• Journal of the korean academy of Pediatric Dentistry
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• v.27 no.2
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• pp.229-236
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• 2000

For the purpose of evaluating the microleakage of compomer restorations in cervical cavities of primary molars according to the length of etching time, an experiment was performed through next procedures. 48 extracted human primary molars were divided into 6 groups according to applied compomers and the etching time of 0, 15, 30 seconds. All the restorations were filled under the manufacturer's direction, and the degree of dye penetration was evaluated with stereomicroscope. The microleakage of etch group was measured and statistically analyzed and obtained the results as follows: 1. Compared with groups without etching, the degree of microleakage was reduced by acid etching the cavities (p<0.05). 2. There revealed similar preventive effects of microleakage when the teeth were etched for 15 seconds and 30 seconds respectively(p>0.05). 3. No significant difference was observed between two compomers examined in this study(p>0.05). It was, therefore, thought acid etching is effective to minimize the microleakage of compomer restorations in primary teeth, and in cases of performing, 15 seconds is adequate for etching.

• Korean Journal of Occupational Health Nursing
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• v.10 no.2
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• pp.142-152
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• 2001

This study examined all the papers published in the Journal of Occupational Health Nursing from 1991 to May 2000 based on an objective frame of evaluation. The purpose of study is to prospect the trend of occupational nursing research and to provide an optimal direction for future occupational nursing service. The results of total 94 studies were analyzed as follows. 1. The number of papers published in 1991-1992, 1993-1995, 1996-1997 was not significantly increased. However, the number of papers were obviously increased after 1998. 2. In the design of research, survey studies were definitely dominant. But, they are gradually decreasing and experimental studies are increasing. 3. In the fields of research, health problems, health risk factors and health awareness were higher than others. Occupational health nurse's task and job satisfaction were main areas of research until the middle of 1990's. However, after then, not only health problem, risk factor and awareness of health but also health promotion and preventive health behavior are increasing in the research areas. 4. The collaborative researches have gradually increased and the type of author has been varied. The number of researches completed by funds was undertaking only 3 among the total 94. 5. In the research analysis, except for case studies and literature studies, the research subjects have been shifted from the occupational health nurses to the industrial workers, and more diversified. The sample size has been enlarged and the major place of the study is industry. The questionnaire was used in many studies as instrument for data collection and measurement. But, complementary methods of diverse instruments have been increased. The method of data analysis has obviously showed some changes moving from descriptive statistics to inferential and advanced statistics. 6. The ways of nursing intervention have prominently diversified in experimental studies. The contents of case studies were mainly focused on the health management programs and activities in industry. The research concepts and the contents of literature study were also changed progressively in various way. Based on the above findings, conclusions are extended to the following discussion: Since the Korean Academic Society of Occupational Health Nursing was instituted in 1990, the researches of occupational health nursing have shown an acute methodological development in both quantity and quality. However, they were considered still in the lack of research verifying the effects of nursing intervention program. Also, the development of nursing intervention and nursing theory lacked. Therefore, more empirical researches are strongly needed to utilize the field of occupational health nursing in Korea Researchers are also encouraged to exert more efforts to get research funds.

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.8
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• pp.1119-1125
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• 2010

To evaluate resveratrol as a prostate cancer preventive material, we investigated its anti-proliferative and apoptotic effects in RC-58T/h/SA#4 primary human prostate cancer cells. Resveratrol significantly decreased the number of viable RC-58T/h/SA#4 cells in a dose- and time-dependent manner. Resveratrol showed cytotoxicity against RC-58T/h/SA#4, LNCaP, PC-3 human prostate cancer cells with $IC_{50}$ values of 245, 320 and $340\;{\mu}M$, respectively. However the cytotoxic potential of resveratrol against normal RWPE-1 cells was lower ($IC_{50}=982\;{\mu}M$). Resveratrol induced cell death as evidenced by the increased formation of apoptotic bodies, nuclear condensation, sub-G1 phase, and DNA fragmentation. Resveratrol activated initiator caspases 8, and 9 as well as effector caspase 3 in a dose-dependent manner. Furthermore, the general caspase inhibitor z-VAD-fmk significantly inhibited resveratrol-induced apoptosis compared to cells without treatment. These results clearly indicate that resveratrol-induced apoptosis was dependent on caspase activation. Further, resveratrol modulated the down regulation of Bcl-2 (anti-apoptotic), and Bid. However, the level of Bax (pro-apoptotic) remained unchanged. These results suggest that resveratrol induced apoptosis in RC-58T/h/SA#4 cells via a mitochondrial-mediated caspase-dependent pathway, suggesting therapeutic potential against prostate cancer.

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.8
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• pp.1107-1112
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• 2010

This study was conducted to investigate the effect of 70% ethanol and water extract of Korean rough rice ('Ilpum', 'Goami2', 'Keunnun', 'Sulgaeng', 'Baegjinju', and 'Heugkwang') before and after germination on proliferation of human cancer cell lines (HepG2, PC-3, and MCF-7). Antiproliferation effect was higher in ethanol extract than water extract, and was higher in after germination. 'Ilpum' ethanol extract after germination showed higher anti-proliferation effect on HepG2 and PC-3 cell lines than before germination. The cell viability on HepG2 and PC-3 cell lines of 'Ilpum' ethanol extract after germination was 27.23% and 5.05% at 1.0 mg/mL, respectively. The anti-proliferation effect on MCF-7 was the highest in 'Ilpum' and 'Heugkwang' 70% ethanol extract after germination and those cell viabilities were 7.27% and 17.00% at 0.5 mg/mL, respectively. These results suggest that germinated rough rice might have a potentially preventive effect on human cancer cells.

• Preventive Nutrition and Food Science
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• v.15 no.2
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• pp.137-142
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• 2010

Previous studies report that organo-sulfur compounds derived from garlic inhibited smooth muscle cell (SMC) proliferation and induced apoptosis of cancer cells. Recently, lipid-soluble compounds such as diallyl sulfides (DAS) and diallyl disulfides (DADS) have been reported to more effectively suppress tumor cell proliferation. However, there were few studies on the suppressive effects of lipid-soluble garlic sulfur compounds on the proliferation and migration of vascular smooth muscle cells (VSMC). Therefore, this study investigated the effect of DAS and DADS on VSMC proliferation/migration induced by oleic acid (OA), a principal fatty acid in circulating triglyceride of blood stream. Assays performed include a tetrazole (MTT) assay, a wound healing assay and a Western blots. VSMC proliferations were enhanced by OA in a dose-dependent manner at concentrations of $10{\sim}50\;{\mu}M$ and inhibited by DAS and DADS compared to non-treated control. OA-induced proliferations were also attenuated by DAS and DADS. OA-induced cell migrations were 2.5 times higher than non-treated control, and they were significantly attenuated by DAS (32% at $150\;{\mu}M$ and 50% at $200\;{\mu}M$) and DADS (40% at $150\;{\mu}M$ and 46% at $200\;{\mu}M$). OA-induced cell migration was also attenuated by PD98059 (ERK inhibitor), SB203580 (P38 inhibitor) and particularly by LY204002 (PI3K inhibitor) and SP600125 (JNK2 inhibitor). Additionally, Western blot assays showed that OA-induced JNK1/2-phosphorylation was down-regulated after treatment with DAS and DADS. In conclusion, the findings of our study support the idea that DAS and DADS may have a suppressive effect on the proliferation and migration of OA-induced VSMC and that this effect may be partly associated with PI3K and JNK2 pathways.

• Women's Health Nursing
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• v.3 no.2
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• pp.129-156
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• 1997

The purpose of this study is to investigate the relationship between depression and ego identity of middle-aged women and to identify the variables that show differences in the depression and ego identity of middle-aged women. The subjects in the study were 321 mothers of high school students whose age were 40-59 years old. The instruments for this study were Beck Depression Inventory(BDI) developed Beck(1978) and translated by Lee(1981) and Ego identity Scale developed Suh(1975) and modified by Nam(1975). The reliability values of BDI range from 0.83 to 0.87 and Ego identity range from 0.81 to 0.85 using Cronbach alpha. The data were analysed by using the SAS program and included Frequency, percentage Pearson Correlation MANOVA, t-test, ANOVA. The conclusion obtained from this study were as follows ; 1) There was a negative correlation(r=-0.21, p=0.0002) between depression and ego identity of middle-aged women. Thus the lower depression the higher ego identity for middle-aged women. 2) According to the analysis of interacting effects of depression and ego identity, there were significant differences in the household income(F=0.38, p=0.0035), level of education (F=6.50, p=0.0001), satisfaction of marriage(F=10.45, p=0.0001), family pattern (F=6.18, p=0.0001), menopausal status(F=7.23, p=0.0001), present disease(F=4.85, p=0.0110) and health status(F=9.00, p=0.0001). 3) There were significant differences on the level of education(F=12.98, p=0.0001) household income(F=5.78, p=0.0007), support of spouse(F=8.58, p=0.0002), satisfaction of marriage(F=20.08, p=0.0001), menopausal status(F=11.32, p=0.0001), present disease(t=2.76, p=0.0062) and health status(F=17.23, p=0.0001) of the depression of middle-aged women. 4) There were significant differences on the patterns of household(t=-2.64, p=0.0086), support spouse(F=3.58, p=0.0291), satisfaction of marriage(F=3.90, p=0.0212), menopausal status(F=4.59, p=0.0108) and disease(t=2.11, p=0.0359) of the ego identity of middle-aged women. On the basis of the above findings the following recommendations are made ; 1) According to results of this study, middle-aged women's depression is correlated with ego identity. Thus when the nurse plans the preventive strategy of middle-aged women's depression, the nurse must be considered with level of ego identity. 2) To study for middle-aged women in depth, further research is need to study regard to middle-aged men and their children.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3545-3549
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• 2016

Background: The incidence of bladder cancer is lower in Asian than in Western countries. However, the crude incidence and mortality of bladder cancer have recently increased in Japan because of the increased number of senior citizens. We have already reported risk factors for urothelial cancer in a large population-based cohort study in Japan (JACC study). However, we did not evaluate the cancer risk in the upper and lower urinary tract separately in our previous study. Materials and Methods: Here we evaluated the risk of cancer death in the upper and lower urinary tracts, separately, using the database of the JACC study. The analytic cohort included 46,395 males and 64,190 females aged 40 to 79 years old. The Cox proportional hazard model was used to determine hazard ratios and their 95% confidence intervals. Results: Current smoking increased the risk of both upper and lower urinary tract cancer deaths. A history of kidney disease was associated with an increased risk of bladder cancer death, even after controlling for age, sex and smoking status. Conclusions: The present study confirmed that current smoking increases the risk of both upper and lower urinary tract cancer deaths and indicated the possibility that a history of kidney disease may be a risk factor for bladder cancer death in the Japanese population.

• The Journal of the Korea Contents Association
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• v.16 no.3
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• pp.498-512
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• 2016

The purpose of this study was to raise validity of the result through using national data, to analyze the effect of children's smartphone addiction on aggression and moderating effect of parenting styles on the relationship between children's smartphone addiction and aggression. The data were obtained from 4th waves of KCYPS(Korean Children Youth Panel Study), and 1,686 4th graders in elementary schools who have smartphone were analysed. To achieve the purpose, this study executed frequency analysis, descriptive statistic, and hierarchical multiple regression analysis through SPSS 21.0. The results of this study are as follows: First, the higher children's smartphone addiction level, the higher children's aggression goes. Second, parents' supervision, affection, neglect have moderating effects on the relationship between children's smartphone addiction and aggression which means parenting styles could reduce children's aggression despite serious smartphone addiction. Based on these results, this study suggests that the combination of preventive discipline of smartphone addiction and parental education program is needed to reduce children's aggression which is main factor of bullying. In addition, this study suggests the establishment of special arrangement such as 'shut down' for smartphone addiction prevention.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.391-404
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• 2018

The purpose of this study was to determine the status of interventional studies to prevent falling in elderly with dementia and to determine the contents and effectiveness of intervention programs to prevent falling. Existing reports published between January 1, 2000 and December 31, 2016 were searched electronically using the RISS, National Library, KISS, PubMed, and CINAHL database with the keywords dementia, Alzheimer's or Alzheimer's disease, falling, and prevention of falling. After checking the original sources of the articles, 13 articles were included in the review. Therapeutic interventions used in the articles included exercise therapy (8, 61.5%), physiotherapy and occupational therapy (2, 15.4%), complementary therapies (2, 15.4%), and music therapy (1, 7.7%). As a result of the qualitative evaluation of the papers using a checklist of the Scottish Intercollegiate Guideline Network, two studies scored 9 out of 10 points, five studies scored 8 out of 10, and six studies scored 7 out of 10. Intervention sessions were conducted for 55 minutes, on average, for a total of 37 sessions. This study found that exercise, music therapy, physical and occupational therapy, and rhythmic motion therapy were effective in preventing falling in the elderly with dementia. In the future, these findings are expected to be used as a basis for the development of a preventive intervention program for nurses in a clinical setting.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.264-274
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• 2018

This study constructed a prediction model based on covariance structure to identify the causal relationship between job stress, fatigue, burnout, and job satisfaction on turnover intention in nurses working in general hospitals. The study subjects were 648 nurses at a general hospital in D city. Data collection was surveyed by using self-administered questionnaires structured during the period from November 1, 2016 to December 31, 2016. As a result, the level of turnover intention was significantly higher in the group showing higher job stress, fatigue, and burnout and significantly higher in the group showing lower job satisfaction. The turnover intention of subjects showed a significant positive correlation with job stress, fatigue, and burnout but showed a negative correlation with job satisfaction. As a result of covariance structure analysis, job stress had greater influence on turnover intention than fatigue, burnout, and job satisfaction. Higher job stress, fatigue, and burnout and lower job satisfaction were associated with increased turnover intention. The results of this study show that the turnover intention of general hospital nurses is significantly related to job stress, fatigue, burnout, and job satisfaction. In particular, job stress had a greater effect on turnover than fatigue, burnout, and job satisfaction. Therefore, in order to lower the turnover intention of general hospital nurses, it is necessary to seek ways to mitigate job stress.