• Title/Summary/Keyword: proper actions

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Angiogenic Effect of Cardiac Ankyrin Repeat Protein Overexpression in Vascular Endo-thelial Cell (Cardiac Ankyrin Repeat Protein의 과량발현이 혈관내피세포에서 갖는 혈관신생 촉진 효과)

  • Kong, Hoon-Young;Byun, Jong-Hoe
    • Korean Journal of Microbiology
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    • v.44 no.4
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    • pp.282-288
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    • 2008
  • Tissue ischemia resulting from the constriction or obstruction of blood vessels leads to an illness that may affect many organs including the heart, brain, and legs. In recent years, considerable progress has been made in the field of therapeutic angiogenesis and the new approaches are expected to cure those "no-option patients" who are unsuited to conventional therapies. Although single angiogenic growth factor may be successful in inducing angiogenesis, combination of multiple growth factors is increasingly sought these days to augment the therapeutic responses. This trend is proper in light of the fact that blood vessel formation is a complex and multi-step process that requires the actions of many different factors. To meet the growing need for functionally significant blood flow recovery in the ischemic tissues, a novel strategy that can provide concerted actions of multiple factors is required. One way to achieve such a goal is to use a transcription factor that can orchestrate the expression of multiple target genes in the ischemic region and thus induce significant level of angiogenesis. Here, a putative transcription factor, cardiac ankyrin repeat protein (CARP), was evaluated in adenoviral vector context for angiogenic activity in human umbilical vein endothelial cells. The results indicated significant increase in proliferation, capillary-like structure formation, and induction of vascular endothelial growth factor, a typical angiogenic gene. Taken together, these results suggest that CARP represents itself as a novel target for therapeutic angiogenesis and warrants further investigation.

Effects of Message Framining & Value-orientation on Preventive Behavior : Focus on the Magnitude of the Required Behavior for Environmental Problems (메시지 프레이밍과 가치지향성이 예방 행동에 미치는 영향 : 환경문제 예방 행동 요구 수준을 중심으로)

  • Park, Hui Jeong;Choi, Youjin
    • The Journal of the Korea Contents Association
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    • v.22 no.4
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    • pp.352-364
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    • 2022
  • As the types of actions and the magnitude of the required actions for environmental improvement get diversified, the necessity to develop effective messages is increasing. This research tries to develop proper messages with message characteristics of message framing and value orientation per different types of behaviors using a 2(message framing: gain/loss) × 2(value orientation: individual/social) × 2(magnitude of the requested behaviors: high/low). The results showed that framing and the magnitude of the requested behaviors had main effects on message attitudes and behavioral intentions. The gain framing showed more favorable effects than the loss framing, and the low magnitude of the requested behaviors showed better persuasive effects. According to the results of interaction effects, the gain framing showed higher behavioral intentions than the loss framing in the individual-oriented message, and there were no differences between the frames in the social-oriented message. When the magnitude of the requested behavior was high, the gain framing in the individual-oriented message was more favorable than the loss framing. On the other hand, when the magnitude of the requested behavior was low, the gain framing in the social-oriented message was more favorable. Although there were differences in the form of interactions by the magnitude of the requested behaviors, the individual-oriented gain framing message was found to be the most effective.

Effect of Press Temperature and Time on Physical Properties of Larch Particleboard (압체온도(壓締温度)와 시간(時間)이 낙엽송(落葉松) 파티클 보오드의 물리적(物理的) 특성(特性)에 미치는 영향(影響))

  • Lee, Phil Woo;Chung, Gyun
    • Journal of Korean Society of Forest Science
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    • v.63 no.1
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    • pp.12-20
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    • 1984
  • This research was performed to estimate the properties of particleboard based on the press time and temperature which was made of chip of larch that grows in Korea. The results in this study were as follows: 1) Even though the chips, 1:1-35 ratio between length and thickness, are relatively bad condition, the surface smoothness that can easily spread the adhesive evenly and thoroughly and bonding ability of chips can give proper physical properties. 2) It shows more mechanical properties at the press time of 10 min. in MOR (Modulus of Rupture), MOE (Modulus of Elasticity) and SHA (Screw Holding Ability). 3) It is not significant according to the press time 20 min. in MOR, IBS (Internal Bonding Strength) and SHA, for the reciprocal actions between the accelerating aging effect of chip and the softening effect of adhesion are occured. 4) IBS is rising according to the increasing temp at the press time of 10 min. Because it needs to transfer the plate heat to make the proper hardening temp. In the layer. 5) The heat treatment effects have greatly influenced the stahility of dimension by falling the absorption, anisotropy and inhomegenity. As a result of these the values of thickness and linear expansion ratio were respectively dropped by the increase of press temp and the time and so did absorption.

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Effects of Relational and Mandatory Influence Strategies on Sales Representatives and Headquarter Trust (관계적과 강제적 영향전략이 본사 신뢰에 미치는 영향 : 영업사원 신뢰의 매개역할)

  • Lee, Chang-Ju;Lee, Phil-Soo;Lee, Yong-Ki
    • Journal of Distribution Science
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    • v.14 no.6
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    • pp.53-63
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    • 2016
  • Purpose - This study examines the effects of the influence strategies on sales representative and headquarter trust, and investigates how sales representative trust plays a mediating role in the relationship between influence strategies and headquarter trust. For these purposes, a structural model which consists of several constructs was developed. In this model, influence strategies that consist of relational influence strategies (information exchange, recommend, promise) and mandatory influence strategies (legal plea, request, threat) were proposed to affect the sales representative trust and in turn, increase the headquarter trust. Thus, this study proposed that sale representative trust plays a core mediating role in the relationship between relational and mandatory influence strategies and headquarter trust in B2B food materials distribution context. Research design, data, and methodology - For these purposes, the authors collected the data from 208 B2B specialized complex agents. We used the 2,200 B2B specialized complex agents which trade with CJ, Ottogi, and Daesang firms and supply food materials to restaurant, school cafeteria, supermarket and traditional market as a sample frame. Once we identified 330 B2B specialized complex agent owners, CEOs, and/or Directors who had agreed to participate in this study, we dropped off a questionnaire at each B2B specialized complex agent and explained the purpose of this study. The survey was conducted from October 1, 2015 to December 15, 2015. A total of 230 questionnaires were collected. Of these collected questionnaires, 28 questionnaires excluded since they had not been fully completed. The data were analyzed using frequency test, reliability test, measurement model analysis, and structural equation modeling with SPSS and SmartPLS 2. Results - First, information exchange, recommendation, and promise of relational influence strategies had positive effects on sales representative trust. The threat of mandatory influence strategies had a negative effect on sales representative trust, but legal plea and request did not have a significant effect on sales representative trust. Second, information exchange and recommendation of relational influence strategies had positive effects on headquarter trust, but promise did not. Also, legal plea, request, and threat of mandatory influence strategies did not have a significant effect on headquarter trust. Third, this findings show that sales representative trust plays a partial mediator between information exchange and headquarter trust, and threat and headquarter trust, and a full mediator between promise and headquarter trust, and recommendation and headquarter trust. Conclusions - The aim of this study was to examine the effects how diverse dimensions of relational and mandatory influence strategies relate to sales representative trust and headquarter trust. To do so, we integrated the influence strategies and the trust transfer theory to hypothesize that various influence strategies increase sales representative and headquarter trust. The findings of this study suggest that headquarter firms should establish and enforce proper influence strategies guidelines to make clear what proper actions sales representatives should implement in relationship with B2B specialized complex agents. Also, relational and mandatory influence strategies must be regarded as a long-term and ongoing strategy that eventually build a long-term orientation with B2B specialized complex agents and guarantee a company's sustainable growth and success.

Influences of School Food Service Dietitians' Job Satisfaction and Perception of Barriers to HACCP Implementation on Food Sanitation/Safety Management Performance in Gyeongbuk Province (영양사의 직무만족도와 HACCP 시스템 적용 장애요인 인식정도가 위생.안전관리 수행에 미치는 영향 - 경북지역 학교급식소를 대상으로 -)

  • Lee, Gyeong-Eun;Lee, Hye-Sang
    • Journal of the Korean Dietetic Association
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    • v.11 no.2
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    • pp.179-189
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    • 2005
  • The purpose of the study was to investigate the relationships between dietitian’s job satisfaction and perception of barriers to HACCP implementation and food safety/sanitation management performance in school food service. An e-mail survey was conducted to 144 dietitians in Gyeongbuk Province. A response rate was 57.6%(N=83) and data were analyzed using SPSS Windows(ver. 10.0). Dietitians were more satisfied with ‘supervision’ and 'co-workers' than 'pay' and 'promotion.' Dietitians perceived 'lack of teachers' support on student education' and ‘limited availability of facilities/equipment' as the biggest challenges in implementing a HACCP system. A total score of sanitation/safety management performance evaluated by school districts was 92 out of 100. By category, 'safety management' and 'personal hygiene' were rated the highest whereas 'facilities/equipment' and 'HACCP system' categories were rated the lowest. The food sanitation/safety management performance scores were not correlated to dietitian’s job satisfaction, but significantly correlated to dietitian’s perceptions of barriers to HACCP implementation. As dietitians perceived facilities/equipment-related barriers greater, the scores of 'facilities/equipment(p<.01),' 'production process(p<.05),' and 'total score(p<.01)' were significantly lower. The findings suggest that more investment on facilities/equipment are needed for food safety improvement and successful HACCP implementation in school food service. Proper facilities and equipment will make employees monitor CCPs and take corrective actions more easily.

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Assessment and Corrective Measures of Child-care Foodservices by Sanitary Inspection Checklist Suggested by Korea Food and Drug Administration (식품의약품안전처의 위생점검표에 의한 육아지원기관 급식소 평가 및 개선대책)

  • An, Su-Jung;Moon, Hye-Kyung
    • Journal of the Korean Dietetic Association
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    • v.21 no.3
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    • pp.227-240
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    • 2015
  • The purpose of this study was to assess the hygiene status of 145 child-care foodservices, which were newly registered in the Center for the Children's Foodservice Management (CCFSM) in Changwon, Gyeongnam. Sanitary inspection checklist (40 food safety items) of Korea Food and Drug Administration (KFDA) was used by the CCFSM in Changwon, Gyeongnam. Average score from the total safety items in 145 child-care foodservices was 21.41 points out of 40 points. Score gaps between the lower group (71 foodservices, 13.92 points) and higher group (74 foodservices, 28.61 points) showed a significant difference (P<0.001). The top five priorities of sanitary measures needing corrective actions for child-care foodservices were as follows: 'provide hand washing and sanitizing tools, and supply manuals on how to wash hands properly', 'supply record form for access/inspection', 'conduct education for cooks on standards in the selection of sanitizer for raw vegetables and proper methods to wash and sanitize raw vegetables', 'provide a refrigerator and a freezer with installed thermometers and temperature record monitoring logs', 'encourage separation of contamination operating zone and clean zone or conduct training for cooks on ways to prevent cross-contamination by performing work separately by the hour'. For the higher group, most were national/public facilities (83.3%), whereas in the lower group, private facilities (62.1%) were more common than national/public ones (37.9%). Therefore, a significant difference (P<0.001) was detected in the two groups. These private facilities should be supported.

Process operation improvement methodology based on statistical data analysis (통계적 분석기법을 이용한 공정 운전 향상의 방법)

  • Hwang, Dae-Hee;Ahn, Tae-Jin;Han, Chonghun
    • 제어로봇시스템학회:학술대회논문집
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    • 1997.10a
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    • pp.1516-1519
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    • 1997
  • With disseminationof Distributed Control Systems(DCS), the huge amounts of process operation data could have been available and led to figure out process behaviors better on the statistical basis. Until now, the statistical modeling technology has been susally applied to process monitoring and fault diagnosis. however, it has been also thought that these process information, extracted from statistical analysis, might serve a great opportunity for process operation improvements and process improvements. This paper proposed a general methodolgy for process operation improvements including data analysis, backing up the result of analysis based on the methodology, and the mapping physical physical phenomena to the Principal Components(PC) which is the most distinguished feature in the methodology form traditional statistical analyses. The application of the proposed methodology to the Balst Furnace(BF) process has been presented for details. The BF process is one of the complicated processes, due to the highly nonlinear and correlated behaviors, and so the analysis for the process based on the mathematical modeling has been very difficult. So the statisitical analysis has come forward as a alternative way for the useful analysis. Using the proposed methodology, we could interpret the complicated process, the BF, better than any other mathematical methods and find the direction for process operation improvement. The direction of process operationimprovement, in the BF case, is to increase the fludization and the permeability, while decreasing the effect of tapping operation. These guide directions, with those physical meanings, could save fuel cost and process operator's pressure for proper actions, the better set point changes, in addition to the assistance with the better knowledge of the process. Open to set point change, the BF has a variety of steady state modes. In usual almost chemical processes are under the same situation with the BF in the point of multimode steady states. The proposed methodology focused on the application to the multimode steady state process such as the BF, consequently can be applied to any chemical processes set point changing whether operator intervened or not.

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A Study on the Influencing Factors of Knowledge Sharing at GKMC (GKMC하 지식공유영향요인에 관한 연구)

  • Song, Chung Geun
    • Informatization Policy
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    • v.21 no.3
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    • pp.85-101
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    • 2014
  • This study analyzed the influencing factors for knowledge sharing at GKMC, and then tried to illuminate the policy meanings implied in the results. To build a framework of analysis, reviewing the KM-related studies, the author selected five influencing factors for knowledge sharing, such as CMC quality, community commitment, structural social capital, cognitive social capital, and relational capital, and actors, and identified the fact that all the factors have a positive effect on knowledge sharing. In the case of Kwang-ju metropolitan city, the first factor that affects knowledge sharing is community commitment, the second one is CMC quality, and the third one is structural social capital. This result means that to succeed in knowledge sharing, the local government managers should try to shape the bonding among members, and then to get rid of the causes of complaints. In addition, local government also needs to predict problems claims and take proper actions for GKMC to be used conveniently through monitoring their work continuously. Furthermore, they should make a free and happy working environment, closely examining the change of the relationship among social capitals.

Effects of Antithyroid Drugs on Accidentally Internal Contamination of Iodine-131 (Iodine-131 체내오염 사고에 대한 항갑상선제의 효과)

  • Chung, In-Yong;Kim, Tae-Whan;Chin, Soo-Yil;Yun, Taik-Koo
    • Journal of radiological science and technology
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    • v.11 no.1
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    • pp.63-69
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    • 1988
  • In case of occuring the atomic energy accidents the proper medical treatments should be necessary. As the aim of the basic data for protective actions, the present studies were carried out to evaluate the decontamination of radioiodine by the administration of the antithyroid drugs (KI, NaI) and isotonic saline. Some recommended methods of decorporating radioiodine were investigated using 450, NIH-GP mice, each injected intraperitoneally with $1{\mu}Ci$ of $NaI^{131}$ as the internal contamination and treated with 2mg/0.2ml-saline of NaI and 2.6mg/0.2ml-saline of KI as the antithyroid drugs. Accordingly, effects of antithyroid drugs for internal contamination were: 1. Administration of NaI and KI caused to rapidly excrete internal radioiodine as the antithyroid drugs and decrease in whole body retention was reduced than in the saline group. 2. After internal contamination NaI and KI were to be administered for radioprotective effects as quickly as possible. 3. Decrease in body-retention made temporary shifts with enough fluids (water), however, as far as radioprotective effects is concerned, saline was not more significant than in the other group (NaI and KI). 4. Regarding to thyroid protective effects NaI, KI and saline were significant in effectively order.

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A Study on the Proper Position of Guide Sign for Bikeway in Korea (자전거 도로의 안내표지 설치 위치에 관한 연구)

  • Jeong, Gyu-Su;Lee, Yeong-In
    • Journal of Korean Society of Transportation
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    • v.28 no.6
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    • pp.99-108
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    • 2010
  • Due to the recent emergence of global warming concerns, the UN has made the issue of climate change its top priority. Accordingly, Korea has announced a new national master plan titled, 'Participation in global efforts in climate change through -Low Carbon, Green Growth-'. As part of the plan, the constructions of bicycle path networks are being pushed forward. Although the building of bicycle paths and infrastructure is being implemented, little consideration has been given for bicycle path signage. This essay is the study of methodology in the installation of signs on bicycle paths. The research includes a theoretical study of the standard and installation position of signs with consideration of the geometry of bicycles as well issues such as the distance required for the bicyclist to recognize and understand the road sign and to take actions like stopping, In addition, experimental verification of the test results has been carried out. Also, the test on height of signs by changing the installation heights according to a bicyclist's forward vision angle has been conducted.