• Journal of Life Science
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• v.32 no.2
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• pp.86-93
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• 2022

Lupeol is a type of pentacyclic triterpene and has been reported to have pharmacological activities against various diseases; however, the effect of lupeol on glucose absorption has not been elucidated yet. This study aimed to investigate the effect of lupeol on glucose uptake in 3T3-L1 adipocytes. Lupeol significantly facilitated glucose uptake by translocating glucose transporter type 4 (GLUT4) to the plasma membrane of the 3T3-L1 adipocytes, which was related to activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and 5 'adenosine monophosphate-activated protein kinase (AMPK) pathways. In the PI3K/AKT pathway, lupeol stimulates the phosphorylation of insulin receptor substrate 1 (IRS-1), which activates PI3K. Its activation by lupeol promotes the phosphorylation of AKT, but not the atypical protein kinase C isoforms ζ and λ. Lupeol also promoted the phosphorylation of AMPK. The activation of AMPK increased the expressions of the plasma membrane GLUT4 and the intracellular glucose uptake. The increase in the glucose uptake by lupeol was suppressed by wortmannin (PI3K inhibitor) and compound C (AMPK inhibitor) in the 3T3-L1 adipocytes. The results indicate that lupeol can facilitate glucose uptake by increasing insulin sensitivity through the stimulation of the expression of plasma membrane glucose transporter type 4 via the PI3K/AKT and AMPK pathways in the 3T3-L1 adipocytes.

• Korean Journal of Radiology
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• v.22 no.7
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• pp.1100-1109
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• 2021

Objective: To compare the diagnostic performance between Prostate Imaging-Reporting and Data System version 2.0 (PI-RADSv2.0) and version 2.1 (PI-RADSv2.1) for clinically significant prostate cancer (csPCa) in the peripheral zone (PZ). Materials and Methods: This retrospective study included 317 patients who underwent multiparametric magnetic resonance imaging and targeted biopsy for PZ lesions. Definition of csPCa was International Society of Urologic Pathology grade ≥ 2 cancer. Area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for csPCa were analyzed by two readers. The cancer detection rate (CDR) for csPCa was investigated according to the PI-RADS categories. Results: AUC of PI-RADSv2.1 (0.856 and 0.858 for reader 1 and 2 respectively) was higher than that of PI-RADSv2.0 (0.795 and 0.747 for reader 1 and 2 respectively) (both p < 0.001). Sensitivity, specificity, PPV, NPV, and accuracy for PI-RADSv2.0 vs. PI-RADSv2.1 were 93.2% vs. 88.3% (p = 0.023), 52.8% vs. 76.6% (p < 0.001), 48.7% vs. 64.5% (p < 0.001), 94.2% vs. 93.2% (p = 0.504), and 65.9% vs. 80.4% (p < 0.001) for reader 1, and 96.1% vs. 92.2% (p = 0.046), 34.1% vs. 72.4% (p < 0.001), 41.3% vs. 61.7% (p < 0.001), 94.8% vs. 95.1% (p = 0.869), and 54.3% vs. 78.9% (p < 0.001) for reader 2, respectively. CDRs of PI-RADS categories 1-2, 3, 4, and 5 for PI-RADSv2.0 vs. PI-RADSv2.1 were 5.9% vs. 5.9%, 5.8% vs. 12.5%, 39.8% vs. 56.2%, and 88.9% vs. 88.9% for reader 1; and 4.5% vs. 4.1%, 6.1% vs. 11.1%, 32.5% vs. 53.4%, and 85.0% vs. 86.8% for reader 2, respectively. Conclusion: Our data demonstrated improved AUC, specificity, PPV, accuracy, and CDRs of category 3 or 4 of PI-RADSv2.1, but decreased sensitivity, compared with PI-RADSv2.0, for csPCa in PZ.

• Journal of Institute of Control, Robotics and Systems
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• v.9 no.4
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• pp.259-269
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• 2003

This paper considers the problem of determining a set of PI, PD and PID controller gains, for a given linear time invariant plant, that meets or exceeds the closed loop step response specifications. The proposed method utilizes two recent results: for a given system, (1) finding a set of stabilizing PI, PD and PID gains and (2) the relationship between time response (overshoot and speed) and the coefficients of the characteristic polynomial. The method allows us to extract a subset of PI, PD and PID gains that meets stability as well as time domain performance requirements. The intersections of two dimensional sets described by linear and quadratic inequalities in the controller design space are need to be Identified through numerical computation. The procedure is illustrated by examples.

• Journal of Institute of Control, Robotics and Systems
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• v.15 no.3
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• pp.255-257
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• 2009

The robust stabilization problem of a multivariable uncertain system with a polytopic model is considered. A PI-type $H_{\infty}$ controller with a low pass filter is used for robust stabilization and noise rejection. The problem is reduced to an LMI optimization problem. A sufficient condition for the existence of the PI controller is derived in terms of LMIs. The PI gain matrices are parameterized by using the solution matrices to the existence conditions. Finally, a numerical design example is given.

• Journal of the Chungcheong Mathematical Society
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• v.21 no.3
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• pp.371-376
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• 2008

Let $P(M,G,{\pi})=:P$ be a principal fibre bundle with structure Lie group G over a base manifold M. In this paper we get the following facts: 1. The tangent bundle TG of the structure Lie group G in $P(M,G,{\pi})=:P$ is a Lie group. 2. The Lie algebra ${\mathcal{g}}=T_eG$ is a normal subgroup of the Lie group TG. 3. $TP(TM,TG,{\pi}_*)=:TP$ is a principal fibre bundle with structure Lie group TG and projection ${\pi}_*$ over base manifold TM, where ${\pi}_*$ is the differential map of the projection ${\pi}$ of P onto M. 4. for a Lie group $H,\;TH=H{\circ}T_eH=T_eH{\circ}H=TH$ and $H{\cap}T_eH=\{e\}$, but H is not a normal subgroup of the group TH in general.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.30B no.12
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• pp.87-97
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• 1993

To improve the limitation of fuzzy PI controller when is applied to systems of order higher than one, a fuzzy PI controller that fuzzily resets or amplifies the accumulated control input according to fuzzy rules defined on (error, change of error) space is proposed. The proposed controller structure was motivated by the characteristics of fuzzy PI controller that it generally gives unevitable large overshoot in trial of reducing rise time of response especially when a system of order higher than one is considered. Based on the observation that the undesirable characteristics of the fuzzy PI controller is caused by integrating control input excessively, even though the integrator is introduced to overcome steady state error, we propose a controller that clear out or doubles integrated control input in a fuzzy manner according to the situation to reduce rise time as well as overshoot. To show the usefulness of the proposed controller, it is applied to the systems that are difficult to stabilize or difficult to get satisfactory response by conventional fuzzy PI controllers.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2001.11a
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• pp.171-177
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• 2001

The adhesion enhancement from inserting a RF bias-sputtered Cr layer between Cu and polyimide (PI) has been studied. The RF bias power applied in this study was ranged from 0 to 400 W. Without the RF bias, the peel strength, which measures the adhesion strength, was nearly o g/mm. As the RF power was increased, the peel strength rose up to ~130 g/mm at 200 W, which remained constant with further increase of the RF bias power. Cross-sectional transmission electron microscopy(TEM) was used to investigate the interfacial reaction between the Cr film and PI substrate during the bias sputtering. The Cr/PI interface without the application of RF dais showed a clean, sharp interface while the RF raised Cr/PI interface had about 10~30 nm thick atomistically mixed interlayer between the metal film and PI substrate. This interlayer appeared to have resulted from the implantation of high energy adatoms during the RF bias sputtering of Cr film. This mixed layer serves as an interlocking layer, which enhances adhesion between the metal and PI layers.

• Proceedings of the KIPE Conference
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• 1997.07a
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• pp.357-363
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• 1997

The windup phenomenon appears and results in the performance degradation when the PI controller output is saturated. A new anti-windup PI controller is proposed to improve the control performance of the variable-speed motor drives and it is experimentally applied to the speed control of a vector-controlled induction motor driven by a pulse width modulated(PWM) voltage source inverter (VSI). The integral state is separately controlled corresponding to whether the PI controller output is saturated or not. The experimental results show that the speed response has the much improved performances such as small overshoot and fast settling time over the conventional anti-windup technique. Although the operating speed command is changed, the similar control performance can be obtained by using the PI gains selected in the linear region.

• Journal of Power System Engineering
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• v.20 no.4
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• pp.83-90
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• 2016

This study proposes a high-performance PI controller design method for an oil cooler system in conjunction with zero position adjustment and the characteristic parameters in its closed loop control system. The characteristic parameters included PI gains are decided by design specifications such as settling time and overshoot. The fine tuning on decided gains was performed by adjustment the zero position to get more desirable control performances. The simulations and experimental results show that the proposed PI controller design for an oil cooler system was possible to accomplish good control performances and to satisfy the design specifications.

• Bulletin of the Korean Mathematical Society
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• v.52 no.2
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• pp.439-452
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• 2015

In this paper we introduce and study the new properties ($W_{\Pi}$), ($UW_{{\Pi}_a}$), ($UW_E$) and ($UW_{\Pi}$). The main goal of this paper is to study relationship between these new properties and other Weyl type theorems. Moreover, we reconsider several earlier results obtained respectively in [11], [18], [14], [1] and [13] for which we give stronger versions.