• 대한한의학방제학회지
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• 제32권3호
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• pp.247-261
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• 2024

Objectives : Zuojin Pill, recognized as an effective herbal remedy, has undergone investigation for its potential in alleviating symptoms like indigestion, vomiting, and abdominal distension. The purpose of this study was to investigate the mechanism of digestive function activation through network pharmacology, particularly focused on improving functional dyspepsia. Methods : The two components, Coptidis Rhizoma and Evodiae Fructus, constituting Zuojin Pill were analyzed based on broad information on chemical and pharmacological properties, confirming 40 active compounds and 115 digestive-related molecular targets. Concentration analysis revealed impacts on various pathways related to digestive functions. Results : According to network pharmacological analysis of Zuojin Pill, quercetin and beta-sitosterol were exhibited relatively numerous targets, suggesting their potential significance in the therapeutic activity of Zuojin Pill and by a Protein-Protein Interaction (PPI) network, JUN, RELA, MAPK1, HSP90AA1, TP53, TNF, AKT1, IL6, MAPK14, ESR1, FOS, MYC were identified. Also, berberine exhibited the highest contribution index (92.58%), indicating that this compound may be a major contributor to the digestive activity of Zuojin Pill. Additionally, functional interaction analysis by GeneMANIA indicated that targets of Zuojin Pill could functionally interact through various mechanisms, implying similarities in pharmacological roles. Conclusions : These findings contribute valuable insights into the digestive function activation mechanism and highlight the therapeutic potential of Zuojin Pill in improving functional dyspepsia.

• 제어로봇시스템학회논문지
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• 제11권9호
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• pp.810-815
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• 2005

As the pharmaceutical industry grows and becomes more competitive, the need of automation increases to establish effective mass production and to maintain consistent quality control. Accurate counting and packing of medicinal pills is one of the most essential processes that the automation can benefit. In conventional automated counting and packing processes, the performance of counting process varies with the size, the shape and the dispersion degree of pills. In this research, the authors developed a new pill-counting algorithm based on carefully analyzed characteristics of the pill-drop behavior. Also a new scheme for the packing of an exact number of pills has been implemented. A pill counting and packing machine with the new pill-counting algorithm and the new packing scheme has been constructed and put in an actual production line. To achieve precise and quick sensing of pills dropping at a high speed from the preceding processors, the machine uses non-contact photo sensors. Experimental results from the actual process using the machine are included to verify the effectiveness of the proposed algorithm and the machine.

• 약학회지
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• 제43권2호
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• pp.251-262
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• 1999

In order to investigate pharmacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH) and Wonbang Woohwangchungsimwon Pill (SCH), the effects of NSCH and SCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in mongolian gerbils. The histological observations showed preventive effects of NSCH and SCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by SCH treatment. In contrast to what was inhibited by NSCH and SCH treatments. While NSCH and SCH had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by electric shock and strychnine. NSCH and SCH showed sedative effect in rotarod and spontaneous activity test. Furthermore, NSCH and SCH showed anti-stress effect. Our findings suggest that the pharmacological profiles of NSCH on cerebral ischemia and central nervous system are similar to those of SCH.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1628-1631
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• 2005

Ship Autopilots are usually designed based on the PD and Pill controllers because of simplicity, reliability and easy to construct. However their performance in various environmental conditions is not as good as desired. This disadvantage can be overcome by adjusting works or constructing adaptive controllers. But those methods are complex and not easy to do. This paper presents a new method for constructing a Ship Autopilot based on the combination of Fuzzy Logic Control (FLC) and Linear Control Theory (Pill control). The new Ship Autopilot has the advantages of both the Pill and FLC control methodologies: easy to construct, and optimal control laws can be established based on ship masters' knowledge. Therefore, the new ship autopilot can be well adapted with parameter variations and strong environment effects. Simulation using MATLAB software for a ship with real parameters shows high effectiveness of the Fuzzy Pill autopilot in course keeping and course changing manoeuvres in comparison with the ordinary Pill ship autopilots.

• Journal of Multimedia Information System
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• 제5권2호
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• pp.143-146
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• 2018

The eigen value problem of a coaxial cavity and a modified pill box cavity is investigated using the mode matching technique. The coaxial cavity has a cylindrical cavity with beam ports and center conductor. The pill box cavity is the same as a coaxial cavity without center conductor. The electric field and magnetic field are formulated in propagation region and resonance region. The boundary and orthogonal conditions are applied to the electric and magnetic fields. We derived the eigen value equation by the proposed procedure in a coaxial cavity and a modified pill box cavity. The electromagnetic field of the real structure is disturbed by the coaxial wire. The effect of the coaxial wire in pill box cavity with beam ports increase the dominant resonant frequency. The coaxial line method of the coupling impedance is not adequate for a cylindrical cavity. The results of the mode matching technique and simulation agree well. The results confirm the proposed formulation is valid.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 추계학술대회 논문집
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• pp.683-686
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• 2002

It is fundamental to count and pack the pills in the medicine manufacture field but those tasks are time and labor consuming. Thus, the need fur automation of those tasks is necessarily getting increased in order to get effective mass production. It Is significant to perceive pills quickly and precisely. There were many trials for this processing but the performance of the existing counting machines varies about size, shape and dispersion tendency of pills. In this paper, the authors try to improve the counting performance of a pill counting machine that has optical sensors with the neural network. The passing signal of pill is acquired with optical sensor and the passage signal of the pill is extracted as input patterns. The gradient and integration of signal during passing time and the time keeping the pill interrupt the light from the LED are used as characteristic feature. The back propagation and perception algorithm are used for training. Experimental results with several pills show that the designed algorithm is a little bit effective to reduce the noise effect which is generated from interference among the machine components and unreliable environment.

• 생명과학회지
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• 제19권11호
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• pp.1605-1610
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• 2009

체지방률 30% 이상인 비만 남고생을 대상으로 복합운동과 마늘환을 섭취시켜 신체조성, C-반응단백, 아디포넥틴에 미치는 영향을 구명하였다. 복합운동은 주 3회 70분씩 16주간 실시 하였으며, 마늘환 섭취는 점심 저녁 식후 5 g씩 섭취시켰으며, 실험 시작 전과 후에 신체조성과 혈액 분석결과 다음과 같은 결론을 얻었다. 신체조성에서 제지방률은 집단 내 복합운동+마늘환 섭취군에서 유의하게 감소하였다. 체지방률은 복합운동+마늘환 섭취군이 유의하게 감소하였고, 집단간 복합운동+마늘환 섭취군이 대조군보다 유의하게 감소하였다. 체수분은 집단 내 복합운동+마늘환 섭취군이 감소하였다. C-반응단백은 복합운동+마늘환 섭취군이 집단 내 유의하게 감소하였으며, 운동과 마늘의 성분의 상승작용으로 인해 긍정적인 효과가 나타난 것으로 생각된다. 아디포넥틴은 집단 내 모두 유의하게 감소하였다. 이상의 결과 복합운동과 마늘환의 섭취는 비만남고생의 체지방률 개선에 도움을 주었으며, 아디포넥틴에 대한 연구들이 필요하다고 생각된다.

• Journal of Nutrition and Health
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• 제41권1호
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• pp.5-12
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• 2008

In order to investigate whether Eisenia bicyclis (EB) as a functional food material improves serum lipid status, supplementation of EB powder or EB extract to the high fat/cholesterol diet was tested in 6-week old male Sprague-Dawley rats for four weeks. In the first experiment, four kinds of seaweed powder -Eisenia bicyclis (EB), Undaria pinnatifida (Up), Laminaria japonica (LJ), and Ecklonia stolonifera (ES) were compared with alginic acid (ALG) as well as control. In the second experiment, EB water extract and EB ethanol extract and EB pill containing EB and LJ powder were compared with the EB powder. Amounts of dietary fiber contained in experimental diets were adjusted to provide 5% of diets. Serum total cholesterol was significantly lower only in rats fed LJ or EB powder, but HDL cholesterol was higher in rats fed UP, LJ, ES or EB powder. Ratios of HDL-/total cholesterol of all seaweed groups including ALG were significantly higher than that of the control group. Serum triglyceride was lower in LJ, EB nd ES powder groups than the control group. In comparison of EB extracts, triglyceride level was decreased in rats fed only EB water extract as compared to control rats, but HDL cholesterol was elevated with both water and ethanol extracts. Serum levels of total cholesterol, triglyceride were decreased and HDL cholesterol was increased by the EB pill. Serum levels of thiobarbituric acid-reactive substances were lower in rats fed ES powder, and EB powder, EB water extract or EB pill, as compared to the control rats. Supplementation of EB powder and EB pill reduced serum level of GOT and GPT, respectively, as compared to the control group. In conclusion, EB and EB pill improve serum lipid status and may be utilized as ingredient of functional foods for the purpose of improving serum lipid profile and inhibiting peroxidation of lipids.

• 대한본초학회지
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• 제36권1호
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• pp.51-57
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• 2021

Objects : In this study, I aimed to determine the size and administration Method of pills preparation in Treatise on Cold Damage Diseases. Methods : I investigated the Treatise on Cold Damage Diseases, Newly Revised Materia Medica, Variorum of the Classic of Materia Medica, The Korean Herbal Pharmacopoeia, and recent studies. Results : There were four kinds of pills preparation. Each size of pill preparation was equal to the Odongja, Tanwhan, Yolk, and quarter of daily dosage of Decoction. One pill of Tanwhan was equivalent to 16 pills of Odongja, and one Yolk was equal to 40 pills of Odongja. The Diameter of Odongja was 6.5 mm, Tanwhan was 16.37897 mm, and Yolk was 22.11484 mm. Jeodangwhan was equal to one quarter daily dosage of Jeodangtang. Maximum size to swallow with water was Odongja and daily dosage, which was 16 pills, includes one square-inch-spoon of powder preparation. When we made the pill preparation, it is difficult to make 16 pills using one square-inch-spoon of powder. Therefore, Zhang Zhongjing made one dosage started from 10 pills to 20 pills to find out optimum dose. Due to the difficulty of making precise size of pills and considerable amount of daily dosage, there was no smaller size than Odongja. When the size of Pill preparation was larger than Odongja, it was ground or boiled slightly to make suspensions. Conclusions : These results suggest that the sizes of Pill preparation in the Treatise on Cold Damage Diseases were true compared with reality.

• 한국식생활문화학회지
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• 제18권2호
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• pp.134-138
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• 2003

Quality stability of the herb pill coated with edible oils containing rosemary was investigated. Herb pills were made of herb powders such as Panax ginseng, Cinnamomum cassia, Lycium chinense, Zyzyphus jujuba and Zingiber officinale. Rapeseed oil and lubriol were used as edible coating oil. After herb pills coated with edible oils with or without rosemary were stored at $40^{\circ}C$ for 180 days, the microbial viable cell counts and peroxide values(POV) of the herb pill were investigated. After 180 day storage, POVs of herb pills with only rapeseed oil or lubriol were 0.51 and 0.49 meq/kg, respectively. However, when rosemary was added in herb pills the POVs were decreased to 0.30 and 0.39 meq/kg, respectively. The addition of rosemary to the rapeseed oil and lubriol tended to decrease the microbial viable cell counts of the herb pill. The microbial viable cell counts of rapeseed oil and lubriol were 940 and 820CFU/g, respectively after 180 days of storage. However, these levels were suppressed to 720 and 640CFU/g by the resemary addition. On the other hand, the ginseng saponin content of herb pills was not affected by the rosemary addition during storage.