• Title/Summary/Keyword: problem in controlling

Search Result 665, Processing Time 0.028 seconds

Anti-obese Effects and Signaling Mechanisms of Chaenomeles sinensis extracts in 3T3-L1 Preadipocytes and Obese Mice Fed a High-fat Diet (3T3L-1 지방전구세포와 고지방식이로 유도된 비만 마우스 모델에서 모과 추출물의 항비만 효과와 억제 기전)

  • Kim, Da-Hye;Kwon, Bora;Kim, Sang Jun;Kim, HongJun;Jeong, Seung-Il;Yu, Kang-Yeol;Kim, Seon-Young
    • Herbal Formula Science
    • /
    • v.25 no.4
    • /
    • pp.457-469
    • /
    • 2017
  • Obesity is one of the most serious health problem because it induced numerous metabolic syndrome and increases the incidence of various disease, including diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. In 3T3-L1 adipocytes, increases in reactive oxygens species (ROS) occur with lipid accumulation. NADPH oxidase, producing superoxide anion, may contribute to the development of obesity-associated insulin resistance and type 2 diabetes. In this study, we elucidated the effect of Chaenomeles sinensis koehne extract (CSE) against the development of obesity and the inhibition mechanisms in 3T3-L1 preadiocytes. CSE decreased triglyceride content and inhibited the expression of adipogenic transcription factors including peroxisome proliferator-activated receptor $(PPAR){\gamma}$, CCAT/enhancer binding protein $(C/EBP){\alpha}$ and sterol regulatory element-binding protein (SREBP-1). In addition, CSE highly increased antioxidant activity in a dose-dependent manner. CSE remarkably reduced intracellular ROS increase and NAD(P)H oxidase activity, NOX1, NOX4, Rac1 protein expression, and phosphorylation of p47phox and p67phox We also studied the effect of CSE on weight gain induced by high-fat diet. The oral treatment of CSE (500 mg/kg, body weight) in diet-induced obese (DIO) mice showed decrease in triglyceride and adipocyte size. Therefore, these results indicate that the effect of CSE on anti-obese effects, adipocyte differentiation and reducing triglyceride contents as well as adipocyte size in obese mice, may be associated with inhibition of NAD(P)H oxidase-induced ROS production and adipose transcription factors. These results showed the potential to inhibit the obesity by CSE treatment through controlling the activation of NAD(P)H oxidase in vitro and in vivo obese model.

The Survey on Construction of Obesity Management Program for Primary, Middle and High Schools (초 . 중 . 고등학교 비만관리프로그램 구축에 관한 연구)

  • 김이순;주현옥;신유선;송미경
    • Korean Journal of Health Education and Promotion
    • /
    • v.19 no.3
    • /
    • pp.97-105
    • /
    • 2002
  • This study attempts to develop a program for obesity prevention and management for students in primary, middle, and high school and was carried based on the program development process as suggested by Ewles and Simnett. Data were collected from September 1st to September 30th, 2000. The study method is as follows: 1) Reviewing the present obesity control programs practiced in primary, middle, and high school (196 schools total) in metropolitan, medium-sized, and small cities, 2) Surveying obesity students'(682 students total) perception of the obesity management in their school. 3) Reviewing the annual plan for obesity in primary, middle, and high schools 4) Analyzing the educational data (CD, VIDEO) for obesity The results are as below: I. The media researched related to obesity were mainly CD and video, aimed primarily primary school students and are biased in nature. 2. The results of how to manage obesity in students: the difficulty of obesity education in the primary school, is the arousal of a sense of shame among obese students and the lack of various educational data are the most. In the middle and high schools, a lack of various educational data, and no time or lack of time were prevailing concerns. Paramount in managing obesity is weight control, as answered by majority of primary, middle, and high school students. The major problem of obesity management is the non-cooperation of children. 3. Asked whether the weight controlling aspect of health care class was helpful or not, 51.4% of primary school students, and 71.6% of middle and high school students answered not. The most popular educational method used in health care class is the computer, with a 56.4% approval rating. Most 43.5% of respondents answered that they wanted the content of obesity management program to focus on how to lose weight. Therefore, based on the results, the obesity management program is constructed to the steps of assessment, planning, implementation, and evaluation. Assessment includes administering surveys on health needs among students and their parents and physique tests. Planning includes the set-up of long term and short term educational goal and the establishment of an operation system. Implementation includes education, exercise, behavior modification, and health service programs. Evaluation includes step-by-step evaluations for obesity reduction. After this study is conducted, the following should be further researched: More practical and systematic obesity management programs should be developed for the evaluation results. In addition, it is important to develop an appropriate media for obesity management the primary, middle and high school students.

A Comparison Between the Perceptions of Elementary Gifted Child and Science Teacher about the Good Science Class (좋은 과학 영재 수업에 대한 학생과 교사의 생각 비교)

  • Yang, Ilho;Choi, Hyun;Lim, Sungman
    • Journal of The Korean Association For Science Education
    • /
    • v.34 no.1
    • /
    • pp.10-20
    • /
    • 2014
  • This study compares the perceptions of elementary gifted child and science teacher in a science class for the gifted. In order to explore the research problem, students and teachers answered a written semi-structured questionnaire and participated in interviews regarding the gifted science class. The data was collected and analyzed. Science teachers recognized the characteristics of a good science class, especially in terms of educational content and teaching methodology. First, they suggested promoting inquiry skills, presenting a challenging task in atypical topic selection, student-centered curriculum, and controlling the pace of learning to recognize individual differences. Second, in terms of the science class skills and attitudes category, teachers recommended raising mutual satisfaction through vigorous interaction within a permissible atmosphere. Finally, science teachers need to strive for continued professional growth. Gifted children, meanwhile, want to investigate a wide range of topics without time constraints. Additionally, they may have to explore challenging topics further. They prefer to act like scientists in that they enjoy group activities, communication and cooperation. In particular, they want to be evaluated by others in a totally embedded assessment. Gifted children also expect teachers to understand the life circumstances and needs of the students. In addition, they asked for teachers to respect individual experiments and to show them how to safely use new equipment or research methods. As a result, gifted children and science teachers have to recognize the differences of opinion concerning a good science class for the gifted. This study can help formulate strategies to establish quality management of materials in gifted science classes.

Study for grain-filling of rice using 13C labeling flow-metabolome analysis

  • Okamura, Masaki;Hirai, Masami Yokota;Sawada, Yuji;Okamoto, Mami;Arai-Sanoh, Yumiko;Yoshida, Hiroe;Mukouyama, Takehiro;Adachi, Shunsuke;Fushimi, Erina;Yabe, Shiori;Nakagawa, Hiroshi;Kobayashi, Nobuya;Kondo, Motohiko
    • Proceedings of the Korean Society of Crop Science Conference
    • /
    • 2017.06a
    • /
    • pp.59-59
    • /
    • 2017
  • Rice (Oryza sativa L.) is the most important crop and its yield must be improved to feed the increasing global population. Recently developed high-yielding varieties with extra-large sink capacity often have a problem in unstable grain-filling. Therefore, understanding limiting factors for improving grain-filling and controlling them are essential for further improvement of rice grain yield. However, since grain-filling rate was determined by complex sink-source balance, the ability of grain-filling was very difficult to evaluate. Source ability for 'grain' was not only determined by the ability of carbon assimilation in leaves, but also that of carbon translocation from leaves to panicles. Sink strength was determined by the complex carbon metabolism from sucrose degradation to starch synthesis. Hence, to evaluate the grain-filling ability and determine its regulatory steps, the whole picture of carbon flow from photosynthesis at leaves to starch synthesis at grains must be revealed in a metabolite level. In this study, the yield and grain growth rate of three high-yielding varieties, which show high sink capacity commonly, were compared. Momiroman showed lower grain filling rate and slower grain growth rate than the other varieties, Hokuriku 193 and Tequing. To clarify the limiting point in the carbon flow of Momiroman, $CO_2$ labeled by stable isotope ($^{13}C$) was fed to three varieties during ripening period. The ratio of $^{13}C$ left in the stem was higher in Momiroman 24 hours after feeding, suggesting inefficient carbon translocation of Momiroman. More interestingly, $^{13}C$ translocation from soluble fraction to insoluble one in the grain seemed to be slower in Momiroman. To get the further insight in a metabolite level, we are now trying the $^{13}C$ labeling metabolome analysis in the developing grains.

  • PDF

Effect of Cultural Practices on the Occurrence of Pod and Stem Blight and Purple Blotch, and on Soybean Growth (콩 재배방법이 미이라병과 자주무늬병의 발생 및 식물생육에 미치는 영향)

  • 오정행;김동윤
    • Research in Plant Disease
    • /
    • v.7 no.2
    • /
    • pp.107-111
    • /
    • 2001
  • Deterioration of pod and seed quality by pod and stem blight and purple blotch is a serious problem in the production of vegetable soybean. Major inoculum sources for the causal pathogens, Phomopsis spp. and Cercospora kikuchii, are soybean straw and debris. Phomopsis spp. have been known to be either limited for hyphal growth or latent in immature soybean tissues. In this experiment, cultural practices using these ecological traits of the pathogens were applied as a control measure. In plastic mulching, seed infection was remark ably reduced by drip irrigation as compared to overhead sprinkling, but not reduced in no mulching cultivation. Control value of plastic mulching was 28.0% for pod and stem blight and 29.3% for purple blotch, which was lower than that of benomyl application. By the first week in June, 78% of overwintered soybean straw examined contained matured alpha spores in pycnidia, acting as primary inoculum. Secondary inoculum of phomopsix spp. was observed abundantly throughout from mid June to September on fallen cotyledons from current crops and subsequently was found on petiole debris. Consequently, both plastic mulching and drip irrigation were effective to some extent for controlling pod and stem blight and purple blotch without significant reduction in soybean yield, and the cultural practices in combination with field sanitation resulted in removing more the secondary inoculum.

  • PDF

Studies on Manufacturing Wood Particle-Polypropylene Fiber Composite Board

  • Lee, Chan-Ho;Eom, Young-Geun
    • Journal of the Korean Wood Science and Technology
    • /
    • v.29 no.3
    • /
    • pp.47-58
    • /
    • 2001
  • For finding both ways of recycling the wood and plastic wastes and solving the problem of free formaldehyde gas emission through manufacturing wood particle-polypropylene fiber composite board without addition of formaldehyde-based thermosetting resin adhesive, control particleboards and nonwoven web composite boards from wood particle and polypropylene fiber formulation of 50 : 50, 60 : 40, and 70 : 30 were manufactured at density levels of 0.5, 0.6, 0.7, and 0.8 g/$cm^3$, and were tested both in the physical and mechanical properties according to ASTM D 1037-93. In the physical properties, control particleboard had significantly higher moisture content than composite board. In composite board, moisture content decreased with the increase of target density only in the board with higher content of polypropylene fiber and also appeared to increase with the increase of wood particle content at a given target density. Control particleboard showed significantly greater water absorption than composite board and its water absorption decreased with the increase of target density. In composite board, water absorption decreased with the increase of target density at a given formulation but increased with the increase of wood particle content at a given target density. After 2 and 24 hours immersion, control particleboard was significantly higher in thickness swelling than composite board and its thickness swelling increased with the increase of target density. In composite board, thickness swelling did not vary significantly with the target density at a given formulation but its thickness swelling increased as wood particle content increased at a given target density. Static bending MOR and MOE under dry and wet conditions increased with the increase of target density at a given formulation of wood particle and polypropylene fiber. Especially, the MOR and MOE under wet condition were considerably larger in composite board than in control particleboard. In general, composite board showed superior bending strength properties to control particleboard, And the composite board made from wood particle and polypropylene fiber formulation of 50 : 50 at target density of 0.8 g/$cm^3$ exhibited the greatest bending strength properties. Though problems in uniform mixing and strong binding of wood particle with polypropylene fiber are unavoidable due to their extremely different shape and polarity, wood particle-polypropylene fiber composite boards with higher performance, as a potential substitute for the commercial particleboards, could be made just by controlling processing variables.

  • PDF

A Study of High School Students' and Science Teachers' Understanding of Ideal Conditions involved in the Theoretical Explanation and Experiment in Physics: Part II- Focused on the Implications to the Physics Learning - (물리학에서 이론적 설명과 실험에 포함된 이상조건에 대한 고등학생과 과학교사의 이해조사 II-이상화가 물리학습에 주는 시사점을 중심으로-)

  • Park, Jong-Won;Chung, Byung-Hoon;Kwon, Sung-Gi;Song, Jin-Woon
    • Journal of The Korean Association For Science Education
    • /
    • v.18 no.2
    • /
    • pp.245-256
    • /
    • 1998
  • In this study, we discussed about the implications of the idealization, which take an important role in physics, to the physics education. First, understanding of the idealization help the physics learning itself. This is because that various types of idealizations are included in the physics terms and concepts, derivation processes of physics laws and formulas, and explanation of natural phenomena and problem solving activities. Second, understanding of the idealization can help the application of the physics world to the real world. That is, by understanding the extent and the limit of idealization used in physics world, physics students can understand the discrepancies between the real world and the physics world. And also, by modifying or eliminating the idealization, students can extend the extent of understanding about how predictions based on the idealization used in the physics world will change. To do this, we suggested the application of computer simulation program in physics laboratories. Third, idealization take an important role in the inquiry learning for students' originality. The activities of identifying or controlling the variables, as one of the principal factors of scientific inquiry, need the appropriate establishment of the ideal conditions. And to analyze the limiting case or practice the thought experiments for understanding the impossible situation in the real world, ideal conditions also are needed. This study discussed above three aspects with various concrete examples and, with Park et al.'s study (Park et al., 1998), present the theoretical basis for the study of students' and teachers' understanding the idealization.

  • PDF

Development of U-Service Priority Model Based on Customer and Provider's View (수요·공급자를 통합한 u-서비스 우선순위 평가모형 개발)

  • Jang, Jae-Ho;Um, Jung-Sup
    • Journal of the Korean Association of Geographic Information Studies
    • /
    • v.11 no.2
    • /
    • pp.132-147
    • /
    • 2008
  • So far ubiquitous service (u-service) priority has seldom been empirically examined based on the customer's view. It is usual to prioritize the relative importance of u-service variables by the supplier's intuition and a few specialist's experienced knowledge. Such approaches have the disadvantage that they provide only limited empirical information on the field practices in relation to u-service since customer demand of u-service is poorly defined despite abundant interest in this problem. Therefore, the aim of this research was to develop u-service priority model in the context of multi-criteria framework integrating customer and supplier's view, using high technology acceptance theory as major controlling factors. An important question was how to measure or represent criteria that is important to u-service and should be included in a priority model. The selection criteria for the model variables were derived from high technology acceptance theory and AHP approach through the analysis of frequency count, elimination of overlapping factors and brainstorming with specialists. Daegu showed top-rankings in transportation-aid service, guidance service for the eyesight disabled and u-telematics service. In contrast, disaster prevention service and industrial specialized town service ranked highly in the typical supplier's approach were not a dominant determining factor in the u-service priority. The model identified the fact that typical high priority service in terms of supplier's view did not necessarily accompany the important predictor for the u-service priority.

  • PDF

A study on the smoke control performance of the damper exhaust system at FCEV fire in tunnel for small vehicles (소형차 전용터널 내 수소연료전지차 화재시 집중배기방식의 제연성능에 관한 연구)

  • Hong, Seo-Hee;Baek, Doo-San
    • Journal of Korean Tunnelling and Underground Space Association
    • /
    • v.24 no.6
    • /
    • pp.745-756
    • /
    • 2022
  • The road tunnel is a semi-closed space that is blocked on all sides except the entrance and exit, and in the event of a fire, the smoke of the fire spreads longitudinally due to heat buoyancy caused by the fire and air currents that always exist in the tunnel. To solve this problem, smoke removal facilities are installed in road tunnels to secure a safe evacuation environment by controlling the direction of movement of smoke or directly smoking at fire points. In urban areas, the service level of urban roads decreases due to the increase in traffic due to the increase in population, and as a solution, the construction of underground roads in urban areas is increasing. When a fire occurs during hydrogen leakage through TPRD of a hydrogen fuel cell vehicle (FCEV), the fire intensity depends on the amount of leakage, and the maximum fire intensity depends on the orifice diameter of the TPRD. Considering the TPRD orifice diameter of 1.8 mm, this study analyzed the diffusion distance of fire smoke according to the wind speed of the roadway and the opening interval of the large exhaust port when the maximum fire intensity was 15 MW. As a result, it was analyzed that air flow in the tunnel could be controlled if the wind speed of the road in the tunnel was less than 1.25 m/s, and smoke could be controlled within 200 m from the fire if the damper interval was 50 m and 100 m.

사회복지사 개인간 갈등 형성요인에 관한 연구

  • Kim, Gyo-Jeong
    • 한국사회복지학회:학술대회논문집
    • /
    • 2004.10a
    • /
    • pp.223-250
    • /
    • 2004
  • In this paper, the proposing a fundamental data for a systematic and effective organizational management by examining the extent of the levels of conflict perceiving among individuals of social welfare workers in the Busan community social welfare center, a social welfare organizations, and investigating the related influencing factors are the purpose of the study, The summary of this study is as follows. At first, it is dysfunctional when the level of conflict is either exceedingly high or low in the interrelational conflict aspect. However, the social welfare workers' working in the community social welfare center, the extent of individual conflict is relatively low as 2.37 out of 5 points. Secondly, the multi-regression analysis is operated for controlling the population sociological factors and measuring the effectiveness of the conflict factors to the level of conflict. The influencing factors affects the result in the order of greater extent are communication factor, leader's flexibility of leadership factor, spontaneity among personality, confidentiality. As a result, Not like the case that in the technological bureaucratic organizations such as the enterprises or industrial organizations, in the human service organizations including social welfare organizations, these technological bureaucratic paradigm does not applying directly since the material of organization is composed of humans who are given moral values. Therefore, this paradigm should be put as a presupposition of the conflict management strategy. And, the communication among colleagues, learning a reasonable problem solution method, or the chances of education or training for establishing a sound human relationship should be prepared in order to lower the level of the conflict among individuals in the community social welfare department. Furthermore, professional education programs are needed for not only supporting an effective supervision and consultation(consultation with superiors and colleagues), but also, working with confidentiality and pride as a professional.

  • PDF