• Korean Journal of Clinical Pharmacy
• /
• v.18 no.2
• /
• pp.84-96
• /
• 2008

In the recent, pharmacokinetic (PK)/pharmacodynamic (PD) modeling has appeared as a critical path tools in new drug development to optimize drug efficacy and safety. PK/PD modeling is the mathematical approaches of the relationships between PK and PD. This approach in new drug development can be estimated inaccessible PK and PD parameters, evaluated competing hypothesis, and predicted the response under new conditions. Additionally, PK/PD modeling provides the information about systemic conditions for understanding the pharmacology and biology. These advantages of PK/PD model development are to provide the early decision-making information in new drug development process, and to improve the prediction power for the success of clinical trials. The purpose of this review article is to summarize the PK/PD modeling process, and to provide the theoretical and practical information about widely used PK/PD models. This review also provides model schemes and the differential equations for the development of PK/PD model.

• Journal of Korean Academy of Nursing
• /
• v.34 no.7
• /
• pp.1351-1361
• /
• 2004

Purpose: The purpose of this study was to evaluate the effect of an East-West Self-help program for Rehabilitation of post-stroke patients, Method: A quasi-experimental design was used. The subjects were 75 post stroke clients(Exp. group : 38, Cont. group:37), The subjects of the experimental group participated in the Self-help group program of six sessions, twice a week, during 6 weeks. The program consisted of health education of stroke, exercise, oriental nursing interventions, and therapeutic recreation. The obtained data were analyzed by using the repeated measure ANOVA of SPSS. Result: 1) The score of rehabilitation self-efficacy increased significantly in the experimental group as compared to the control group. 2) The score of BADL, IADL, amount of use & quality of movement of the affected U/E, and grip power increased significantly in the experimental group as compared to the control group. 3)The level of blood cholesterol decreased significantly in the experimental group as compared to the control group. Conclusion: Considering these research results, the program is effective in improving functional abilities and self-management ability. Therefore this program could be implemented as a community based self-help group program for post stroke clients.

• Investigative Magnetic Resonance Imaging
• /
• v.22 no.1
• /
• pp.26-36
• /
• 2018

Purpose: Children born with single ventricle physiology demonstrate poor growth rate and suffer from malnutrition, which lead to increased morbidity and mortality in this population. We assume that an anabolic steroid, oxandrolone, will promote growth in these infants by improving myocardial energy utilization. The purpose of this paper is to study the efficacy of oxandrolone on myocardial energy consumption in these infants. Materials and Methods: We modeled single ventricle physiology in a lamb by prenatally shunting the aorta to the pulmonary artery and then postnatally, we monitored cardiac energy utilization by quantitatively measuring the first order reaction rate constant, $k_f$ of the creatine-kinase reaction in the heart using magnetization transfer $^{31}P$ magnetic resonance spectroscopy, home built $^1H/^{31}P$ transmit/receive double tuned coil, and transmit/receive switch. We also performed cine MRI to study the structure and dynamic function of the myocardium and the left ventricular chamber. The spectroscopy data were processed using home-developed python software, while cine data were analyzed using Argus software. Results: We quantitatively measured both the first order reaction rate constant and ejection fraction in the control, shunted, and the oxandrolone-treated lambs. Both $k_f$ and ejection fraction were found to be more significantly reduced in the shunted lambs compared to the control lambs, and they are increased in oxandrolone-treated lambs. Conclusion: Some improvement was observed in both the first order reaction rate constant and ejection fraction for the lamb treated with oxandrolone in our preliminary study.

• Journal of Digital Contents Society
• /
• v.17 no.6
• /
• pp.537-543
• /
• 2016

The purpose of this study is to analyze the moderating effect of health privacy information on the relationship between the factors that affect the behavioral intention of the usage of u-health system have. Therefore, as a research hypothesis in TRA (Theory of Reasoned Action), self-efficacy and perceived usefulness will have a positive effect on the behavioral intention of the u-health system, and in the path, that personal information factors have an effect on each path. This study used the PLS-SEM methodology to verify the proposed research model. As a result of the analysis, this study showed that the moderating effect of health personal information in the presented model affects to some extent by the increase of R2 explanatory power. However, it was found that it was more consistent with the role of the independent variable rather than the moderating influence on the perceived usefulness.

• The Journal of Korean Medical History
• /
• v.30 no.2
• /
• pp.13-31
• /
• 2017

This study investigates research trends on the Convergence of Chinese and Western Medicine (中西醫匯通, CCWM), by first defining the concepts and the scope of this emerging field, identifying different types of convergence, and suggesting methods to evaluate the process. The author investigates the relationship of CCWM to the Self-Strengthening Movement and the doctrine of Zhongtixiyong (中體西用). Lessons that Korean Medicine (KM) can learn from this approachto help establish relationship between Korean and Western Medicine, are investigated. Proponents of CCWM suggest different types of convergence such as Zhongzhongcanxi (衷中參西), Zhongxizhezhong (中西折衷), and ZhongyiKexuehua (中醫科學化), to accommodate the change in the power dynamics between Chinese and Western medicines. The rigid dual medical system in Korea significantly hinders the potential for convergence. The current system is based on the relativistic model in which the scope of practice for the KM doctor and the Western Medicine doctor are mutually exclusive. Philosophically, the convergence of East-West medicine can be supported by pluralism and monism, while relativism sees it as impossible. A conservative pluralistic model might consider Bogu (補救) of Eastern Medicine, while a more progressive pluralistic model might build a New Medicine which combines the knowledge and techniques of Eastern and Western medicines. An example of monistic model is CAM (Complementary and Alternative Medicine), which aims to scientifically verify the efficacy and safety of the Eastern therapeutic practices and integrate them into Western medicine. This article proposes that as communication and fusion between medical disciplines are essential virtues of contemporary scholarly development, a change that enables the convergence of East-West medicine is needed.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2004.08a
• /
• pp.795-798
• /
• 2004

After showing 32 inch two-dimensionally integrated fluorescent lamp (TIFL) and its module at SID '04, 40 inch TIFL and its module of prototype have been developed at the first time. It is the biggest size in the world as well as has a backlight unit without BEF optical film. The luminance of TIFL is 14000 nit at 190 watt power consumption and its luminous efficacy is 51 lumen/watt. The use of TIFL simplifies backlight assembly process and removes high price optical sheets. As a result, LCD TV, used by TIFL, is rapidly going to expand its market share in the large size TV area.

• Journal of the Korea Furniture Society
• /
• v.26 no.1
• /
• pp.77-91
• /
• 2015

The appeal of sauna is caused by the fact that through that, one can feel Korea's unique temperament and culture; however, because of its being a public facility and flooding of businesses due to excessive supplies of various additional features such as washing, playing, eating, sleeping and health care functions, issues of social resources and environment come to the fore, so it has reached a situation of red ocean that it is difficult to enter the market anymore. Taking these into account, this study focused on developing a thermal technology and design of the housing of an environment-friendly mobile home sauna, making the most use of the sauna's fundamental purpose and settling it as a tourist product, analyzing the marketing research on the existing sauna and considering the recent housing trends and lifestyles for a new concept sauna. Thus, regarding its characteristics and utilization, it was designed smaller than $10m^2$ (3 pyeong) so that it would be easy to install in any space and convenient to move. It can be installed in separate buildings and rest spaces such as country houses, resorts, pensions, camping grounds as well as outdoor houses, custom produced for a measure of pyeong that customers want so as to match up with the Enforcement Ordinance of the Agricultural Land Act in a concept of the farmer's hut and kitchen, bathroom and bathroom can be installed inside according to an option. In addition, regarding its efficacy, in order to give environment-friendly healing effects, materials such as Hinoki Cypress, red clay and hardwood charcoal were used, a fixed indoor temperature of $70{\sim}100^{\circ}C$ was maintained by heating methods such as electromagnetic wave free, energy saving and low-power boiler, and it was made to have excellent effects on fatigue recovery, relieving stress, skin care and diet through far-infrared emission.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.27 no.9
• /
• pp.600-605
• /
• 2014

The interest in development on luminaires which are available up to $-52^{\circ}C$ is surging as demands in vessels navigating a north pole route increase. A conventional incandescent lamp used in vessels is operated stably at $-52^{\circ}C$, but many countries including Korea have eliminated the use of incandescent lamps gradually because of its low luminous efficacy. In this paper, therefore, to develop the LED luminaires with high-efficiency, long lifetime that enables to substitute for incandescent lamp, it has studied about cryogenic characteristics of LED packages, bulbs, driving circuit and power supply. This experiments were carried out according to standards IEC 60945-8.4.1. Temperature range is from $-60^{\circ}C$ to $25^{\circ}C$, and the light output depending on ambient temperature. It showed that, based on $25^{\circ}C$, light output of a CFL decreased by 80% of CFL at $-20^{\circ}C$ while each increased 12% of LED bulbs and 16~19% of LED packages at $-60^{\circ}C$.

• Journal of Korean Neurosurgical Society
• /
• v.55 no.2
• /
• pp.73-77
• /
• 2014

Objective : The purpose of this study was to evaluate the efficacy of implant removal of percutaneous short segment fixation after vertebral fracture consolidation in terms of motion preservation. Methods : Between May 2007 and January 2011, 44 patients underwent percutaneous short segment screw fixation due to a thoracolumbar burst fracture. Sixteen of these patients, who underwent implant removal 12 months after screw fixation, were enrolled in this study. Motor power was intact in all patients, despite significant vertebral height loss and canal compromise. The patients were divided into two groups by degree of osteoporosis : Group A (n=8), the non-osteoporotic group, and Group B (n=8), the osteoporotic group. Imaging and clinical findings including vertebral height loss, kyphotic angle, range of motion (ROM), and complications were analyzed. Results : Significant pain relief was achieved in both groups at final follow-up versus preoperative values. In terms of vertebral height loss, both groups showed significant improvement at 12 months after screw fixation and restored vertebral height was maintained to final follow-up in spite of some correction loss. ROM (measured using Cobb's method) in flexion and extension in Group A was $10.5^{\circ}$ ($19.5/9.0^{\circ}$) at last follow-up, and in Group B was $10.2^{\circ}$ ($18.8/8.6^{\circ}$) at last follow-up. Both groups showed marked improvement in ROM as compared with the screw fixation state, which was considered motionless. Conclusion : Removal of percutaneous implants after vertebral fracture consolidation can be an effective treatment to preserve motion regardless of osteoporosis for thoracolumbar burst fractures.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.11 no.4
• /
• pp.247-264
• /
• 2016

The purpose of this study is to find the determinants for the type(Franchising or Independent Entrepreneurship) of new venture creation. This study conducted an empirical analysis on a total of 398 samples of survey gathered from people in Seoul, Gyoeng-gi, Daegu, and Gyeonsangbuk-do. This study includes not only personal traits, but also entrepreneurial intention and network as independent variables. Findings of the analysis reported that Entrepreneurial intention, Need for achievement, Autonomy, Entrepreneurship, Self-efficacy, Education, Network, Age, and Income have significant discriminant power, in order of priority, on general two groups of Franchising and Independent Entrepreneurship. However, in the study, autonomy is revealed as the sole discriminant factor on considering venture creation groups. Based on the result, the study contributes theoretical and practical implications in relation to the determinants for the type of franchising or independent entrepreneurship.