($mean=59.0{\pm}SD\;33.5$). For the QLQ-BR23, the worst scores within the functional scales were for "body image" ($mean=52.1{\pm}36.8$ SD) and "future perspective" ($mean=52.9{\pm}38.5$ SD). The worst symptom was "upset by hair loss" ($mean=69.8{\pm}43.0$). The mean HADS scores was $18.{\pm}9.0$ SD. Out of study participants, 53% scored abnormal on the anxiety scale and 45% on the depression scale. Severe depression and severe anxiety were detected among 8% and 14% of study participants, respectively. Statistically significant predictors for individual scores were similar to those reported in published studies, such as the presence of recurrence since baseline, family history of cancer, low educational status, current social problems, extent of the disease, presence of financial difficulties, and employment status. Conclusions and Recommendations: Breast cancer survivors in Jordan have overall good quality of life scores when compared with patients from Western countries. However, their psychological wellbeing is more impaired. There is an urgent need for psychosocial support programs and psychological screening and consultation for breast cancer patients at hospitals of the Ministry of Health in Jordan.

• Journal of Acupuncture Research
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• 제19권2호
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• pp.114-127
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• 2002

Objective : The purpose of this study is to investigate the mechanism and effect of moxibustion objectively and to be used as the quantitative data for developing the new thermal stimulating treatment by observing the combustion time and temperature of commercial moxaes. Methods : We have selected two types(large-size moxa A(LMA), large-size moxa B (LMB)) among large moxaes used widely in the clinic. We examined combustion times, temperatures in each period during a combustion of moxa. Results : 1. The combustion time in the preheating period was about 30sec in both moxaes on the non-contact heated surface. 2. The combustion time in the heating period was about 345sec in LMA and about 1391 sec in LMB, about 4 times longer in LMB on the non-contact surface. 3. The maximum temperature in the heating period was $44.5^{\circ}C$ in LMA and $45.4^{\circ}C$ in LMB respectively, higher by $0.9^{\circ}C$ in LMB. The average temperature in the heating period was $35.5{\sim}37.6^{\circ}C$ in LMA and $36.0{\sim}39.8^{\circ}C$ in LMB, a little higher in LMB. 4. The combustion time in the retaining period in LMA was 45.4sec and 13% of that in the heating period, and in LMB 594.7sec and 43% of that in the heating period on the non-contact surface. 5. On the point(PH) measured maximum temperature, the average temperature during the retaining period was $44.0^{\circ}C$, $42.9^{\circ}C$ respectively and the temperature at an end of the retaining period was $43.0^{\circ}C$, $40.2^{\circ}C$ respectively. 6. The time at a beginning of the cooling period was about 418 sec from ignition in LMA and 2021sec in LMB, and the temperature at that time was $36.9{\sim}39.1^{\circ}C$ on the non-contact surface. Conclusion : It was thought that not only the figure of moxicombustion device, but also the form and size of moxa had influence on the combustion characteristics deciding the performance of stimulus seriously.

• 벤처창업연구
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• 제13권4호
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• pp.169-181
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• 2018

지속적으로 심화되고 있는 글로벌 경쟁 환경 하에서 많은 기업들은 공유가치 창출 (CSV, Creating Shared Value)을 통해 사회혁신 분야에서 새로운 사업 기회를 모색하고 있다. 사회혁신을 추구함에 있어 해결하고자 하는 문제를 명확히 도출하고, 문제의 원인을 파악하는 것이 사회혁신의 핵심 출발점이다. 수많은 문제해결 방법론 중에 최근 다양한 분야에서 가장 많은 관심을 받는 것은 디자인 씽킹 (Design Thinking)이다. 디자인 씽킹은 인간의 필요에 공감하고 대중도 인식하지 못하는 잠재적 욕구를 발굴하여 해결하는 창의적 문제해결 방법론으로 비즈니스 혁신도구로도 사용되지만 사회 문제를 해결하는 사회혁신을 위한 도구로서 활발히 이용되고 있다. 그러나 디자인 씽킹 프로젝트를 수행하는 많은 주체들이 겪는 어려움 중의 하나가 관찰 데이터의 효율적 분석이 어렵다는 것이다. 오프라인 방식으로만 데이터를 분석할 경우 대량의 데이터를 처리하는데 시간이 오래 걸리며, 비정형데이터의 경우 처리가 어려워 관찰을 통해 어렵게 수집한 데이터로부터 문제점을 발견하는데 어려움을 호소한다. 이에 본 연구는 디자인 씽킹 프로세스의 한계점을 보완하고자 사회혁신을 위한 디자인 씽킹 프로젝트의 관찰단계에서 수집한 데이터 분석이 보다 과학적으로 이루어질 수 있도록 질적 자료 분석과 양적 자료 분석 방법을 균형 있게 사용하는 통합방법론을 제시하고자 한다.

• 실천공학교육논문지
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• 제12권1호
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• pp.145-162
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• 2020

일학습병행제는 국내 평생직업능력개발 체계에서 양적으로는 이미 중요한 한 축을 담당하고 있다. 하지만 기존의 일학습병행제 성과관리 방안들은 대부분 자격연계형 일학습병행제에 초점을 맞추고 있어, 4년제 대학이 담당하는 대학연계형 일학습병행제의 효과적인 성과관리체계구축에 대한 연구가 매우 부족한 실정이다. 본 논문에서는 일학습병행제 계약학과의 질적 내 실화를 이루기 위해, 대학연계형 일학습병행제에 적합한 성과관리체계를 구축하기 위한 방안을 제시한다. 이를 위해, 대학연계형 일학습병행 계약학과의 성과평가 항목 및 지표를 개발하여 성과평가체계를 구축한다. 다음, 국내 학습근로자, 코리아텍 OJT 전담교수, 참여기업의 현장교사 등 다양한 이해관계자집단의 요구를 FGI와 설문조사를 통해 분석하여 현재의 계약학과 운영성과와 특별히 높은 중도탈락률의 원인을 진단한다. 이를 기초로 성과지표별 측정방법을 개발하고, 투입-변환-산출-피드백 구조의 시스템적 성과관리체계를 구축하기 위한 제 방안을 제시한다. 또한 높은 중도탈락률의 개선과 성과향상을 위한 방안을 각 이해관계자 측면에서 제시한다.

• 한국산학기술학회논문지
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• 제21권4호
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• pp.311-316
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• 2020

무기체계발 및 운영 간 지속적으로 발생하는 부품단종 문제를 해소하고, 비용대비 가장 효과적인 부품단종 대응방안을 선정하기 위해, 총수명주기 비용분석을 통해 정량적 성능개량 시점판단 기준을 제시한다. 이를 위해 국내외 비용분석 방안을 조사하고, 본 연구를 검증하기 위해 국내 운영장비 1종에 시범적용 하였다. 부품단종(DMSMS)이 발생하는 가장 큰 원인은 긴 수명주기를 갖는 무기체계에 비해 과학의 발전에 따라 부품의 빠른 교체주기와 짧은 수명주기 때문이다. 특히 군수품 양산 및 전력화단계 이후 운영유지 단계 시에는 이러한 부품수급문제가 더욱더 심화된다. 부품의 수명주기 초기 단계에는 신기술과 기능으로 인해 부품의 수정이 빈번하며 사용도는 낮은 반면 비용은 고가이다. 성숙 단계에서는 사용도는 최고이나 비용은 최저가 되며 이후 부품의 쇠퇴 단계를 거쳐 단종에 가까워지면 가격은 다시 상승하는 경향을 나타낸다. 또한 운용유지단계 장비의 경우 부품단종에 대한 소극적인 대응(재고확보 위주)으로 인해 소요군 장비유지 필수품목의 조달이 제한되고 있는 실정이다. 본 연구에서는 부품단종관리를 위한 수명주기비용 분석을 통해 정량적 성능개량 시점 판단기준을 수립하여 부품단종 문제에 대응하고 군수품의 총수명주기 소요비용 절감에 기여하고자 한다.

• 한국환경농학회지
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• 제33권3호
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• pp.205-212
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• 2014

BACKGROUND: This study focused on the contents of flavonoid compounds in vegetables. Generally vegetables have contributed to a healthy diet, arisen from contains a large amount of fiber and functional ingredients. And flavonoid compounds are one of major functional components in the vegetables. currently research of flavonoid contents does not enough, specially in the part of homegrown vegetable. METHODS AND RESULTS: Vegetable samples were purchased in domestic market. Sample extraction by methanol, distilled water, and formic acid based solvent. Also same solvent used for mobile phase in UPLC. Eleven types of flavonoid compounds were analyzed with same kind of external standard and one kind of internal standard (galangin) for quantification. Standard calibration curve presented linearity with the correlation coefficient $R^2$ > 0.98, analysed from 1 to 50 ppm concentration. The quantitative value and multivariate analysis results were derived from the Excel and SIMCA-P11. Overall, onion has largest amount(916.5 mg/100 g) of flavonoid and also other vegetables have has significant amount[Mugwort: 138.8, Galic stem:123.6 mg/100 g etc.] of flavonoid compounds. Edible portion of vegetables per share for simulating by SIMCA-P11, root vegetables has had difference with other vegetables according to distributions and amounts of flavonoid compounds. CONCLUSION: Optionally, the results from this experiment can use to select the material for flavonoid researches. And based on these results, if this experiment will be continuously complemented, and performed, could used in various fields.

• 한국공간정보시스템학회 논문지
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• 제2권2호
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• pp.59-74
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• 2000

투자의 효율성제시가 불명확한 1단계 국가GIS사업(1995-2000)에 대한 대책으로, 최근 GIS예산 집행의 타당성에 대한 분석이 요구되고 있다. 특히 국가GIS사업의 많은 비중을 차지하는 지자제GIS사업에서 효율적인 투자는 성공적인 사업추진을 위해 매우 중요하다. 그러나 GIS투자의 타당성을 판단하기 위해서는 투자비용의 산정과 함께 그로 인한 편익 내지 효과를 측정할 수 있어야 한다. 또 측정할 수 있다면 얼마나 측정할 수 있고 얼마나 설득력있는 편익을 측정하여 정책결정이나 정치적, 재정적 지지를 얻는 데에 활용할 수 있는가가 핵심적인 주요사안으로 받아들여지고 있다. 따라서 본 연구는 지자체에서 합리적인 의사결정의 자료로 활용될 수 있도록 기존의 다양한 GIS비용효과 분석에 대한 이론적 고찰을 실시하고, 지자제GIS의 특성을 고려한 GIS비용효과분석방안을 고찰하였다. 이를 위해 지자체 GIS 발전단계에 따르는 효과 및 지자체 응용시스템별의 활용효과에 대한 국내외사례를 종합, 국내 지자체 GIS비용효과분석에 적용될 수 있는 비용과 효과의 정량적 정성적 평가항목을 구성하였다. 아울러 편익비용비, 순현재가치, 내부수익률의 평가기법에 따라 다양한 대안선정을 위한 민감도분석과 불확실성분석에 대해서도 살펴봄으로써, 지자제 GIS사업의 투자타당성확보 및 합리적인 의사결정 및 대안선택방향을 모색하였다.