• Genomics & Informatics
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• v.6 no.4
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• pp.192-201
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• 2008

Erythropoietin-producing human hepatocellular carcinoma receptor B1 (EPHB1) is a member of the Eph family of receptor tyrosine kinases that mediate vascular system development. Eph receptor overexpression has been observed in various cancers and is related to the malignant transformation, metastasis, and differentiation of cancers, including hepatocellular carcinoma (HCC). Eph receptors regulate cell migration and attachment to the extracellular matrix by modulating integrin activity. EphrinB1, the ligand of EPHB1, has been shown to regulate HCC carcinogenesis. Here, we sought to determine whether EPHB1 polymorphisms are associated with hepatitis B virus (HBV)-infected liver diseases, including chronic liver disease (CLD) and HCC. We genotyped 26 EPHB1 single nucleotide polymorphisms (SNPs) in 399 Korean CLD, HCC, and LD (CLD+HCC) cases and seroconverted controls (HBV clearance, CLE) using the GoldenGate assay. Two SNPs (rs6793828 and rs11717042) and 1 haplotype that were composed of these SNPs were associated with an increased risk for CLD, HCC, and LD (CLD+HCC) compared with CLE. Haplotypes that could be associated with HBV-infected liver diseases by affecting downstream signaling were located in the Eph tyrosine kinase domain of EPHB1. Therefore, we suggest that EPHB1 SNPs, haplotypes, and diplotypes may be genetic markers for the progression of HBV-associated acute hepatitis to CLD and HCC.

• Korean Journal of Social Welfare
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• v.63 no.3
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• pp.133-156
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• 2011

This study used the qualitative research for deeply interviewing Chinese-Koreans who live and work in Dearim-dong area, Yeongdeungpo-gu, Seoul, collectively. The variation of recognition to the local community at the migration early and the present and their response for overcoming their pending issues are studied through this, To understand the reality and conflict they encounter, the effort for overcoming the pending issues, the inner change of their own community, their fixed direction and so on becomes the core variables for integrating them to our society. They have formed the enormous cluster and have been already developed as the minority group. They are doing 'the struggle for recognition' for being recognized from the dominant group and trying to approach the politics for overcoming the inferiority of power. Accordingly, the intervention of social welfare to this minority group should be a more active working to protect the fragmentation of our society which can be resulted from the increasing influx of the foreigners and be also an approach to mutual enlightenment for making our society adapt to the phenomena of multi-nations and multi-cultures and for accepting them as the population.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2499-2506
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• 2016

Background: Gastric cancer (GC) is the second leading cause of cancer-related death worldwide. Several environmental, genetic and epigenetic factors have been suggested to have a role in GC development. Epigenetic mechanisms like histone changes and promoter hyper-methylation are now being increasingly studied. Associations between methylation of many gene promoters with the risk of gastric cancer have been investigated worldwide. Such aberrant methylation may result in silencing of specific genes related to cell cycling, cell adhesion, apoptosis and DNA repair. Thus this molecular mechanism might have a key role in proliferation and migration of cancerous cells. Materials and Methods: In this review article we included studies conducted on DNA methylation and gastric cancer in Iranian populations. Using Science direct, Pubmed/PMC, Springer, Wiley online library and SciELO databases, all published data until 31 January 2016 were gathered. We also searched Science direct data base for similar investigations around the world to make a comparison between Iran and other countries. Results: By searching these databases, we found that the association between methylation of seven gene promoters and gastric cancer had been studied in Iran until 31 January 2016. These genes were p16, hLMH1, E-cadherin, CTLA4, $THR{\beta}$, mir9 and APC. Searching in science direct database also showed that 92 articles had been published around the world till January 2016. Our investigation revealed that despite the importance of GC and its high prevalence in Iran, the methylation status of only a few gene promoters has been studied so far. More studies with higher sample numbers are needed to reveal the relation of methylation status of gene promoters to gastric cancer in Iran. Conclusions: Further studies will be helpful in identifying associations of DNA methylation in candidate genes with gastric cancer risk in Iranian populations.

• Journal of the Korean Institute of Landscape Architecture
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• v.28 no.1
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• pp.70-82
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• 2000

This is a study to generate a theoretical base for the development of wildlife corridor as a solution to the problems of wildlife population size reduction and declining bio-diversity resulting from the fragmented habitats caused by road constructions. This study seeks to examine and define techniques in very aspect of wildlife corridor including planning, site selection, design and development, and maintenance through an actual application. The results of this study are as follows. 1) The wildlife corridor should be developed in an approach supplementing a landscape ecological approach and a restoration ecological approach bilaterally. To this end, systematic methodology and process are required. 2) It was restored an ecosystem as close as possible go to the forest ecosystem before road development. In addition, in order to allow it to function as an ecological corridor, topography restoration, stream development, and ecological plantation were implemented. 3) The result of monitoring activities that continued for one year since the development confirmed the migration and inhabitation of a number of animals including small mammals. It is judged that it functions as a corridor in fragmented habitats as initially expected. 4) Through continuous monitoring in the future, the effects of corridor development on ecological restoration need to be reviewed in a long-term perspective. There is also a need to develop and refine a comprehensive maintenance plan for wildlife corridors and their surroundings. Based on such study results, actual data on the development of wildlife corridor should be accumulated. In follow-up studies, after continuous monitoring for a long period of time, the effects of wildlife corridor development should be evaluated comprehensively and wildlife corridor applicable to Korea should be standardized by correcting disclosed problems.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.54 no.8
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• pp.375-387
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• 2005

This paper presents an application of parallel Genetic Algorithm-Tabu Search (GA-TS) algorithm to search an optimal solution of a service restoration in distribution systems. The main objective of service restoration of distribution systems is, when a fault or overload occurs, to restore as much load as possible by transferring the do-energized load in the out of service area via network reconfiguration to the appropriate adjacent feeders at minimum operational cost without violating operating constraints, which is a combinatorial optimization problem. This problem has many constraints with many local minima to solve the optimal switch position. This paper develops parallel GA-TS algorithm for service restoration of distribution systems. In parallel GA-TS, GA operators are executed for each processor. To prevent solutions of low fitness from appearing in the next generation, strings below the average fitness are saved in the tabu list. If best fitness of the GA is not changed for several generations, TS operators are executed for the upper $10\%$ of the population to enhance the local searching capabilities. With migration operation, best string of each node is transferred to the neighboring node after predetermined iterations are executed. For parallel computing, we developed a PC cluster system consists of 8 PCs. Each PC employs the 2 GHz Pentium IV CPU and is connected with others through ethernet switch based fast ethernet. To show the validity of the proposed method, proposed algorithm has been tested with a practical distribution system in Korea. From the simulation results, we can find that the proposed algorithm is efficient for the distribution system service restoration in terms of the solution quality, speedup, efficiency and computation time.

• Journal of Korean Society of Rural Planning
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• v.19 no.2
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• pp.75-91
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• 2013

In rural areas, in spite of the development projects of town and houses has been performed after the New Community Movement, due to rapid industrialization and urbanization, which lasted until the 2000s from the 1980s, out-migration to the cities, changes in the industrial structure, rapid aging was carried. As a result, the gap of housing environment between urban and rural areas became more serious. The meantime, the housing problem is recognized only to the problems of the big cities, mostly urban public housing policy oriented. However, when you check the indicator of the housing environment, such as the percentage of aging housing, rural environment has become a relatively poor compared to the city. In addition, due to a decrease in income and aging of the population living in rural areas of existing infrastructure to improve the living environment is weakened. And inside of the rural areas, changes in the housing environment and polarization phenomenon is becoming increasingly serious. Therefore, in this study, there is a purpose to be presented the improvement direction for efficient implementation of house remodeling support program for underprivileged group in rural areas and requires immediate attention improvement of housing environment. Previously, House remodeling support project in rural areas was carried out at the initiative of local governments and government mainly. For this reason, it is difficult due to limited institutional, to reflect the necessary parts directly to the real life of the residents. And, the demand for improvement of housing environment need modifications to solve the inconvenience of life of residents directly in many cases. It is considered that community-based house remodeling support project is to be carried out through the participation of local residents.

• International Journal of Industrial Entomology and Biomaterials
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• v.16 no.2
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• pp.75-86
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• 2008

In order to understand geographic genetic variation and relationship among populations of the mason bee (Osmia cornifrons Radoszkowsky), which is used as pollinator for apple tree, we sequenced a portion of mitochondrial (mt) COI gene, which corresponds to "DNA Barcode" region (658 bp) from 81 O. cornifrons individuals collected over eight localities in Korea. The sequence data revealed overall moderate to low genetic diversity within species, with a maximum sequence divergence of 0.76%. Geographically, two haplotypes (BAROC01 and BAROC02) were widespread with a frequency of 82.7%, whereas several haplotypes were found in a locality as a single individual, suggesting that haplotype distribution can be summarized as coexistence of a few widespread haplotypes and several regionally restricted haplotypes. Overall, high rate of per generation female migration (Nm=$1.1{\sim}$infinite) and low level of geographic subdivision ($F_{ST}=0{\sim}0.315$) among localities were characteristic. Although two populations (p < 0.026) were genetically subdivided from the remaining localities, no clear polarity was observed. Taken together, the nature of genetic divergence of the mason bee populations is characterized as one that possessing moderate to low genetic diversity, high gene flow, and wide spread haplotypes with ahigh frequency, concordant with the capability of dispersal in connection with the lack of historical biogeographic barriers.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.3
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• pp.251-256
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• 2009

Previous observations suggest that Bis, a Bcl-2-binding protein, may playa role the neuronal and glial differentiation in vivo. To examine this further, we investigated Bis expression during the in vitro differentiation of P19 embryonic carcinoma cells induced by retinoic acid (RA). Western blotting and RT-PCR assays showed that Bis expression was temporarily decreased during the free floating stage and then began to increase on day 6 after the induction of differentiation. Double immunostaining indicated that Bis-expressing cells do not express several markers of differentiation, including NeuN, MAP-2 and Tuj-1. However, some of the Bis-expressing cells also were stained with GFAP-antibodies, indicating that Bis is involved glial differentiation. Using an shRNA strategy, we developed bis-knock down P19 cells and compared them with control P19 cells for the expression of NeuroD, Mash-1 and GFAP during RA-induced differentiation. Among these, only GFAP induction was significantly attenuated in Pl9-dnbis cells and the population showing GFAP immunoreactivity was also decreased. It is noteworthy that distribution of mature neurons and migrating neurons was disorganized, and the close association of migrating neuroblasts with astrocytes was not observed in P19-dnbis cells. These results suggest that Bis is involved in the migration-inducing activity of glial cells.

• Journal of Nutrition and Health
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• v.33 no.3
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• pp.324-331
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• 2000

A deteriorating North Korean economy, coupled with a devastating natural disaster such as flooding and drought in recent years, brought about a severe food shortage and malnutrition problem which caused a migration of its population including young children to neighboring countries. We conducted a nutritional survey on a total of 436 children, aged 4-19 years old, who migrated to the China side of the border from July to September, 1999. The study subjects were interviewed by Korean-Chinese interviewers who were trained for anthropometric measurements and dietary surveys. Heights, weights, and chest circumference of the subjects were 70-90% of the South Korean reference values for the corresponding age and sex. Dietary intakes of the subjects were found to be extremely poor-the average number of food, mostly of plant origin, consumed in a day was 2.8, and the proportion of the subject who reported to take all three meals in a day while residing in North Korea was as low as 36.2%. Ninety five percent of the subjects had at least one clinical symptom related to malnutrition, 68.6% had 2-4 symptoms, and 15.1% had 5 or more symptoms. The results of this study provided an objective data for the first time on the severity of the food crisis and malnutrition problem that afflicted North Korean older children and adolescents as well as children aged 7 or under as previously reported elsewhere. the wasted and stunted children and youths prevailing in North Korea could exert a negative influence on the country's health and economy. More researches are needed in the future to investigate on the impact of malnutrition in North Korean children on the country's social, economic, and cultural state as well as on the health and nutrition situation.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.53 no.10
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• pp.556-564
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• 2004

This paper presents an application of parallel Genetic Algorithm-Tabu Search(GA-TS) algorithm to search an optimal solution of a reconfiguration in distribution system. The aim of the reconfiguration of distribution systems is to determine switch position to be opened for loss minimization in the radial distribution systems, which is a discrete optimization problem. This problem has many constraints and very difficult to solve the optimal switch position because it has many local minima. This paper develops parallel GA-TS algorithm for reconfiguration of distribution systems. In parallel GA-TS, GA operators are executed for each processor. To prevent solution of low fitness from appearing in the next generation, strings below the average fitness are saved in the tabu list. If best fitness of the GA is not changed for several generations, TS operators are executed for the upper 10% of the population to enhance the local searching capabilities. With migration operation, best string of each node is transferred to the neighboring node aster predetermined iterations are executed. For parallel computing, we developed a PC-cluster system consisting of 8 PCs. Each PC employs the 2 GHz Pentium Ⅳ CPU and is connected with others through ethernet switch based fast ethernet. To show the usefulness of the proposed method, developed algorithm has been tested and compared on a distribution systems in the reference paper. From the simulation results, we can find that the proposed algorithm is efficient and robust for the reconfiguration of distribution system in terms of the solution qualify. speedup. efficiency and computation time.