• Elastomers and Composites
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• 제34권2호
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• pp.147-155
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• 1999

고무와 혼합된 왁스는 고무 표면으로 이동하여 방어막을 형성한다. 일반적으로 고무의 오존화를 방지하기 위해 오존노화방지제를 왁스와 함께 사용하고 있다. 다양한 종류의 왁스가 첨가된 천연고무 가류물을 이용하여 왁스막이 오존노화방지제의 이동에 미치는 영향을 연구하였다 오존노화방지제로 IPPD (N-isopropyl-N'-phenyl-p-phenylenediamine), HPPD (N-l,3-dimethylbutyl-N'-phenyl-p-phenylenediamine), SBPPD (N,N'-di(sec-butyl)-p-phenylenediamine), 그리고 DMPPD (N,N'-di(1,4-dimethylpentyl)-p-phenylenediamine)를 사용하였다. 노화방지제 이동 실험은 $60^{\circ}C$ 와 $80^{\circ}C$에서 10, 20, 30일간 실시하였다. 노화방지제의 이동속도는 고무가류물에 왁스가 없을 때가 있을 때보다 빨랐으며 분자량이 큰 왁스가 혼합되었을 때가 분자량이 작은 왁스가 혼합되었을 때보다 느렸다. DMPPD와 SBPPD의 이동속도가 HPPD와 IPPD의 이동속도보다 빨랐다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7687-7692
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• 2014

Aim: To observe the effects of a novel all-trans retinoid acid (ATRA) derivative, N-(3-trifluoromethyl-phenyl)-retinamide (ATPR), on lung adenocarcinoma A549 cells and to explore the potential mechanism of ATPR inhibiting of A549 cell migration. Materials and Methods: The cytotoxicity of ATRA and ATPR on A549 cells was assessed using MTT assay. Wound healing assays were used to analyze the influences of ATRA, ATPR, ML-7 (a highly selective inhibitor of myosin light chain kinase (MLCK)), PMA (an activator of MAPKs) and PD98059 (a selective inhibitor of ERK1/2) on the migration of A549 cells. Expression of MLCK and phosphorylation of myosin light chain (MLC) were assessed by Western blotting. Results: ATRA and ATPR inhibited the proliferation of A549 cells in a dose- and time-dependent manner, and the effect of ATPR was much more remarkable compared with ATRA. Relative migration rate and migration distance of A549 cells both decreased significantly after treatment with ATPR or ML-7. The effect on cell migration of PD98059 combining ATPR treatment was more notable than that of ATPR alone. Moreover, compared with control groups, the expression levels of MLCK and phosphorylated MLC in A549 cells were both clearly reduced in ATRA and ATPR groups. Conclusions: ATPR could suppress the migration and invasion of A549 cells, and the mechanism might be concerned with down-regulating the expression of MLCK in the ERK-MAPK signaling pathway, pointing to therapeutic prospects in lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7265-7270
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• 2013

Objective: The present study was designed to investigate the probable mechanisms of synthetic retinoid 4-amino-2-tri-fluoromethyl-phenyl ester (ATPR) inhibition of the proliferation and migration of A549 human lung carcinoma cells. Materials and Methods: After the A549 cells were treated with different concentrations of ATPR or all-trans retinoic acid (ATRA) for 72 h, scratch-wound assays were performed to assess migration. Immunofluorescence was used to determine the distribution of CAV1 and $RXR{\alpha}$, while expression of CAV1, MLCK, MLC, P38, and phosphorylation of MLC and P38 were detected by Western blotting. Results: ATPR could block the migration of A549 cells. The relative migration rate of ML-7 group had significantly decreased compared with control group. In addition, ATPR decreased the expression of a migration related proteins, MLCK, and phosphorylation of MLC and P38. ATPR could also influence the expression of RARs or RXRs. At the same time, CAV1 accumulated at cell membranes, and $RXR{\alpha}$ relocated to the nucleus after ATPR treatment. Conclusions: Caveolae may be implicate in the transport of ATPR to the nucleus. Change in the expression and distribution of $RXR{\alpha}$ may be implicated in ATPR inhibition of A549 cell proliferation. The mechanisms of ATPR reduction in A549 cell migration may be associated with expression of MLCK and phosphorylation of MLC and P38.

• Bulletin of the Korean Chemical Society
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• 제18권6호
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• pp.657-662
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• 1997

Gas-phase phenyl group migration within the protonated ketones has been studied MO theoretically using the AM1 method. The initial state structure shows relatively strong resonance delocalization of positive charge into the nonmigrating (Y) ring, while the ring migration (Z-ring) is nearly complete in the transition state. These results are reflected in the large $p^+_Z$ (<0) and $p^+_$Y (>0) values and in the predominant contribution of resonance (r) over inductive (field, f) effect, r/f ranging from 1.3 ($p^+_r$) to 1.5 ($p^+_z$). The cross-interaction constant $p_{YZ}$ is vanishingly small ($p_{YZ}$=0.03) which is in contrast to the larger magnitudes for benzilic ($p_{YZ}$=-0.48) and azibenzil ($p_{YZ}$=-0.53) rearrangement processes. The relationship found between the extent of resonance contribution in the initial state and the magnitude of $p_{YZ}$ provides strong support for the proportionality between the magnitude of $p_{YZ}$ and the change in the intensity of interaction, ${\Delta}I^{\cdot}_{YZ}$, in the activation process.

• Rapid Communication in Photoscience
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• 제2권1호
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• pp.31-33
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• 2013

The irradiation of electron-beam onto bis-(diphenylphosphino)methane, ethane, propane and butane initiated phenyl-shift from a phosphine to another phosphine atom and subsequent fragmentation resulted in the formation of triphenylphosphine derivative as key intermediate. The mechanism of those processes is speculated.

• Bulletin of the Korean Chemical Society
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• 제18권2호
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• pp.218-221
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• 1997

When phenylation of styrene was carried out in the presence of Pd(OAc)2 and PPh3 in benzene, trans-stilbene was obtained in good yield (566%) with high selectivity (98%) under mild condition (55 ℃, 50 psi O2, 20 h). Since trans-stilbene could be produced not only from benzene but also from phenyl group of PPh3 by migration of its phenyl group to Pd, the competitiveness of benzene and the migratory aptitude of aryl group of triarylphosphine toward styrene has been investigated with various phosphines (PR3: P(p-C6H4CH3)3, P(p-C6H4OCH3)3, P(p-C6H4F)3, P(p-C6H4Cl)3, P(C6H5)3, P(C6H11)3, P(OC4H9n)3, P(CH2C6H5)3 and P(C6F5)3). The yield and selectivity toward trans-stilbene are increased as the basicity of the phosphines increases. The composition of arylated olefin from arylphosphine, in turn, increases as the electronegativity of the substituent on the aryl group of arylphosphines increases.

• 한국의류산업학회지
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• 제5권5호
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• pp.545-549
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• 2003

Dyeing properties such as migration of disperse dye and color fastness of 4 types of the carrier[Carrier-I(methyl napthalene). Carrier-II(chloro benzene). Carrier-III(aromatic ether) and Carrier-IV(o-phenyl phenol)] were evaluated for the study. For the results, the optimum dyeing time and concentration of the carrier was 30min at $110^{\circ}C$ and 2g/l, respectively. The redyeing ratio of the fabric samples treated with Carrier-II and III was higher than that treated with Carrier-I and IV, thus, if was conclude that the redyeing ratio of the samples treated with Carrier-II and III was excellent. The light fastness of the samples treated with Carrier-III and IV was higher than that of Carrier-I and II in order of 2-4 grades. However, there were little changes in terms of washing and sublimation and rubbing fastness for the samples.

• Bulletin of the Korean Chemical Society
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• 제21권5호
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• pp.477-482
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• 2000

Phenyl group migration within protonated 1,2-diphenyl hydrazines has been studied theoretically using the semi-empirical AM1 method. This reaction proceeds through a 3-membered cyclic transition state and requires high activation energy. In the reactant, there was no resonance stabilization for the moving Z-ring, however, hammett $p_Z^+$ values are large due to the direct involvement of the Z-ring inthe reaction, and the development of a negative charge on the reaction center gives them a posifive value. In the case of the non-moving ring, $p_Y^+$ values are small and negative owing to the smaller positive charge increase in the reaction center. The cross-interaction constant, $p_YZ^+$, was obtained from the activation enthalpies, using the multipe linear regression methdo, and the interaction between two substituents, Y and Z, is examined.

• Archives of Pharmacal Research
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• 제26권9호
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• pp.667-678
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• 2003

We examined the effect of p-substituents in p-substituted cinnamyl methyl ethers and 1-(p-substituted phenyl)allyl methyl ethers with CSI, and confirmed that the CSI reaction of allyl ethers (p-substituted ethers) is a competitive reaction of $S_Ni{\;}and{\;}S_N1$ mechanism according to the stability of the carbocation. And, the only terminal allylic amine was obtained through the migration reaction in thermodynamic reaction condition.

• 농약과학회지
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• 제8권3호
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• pp.175-183
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• 2004

신규한 벼 제초제 후보화합물 EK-3439 [3-chloro-2-[4-chlore-2-fluoro-5-(5-methyl-3-phenyl-4,5-dihydroisoxazol-5-yl-methoxy)-phenyl]-4,5,6,7-tetrahydro-2H-indazole]의 실용화를 위한 선택성과 토양 중 행동특성을 조사하였다. 직파 벼와 피 간의 선택성은 파종 후 4일 이내에 처리할 경우에 높게 나타났으며, 처리 후 12시간이 경과되면 환수되어도 제초효과의 변동이 일어나지 않았다. EK-5439와 oxadiazon은 모두 토양 중 이동 폭이 5cm/일의 누수 조건에서 1 cm 이내 이었다. EK-5439의 잔효 반감기는 6.1일 이었고, 동일 조건에서 oxadiazon은 9.6일 이었다. 토양 점토광물 bentonite에 의한 흡착은 oxadiazon에 비하여 상대적으로 큰 것으로 나타났으며 흡착력을 간단하게 평가하는 새로운 방법을 적용하였다.