Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Study of the therapeutic mechanism of Zuojin Pill about functional dyspepsia through network pharmacology research

네트워크 약리학 연구를 통한 좌금환의 기능성 소화불량증 치료기전 연구

  • Ju eun Lee (Department of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Na Ri Choi (Department of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Seung Hyeon Koo (Department of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Woo Gyun Choi (Department of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Byung Joo Kim (Department of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University)
  • 이주은 (부산대학교 한의학전문대학원 양생기능의학교실) ;
  • 최나리 (부산대학교 한의학전문대학원 양생기능의학교실) ;
  • 구승현 (부산대학교 한의학전문대학원 양생기능의학교실) ;
  • 최우균 (부산대학교 한의학전문대학원 양생기능의학교실) ;
  • 김병주 (부산대학교 한의학전문대학원 양생기능의학교실)
  • Received : 2024.08.10
  • Accepted : 2024.08.19
  • Published : 2024.08.31
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Abstract

Objectives : Zuojin Pill, recognized as an effective herbal remedy, has undergone investigation for its potential in alleviating symptoms like indigestion, vomiting, and abdominal distension. The purpose of this study was to investigate the mechanism of digestive function activation through network pharmacology, particularly focused on improving functional dyspepsia. Methods : The two components, Coptidis Rhizoma and Evodiae Fructus, constituting Zuojin Pill were analyzed based on broad information on chemical and pharmacological properties, confirming 40 active compounds and 115 digestive-related molecular targets. Concentration analysis revealed impacts on various pathways related to digestive functions. Results : According to network pharmacological analysis of Zuojin Pill, quercetin and beta-sitosterol were exhibited relatively numerous targets, suggesting their potential significance in the therapeutic activity of Zuojin Pill and by a Protein-Protein Interaction (PPI) network, JUN, RELA, MAPK1, HSP90AA1, TP53, TNF, AKT1, IL6, MAPK14, ESR1, FOS, MYC were identified. Also, berberine exhibited the highest contribution index (92.58%), indicating that this compound may be a major contributor to the digestive activity of Zuojin Pill. Additionally, functional interaction analysis by GeneMANIA indicated that targets of Zuojin Pill could functionally interact through various mechanisms, implying similarities in pharmacological roles. Conclusions : These findings contribute valuable insights into the digestive function activation mechanism and highlight the therapeutic potential of Zuojin Pill in improving functional dyspepsia.

Keywords

Acknowledgement

이 논문은 2021년도 정부(교육부)의 재원으로 한국연구재단의 지원을 받아 수행된 기초연구사업임 (No. 2021R1I1A3042479).

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