• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.22 no.1
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• pp.3-9
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• 2011

Autism and autistic spectrum disorder are chronic neuro-developmental disorders characterized by social and language impairments and stereotyped, repetitive patterns of behavior. The etiology of autism remains unknown; however, a strong genetic component has been detected and environmental factors may also be involved in their etiologies. In the current study, we reviewed evidence for the presence of prenatal and perinatal factors, gastrointestinal factors, food allergies, metabolic and heavy metal factors, and other nutritional factors that may represent risk factors for the development of autism and autistic spectrum disorder.

• Speech Sciences
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• v.4 no.2
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• pp.103-113
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• 1998

The human baby appears to be born with preexistent knowledge of language. This specialized neural structure in the brain awaits auditory experience with language to trigger it into functioning. The auditory-linked acquisition of language is a time-locked function related to early maturational periods in the infant's life. The longer auditory language stimulation is delayed, the less efficient the language facility will be. It is for these reasons that it is urgent to fight the hearing problems of children with all the skill, knowledge and insights of which we are capable, the so called 'rehabilitative process'. An understanding of the timetable and the origin of prenatal to early life development of auditory mechanism will help in planning the aural rehabilitation. Further interests and studies are needed to establish the systematic structure of rehabilitative audiology.

• Women's Health Nursing
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• v.22 no.3
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• pp.128-138
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• 2016

Purpose: The purpose of this study was to analyze the concept of happiness among pregnant women. Methods: Walker and Avant's method for concept analysis was used. Results: The defining attributes of happiness among pregnant women were 1) period of pregnancy, 2) emotional dimension (positive affect), and 3) cognitive dimension(existence need-satisfaction, relatedness need-satisfaction, growth need-satisfaction). The antecedents of happiness among pregnant women were 1) intrapersonal characteristics, 2) reproductive history and related characteristics, 3) interpersonal relationship, and 4) external factors. The consequences included 1) pregnant women's well-being, 2) fetal well-being, 3) maternal well-being, and 4) child's happiness. Conclusion: Although further studies are required to refine the diverse attributes of the concept, the results of this study contribute to explaining happiness among pregnant women. In addition, the development of adequate interventions to increase prenatal happiness is needed.

• 대한예방의학회:학술대회논문집
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• 2000.10a
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• pp.258-259
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• 2000

• Clinical and Experimental Pediatrics
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• v.64 no.6
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• pp.269-279
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• 2021

Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) is an ancient prokaryotic defense system that precisely cuts foreign genomic DNA under the control of a small number of guide RNAs. The CRISPR-Cas9 system facilitates efficient double-stranded DNA cleavage that has been recently adopted for genome editing to create or correct inherited genetic mutations causing disease. Congenital heart disease (CHD) is generally caused by genetic mutations such as base substitutions, deletions, and insertions, which result in diverse developmental defects and remains a leading cause of birth defects. Pediatric CHD patients exhibit a spectrum of cardiac abnormalities such as septal defects, valvular defects, and abnormal chamber development. CHD onset occurs during the prenatal period and often results in early lethality during childhood. Because CRISPR-Cas9-based genome editing technology has gained considerable attention for its potential to prevent and treat diseases, we will review the CRISPR-Cas9 system as a genome editing tool and focus on its therapeutic application for CHD.

• Biomedical Science Letters
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• v.28 no.2
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• pp.59-66
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• 2022

The Cyr61/CTGF/NOV (CCN) family is dynamically expressed in various tissues, including the nervous system, from the prenatal period to adulthood. However, major studies have been conducted only in limited fields, such as the cardiovascular and muscular systems, skeletal development, and cancer. In addition, although the CCN family is a secretory protein, very few studies have described its mechanism of secretion. Recently, it has been suggested that overexpression of CCN3 or intracellular accumulation due to problems in the secretory pathway can inhibit neuronal axonal growth. In this review, we have briefly summarized the structure and characteristics of the CCN family and its related diseases, with particular emphasis on the secretory mechanism and modifiers of the CCN family, newly identified in the nervous system.

• Journal of Nutrition and Health
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• v.10 no.2
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• pp.5-11
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• 1977

The mature human braun contains over 10 billion nerve cells (neurons), whose functions are directly related to the acquisition, transfer, processing, analysis, and utilization of all the information. There are also billions of glial cells, which serve primarily to support and to maintain the integrity of the neuron network and to synthesize an essential fatty strucfure, myelin. In the human brain DNA content therefore cell number rises rapidly until birth and then more slowly until $5{\sim}6$ months of age, when it reaches a maximum. While glial cells may be replaced, the more important nerve cell neurons can never be replaced once they are formed. Humans are born with their full complement of neurons and every neuron is as old as each individual. Thus prenatal malnutrition can seriously affect a person's entire life by severely inhibiting the production of neurons before birth.It has been demonstrated that in humans severe malnutrition during the fetal period and in infancy is associated with intellectual impairment. Severely malnourished children have brains smaller than average size and have been found to have $15{\sim}20%$ fewer brain cells than wellnourished childen. There is growing body of literature pointing to malnutrition as a cause of abnormal behavior as evidence that suggests these abnormalities may produce chromosomal damage that may persist forever. Although cognitive development in children is affected by multiple environmental factors, nutrition certainly deaerves more attention than it has received.

• Journal of East-West Nursing Research
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• v.17 no.1
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• pp.71-79
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• 2011

Purpose: The purpose of this study was to compare the neonatal birth weight, birth height, Apgar scores, sucking power, and digestion difficulties between smoking and non-smoking women following cesarean birth. This study analyzed the effects of smoking on the neonatal health status in pregnant women to provide fundamental data for smoking prevention education for women of childbearing ages and non-smoking practice protocols for pregnant women with smoking. Methods: A comparative survey design was used. Fifty-four newborn infants of pregnant women with smoking and seventy-four newborn infants of pregnant women with non-smoking participated in this study. The scores of neonatal birth weight, birth height, Apgar scores, sucking power, and digestion difficulties were assessed. Data were analyzed using SPSS Windows 15.0 program. Results: Smoking in pregnant women leads to the decrease of birth weight (F=4.75, p=.030) and birth height (F=14.19, p<.001), negative effects on the Apgar scores (F=36.02, p<.001) and sucking power (t=-4.26~-5.60, p<.001), and digestion difficulties ($x^2$=6.72, p=.010) of neonates. Conclusions: This study demonstrated that smoking in pregnant women leads to the decrease of fetus development. These findings would be utilized for the development of not only smoking prevention programs for women of childbearing ages but also prenatal education programs for pregnant women.

• Women's Health Nursing
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• v.24 no.3
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• pp.297-309
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• 2018

Purpose: To develop Pregnancy Risk symptom Perception Scale (PRPS) and evaluate its validity and reliability. Methods: A preliminary 30-item version of PRPS was developed through literature review, in-depth interview, and Content Validity. Each item was scored on a four-point Likert scale. The preliminary scale was developed based on 301 pregnant women who visited a hospital. Date were analyzed using item analysis, factor analysis, confirmatory factor analysis, Pearson's correlation coefficients, and Cronbach's ${\alpha}$ (0.90 for total item, 0.80 to 0.88 for factors). Results: The PRPS consisted of 27 items. Three factors (physical, environmental, and emotional factors) explained 55% of the total variance. Cronbach's Criterion validity was supported by comparison with the Perception of Pregnancy Risk Questionnaire (r=0.34). In reliability test, the reliability coefficient of pregnancy risk symptom perception was high at 0.90. Conclusion: These results suggest that the pregnancy risk symptom perception scale developed in this study comprises items that can assess the level of pregnant women's pregnancy risk symptom perception in Korea. Its validity and reliability were proven. PRPS can be utilized to measure pregnant women's risk symptom perception during pregnancy. PRPS will contribute to the development of systematic prenatal care and effective risk management.

• Biomedical Science Letters
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• v.17 no.2
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• pp.129-134
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• 2011

Mosaicism is the presence of two or more chromosomally distinct cell lines, each seen in two or more cells. Chromosomal mosaicism presents one of the most difficult problems in prenatal cytogenetic diagnosis, requiring the differentiation of true mosaicism from pseudomosaicism. To overcome associated problems we investigated 24 cases (amniotic fluid 13 cases, abortus tissue 3 cases, peripheral blood 8 cases) in which mosaicism has been found in cytogenetic analysis. 5 cases (38.5%) of 13 amniotic fluid cells in which mosaicisms showed single cell pseudomosaicism. Chromosomal true mosaicism is found in about 0.28% (8/2,826) of amniotic fluid cell cultures. The 24 cases involved 12 cases (50%) with sex chromosomal abnormalities, 7 cases (29.2%) with autosomal structural defects, 3 cases (12.5%) with autosomal abnormalities, 2 cases (8.3%) with a supernumerary marker. Mosaicism detected in amniotic fluid may represent the true mosaicism or may pseudomosaicism. If the same chromosome abnormality is seen in more than one cell and in two different cultures, it is considered a true mosaicism, whereas single-cell abnormalities from a single culture are regarded as pseudomosaicism. In this study, we describe a mosaicism in chromosome analysis, its diagnostic problems and clinical significance.