• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.97-102
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• 2010

A novel surface-attached solid dispersion is designed to improve the solubility and oral bioavailability of poorly water-soluble drugs without crystalline change. Accordingly, it draws increasing interest because of excellent stability and no pollution for accomplishing enhanced solubility and bioavailability, which have recently been highlighted in connection with a number of higher value-added poorly water-soluble drugs. In addition, excellent stability can be attained when the poorly water-soluble drugs are not dissolved but dispersed in water and provide no crystallinity change. This solid dispersion is given by means of attaching the dissolved carriers such as hydrophilic polymer and surfactant to the surface of dispersed drug particles followed by changing the hydrophobic drug to hydrophilic form. The aim of the present review is to outline the preparation, physicochemical property and bioavailability of novel surface-attached solid dispersion with improved solubility and bioavailability of poorly water-soluble drugs without crystalline change.

• Ocean and Polar Research
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• v.33 no.spc3
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• pp.325-336
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• 2011

Seasonal to inter-annual variations of water properties in the western channel of the Korea Strait are investigated using quasi-monthly hydrographic observations collected during 2006-2010. Weak vertical temperature and salinity gradients are observed during the winter months and these remain until May. At the upper layer, temperature increases from March and reaches a maximum in August, while salinity decreases during the same period. Near-bottom water shows low temperatures during late winter and fall with a minimum peak in September. Korea Strait Bottom Cold Water produces thick layers (>20 m) in 2006 and 2010, while it is observed very near the bottom with relatively high temperature in 2008 and 2009.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.890-897
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• 2005

Stability of embankment is influenced on landfill condition, permeability, shear strength and soil engineering propensity and so on, and need examination in reply because is different according to change of soil property of foundation ground and permeability condition. Analyzed seepage behaviour by finite element method for embankment, and change permeability of base to analyze effect that permeability of ground water table formation before embankment and analyze seepage behaviour to typical embankment in this research. In the case of permeability of foundation ground is 10 more than landfill permeability, rise of groundwater table was changed slightly. Pore water pressure was decreased slowly in landfill after rainfall. The effect of permeability of foundation ground was effected in change of pore water pressure. For permeability of foundation ground is 10 more than landfill, stability of road landfill was small changed during rainfall. But in the case of permeability of base soil similar to landfill permeability, road landfill stability was large decreased during rainfall.

• Journal of Sensor Science and Technology
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• v.26 no.6
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• pp.402-407
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• 2017

Characteristics of various material surface plasmon resonance (SPR) chips were investigated in angular interrogation mode and intensity interrogation mode. Among five metals, silver (Ag), gold (Au), copper (Cu), chromium (Cr) and titanium (Ti), three metals, Ag, Au and Cu were paid attention to since their characteristics can be easily analyzed in angular interrogation mode by investigating the change of their reflectance curves according to refractive index change from 1.331 to 1.335. Most of SPR chips with various configurations showed the similar property in angular interrogation mode. The application of the SPR chip made of Ag, Au and Cu or their combinations depends on their reflectance properties. In intensity interrogation mode, the operation range may be limited since the variation of the intensity was not linearly related to refractive index change ranging from 1.331 to 1.335. However, the SPR chip containing high ratio of Ag may be applicable to high sensitive detection due to their sharp reflectance curves in intensity interrogation mode.

• Journal of the Korean Society for Precision Engineering
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• v.10 no.1
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• pp.134-141
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• 1993

Electro-Rheological(ER) fluids undergo a phase-change when subjected to an external electic field, and this phase-change typically manifests itself as a many-order-of-magnitude change in the rheological behavior. This phenomenon permits the global stiffness and energy- dissipation properties of the beam structures to be tuned in order to synthesize the desired vibration characteristics. This paper reports on a proof-of-concept experimental investigation focussed on evaluation the vibration properties of hollow cantilevered beams filled with an ER fluid. and consequently deriving an empirical model for predicting field-dependent vibration characteristics. A hydrous-based ER fluid consisting of corn starch and silicone oil is employed. The beams are considered to be uniform viscoelastic materials and modelled as a viscously-damped harmonic oscillator. Natural frequency, damping ratio and elastic modulus are evaluated with respect to the electric field and compared among three different beams: two types of different volume fraction of ER fluid and one type of different particle concentration of ER fluid by weight. Transient and forced vibration responses are examined in time domain to demonstrate the validity of the proposed empirical model and to evaluate the feasibility of using the ERfluid as an actuator in a closed-loop control system.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.6
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• pp.414-419
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• 2012

In this paper, the properties of SnZnO films obtained from solution process with different component fractions were compared. The thermal behavior of the SnZnO solutions showed only a slight change according to the component fraction change. However, the definite changes were revealed at the structural properties of the SnZnO films. With diverse analyses, the origin of the changes was proved to the influence of phase change from $SnO_2$ to ZnO in SnZnO lattice. With the $SnO_2$-phase-dominant SnZnO, the highest field effect mobility and on/off ratio of about 8.6 $cm^2/Vs$ and $2{\times}10^8$ were achieved, respectively.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.3 no.3
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• pp.161-165
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• 2002

Ge-doped rnulticomponent oxide glasses were prepared by a conventional melting method. The change of micro structure in glasses was investigated by using PL (photoluminescence) and ESR (electron spin resonance). Before UV irradiation, the PL intensity increased according to germanium contents, but decreased the intensity as soon as UV irradiation. A changed property was recovered near it original properties when it was annealed. These photodarkening and thermal bleaching effect were observed by ESR intrument. These effect did not change the glass phase but vary only change of micro structure.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.19 no.3
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• pp.246-249
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• 2006

We fabricated self-assembled monolayers(SAMs) onto quartz crystal microbalance(QCM) using viologen, which has been widely used as electron acceptor and electron transfer mediator. We determined the time dependence on resonant frequency shift during self-assembly process and observed the morphology of self-assembled monolayers by STM and investigated the electrochemical behavior of SAMs by cyclic voltammetry. Electrochemical deposition of viologen was investigated using electrochemical quartz crystal microbalance(EQCM). The redox reactions of viologen were highly reversible and the EQCM has been employed to monitor the electrochemically induced adsorption of SAMs during the redok reactions. The total frequency change was about 9.5 Hz, and 7.1 Hz. From the data, we could know the mass change was about 10.16 ng and 7.60 ng, respectively. Finally, the EQCM has been employed to monitor the electrochemically induced adsorption of self-assembled monolayers on Au surfaces.

• 정보저장시스템학회:학술대회논문집
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• 2005.10a
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• pp.124-127
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• 2005

Rewritable optical memory devices such as an CD-RW and DVD+RW are data storage media, which take advantage of the different optical properties in the amorphous and crystalline states of phase change materials. The switching property, structural transformation, transformation kinetics and chemical bindings of $Ge_xSb_{100-x}$($6{\le}x{\le}$34) were studied to investigate the feasibility of applying $Ge_xSb_{100-x}$ alloys in optical memory. The $Ge_xSb_{100-x}$ thin film was deposited by RF magnetron co-sputtering system and phase change characteristics were investigated by X-ray diffraction (XRD), static tester, inductively coupled plasma atomic emission spectrometer (ICP-AES) and atomic force microscopy (AEM). Optimum fiim composition of $Ge_xSb_{100-x}$ was studied and its minimum time fur laser induced crystallization and optical contrast fur phase transition was performed. These results might be correlated with the binding energies between Ge and Sb, and indicate that $Ge_xSb_{100-x}$ have an potential far optical memory applications.

• The Journal of Korean Academy of Prosthodontics
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• v.19 no.1
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• pp.47-54
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• 1981

Dental porcelains are widely used for restorative material because of its excellent esthetic property. But according to contact with natural teeth or metal in oral cavity, the porcelain may be worn and may effect on masticatory physiology and prosthetic function. The purpose of this experiment was to study on wear of porcelain surface which treated in different method. Using the abrasion device which was designed and constructed by myself, the different porcelain surface were abraded by gold alloy, nickel-chrome alloy and natural teeth in order to compare roughness. Results were as follows. 1. The group of porcelain abraded by gold alloy showed less surface roughness change (t=2.92, p<0.05), and the group of porcelain abraded by natural teeth had high surface roughness. change (t=6.84, p<0.05). 2. According to the method of surface treatment, the surface roughness were very significant (F=9.12, p<0.05). 3. After abrading, the porcelain surface roughness change was very significant (F=54.49, p<0.05). 4. There was no significant between surface treatment method and the kind of abrading materials. (F=1.01, p>0..05). 5. The group of natural glazing had the most smooth surface ($2.1{\pm}1.13{\mu}m$).