• Archives of Pharmacal Research
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• 제12권3호
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• pp.160-165
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• 1989

Binding of sulfaethidole to bovine serum albumin was studied by equilibrium dialysis, fluorescence probe technique, uv difference spectrophotometry and circular dichroism. Equilibrium dialysis method enabled us to estimate the total number of drug binding sites of albumin molecule. For sulfaethidole, albumin had 6 primary and 40 secondary binding sites. The primary and secondary binding constants were 0.9 * 10/sup 5/ M/sup -1/ and 0.2 * 10/sup 6/ M/sup -1/, respectivitely. 1-Anilino-8-naphthalenesulfonate (ANS) and 2-(4-hydroxylbenzeneazo)- benzoic acid (HBAB) were used as the fluorescence probe and the uv spectrophotometric probe, respectively. In fluorescence probe technique, results indicated that the number of higher affinity drug binding site of albumin was 1 and the number of lower affinity drug binding sites of albumin was 3, and the primary and secondary drug binding constants for bovine serum albumin were 2.15 * 10/sup 5/M/sup -1/ and 1.04 * 10/sup 5/ M/sup -1/, respectively. In uv difference spectrophotometry, binding sites were 3 and binding constant was 1.88 * 10/sup 5/M/sup -1/. The above spectrophotometry, binding sites were 3 and binding constant was 1.88 * 10/sup 5/M/sup -1/. The above results suggest that several different methods should be used in ompensation for insufficient information about drug binding to albumin molecule given by only one method.

• 전자공학회논문지SC
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• 제45권3호
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• pp.80-85
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• 2008

기존의 캡슐형 내시경은 공간적 제약으로 인해 약 30mW 용량의 1차 전지를 사용한다. 그러나 1차 전지를 사용하는 방식은 배터리 용량의 한계와 1회용 소모품으로 가격이 비싸다. 이러한 문제를 해결하기 위해 신체 외부에서 캡슐형 내시경에 무선으로 에너지를 전송 방식을 제안하였다. 제안된 방식은 송 수신측 양단에 LC공진 회로를 이용하여 $10{\sim}20cm$의 공극을 통해 송신측 코일에서 캡슐형 내시경으로 에너지를 전달하는 방식이다. 위치와 방향성에 상관없이 에너지 효율의 증가를 위해 수신측 코일은 페라이트 코어를 이용한 3축 권선 방식을 이용하였다. 실험에 의한 측정 결과 제안된 방식은 수신측 회로에 안정적으로 30mW의 전력을 공급할 수 있음을 확인하였다.

• 한국발생생물학회지:발생과생식
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• 제20권4호
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• pp.367-377
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• 2016

Red spotted grouper, Epinephelus akaara, is a popular aquaculture species and a protogynous hermaphrodite. Induction of artificial sex change at the time of primary sex differentiation is of interest but has not been successful due to the lack of necessary basic information. To find out the potential neuroendocrine influence on the primary sex differentiation, the expression of key genes in the brain was investigated during the formation of ovarian cavity. Expression of cyp19a1b, esr1, gnrhr1, fsh, lh and cga in the brain was positively associated with the formation of ovarian cavity, showing gradual increase as the formation proceeds. However, the expression of gnrh1 was suppressed during the early part of the ovarian cavity formation, signifying potential hypothalamic influence on the primary sex differentiation in this species.

• Childhood Kidney Diseases
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• 제22권2호
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• pp.67-70
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• 2018

Primary polydipsia (PP) is marked by an increase in thirst, and most often presents in patients with psychiatric illnesses. Although uncommon in children, we experienced cases of PP in a 15-month-old boy and a 5-year-old girl. Both were admitted to the hospital with symptoms of polydipsia and polyuria that appeared 1-3 months before admission. Brain magnetic resonance imaging in both patients was normal. A water restriction test was performed after hospitalization and showed normal results. The symptoms improved after the parents were instructed to implement water-intake restriction for 2 weeks. Our report provides useful information for the treatment of PP in children.

• The Journal of Korean Physical Therapy
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• 제17권3호
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• pp.421-428
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• 2005

The tenn 'Brain plasticity' has been identified that our central nervous system is continuously being adapted and modulated according to environmental needs and demands, and has been used to encompass the multifarious mechanisms related to learning, development, and recovery from damage to the nervous system. The purpose of this study was to demonstrate cortical reorganization in a 26-year-old right-handed hemiparetic patient with traumatic primary motor cortex (M1) injury, using functional MRI (fMRI). The unaffected (left) primary sensori-motor cortex centered on the precentral knob was activated during unaffected (right) hand movements. However, the medial area of the injured M1 was activated during affected (left) hand movements. It seems that the motor function of the affected hand in this patient was reorganized into the medial area of the injured precentral knob. These investigations provide a great useful information and clinical evidences with the specialized clinician in stroke physical therapy about patient's prognosis and therapeutic guidelines.

• Journal of Communications and Networks
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• 제16권2호
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• pp.130-139
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• 2014

Due to the unpredictable nature of channel availability, carrying delay-sensitive traffic in cognitive radio networks (CRNs) is very challenging. Spectrum leasing of radio resources has been proposed in the so called coordinated CRNs to improve the quality of service (QoS) experienced by secondary users (SUs). In this paper, the performance of coordinated CRNs under fixed-rate with hard-delay-constraints traffic is analyzed. For the adequate and fair performance comparison, call admission control strategies with fractional channel reservation to prioritize ongoing secondary calls over new ones are considered. Maximum Erlang capacity is obtained by optimizing the number of reserved channels. Numerical results reveal that system performance strongly depends on the value of the mean secondary service time relative to the mean primary service time. Additionally, numerical results show that, in CRNs without spectrum leasing, there exists a critical utilization factor of the primary resources from which it is not longer possible to guarantee the required QoS of SUs and, therefore, services with hard delay constraints cannot be even supported in CRNs. Thus, spectrum leasing can be essential for CRN operators to provide the QoS demanded by fixed-rate applications with hard delay constraints. Finally, the cost per capacity Erlang as function of both the utilization factor of the primary resources and the maximum allowed number of simultaneously rented channels is evaluated.

• 대한전자공학회논문지TC
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• 제47권10호
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• pp.43-48
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• 2010

비동기 W-CDMA 시스템에서의 초기 셀 탐색 과정은 일반적으로 슬롯 동기 획득, 프레임 동기 획득, 그리고 프라이머리 스크램블링 코드 획득의 3단계로 수행되며, 본 논문에서는 이 중 두 번째 단계인 프레임 동기 획득과정을 고려한다. 프레임 동기 획득 시 P-SCH (primary synchronization channel)로부터 채널을 추정하여 사용하는 방식을 coherent 검출 방식이라 하며, 본 논문에서는 기존의 coherent 검출 방식의 성능 개선을 위해 P-SCH로부터 추정된 채널 값에 1차 순환 필터(first order recursive filter)를 사용하는 간단한 형태의 검출 방식을 제안한다. 컴퓨터 모의실험을 통해 제안된 방식이 기존 방식틀에 비해 주파수 오차 범위가 넓은 환경에서 프레임 동기 검출 성능이 우수함을 보이고자 한다.

• Journal of Communications and Networks
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• 제13권4호
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• pp.360-366
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• 2011

In this paper, we investigate the problem of power allocation in a heterogeneous network that is composed of a pair of cognitive users (CUs) and an infrastructure-based primary network. Since CUs have only limited effective spectrum-sensing ability and primary users (PUs) are not active all the time in all locations and licensed bands, we set up a new multi-area model to characterize the heterogeneous network. A novel combined interference-avoidance policy corresponding to different PU-appearance situations is introduced to protect the primary network from unacceptable disturbance and to increase the spectrum secondary-reuse efficiency. We use dual decomposition to transform the original power allocation problem into a two-layer optimization problem. We propose a low-complexity joint power-optimizing method to maximize the transmission rate between CUs, taking into account both the individual power-transmission constraints and the combined interference power constraint of the PUs. Numerical results show that for various values of the system parameters, the proposed joint optimization method with combined PU protection is significantly better than the opportunistic spectrum access mode and other heuristic approaches.

• Journal of Communications and Networks
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• 제15권1호
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• pp.102-110
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• 2013

This paper considers a cooperative orthogonal frequency division multiple access (OFDMA)-based cognitive radio network where the primary system leases some of its subchannels to the secondary system for a fraction of time in exchange for the secondary users (SUs) assisting the transmission of primary users (PUs) as relays. Our aim is to determine the cooperation strategies among the primary and secondary systems so as to maximize the sum-rate of SUs while maintaining quality-of-service (QoS) requirements of PUs. We formulate a joint optimization problem of PU transmission mode selection, SU (or relay) selection, subcarrier assignment, power control, and time allocation. By applying dual method, this mixed integer programming problem is decomposed into parallel per-subcarrier subproblems, with each determining the cooperation strategy between one PU and one SU. We show that, on each leased subcarrier, the optimal strategy is to let a SU exclusively act as a relay or transmit for itself. This result is fundamentally different from the conventional spectrum leasing in single-channel systems where a SU must transmit a fraction of time for itself if it helps the PU's transmission. We then propose a subgradient-based algorithm to find the asymptotically optimal solution to the primal problem in polynomial time. Simulation results demonstrate that the proposed algorithm can significantly enhance the network performance.

• 한국임상수의학회지
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• 제24권3호
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• pp.457-460
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• 2007

Primary hyperparathyroidism (PHP) is rare in dogs. Mainly functional solitary parathyroid adenoma causes hypercalcemia due to excessive autonomous secretion of parathyroid hormone (PTH). PHP can be diagnosed based on serum calcium phosphorus, ionized calcium and PTH, and cervical ultrasound provides important information about the number size and location of parathyroidal lesion. Ultrasound guided intralesional ethanol injection has been used as an alternative to surgical treatment of PHP. In this case, PHP was diagnosed in 12 year-old Pug with clinicopathologic examination and cervical ultrasound, and the parathyroidal mass was ablated successfully through ultrasound guided ethanol injection.